Yimuphi umdlavuza ongazuza ngokufaka i-dandelion ekudleni kwabo?

Amaphuzu avelele

I-Dandelion yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kweDandelion ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Dandelion ingase izuze labo abane-Primary Solitary Fibrous Tumor abathola i-Avastin, kodwa ingase ingabi yinhle ezigulini ezithola i-Gemcitabine ye-Primary Inflammatory Myofibroblastic Tumor. Ngaphezu kwalokho, nakuba i-Dandelion ingasiza abantu abane-genetic risk factor "CTNNB1", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ALK". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Dandelion esigulini somdlavuza kudinga ukuthi kube nomuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Dandelion iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhethwa kokudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana neDandelion esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uphakama: Ingabe kufanele ufake i-dandelion ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Dandelion uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-CTNNB1? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kufuzo lwe-ALK? Ingabe kunenzuzo ukufaka i-Dandelion ekudleni kwakho uma kutholakala ukuthi une-Primary Inflammatory Myofibroblastic Tumor, noma uma ukuxilongwa kwakho kuyi-Primary Solitary Fibrous Tumor? Ngaphezu kwalokho, ukusebenzisa kwakho i-Dandelion kufanele kulungiswe kanjani uma welashwa nge-Avastin noma uma uhlelo lwakho lokwelapha lusuka ku-Avastin luye ku-Gemcitabine? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Dandelion ingokwemvelo, ngakho ihlale inenzuzo' noma 'i-Dandelion ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Dandelion ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Dandelion ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Solitary Fibrous Tumor noma Primary Inflammatory Myofibroblastic Tumor, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ngabe kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeDandelion. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-CTNNB1 inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-ALK? Ngokombono wokudla okunempilo, ingabe ubungozi obuhambisana ne-Primary Solitary Fibrous Tumor bulingana ne-Primary Inflammatory Myofibroblastic Tumor? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kufana nalabo abathola i-Gemcitabine njengalabo abathola i-Avastin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Dandelion - Isengezo Esinomsoco

I-Dandelion eyengeziwe ihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Hexadecanoic Acid ne-Retinol, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MYC Signaling, i-MAPK Signaling, i-PI3K-AKT-MTOR Signaling kanye ne-Focal Adhesion, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele njengeDandelion, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-dandelion yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufanayo nokwelashwa komdlavuza, ukusetshenziswa kwe-Dandelion akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako zeDandelion

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Dandelion esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Dandelion kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Dandelion ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe I-Dandelion Supplements izozuza Iziguli Eziyinhloko Zokuvuvukala kwe-Myofibroblastic Tumor ezilashwa nge-Gemcitabine?

I-Primary Inflammatory Myofibroblastic Tumor ibonakala ngokuguqulwa kwezakhi zofuzo ezithile, okuyi-ARID2, FLT4 kanye ne-IGF1R, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-MAPK Signaling, i-Chromatin Remodeling, i-Angiogenesis, i-Growth Factor Signaling kanye ne-PI3K-AKT-MTOR Signaling. Ukusebenza kokwelashwa komdlavuza, okufana ne-Gemcitabine, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isengezo se-Dandelion, esithinta Ukusayinda kwe-MAPK, kungase kungabi inketho elungile esimweni se-Primary Inflammatory Myofibroblastic Tumor lapho i-Gemcitabine. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe I-Dandelion Supplement izozizuzisa Iziguli Eziyisisekelo Ezingamele I-Fibrous Tumor ezilashwa nge-Avastin?

I-Primary Solitary Fibrous Tumor ibonakala ngokuguqulwa kofuzo okukhethekile, okufana ne-BRD4, FLI1 kanye ne-KMT2C, okuholela ezinguqukweni zezindlela ze-biochemical, ikakhulukazi i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kanye ne-Amino Acid Metabolism. Ukusebenza kokwelashwa komdlavuza, njenge-Avastin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isengezo se-Dandelion siyindlela enengqondo kulabo abane-Primary Solitary Fibrous Tumor ababhekana ne-Avastin. Lokhu kungenxa yokuthi i-Dandelion ithonya izindlela ezifana ne-MYC Signaling, engavimbela izici eziqhuba I-Primary Solitary Fibrous Tumor noma izuzise ukusebenza kahle kwe-Avastin.

3. Ingabe Izithasiselo Ze-Dandelion Ziphephile Kubantu Abanempilo Ene-ALK Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Isakhi sofuzo se-ALK sivame ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-ALK kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-PI3K-AKT-MTOR Signaling and Growth Factor Signaling, ezihileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba ukuguquka kwezakhi zofuzo ku-ALK okuhlobene nengozi eyengeziwe Yesistimu Yezinzwa Emaphakathi, ukucabanga okungokwesayensi kuphakamisa ukugwema ukusetshenziswa kwe-Dandelion yokwengeza. Lokhu kungenxa yokuthi i-Dandelion eyengeziwe ithonya izindlela ezifana ne-PI3K-AKT-MTOR Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ALK kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Dandelion Ziphephile Kubantu Abanempilo Ene-CTNNB1 Mutation Associated Genetic Risk?

I-CTNNB1 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-CTNNB1 kungaphazamisa izindlela ezibucayi zamakhemikhali ezinto eziphilayo, okuhlanganisa i-Focal Adhesion, i-Adherens junction kanye ne-Epithelial to Mesenchymal Transition, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-CTNNB1 ehambisana ne-Adrenocortical Carcinoma, cabanga ukufaka izithasiselo ze-Dandelion ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Focal Adhesion, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-CTNNB1 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza kanye nokudla okunomsoco akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana neDandelion, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics