Yimuphi umdlavuza ongazuza ngokufaka i-Gamma-linolenic Acid ekudleni kwabo?

Amaphuzu avelele

I-Gamma-linolenic Acid yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kwe-Gamma-linolenic Acid ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Gamma-linolenic Acid ingase izuze labo abane-Primary Mucinous colorectal adenocarcinoma abathola i-Cetuximab, kodwa ingase ingabi yinhle ezigulini ezithola i-Radiation for Primary Embryonal Carcinoma. Ngaphezu kwalokho, nakuba i-Gamma-linolenic Acid ingasiza abantu abanengozi yofuzo “CDH1”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Gamma-linolenic Acid esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Gamma-linolenic Acid iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izakhi ezisebenzayo ekudleni/izithasiselo ezifana ne-Gamma-linolenic Acid esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Gamma-linolenic Acid ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyatuseka ukuthi udle i-Gamma-linolenic Acid uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana ne-CDH1? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Gamma-linolenic Acid ekudleni kwakho uma kutholakala ukuthi une-Primary Embryonal Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Mucinous colorectal adenocarcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Gamma-linolenic Acid kufanele kulungiswe kanjani uma welashwa nge-Cetuximab noma uma uhlelo lwakho lokwelapha lusuka ku-Cetuximab luye kwiRadiation? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana ne-'Gamma-linolenic Acid kungokwemvelo, ngakho kuhlale kunenzuzo' noma 'i-Gamma-linolenic Acid boosts immune' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Gamma-linolenic Acid ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Gamma-linolenic Acid ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele yonke imiphumela ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo. , izakhi zofuzo, nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Mucinous colorectal adenocarcinoma noma i-Primary Embryonal Carcinoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-Gamma-linolenic Acid. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguquka kwezakhi zofuzo ku-CDH1 inemithelela efanayo ye-biochemical pathway njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Mucinous colorectal adenocarcinoma bulingana ne-Primary Embrynal Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Cetuximab? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kwabantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Gamma-linolenic Acid - Isengezo Somsoco

Isithasiselo se-Gamma-linolenic Acid sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Gamma-linolenic Acid, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Growth Factor Signaling, i-Oxidative Stress kanye ne-Complement Cascade, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Gamma-linolenic Acid, iyodwa noma ihlangene, kuba yisinqumo esibalulekile kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Gamma-linolenic Acid yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Gamma-linolenic Acid akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa komuntu siqu.

Ukukhetha Izithasiselo ze-Gamma-linolenic Acid

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Gamma-linolenic Acid esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - kumane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Gamma-linolenic Acid kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Gamma-linolenic Acid ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka ukucatshangelwa komuntu siqu ezinqumweni ezinjalo.

1. Ingabe Izithasiselo ze-Gamma-linolenic Acid zizozizuzisa Iziguli Eziyi-Primary Embrynal Carcinoma ezelashwa ngeRadiation?

I-Primary Embryonal Carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-CAPN7, B3GNT8 kanye ne-KNTC1, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi I-Oxidative Stress. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Gamma-linolenic Acid, esithinta i-Oxidative Stress, singase singabi yinketho elungile esimweni se-Primary Embryonal Carcinoma lapho sithola i-Radiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Gamma-linolenic Acid zizozizuzisa Iziguli Eziyi-Primary Mucinous colorectal adenocarcinoma ezelashwa nge-Cetuximab?

I-Primary Mucinous colorectal adenocarcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TTN, i-APC ne-KRAS, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi i-Angiogenesis, i-G-protein-coupled Receptor Signaling kanye ne-Growth Factor Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Cetuximab, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Gamma-linolenic Acid siyinketho enengqondo yalabo abane-Primary Mucinous colorectal adenocarcinoma abathola i-Cetuximab. Lokhu kungenxa yokuthi i-Gamma-linolenic Acid ithonya izindlela ezifana ne-Growth Factor Signaling, engavimbela izici ezishayela i-Primary Mucinous colorectal adenocarcinoma noma izuzise ukusebenza kahle kwe-Cetuximab.

3. Ingabe Izithasiselo Ze-Gamma-linolenic Acid Ziphephile Kubantu Abanempilo Ene-CDH1 Mutation Associated Genetic Risk?

I-CDH1 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-CDH1 kungaphazamisa izindlela ezibalulekile zamakhemikhali ezinto eziphilayo, okuhlanganisa i-Growth Factor Signaling, i-Adherens junction kanye ne-Epithelial to Mesenchymal Transition, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-CDH1 ehambisana Nomdlavuza Wesisu, cabanga ukufaka izithasiselo ze-Gamma-linolenic Acid ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Growth Factor Signaling, zizuze ngokunikeza ukwesekwa okufanelekile kubantu abanezinguquko ze-CDH1 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-Gamma-linolenic Acid, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Iqhaza le-KEAP1/NRF2 kanye ne-TP53 Ukuguqulwa Kwe-Lung Squamous Cell Carcinoma Development kanye Nokumelana Nemisebe.
• Umthelela we-gamma-linolenic acid kumsebenzi wokuloba we-Her-2/neu (erbB-2) oncogene.
• Inkundla enezichasiselo ze-molecularly yama-xenografts asuselwa esigulini (iziguli zangaphandle”) ihlonza i-HER2 njengendlela yokwelapha esebenzayo kumdlavuza we-colorectal ongamelana ne-cetuximab.”
• Ucwaningo nge-Rett syndrome: isu kanye nemiphumela yokuqala.
• cBioPortal for Cancer Genomics
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• cBioPortal for Cancer Genomics
• Amaphethini Eseli-Omsuka Abusa Ukuhlukaniswa Kwemolekyuli Yezimila Eziyi-10,000 Ezinhlotsheni Ezingu-33 Zomdlavuza.