Yimuphi umdlavuza ongazuza ngokufaka i-artichoke ekudleni kwabo?

Amaphuzu avelele

I-artichoke yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Kodwa-ke, ukuphepha nokusebenza kahle kwe-Artichoke ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla kanye nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Artichoke ingase izuze labo abane-Primary Systemic mastocytosis abathola i-Midostaurin, kodwa ingase ingabi yinhle ezigulini ezithola i-Radiation for Primary Urethral Squamous Cell Carcinoma. Ngaphezu kwalokho, nakuba i-artichoke ingasiza abantu abanesici esiyingozi sofuzo "ALK", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ERCC2". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo ngokufaneleka kwe-artichoke esigulini somdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-artichoke iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Artichoke esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uphakama: Ingabe kufanele ufake i-artichoke ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyatuswa ukuthi udle i-Artichoke uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ALK? Kuthiwani uma esikhundleni salokho ingozi yakho yofuzo ivela ohlotsheni lofuzo lwe-ERCC2? Ingabe kunenzuzo ukufaka i-Artichoke ekudleni kwakho uma kutholakala ukuthi une-Primary Urethral Squamous Cell Carcinoma, noma uma ukuxilongwa kwakho kuyi-Primary Systemic mastocytosis? Ngaphezu kwalokho, ukusebenzisa kwakho i-Artichoke kufanele kulungiswe kanjani uma welashelwa i-Midostaurin noma uma uhlelo lwakho lokwelapha lusuka e-Midostaurin luye kuMisebe? Kubalulekile ukuqaphela ukuthi ukugomela okulula okufana nokuthi 'I-Artichoke ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'I-Artichoke ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka i-artichoke ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-artichoke ekudleni kwakho ukuze uthole izinzuzo zayo, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangele izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Lapho kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Systemic mastocytosis noma i-Primary Urethral Squamous Cell Carcinoma, amasu okwelapha kudingeka enziwe ngokwezifiso ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili.”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ukuthi ngabe kufanele kufakwe engcupheni yofuzo kanye nokuxilongwa okuthile komdlavuza lapho unquma ngokukhetha ukudla, njenge-Artichoke. Ingabe ingozi yofuzo yomdlavuza obangelwa ukuguqulwa kwe-ALK inemithelela efanayo yendlela ye-biochemical njengokuguqulwa kwe-ERCC2? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Systemic mastocytosis ilingana ne-Primary Urethral Squamous Cell Carcinoma? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Radiation njengalabo abathola i-Midostaurin? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kwabantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Artichoke - Isengezo Esinomsoco

I-artichoke ye-supplement ihlanganisa uhla lwezithako ezisebenzayo, kufaka phakathi i-Vitamin K, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi i-Growth Factor Signaling, Ukulungiswa Kwe-DNA, Ukusayina kwe-MAPK kanye ne-PI3K-AKT-MTOR Signaling, elawula izici ezibucayi zomdlavuza ezingeni lamaselula, njengokukhula kwesimila, ukusabalala, nokufa kweseli. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele njenge-Artichoke, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-artichoke yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Artichoke akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha Izithako ze-Artichoke

Ukubhekana nombuzo othi 'Kunini lapho kufanele ngigweme i-artichoke esimweni somdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Artichoke kuyehluka kuye ngezimo zomuntu siqu. Izici ezifana nohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi i-artichoke ifanelekile noma kufanele igwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe Izithasiselo ze-Artichoke zizozizuzisa Iziguli Eziyinhloko ze-Urethral Squamous Cell Carcinoma ezelashwa ngeRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakala ngokuguquguquka okuthile kofuzo, okuyi-BLM, BRCA1 kanye ne-CTCF, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Androgen Signaling kanye nokulungiswa kwe-DNA. Ukusebenza kokwelashwa komdlavuza, okufana neRadiation, kuncike endleleni yokusebenza kwayo kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isithasiselo se-Artichoke, esithinta Ukulungiswa Kwe-DNA, kungase kungabi yisinqumo esifanele esimweni se-Primary Urethral Squamous Cell Carcinoma lapho sibhekene Nokukhishwa Kwemisebe. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe Izithasiselo ze-Artichoke zizozuzisa Iziguli Eziyisisekelo ze-Systemic mastocytosis ezelashwa nge-Midostaurin?

I-Primary Systemic mastocytosis ikhonjwa ngokuguqulwa kwezakhi zofuzo ezithile, njenge-CNOT3, DNMT3A kanye ne-FLT3, okuholela ezinguqukweni zezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-Growth Factor Signaling, i-Oncogenic Cancer Epigenetics, i-Hypoxia kanye ne-JAK-STAT Signaling. Ukusebenza kokwelashwa komdlavuza, njengeMidostaurin, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Artichoke siyindlela enengqondo yalabo abane-Primary Systemic mastocytosis ababhekana ne-Midostaurin. Lokhu kungenxa yokuthi i-Artichoke ithonya izindlela ezifana ne-Growth Factor Signaling, engavimbela izici ezishayela i-Primary Systemic mastocytosis noma izuzise ukusebenza kahle kwe-Midostaurin.

3. Ingabe Izithasiselo Ze-Artichoke Ziphephile Kubantu Abanempilo Enempilo Nge-ERCC2 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ERCC2 luvamise ukufakwa kulawa maphaneli ukuze kuhlolwe ubungozi bomdlavuza.

Ukuguqulwa kofuzo lwe-ERCC2 kuthinta izindlela ze-biochemical noma izinqubo, ezifana ne-MAPK Signaling and DNA Repair, ezibandakanyeka ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba uguquko ku-ERCC2 oluhlobene nengozi eyengeziwe Yomdlavuza Wesikhumba, ukucabanga okungokwesayensi kuphakamisa ukugwema ukusetshenziswa kwe-artichoke yesithako. Lokhu kungenxa yokuthi ukwesekwa kwe-Artichoke kuthonya izindlela ezifana ne-MAPK Signaling, engaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ERCC2 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe Izithasiselo Ze-Artichoke Ziphephile Kubantu Abanempilo Ene-ALK Mutation Associated Genetic Risk?

I-ALK idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezakhi zofuzo ku-ALK kungaphazamisa izindlela ezibucayi zamakhemikhali ezinto eziphilayo, okuhlanganisa i-PI3K-AKT-MTOR Signaling and Growth Factor Signaling, enomthelela ekuthuthukisweni komdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-ALK ehambisana ne-Central Nervous System, cabanga ukufaka izithako ze-Artichoke ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-PI3K-AKT-MTOR Signaling, zizuze ngokunikeza ukwesekwa okufanelekile kwabantu abanezinguquko ze-ALK kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla kanye nezithako ezifana ne-Artichoke, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• Inqubekelaphambili yocwaningo emiphumeleni yokulwa nomdlavuza kavithamini K2.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• I-Genomic Classification kanye ne-Prognosis ku-Acute Myeloid Leukemia.
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.