Yimuphi umdlavuza ongazuza ngokufaka i-Indole-3-carbinol ekudleni kwabo?

Amaphuzu avelele

I-Indole-3-carbinol yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Indole-3-carbinol yeziguli ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Indole-3-carbinol ingazuzisa labo abane-Primary Basal Cell Carcinoma abathola i-Vismodegib. Ngaphezu kwalokho, nakuba i-Indole-3-carbinol ingasiza abantu abane-genetic risk factor "TERT", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Indole-3-carbinol yesiguli esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Indole-3-carbinol iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo zokudla/izithasiselo ezifana ne-Indole-3-carbinol esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Indole-3-carbinol ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Indole-3-carbinol uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-TERT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Indole-3-carbinol ekudleni kwakho uma kutholakala ukuthi une-Primary Basal Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Indole-3-carbinol kufanele kulungiswe kanjani uma welashwa nge-Vismodegib noma uma uhlelo lwakho lokwelapha lusuka ku-Vismodegib? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana ne-'Indole-3-carbinol kungokwemvelo, ngakho kuhlale kunenzuzo' noma 'I-Indole-3-carbinol boosts immune' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Indole-3-carbinol ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Indole-3-carbinol ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, izindlela zokwelapha ezithile ozithathayo. okwenzekayo, izakhi zofuzo, nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Basal Cell Carcinoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-Indole-3-carbinol. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-TERT inemithelela efanayo ye-biochemical pathway njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Basal Cell Carcinoma ilingana nomunye umdlavuza? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola olunye ukwelashwa njengalabo abathola i-Vismodegib? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Indole-3-carbinol - Isengezo Sokudla Okunomsoco

Isithasiselo se-Indole-3-carbinol sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Indole-3-carbinol, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Inositol Phosphate Signaling, i-DNA Repair kanye ne-Cell Cycle, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele njenge-Indole-3-carbinol, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Indole-3-carbinol yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Indole-3-carbinol akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako ze-Indole-3-carbinol

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Indole-3-carbinol esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Indole-3-carbinol kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Indole-3-carbinol ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka. yokucatshangelwa komuntu siqu ezinqumweni ezinjalo.

1. Ingabe I-Indole-3-carbinol Supplements izozizuzisa Iziguli Eziyinhloko ze-Basal Cell Carcinoma ezenza Ukwelashwa kwe-Vismodegib?

I-Primary Basal Cell Carcinoma ibonakala ngokuguqulwa kofuzo okuthile, okufana ne-PTCH1, CSMD3 kanye ne-CSMD1, okuholela ezinguqukweni zezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Vismodegib, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Indole-3-carbinol siyinketho enengqondo kulabo abane-Primary Basal Cell Carcinoma ababhekana ne-Vismodegib. Lokhu kungenxa yokuthi i-Indole-3-carbinol ithonya izindlela ezifana ne-Inositol Phosphate Signaling, engavimbela izici ezishayela i-Primary Basal Cell Carcinoma noma izuzise ukusebenza kahle kwe-Vismodegib.

2. Ingabe Izithasiselo ze-Indole-3-carbinol Ziphephile Kubantu Abanempilo Ene-TERT Mutation Associated Genetic Risk?

I-TERT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-TERT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Cell Cycle kanye ne-DNA Repair, okunomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula uguquko ku-TERT ehambisana Nomdlavuza Wegazi, cabanga ukufaka izithasiselo ze-Indole-3-carbinol ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle, zizuze ngokunikeza ukwesekwa okufanelekile kwabantu abanezinguquko ze-TERT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Indole-3-carbinol, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• I-Molecular Landscape ye-Recurrent and Metastatic Head and Neck Cancers: Imibono Evela Ku-Precision Oncology Sequencing Platform.
• I-Indole-3-carbinol ivimbela ukwanda kwamaseli futhi ibangele i-apoptosis kumaseli omdlavuza we-Hep-2 laryngeal.
• cBioPortal for Cancer Genomics
• I-Indole-3-carbinol (I3C) inyusa i-apoptosis, icindezela ukukhula kwamangqamuzana omdlavuza, futhi ithuthukise i-oncolysis ye-adenovirus-mediated.
• Ukulahlekelwa kwe-PTEN kunciphisa impendulo ye-medulloblastoma ekuvinjweni kwendlela ye-Hedgehog.