Yimuphi umdlavuza ongahlomula ngokufaka i-Lions Mane Mushroom ekudleni kwawo?

Amaphuzu avelele

I-Lions Mane Mushroom yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Lions Mane Mushroom ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Lions Mane Mushroom ingase izuze labo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Adamantinoma. Ngaphezu kwalokho, nakuba i-Lions Mane Mushroom ingasiza abantu abane-genetic risk factor "CDH1", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "CALR". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Lions Mane Mushroom esigulini somdlavuza kudinga umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Lions Mane Mushroom iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana neLions Mane Mushroom esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Lions Mane Mushroom ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Lions Mane Mushroom uma une-genetic predisposition to cancer ehambisana ne-CDH1 gene? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo isukela esakhiwo sofuzo se-CALR? Ingabe kunenzuzo ukufaka i-Lions Mane Mushroom ekudleni kwakho uma kutholakala ukuthi une-Primary Adamantinoma, noma uma ukuxilongwa kwakho kuyi-Primary Penile Squamous Cell Carcinoma? Ngaphezu kwalokho, indlela odla ngayo i-Lions Mane Mushroom kufanele ilungiswe kanjani uma welashelwa i-Mitomycin noma uma uhlelo lwakho lokwelapha lusuka ku-Mitomycin luye ku-Radiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Lions Mane Mushroom ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'I-Lions Mane Mushroom ithuthukisa ukungatheleleki' azanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Lions Mane Mushroom ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Lions Mane Mushroom ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo, nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Penile Squamous Cell Carcinoma noma i-Primary Adamantinoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokudla okudliwayo, njenge-Lions Mane Mushroom. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguqulwa kwe-CDH1 inemithelela efanayo ye-biochemical pathway njengoguquko ku-CALR? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Penile Squamous Cell Carcinoma bulingana ne-Primary Adamantinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Mitomycin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Lions Mane Mushroom - Isengezo Sokudla Okunomsoco

Isengezo se-Lions Mane Mushroom sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Hericerin A, i-Hericerin, i-Hericenone, i-Hep ne-Heg5, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-NFKB Signaling, Oxidative Stress, Histone/Protein Acetylation kanye ne-PI3K-AKT-MTOR Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Njengoba kunikezwe leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Lions Mane Mushroom, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Lions Mane Mushroom umdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Lions Mane Mushroom akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa komuntu siqu.

Ukukhetha Izithasiselo ze-Mushroom zamabhubesi

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngigweme khona i-Lions Mane Mushroom esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - kumane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Lions Mane Mushroom kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Lions Mane Mushroom ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokwenziwa komuntu siqu. ukucatshangelwa ezinqumweni ezinjalo.

1. Ingabe Izithasiselo Zamakhowe Ezine-Lions Mane zizosiza Iziguli Eziyinhloko ze-Adamantinoma ezelashwa ngeRadiation?

I-Adamantinoma eyinhloko ibonakala ngokuguqulwa okuthile kofuzo, okuyi-ARHGAP45, PI4KB kanye ne-SDSL, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Oxidative Stress kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isengezo se-Lions Mane Mushroom, esithinta i-Oxidative Stress, singase singabi yisinqumo esilungile esimweni se-Primary Adamantinoma lapho sithola iRadiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Zamakhowe Ezine-Lions Mane zizosiza Iziguli Eziyinhloko Zomdlavuza We-Penile Squamous Cell Ezokwelapha I-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ABRAXAS1, PIK3CB kanye ne-NUP93, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-NFKB Signaling, Hematopoiesis kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Mitomycin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isengezo se-Lions Mane Mushroom siyindlela enengqondo kulabo abane-Primary Penile Squamous Cell Carcinoma abathola i-Mitomycin. Lokhu kungenxa yokuthi i-Lions Mane Mushroom ithonya izindlela ezifana ne-NFKB Signaling, engavimbela izici ezishayela i-Primary Penile Squamous Cell Carcinoma noma izuzise ukusebenza kwe-Mitomycin.

3. Ingabe Izithasiselo Zekhowe Lomhlwenga Ziphephile Kubantu Abanempilo Ene-CALR Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Isakhi sofuzo se-CALR sivame ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-CALR kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-Histone/Protein Acetylation kanye ne-Antigen Presentation, ezihileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Uma iphaneli yofuzo ihlonza ukuguqulwa kwe-CALR okuhlobene nengozi eyengeziwe ye-Myeloproliferative Neoplasms, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesengezo se-Lions Mane Mushroom. Lokhu kungenxa yokuthi isengezo se-Lions Mane Mushroom sithonya izindlela ezifana ne-Histone/Protein Acetylation, ezingaholela emiphumeleni emibi kumongo wokuguqulwa kwe-CALR kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Zekhowe Lomhlwenga Ziphephile Kubantu Abanempilo Enempilo Ene-CDH1 Mutation Associated Genetic Risk?

I-CDH1 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezinguquko ku-CDH1 kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-PI3K-AKT-MTOR Signaling, i-Adherens junction kanye ne-Epithelial to Mesenchymal Transition, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-CDH1 ehambisana Nomdlavuza Wesisu, cabanga ukufaka izithasiselo ze-Lions Mane Mushroom ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-PI3K-AKT-MTOR Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-CDH1 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-Lions Mane Mushroom, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Iqhaza le-KEAP1/NRF2 kanye ne-TP53 Ukuguqulwa Kwe-Lung Squamous Cell Carcinoma Development kanye Nokumelana Nemisebe.
• Ukuhlukaniswa nokuhlonza izinhlanganisela ezinamakha e-Lion's Mane Mushroom kanye nemisebenzi yazo yokulwa nomdlavuza.
• cBioPortal for Cancer Genomics
• I-Hericium erinaceus polysaccharide-protein HEG-5 ivimbela ukukhula kweseli ye-SGC-7901 ngokuboshwa komjikelezo weseli kanye ne-apoptosis.
• Imiphumela ye-Antihyperglycaemic kanye ne-organic protective ku-pancreas, isibindi nezinso ngama-polysaccharides avela ku-Hericium erinaceus SG-02 kumagundane e-diabetesic streptozotocin-induced.
• cBioPortal for Cancer Genomics
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• I-Piperine (PP) yokwelashwa kwe-mitomycin-C (MMC) ethuthukisiwe yomdlavuza womlomo wesibeletho womuntu ngokucindezela indlela yokusayina ye-Bcl-2 ngokuvala i-STAT3/NF-κB.
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• Uhlelo lokuhlola lokuhlukaniswa kwama-polysaccharides avela kumzimba othela izithelo we-Hericium erinaceus kanye nokuhlonza umkhiqizo wawo wokuthengisa.
• Ukwakhiwa kanye nomsebenzi we-antioxidant wama-oligosaccharides ancibilikayo emanzini avela ku-Hericium erinaceus.
• Ukwakhiwa Kwamakhemikhali kanye Ne-Macrophage Activation ye-Polysaccharides evela ku-Leon's Mane Culinary-Medicinal Mushroom Hericium erinaceus (i-Basidiomycetes Ephakeme) Ezigabeni Ezihlukene Zokuvuthwa.
• I-Benzyl alcohol derivatives evela ku-mushroom I-Hericium erinaceum inciphisa impendulo yokuvuvukala evuselelwe i-LPS ngokulawulwa komsebenzi we-NF-κB kanye ne-AP-1.