Imuphi umdlavuza ongahlomula ngokufaka i-D-limonene ekudleni kwabo?

Amaphuzu avelele

I-D-limonene yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-D-limonene ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-D-limonene ingase izuze labo abane-Primary Mucinous colorectal adenocarcinoma abathola i-Cetuximab, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Adamantinoma. Ngaphezu kwalokho, nakuba i-D-limonene ingasiza abantu abanesici sofuzo esiyingozi “KMT2D”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-D-limonene esigulini somdlavuza kudinga ukwenziwa komuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-D-limonene iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni isiyonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-D-limonene esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-D-limonene ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyancomeka ukuthi udle i-D-limonene uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-KMT2D? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-D-limonene ekudleni kwakho uma kutholakala ukuthi une-Primary Adamantinoma, noma uma ukuxilongwa kwakho kuyi-Primary Mucinous colorectal adenocarcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-D-limonene kufanele kulungiswe kanjani uma welashelwa i-Cetuximab noma uma uhlelo lwakho lokwelapha lusuka ku-Cetuximab luye ku-Radiation? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana ne-'D-limonene kungokwemvelo, ngakho-ke kuhlale kunenzuzo' noma 'i-D-limonene ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-D-limonene ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokuhlanganisa ukudla noma izithasiselo ezifana ne-D-limonene ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo, nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Mucinous colorectal adenocarcinoma noma i-Primary Adamantinoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-D-limonene. Ingabe ubungozi bofuzo lomdlavuza osukela ekuguqukeni kwe-KMT2D bunomthelela ofanayo we-biochemical pathway njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Mucinous colorectal adenocarcinoma bulingana ne-Primary Adamantinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Cetuximab? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-D-limonene – Isengezo Sokudla Okunomsoco

Isengezo se-D-limonene sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-D-limonene, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-MAPK Signaling and Oxidative Stress, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele ezifana ne-D-limonene, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-D-limonene yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-D-limonene akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa umuntu siqu.

Ukukhetha Izithasiselo ze-D-limonene

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-D-limonene esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-D-limonene kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithasiselo ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-D-limonene ifanelekile yini noma kufanele igwenywe, kugcizelela ukubaluleka kokwenziwa komuntu siqu. ukucatshangelwa ezinqumweni ezinjalo.

1. Ingabe Izithasiselo ze-D-limonene zizozuzisa Iziguli Eziyinhloko ze-Adamantinoma ezelashwa ngeRadiation?

I-Adamantinoma eyinhloko ibonakala ngokuguqulwa okuthile kofuzo, okuyi-ARHGAP45, PI4KB kanye ne-SDSL, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Oxidative Stress kanye ne-Inositol Phosphate Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-D-limonene, esithinta i-Oxidative Stress, singase singabi yinketho elungile esimweni se-Primary Adamantinoma lapho sithola Imisebe. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-D-limonene zizozizuzisa Iziguli Eziyinhloko ze-Mucinous colorectal adenocarcinoma ezelashwa nge-Cetuximab?

I-adenocarcinoma eyinhloko ye-Mucinous colorectal ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TTN, i-APC ne-KRAS, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-MAPK Signaling, i-Angiogenesis, i-G-protein-coupled Receptor Signaling kanye ne-Growth Factor Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Cetuximab, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-D-limonene siyinketho enengqondo yalabo abane-Primary Mucinous colorectal adenocarcinoma abathola i-Cetuximab. Lokhu kungenxa yokuthi i-D-limonene ithonya izindlela ezifana ne-MAPK Signaling, engavimbela izici ezishayela i-Primary Mucinous colorectal adenocarcinoma noma izuzise ukusebenza kahle kwe-Cetuximab.

3. Ingabe Izithasiselo ze-D-limonene Ziphephile Kubantu Abanempilo Enempilo Nge-KMT2D Mutation Associated Genetic Risk?

I-KMT2D idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-KMT2D kungaphazamisa izindlela ezibalulekile ze-biochemical, kuhlanganise ne-MAPK Signaling kanye ne-Oncogenic Histone Methylation, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula ukuguqulwa kofuzo ku-KMT2D okuhlotshaniswa ne-Bladder Urothelial Carcinoma, cabanga ukufaka izithako ze-D-limonene ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-MAPK Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-KMT2D kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza kanye nokudla okunomsoco akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-D-limonene, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Iqhaza le-KEAP1/NRF2 kanye ne-TP53 Ukuguqulwa Kwe-Lung Squamous Cell Carcinoma Development kanye Nokumelana Nemisebe.
• cBioPortal for Cancer Genomics
• Umthelela Ovikelayo we-D-Limonene ngokumelene Nokulimala Kweseli Okubangelwa I-Oxidative Kumaseli Epithelial Amalensi Omuntu nge-p38 Pathway.
• I-D-Limonene ishintsha ukuvuvukala, ukucindezeleka kwe-oxidative kanye nendlela ye-Ras-ERK yokuvimbela i-tumorigenesis yesikhumba se-murine.
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• Umsebenzi we-Antitumor we-ZD6474, i-vascular endothelial growth factor receptor tyrosine kinase inhibitor, kumaseli omdlavuza womuntu anokumelana okutholwe ekwelashweni kwe-antiepidermal growth factor receptor.
• cBioPortal for Cancer Genomics