Yimuphi umdlavuza ongazuza ngokufaka i-Chamomile ekudleni kwabo?

Amaphuzu avelele

I-Chamomile yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kweChamomile ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Chamomile ingase izuze labo abane-Primary Smoldering multiple myeloma abathola i-Lenalidomide, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Urethral Squamous Cell Carcinoma. Ngaphezu kwalokho, nakuba i-Chamomile ingasiza abantu abanesici esiyingozi sofuzo “KMT2D”, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile. Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Chamomile esigulini somdlavuza kudinga ukwenziwa komuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi iChamomile iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana neChamomile esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uphakama: Ingabe kufanele uhlanganise i-Chamomile ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Chamomile uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-KMT2D? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela esakhiweni sofuzo? Ingabe kunenzuzo ukufaka iChamomile ekudleni kwakho uma kutholakala ukuthi une-Primary Urethral Squamous Cell Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Smoldering multiple myeloma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Chamomile kufanele kulungiswe kanjani uma welashelwa i-Lenalidomide noma uma uhlelo lwakho lokwelapha lusuka ku-Lenalidomide luye ku-Radiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'I-Chamomile ingokwemvelo, ngakho ihlale inenzuzo' noma 'i-Chamomile ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Chamomile ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Chamomile ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangele izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Smoldering multiple myeloma noma i-Primary Urethral Squamous Cell Carcinoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokudla okudliwayo, okufana ne-Chamomile. Ingabe ingozi yofuzo yomdlavuza obangelwa uguquko ku-KMT2D inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwesinye isakhi sofuzo? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Smoldering multiple myeloma ilingana ne-Primary Urethral Squamous Cell Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kusalokhu kufana kulabo abathola i-Radiation njengalabo abathola i-Lenalidomide? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Chamomile - Isengezo Esinomsoco

Isithasiselo se-Chamomile sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Trans-trans-farnesol, i-Vitamin A, i-Quercetin, i-Chrysoeriol ne-Axillarin, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Angiogenesis, i-DNA Repair kanye ne-Cell Cycle Checkpoints, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele ezifana ne-Chamomile, iyodwa noma ihlanganiswe, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Chamomile yomdlavuza, kubalulekile ukucabangela lezi zici ezihlukahlukene nezindlela. Lokhu kungenxa yokuthi, ngokufanayo nokwelapha umdlavuza, ukusetshenziswa kweChamomile akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa umuntu siqu.

Ukukhetha Izithako ze-Chamomile

Ukubhekana nombuzo othi 'Kufanele ngiyigweme nini i-Chamomile esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Chamomile kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, izingozi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Chamomile ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka ukucatshangelwa komuntu siqu ezinqumweni ezinjalo.

1. Ingabe Izithasiselo Ze-Chamomile zizozizuzisa Iziguli Eziyi-Primary Urethral Squamous Cell Carcinoma ezelashwa ngeRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-BLM, BRCA1 kanye ne-CTCF, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Androgen Signaling kanye nokulungiswa kwe-DNA. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Chamomile, esithinta Ukulungiswa Kwe-DNA, kungase kungabi yisinqumo esifanele esimweni se-Primary Urethral Squamous Cell Carcinoma lapho sibhekene Nokukhishwa Kwemisebe. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo Ze-Chamomile zizozizuzisa Iziguli Ezibhema Ngama-multiple myeloma ezelashwa yi-Lenalidomide?

I-Primary Smoldering multiple myeloma ikhonjwa ngokuguqulwa kofuzo okuthile, okufana ne-BRCA2, CDK8 kanye ne-CDX2, okuholela ezinguqukweni zezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-Angiogenesis kanye ne-DNA Repair. Ukusebenza kokwelashwa komdlavuza, njengeLenalidomide, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Chamomile siyindlela enengqondo yalabo abane-Myeloma Eyisisekelo Ebhemayo ababhekana ne-Lenalidomide. Lokhu kungenxa yokuthi i-Chamomile ithonya izindlela ezifana ne-Angiogenesis, engavimbela izici eziqhuba i-Primary Smoldering multiple myeloma noma izuzise ukusebenza kahle kwe-Lenalidomide.

3. Ingabe Izithasiselo Ze-Chamomile Ziphephile Kubantu Abanempilo Nge-KMT2D Mutation Associated Genetic Risk?

I-KMT2D idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-KMT2D kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa izindawo zokuhlola i-Cell Cycle kanye ne-Oncogenic Histone Methylation, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-KMT2D ezihambisana ne-Bladder Urothelial Carcinoma, cabanga ukufaka izithasiselo ze-Chamomile ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Cell Cycle Checkpoints, zizuze ngokunikeza usekelo olufanele kubantu abanezinguquko ze-KMT2D kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Chamomile, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Ubudlelwano bomsebenzi wesakhiwo se-chrysoeriol nama-analogue njengama-c‑Met amabili kanye ne-VEGFR2 tyrosine kinase inhibitors.
• I-HIF-1α yamaseli we-bone marrow endothelial isho ukuphindaphinda nokuphikiswa kwezidakamizwa ezigulini ezine-myeloma eminingi futhi ingase isebenze njengento ehlosiwe yokwelapha.
• cBioPortal for Cancer Genomics
• I-HyperFoods: Imephu ehlakaniphile yomshini yama-molecule ashaya umdlavuza ekudleni.
• Ukutholwa kwe-chrysoeriol, i-PI3K-AKT-mTOR pathway inhibitor enomsebenzi onamandla we-antitumor ngokumelene namaseli amaningi e-myeloma e-vitro.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• Isisho se-BRCA1 sibuyisela ukumelana nemisebe kumaseli omdlavuza anesici se-BRCA1 ngokuthuthukisa ukulungiswa kwe-DNA okulotshiweyo okuhlanganisiwe.
• [Ukwakhiwa okuyisisekelo kwemisebenzi yemfundo ekhethekile ekuvuseleleni abakhubazekile ngokomzimba].