Yimuphi umdlavuza ongazuza ngokufaka i-Epigallocatechin Gallate ekudleni kwabo?

Amaphuzu avelele

I-Epigallocatechin Gallate yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Epigallocatechin Gallate ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Epigallocatechin Gallate ingazuzisa labo abane-Primary Spindle Cell Sarcoma abathola i-Vinorelbine, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Adamantinoma. Ngaphezu kwalokho, nakuba i-Epigallocatechin Gallate ingasiza abantu abanesici esiyingozi sofuzo, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "KIT". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Epigallocatechin Gallate esigulini esinomdlavuza kudinga ukwenziwa komuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Epigallocatechin Gallate iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/kwezithasiselo ezifana ne-Epigallocatechin Gallate esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Epigallocatechin Gallate ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyatuseka ukuthi udle i-Epigallocatechin Gallate uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela ohlotsheni lofuzo lwe-KIT? Ingabe kunenzuzo ukufaka i-Epigallocatechin Gallate ekudleni kwakho uma kutholakala ukuthi une-Primary Adamantinoma, noma uma ukuxilongwa kwakho kuyi-Primary Spindle Cell Sarcoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Epigallocatechin Gallate kufanele kulungiswe kanjani uma welashelwa i-Vinorelbine noma uma uhlelo lwakho lokwelapha lusuka ku-Vinorelbine luye kuMisebe? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana ne-'Epigallocatechin Gallate kungokwemvelo, ngakho-ke kuhlale kunenzuzo' noma 'I-Epigallocatechin Gallate ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Epigallocatechin Gallate ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Epigallocatechin Gallate ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kofuzo kunikeza isithembiso esibalulekile ekuhloleni ubungozi bomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma sekutholakele ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Spindle Cell Sarcoma noma i-Primary Adamantinoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-Epigallocatechin Gallate. Ingabe ingozi yofuzo yomdlavuza esukela ekuguqukeni kofuzo olulodwa inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-KIT? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Spindle Cell Sarcoma bulingana ne-Primary Adamantinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Vinorelbine? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Epigallocatechin Gallate – Isengezo Esinomsoco

Isengezo se-Epigallocatechin Gallate sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Epigallocatechin Gallate, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Microtubule Dynamics kanye ne-Oxidative Stress, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele njenge-Epigallocatechin Gallate, iyodwa noma ihlangene, kuba yisinqumo esibalulekile kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Epigallocatechin Gallate yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Epigallocatechin Gallate akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa komuntu siqu.

Ukukhetha Epigallocatechin Gallate Izithako

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Epigallocatechin Gallate esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Epigallocatechin Gallate kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Epigallocatechin Gallate ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe Izengezo ze-Epigallocatechin Gallate zizozizuzisa Iziguli Eziyinhloko ze-Adamantinoma ezelashwa ngeRadiation?

I-Adamantinoma eyinhloko ibonakala ngokuguqulwa okuthile kofuzo, okuyi-ARHGAP45, PI4KB kanye ne-SDSL, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Oxidative Stress kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Epigallocatechin Gallate, esithinta i-Oxidative Stress, singase singabi inketho efanele esimweni se-Primary Adamantinoma lapho sibhekene Nokukhishwa Kwemisebe. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izengezo ze-Epigallocatechin Gallate zizozizuzisa Iziguli Eziyinhloko Ze-Spindle Cell Sarcoma ezelashwa nge-Vinorelbine?

I-Primary Spindle Cell Sarcoma ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-ATRX, MED12 kanye ne-TERT, okuholela ezinguqukweni zezindlela ze-biochemical, ikakhulukazi i-Microtubule Dynamics, i-TGFB Signaling, i-Cell Cycle Checkpoints ne-Apoptosis. Ukusebenza kokwelashwa komdlavuza, njengeVinorelbine, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Epigallocatechin Gallate siyinketho enengqondo kulabo abane-Primary Spindle Cell Sarcoma abathola i-Vinorelbine. Lokhu kungenxa yokuthi i-Epigallocatechin Gallate ithonya izindlela ezifana ne-Microtubule Dynamics, engavimbela izici ezishayela i-Primary Spindle Cell Sarcoma noma izuzise ukusebenza kahle kwe-Vinorelbine.

3. Ingabe Izithasiselo ze-Epigallocatechin Gallate Ziphephile Kubantu Abanempilo Enempilo Nge-KIT Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-KIT luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-KIT kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana ne-Oxidative Stress kanye ne-Growth Factor Signaling, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza ukuguqulwa kwezakhi zofuzo ku-KIT okuhlobene nengozi eyengeziwe Yomdlavuza Wesisu, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesithasiselo se-Epigallocatechin Gallate. Lokhu kungenxa yokuthi isengezo se-Epigallocatechin Gallate sithonya izindlela ezifana ne-Oxidative Stress, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-KIT kanye nezimo zomdlavuza ezihlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-Epigallocatechin Gallate, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Iqhaza le-KEAP1/NRF2 kanye ne-TP53 Ukuguqulwa Kwe-Lung Squamous Cell Carcinoma Development kanye Nokumelana Nemisebe.
• cBioPortal for Cancer Genomics
• I-Theaflavin ne-epigallocatechin-3-gallate zenza i-apoptosis ngendlela efanayo ivimbele ukusayina kwe-PI3K/Akt ekukhipheni ama-microtubules kumaseli e-HeLa.
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• Umphumela wama-antimicrotubule agents on signal transduction pathways of apoptosis: ukubuyekezwa.
• cBioPortal for Cancer Genomics