Yimuphi umdlavuza ongazuza ngokufaka i-Boneset ekudleni kwabo?

Amaphuzu avelele

I-Boneset yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kweBoneset yeziguli ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Boneset ingase izuze labo abane-Primary Mucinous colorectal adenocarcinoma abathola i-Cetuximab, kodwa kungase kungabi kuhle ezigulini ezithola i-Radiation for Primary Sinonasal Adenocarcinoma. Ngaphezu kwalokho, nakuba i-Boneset ingasiza abantu abane-genetic risk factor "KMT2D", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "i-ATM". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Boneset yesiguli somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Boneset iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Boneset esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile ophakamayo: Ingabe kufanele ufake i-Boneset ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyancomeka ukuthi udle i-Boneset uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-KMT2D? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela kufuzo lwe-ATM? Ingabe kunenzuzo ukufaka i-Boneset ekudleni kwakho uma kutholakala ukuthi une-Primary Sinonasal Adenocarcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Mucinous colorectal adenocarcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Boneset kufanele kulungiswe kanjani uma welashelwa i-Cetuximab noma uma uhlelo lwakho lokwelapha lusuka ku-Cetuximab luye ku-Radiation? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'i-Boneset ingokwemvelo, ngakho ihlale inenzuzo' noma 'i-Boneset ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-Boneset ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Boneset ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Mucinous colorectal adenocarcinoma noma i-Primary Sinonasal Adenocarcinoma, amasu okwelapha kudingeka enziwe ngendlela oyifisayo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ingabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njengeBoneset. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-KMT2D inemithelela efanayo ye-biochemical pathway njengoguquko ku-ATM? Ngokombono wokudla okunempilo, ingabe ubungozi obuhlobene ne-Primary Mucinous colorectal adenocarcinoma bulingana ne-Primary Sinonasal Adenocarcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Cetuximab? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Boneset - Isengezo Sokudla Okunomsoco

Isithasiselo se-Boneset sihlanganisa uhla lwezithako ezisebenzayo, okuhlanganisa i-Beta-carotene, i-Rutin, i-Astragalin, i-Eupatorin ne-Quercetin, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Growth Factor Signaling, i-Notch Signaling, Ukulungiswa kwe-DNA kanye ne-Hypoxia, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Uma kubhekwa leli thonya lebhayoloji, ukukhetha izithasiselo ezifanele ezifana ne-Boneset, iyodwa noma ihlangene, kuba yisinqumo esibalulekile kumongo wokudla okunomdlavuza. Uma ucabangela ukusebenzisa i-Boneset yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Boneset akusona isinqumo esifanelekile kuwo wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithasiselo ze-Boneset

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngigweme i-Boneset esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Boneset kuyahlukahluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-Boneset ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo zeBoneset zizozuza Iziguli Eziyinhloko ze-Sinonasal Adenocarcinoma ezelashwa ngeRadiation?

I-Primary Sinonasal Adenocarcinoma ibonakala ngokuguqulwa kofuzo okuthile, okuyi-ATRX, NOTCH1 kanye ne-PTPRD, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Notch Signaling kanye ne-RUNX Signaling. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Boneset, esithinta i-Notch Signaling, kungase kungabi inketho elungile esimweni se-Primary Sinonasal Adenocarcinoma lapho ithola I-Radiation. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe I-Boneset Supplements izozizuzisa Iziguli Eziyinhloko ze-Mucinous colorectal adenocarcinoma ezelashwa nge-Cetuximab?

I-Primary Mucinous colorectal adenocarcinoma ikhonjwa ngokuguqulwa kofuzo okukhethekile, okufana ne-TTN, i-APC ne-KRAS, okuholela ezinguqukweni zemizila yamakhemikhali ezinto eziphilayo, ikakhulukazi i-Angiogenesis, i-G-protein-coupled Receptor Signaling kanye ne-Growth Factor Signaling. Ukusebenza kokwelashwa komdlavuza, njenge-Cetuximab, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Boneset siyinketho enengqondo yalabo abane-Primary Mucinous colorectal adenocarcinoma ebhekana ne-Cetuximab. Lokhu kungenxa yokuthi i-Boneset ithonya izindlela ezifana ne-Growth Factor Signaling, engavimbela izici ezishayela i-Primary Mucinous colorectal adenocarcinoma noma izuzise ukusebenza kwe-Cetuximab.

3. Ingabe Izithasiselo Zethambo Ziphephile Kubantu Abanempilo Ene-ATM Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ATM luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ingozi yomdlavuza.

Ukuguqulwa kofuzo lwe-ATM kuthinta izindlela zamakhemikhali ezinto eziphilayo noma izinqubo, ezifana nokulungiswa kwe-DNA, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ihlonza ukuguqulwa kwezakhi zofuzo ku-ATM okuhlobene nengozi eyengeziwe Ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwe-Boneset yesithako. Lokhu kungenxa yokuthi isengezo se-Boneset sithonya izindlela ezifana nokulungiswa kwe-DNA, okungaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ATM kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Zethambo Ziphephile Kubantu Abanempilo Enempilo Nge-KMT2D Mutation Associated Genetic Risk?

I-KMT2D idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezinguquko ku-KMT2D kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Hypoxia ne-Oncogenic Histone Methylation, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-KMT2D ezihambisana ne-Bladder Urothelial Carcinoma, cabanga ukufaka izithasiselo ze-Boneset ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Hypoxia, zizuze ngokunikeza ukwesekwa okufanelekile kwabantu abanezinguquko ze-KMT2D kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Boneset, kuyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• I-retinoic acid receptor β ithuthukise umphumela wamaseli e-anti-cancer we-β-carotene ngokuveza okulawula phansi kwe-delta-like 1 homologue kumaseli e-neuroblastoma yomuntu.
• cBioPortal for Cancer Genomics
• I-Notch eqondiwe ukuze inqobe ukumelana nemisebe.
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• cBioPortal for Cancer Genomics
• Ama-inhibitors we-epidermal growth factor receptor ekukhishweni kwejusi ye-apula.
• Umphumela we-Pasteurella haemolytica cytotoxin ku-bovine polymorphonuclear leukocyte ungancishiswa ngabaphikisi be-beta-adrenoceptor.
• I-β-Carotene ivimbela ukuhlasela kweseli ye-neuroblastoma kanye ne-metastasis ku-vitro kanye ne-vivo ngokunciphisa izinga le-hypoxia-inducible factor-1α.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.