Imuphi umdlavuza ongahlomula ngokufaka i-Horse Chestnut ekudleni kwawo?

Amaphuzu avelele

I-Horse Chestnut yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Horse Chestnut ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Horse Chestnut ingase izuze labo abane-Primary Mucosal Melanoma ye-Urethra abathola i-Doxorubicin, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Sclerosing Epithelioid Fibrosarcoma. Ngaphezu kwalokho, ngenkathi i-Horse Chestnut ingasiza abantu abane-genetic risk factor "CDH1", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ASXL1". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Horse Chestnut esigulini somdlavuza kudinga ukwenziwa komuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Horse Chestnut iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/ezengezo ezifana ne-Horse Chestnut esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukusishaya indiva ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Horse Chestnut ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyatuseka ukuthi udle i-Horse Chestnut uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana ne-CDH1? Kuthiwani uma esikhundleni salokho ubungozi bakho bofuzo busukela kufuzo lwe-ASXL1? Ingabe kunenzuzo ukufaka i-Horse Chestnut ekudleni kwakho uma kutholakala ukuthi une-Primary Sclerosing Epithelioid Fibrosarcoma, noma uma ukuxilongwa kwakho kuyi-Primary Mucosal Melanoma ye-Urethra? Ngaphezu kwalokho, ukusebenzisa kwakho i-Horse Chestnut kufanele kulungiswe kanjani uma welashelwa i-Doxorubicin noma uma uhlelo lwakho lokwelapha lusuka ku-Doxorubicin luye kuMisebe? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Chestnut Yehhashi ingokwemvelo, ngakho ihlale inenzuzo' noma 'i-Horse Chestnut boosts immune' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Horse Chestnut ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Horse Chestnut ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Mucosal Melanoma ye-Urethra noma i-Primary Sclerosing Epithelioid Fibrosarcoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lomuntu ngamunye, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. .”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeHorse Chestnut. Ingabe ingozi yofuzo yomdlavuza esukela ekuguqukeni kwe-CDH1 inemithelela efanayo ye-biochemical pathway njengokuguqulwa kwe-ASXL1? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Mucosal Melanoma ye-Urethra bulingana ne-Primary Sclerosing Epithelioid Fibrosarcoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Doxorubicin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Horse Chestnut – Isengezo Esinomsoco

Isithasiselo se-Horse Chestnut sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Esculin ne-Aescin, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi I-Cell Cycle Checkpoints, i-TGFB Signaling and Inflammation, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele ezifana ne-Horse Chestnut, iyodwa noma ihlangene, iba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Horse Chestnut yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Horse Chestnut akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo ze-Chestnut Yamahhashi

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngigweme i-Horse Chestnut esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - kumane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Horse Chestnut kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Horse Chestnut ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe Izithasiselo ze-Horse Chestnut zizosizakala Iziguli Eziyi-Primary Sclerosing Epithelioid Fibrosarcoma ezelashwa ngeRadiation?

I-Primary Sclerosing Epithelioid Fibrosarcoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-PBRM1, ATRX kanye ne-PIK3C2G, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-TGFB Signaling kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Horse Chestnut, esithinta i-TGFB Signaling, kungase kungabi inketho elungile esimweni se-Primary Sclerosing Epithelioid Fibrosarcoma lapho ubhekene neRadiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Ze-Chestnut Yehhashi zizozuza I-Primary Mucosal Melanoma ye-Urethra Ezigulini ezelashwa nge-Doxorubicin?

I-Primary Mucosal Melanoma ye-Urethra ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-TP53, SMARCA4 kanye ne-FAT1, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi i-Cell Cycle Checkpoints, i-Apoptosis, i-Androgen Signaling kanye ne-Chromatin Remodeling. Ukusebenza kokwelashwa komdlavuza, njenge-Doxorubicin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Horse Chestnut siyindlela enengqondo kulabo abane-Primary Mucosal Melanoma ye-Urethra abathola i-Doxorubicin. Lokhu kungenxa yokuthi i-Horse Chestnut ithonya izindlela ezifana ne-Cell Cycle Checkpoints, engavimbela izici ezishayela i-Primary Mucosal Melanoma ye-Urethra noma izuzise ukusebenza kahle kwe-Doxorubicin.

3. Ingabe Izithasiselo Ze-Chestnut Yamahhashi Ziphephile Kubantu Abanempilo Nge-ASXL1 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ASXL1 luvamise ukufakwa kulawa maphaneli okuhlolwa kwengozi yomdlavuza.

Ukuguqulwa kwezakhi zofuzo ze-ASXL1 kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-Inflammation, i-Oncogenic Cancer Epigenetics kanye ne-Suppressive Histone Methylation, ehileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza uguquko ku-ASXL1 ehambisana nengozi eyengeziwe ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesithasiselo se-Horse Chestnut. Lokhu kungenxa yokuthi ukwengezela i-Horse Chestnut kuthonya izindlela ezifana nokuvuvukala, okungaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ASXL1 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Chestnut Yamahhashi Ziphephile Kubantu Abanempilo Ene-CDH1 Mutation Associated Genetic Risk?

I-CDH1 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-CDH1 kungaphazamisa izindlela ezibucayi zamakhemikhali ezinto eziphilayo, okuhlanganisa I-Cell Cycle Checkpoints, i-Adherens junction kanye ne-Epithelial to Mesenchymal Transition, okuthonya ukukhula komdlavuza. Uma iphaneli yakho yofuzo yembula uguquko ku-CDH1 ehambisana Nomdlavuza Wesisu, cabanga ukufaka izithako ze-Horse Chestnut ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle Checkpoints, zihlomule ngokunikeza ukwesekwa okufanelekile kwabantu abanezinguquko ze-CDH1 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla kanye nezithako ezifana ne-Horse Chestnut, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

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• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• Ukumelana nomsakazo kumaseli omdlavuza webele kulamula nge-TGF-β signalling, hybrid epithelial-mesenchymal phenotype kanye namaseli omdlavuza.