Yimuphi umdlavuza ongazuza ngokufaka i-Cassia Fistula ekudleni kwabo?

Amaphuzu avelele

I-Cassia Fistula yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kweCassia Fistula ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Cassia Fistula ingase izuze labo abane-Primary Sinonasal Adenocarcinoma abathola i-Radiation, kodwa kungase kungabi kuhle ezigulini ezithola i-Avastin ye-Primary Solitary Fibrous Tumor. Ngaphezu kwalokho, nakuba i-Cassia Fistula ingasiza abantu abanengozi yofuzo, ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ASXL1". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kweCassia Fistula esigulini somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Cassia Fistula iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele ekukhetheni ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Cassia Fistula esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Cassia Fistula ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyatuseka ukuthi udle i-Cassia Fistula uma une-genetic predisposition to cancer ehambisana nofuzo? Kuthiwani uma esikhundleni salokho ubungozi bakho bofuzo busukela kufuzo lwe-ASXL1? Ingabe kunenzuzo ukufaka i-Cassia Fistula ekudleni kwakho uma kutholakala ukuthi une-Primary Solitary Fibrous Tumor, noma uma ukuxilongwa kwakho kuyi-Primary Sinonasal Adenocarcinoma? Ngaphezu kwalokho, indlela osebenzisa ngayo i-Cassia Fistula kufanele ilungiswe kanjani uma welashwa ngeRadiation noma uma uhlelo lwakho lokwelapha lusuka ku-Radiation luye ku-Avastin? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'i-Cassia Fistula ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Cassia Fistula ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Cassia Fistula ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Cassia Fistula ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. izibikezelo, kanye nokukhetha kwendlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Sinonasal Adenocarcinoma noma I-Primary Solitary Fibrous Tumor, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokukhetha ukudla, njengeCassia Fistula. Ingabe ubungozi bofuzo lomdlavuza osukela ekuguqukeni kofuzo kunemithelela efanayo ye-biochemical pathway njengokuguqulwa kwe-ASXL1? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Sinonasal Adenocarcinoma bulingana ne-Primary Solitary Fibrous Tumor? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Avastin njengalabo abathola iRadiation? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Cassia Fistula – Isengezo Esinomsoco

Isengezo se-Cassia Fistula sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Sennoside B, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Notch Signaling, i-MYC Signaling kanye ne-Hypoxia, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele ezifana ne-Cassia Fistula, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Cassia Fistula yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Cassia Fistula akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa komuntu siqu.

Ukukhetha Izithako ze-Cassia Fistula

Ukubhekana nombuzo othi 'Kufanele ngigweme nini i-Cassia Fistula esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukuhambisana nokuphepha noma izinzuzo ze-Cassia Fistula kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Cassia Fistula ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu. ezinqumweni ezinjalo.

1. Ingabe I-Cassia Fistula Supplements izozizuzisa Iziguli Eziyisisekelo Eziyi-Solitary Fibrous Tumor ezelashwa nge-Avastin?

I-Primary Solitary Fibrous Tumor ibonakala ngokuguqulwa kofuzo okuthile, okuyi-BRD4, FLI1 kanye ne-KMT2C, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-MYC Signaling, i-Chromatin Remodeling, Ukulungiswa Kwe-DNA, I-Oncogenic Histone Methylation kanye ne-Amino Acid Metabolism. Ukuphumelela kokwelashwa komdlavuza, njenge-Avastin, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Cassia Fistula, esithinta Ukusayinwa kwe-MYC, kungase kungabi inketho efanele esimweni se-Primary Solitary Fibrous Tumor lapho uthola i-Avastin. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe I-Cassia Fistula Supplements izozizuzisa Iziguli Eziyinhloko ze-Sinonasal Adenocarcinoma ezelashwa Ngemisebe?

I-Primary Sinonasal Adenocarcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-ATRX, NOTCH1 ne-PTPRD, okuholela ezinguqukweni zemizila ye-biochemical, ikakhulukazi i-Notch Signaling kanye ne-RUNX Signaling. Ukusebenza kokwelashwa komdlavuza, njengeRadiation, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Cassia Fistula siyinketho enengqondo yalabo abane-Primary Sinonasal Adenocarcinoma ebhekene neRadiation. Lokhu kungenxa yokuthi i-Cassia Fistula ithonya izindlela ezifana ne-Notch Signaling, engavimbela izici ezishayela i-Primary Sinonasal Adenocarcinoma noma izuzise ukusebenza ngempumelelo Kokushisisa.

3. Ingabe Izithasiselo ze-Cassia Fistula Ziphephile Kubantu Abanempilo Ene-ASXL1 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ASXL1 luvamise ukufakwa kulawa maphaneli okuhlolwa kwengozi yomdlavuza.

Ukuguqulwa kofuzo lwe-ASXL1 kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-MYC Signaling, i-Oncogenic Cancer Epigenetics kanye ne-Suppressive Histone Methylation, ehileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza uguquko ku-ASXL1 ehambisana nengozi eyengeziwe ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwesithasiselo se-Cassia Fistula. Lokhu kungenxa yokuthi ukwesekwa kwe-Cassia Fistula kuthonya izindlela ezifana ne-MYC Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ASXL1 kanye nezimo zomdlavuza ezihlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithasiselo ezifana ne-Cassia Fistula, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics
• I-Notch eqondiwe ukuze inqobe ukumelana nemisebe.
• cBioPortal for Cancer Genomics
• Indima ye-tumor microenvironment ekumelaneni ne-anti-angiogenic therapy.