Imuphi umdlavuza ongahlomula ngokufaka iCissus ekudleni kwabo?

Amaphuzu avelele

I-Cissus yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivamise ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kweCissus ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Cissus ingase izuze labo abane-Primary Mucinous colorectal adenocarcinoma abathola i-Cetuximab, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Urethral Squamous Cell Carcinoma. Ngaphezu kwalokho, nakuba i-Cissus ingasiza abantu abanesici sofuzo esiyingozi “KIT”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kweCissus esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Cissus iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo zokudla/izithasiselo ezifana neCissus esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Cissus ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Cissus uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-KIT? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka i-Cissus ekudleni kwakho uma kutholakala ukuthi une-Primary Urethral Squamous Cell Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Mucinous colorectal adenocarcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Cissus kufanele kulungiswe kanjani uma welashelwa i-Cetuximab noma uma uhlelo lwakho lokwelapha lusuka ku-Cetuximab luye ku-Radiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Cissus ingokwemvelo, ngakho ihlale inenzuzo' noma 'i-Cissus ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Cissus ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana neCissus ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangele izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Mucinous colorectal adenocarcinoma noma i-Primary Urethral Squamous Cell Carcinoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lomuntu ngamunye, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokukhetha ukudla, njengeCissus. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguquka kwezakhi zofuzo ku-KIT inemithelela efanayo ye-biochemical pathway njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Mucinous colorectal adenocarcinoma bulingana ne-Primary Urethral Squamous Cell Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Cetuximab? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Cissus - Isengezo Sokudla Okunomsoco

Isithasiselo se-Cissus sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Resveratrol, i-Quercetin, i-Piceatannol, i-Genistein ne-Daidzein, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-PI3K-AKT-MTOR Signaling and DNA Repair, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele njenge-Cissus, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Cissus yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kweCissus akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo zeCissus

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngiyigweme i-Cissus esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Cissus kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, izingozi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Cissus ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka ukucatshangelwa komuntu siqu ezinqumweni ezinjalo.

1. Ingabe I-Cissus Supplements izozizuzisa Iziguli Eziyinhloko ze-Urethral Squamous Cell Carcinoma ezelashwa ngeRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-BLM, BRCA1 kanye ne-CTCF, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Androgen Signaling kanye nokulungiswa kwe-DNA. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Cissus, esithinta Ukulungiswa Kwe-DNA, kungase kungabi yisinqumo esifanele esimweni se-Primary Urethral Squamous Cell Carcinoma lapho sibhekene Nokukhishwa Kwemisebe. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe I-Cissus Supplements izozizuzisa Iziguli Eziyinhloko ze-Mucinous colorectal adenocarcinoma ezelashwa nge-Cetuximab?

I-adenocarcinoma eyinhloko ye-Mucinous colorectal ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TTN, i-APC ne-KRAS, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi i-PI3K-AKT-MTOR Signaling, Angiogenesis, G-protein-coupled Receptor Signaling kanye Nokukhula Kwezimpawu Zokukhula. Ukusebenza kokwelashwa komdlavuza, njenge-Cetuximab, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Cissus siyinketho enengqondo yalabo abane-Primary Mucinous colorectal adenocarcinoma ebhekana ne-Cetuximab. Lokhu kungenxa yokuthi i-Cissus ithonya izindlela ezifana ne-PI3K-AKT-MTOR Signaling, engavimbela izici ezishayela i-Primary Mucinous colorectal adenocarcinoma noma izuzise ukusebenza kwe-Cetuximab.

3. Ingabe Izithasiselo Ze-Cissus Ziphephile Kubantu Abanempilo Enempilo Nge-KIT Mutation Associated Genetic Risk?

I-KIT idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-KIT kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-PI3K-AKT-MTOR Signaling kanye ne-Growth Factor Signaling, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-KIT ezihlobene Nomdlavuza Wesisu, cabanga ukufaka izithasiselo ze-Cissus ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-PI3K-AKT-MTOR Signaling, zizuze ngokunikeza usekelo olufanele kubantu abanokuguqulwa kwe-KIT kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana neCissus, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• I-isoflavone daidzein yokudla ihlanganisa isenzo se-centchroman ngokungeniswa kwe-apoptosis kanye nokuvinjwa kwendlela ye-PI3K/Akt kumaseli omdlavuza webele womuntu we-MCF-7/MDA MB-231.
• I-BRCA1 ne-BRCA2 njengokuhlosiwe kwamangqamuzana e-phytochemicals indole-3-carbinol kanye ne-genistein kumaseli omdlavuza webele kanye ne-prostate.
• cBioPortal for Cancer Genomics
• I-Periodontal ligament cell kinetics elandela izinqubo zokuhlola zokuvuselela kabusha.
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• cBioPortal for Cancer Genomics
• I-Daidzein yenza umsebenzi wokulwa ne-tumor ngokumelene namaseli omdlavuza wesinye ngokuvinjelwa kwendlela ye-FGFR3.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• Isisho se-BRCA1 sibuyisela ukumelana nemisebe kumaseli omdlavuza anesici se-BRCA1 ngokuthuthukisa ukulungiswa kwe-DNA okulotshiweyo okuhlanganisiwe.