Yimuphi umdlavuza ongazuza ngokufaka u-Angelica ekudleni kwabo?

Amaphuzu avelele

I-Angelica yaziwa kabanzi ngezinzuzo zayo zezempilo futhi ivame ukusetshenziswa iziguli ezinomdlavuza nalabo abasengozini yofuzo. Nokho, ukuphepha nokusebenza kahle kwe-Angelica ezigulini ezinomdlavuza kuncike ezintweni eziningi ezifana nenkomba yomdlavuza, i-chemotherapy, ezinye izindlela zokwelapha, kanye nofuzo lwesimila. Ukwazi ukuthi okunye ukudla nezithako zokudla, okufana ne-grapefruit nesipinashi, kungase kuhlanganyele kabi nemithi yomdlavuza futhi kubangele ukusabela okubi kubalulekile.

Ukudla kubalulekile ekwelapheni umdlavuza njengoba kungathinta imiphumela yokwelashwa. Iziguli ezinomdlavuza kufanele zikhethe ngokucophelela futhi zihlanganise ukudla okufanele kanye nezithako zokudla ezidliwayo. Isibonelo, i-Angelica ingase izuze labo abane-Primary Urethral Squamous Cell Carcinoma abathola iRadiation, kodwa kungase kungabi kuhle ezigulini ezithola i-Docetaxel ye-Primary Cervical Neuroendocrine Tumor. Ngaphezu kwalokho, nakuba i-Angelica ingasiza abantu abanesici esiyingozi sofuzo "ERBB2", ingase ingaphakanyiswe kulabo abasengozini yofuzo ehlukile "ASXL1". Ukwenza kube ngokwakho izinhlelo zokudla ezisuselwe empilweni, ukwelashwa, kanye nofuzo kubalulekile.

Ukuqonda ukuthi ukwenza isinqumo mayelana nokufaneleka kwe-Angelica esigulini esinomdlavuza kudinga ukwenziwa umuntu ngamunye kubalulekile. Izici ezibalulekile njengohlobo lomdlavuza, izindlela zokwelapha, ukwakheka kofuzo, izingozi zofuzo, ubudala, isisindo somzimba, nendlela yokuphila zibalulekile ekunqumeni ukuthi i-Angelica iyisinqumo esifanele yini. I-Genomics kanye ne-genomics, ikakhulukazi, ibhekwa njengento ebalulekile. Njengoba lezi zici zingashintsha, kubalulekile ukubuyekeza njalo futhi ulungise ukukhetha kokudla ukuze kufane nezinguquko zesimo sezempilo kanye nokwelashwa.

Sengiphetha, indlela ephelele yokukhetha ukudla ibalulekile, igxile emiphumeleni yonke yazo zonke izingxenye ezisebenzayo ekudleni/izithasiselo ezifana ne-Angelica esikhundleni sokuhlola isithako ngasinye esisebenzayo ngokwehlukana noma ukuziba ngokuphelele. Lo mbono obanzi ukhuthaza indlela enengqondo nengokwesayensi yokuhlelela ukudla komdlavuza.

Ukufingqiwe Okufushane

Ukusetshenziswa kokudla okusekelwe ezitshalweni nezithasiselo, njengamavithamini, amakhambi, amaminerali, ama-probiotics, kanye nezithako ezihlukahlukene ezikhethekile, ziyakhula phakathi kweziguli ezinomdlavuza. Lezi zithako zenzelwe ukuletha ukugxila okuphezulu kwezithako ezithile ezisebenzayo, eziningi zazo ezitholakala ekudleni okuhlukile. Ukugxila kanye nokwehlukahlukana kwezithako ezisebenzayo kuyahluka phakathi kokudla okuphelele nezithako zokudla. Ukudla ngokuvamile kunikeza uhla lwezithako ezisebenzayo kodwa ekugxiliseni okuphansi, kuyilapho izithako zinikeza ukugxila okuphezulu kwezithako ezithile.

Uma kucatshangelwa imisebenzi eyahlukene yesayensi neyebhayoloji yesithako ngasinye esisebenzayo ezingeni lamangqamuzana, kubalulekile ukulandisa ngemiphumela ehlanganisiwe yalezi zingxenye lapho unquma ngokudla nezithako okumelwe uzidle noma cha.

Umbuzo obalulekile uphakama: Ingabe kufanele ufake i-Angelica ekudleni kwakho njengento yokudla noma isengezo? Ingabe kuyafaneleka ukuthi udle i-Angelica uma unezakhi zofuzo ezitholakala kumdlavuza ohambisana nofuzo lwe-ERBB2? Kuthiwani uma esikhundleni salokho ubungozi bakho bofuzo busukela kufuzo lwe-ASXL1? Ingabe kunenzuzo ukufaka u-Angelica ekudleni kwakho uma kutholakala ukuthi une-Primary Cervical Neuroendocrine Tumor, noma uma ukuxilongwa kwakho kuyi-Primary Urethral Squamous Cell Carcinoma? Ngaphezu kwalokho, ukusebenzisa kwakho i-Angelica kufanele kulungiswe kanjani uma welashwa Nge-Radiation noma uma uhlelo lwakho lokwelapha lusuka ku-Radiation luye ku-Docetaxel? Kubalulekile ukuqaphela ukuthi izisho ezilula njengokuthi 'i-Angelica ingokwemvelo, ngakho-ke ihlale inenzuzo' noma 'i-Angelica ithuthukisa ukungatheleleki' akwanele ekukhetheni ukudla/izithasiselo ezinolwazi.

Ukwengeza, kubalulekile ukuhlola kabusha ukufaneleka kokufaka u-Angelica ekudleni kwakho uma kukhona izinguquko ohlelweni lwakho lokwelapha. Kafushane, lapho wenza izinqumo mayelana nokufaka ukudla noma izithasiselo ezifana ne-Angelica ekudleni kwakho ukuze uthole izinzuzo zako, kufanele ucabangele imiphumela yonke ye-biochemical yazo zonke izithako, ucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqondile okwenzayo, izakhi zofuzo. , nokukhetha indlela yokuphila.

Cancer

Umdlavuza useyinselele enkulu emkhakheni wezokwelapha, ngokuvamile obangela ukukhathazeka okusabalele. Kodwa-ke, intuthuko yakamuva iye yathuthukisa imiphumela yokwelashwa, ikakhulukazi ngezindlela zokwelashwa eziqondene nomuntu siqu, izindlela zokuqapha ezingahlaseli kusetshenziswa amasampula egazi namathe, kanye nokuthuthukiswa kwe-immunotherapy. Ukutholwa kusenesikhathi kanye nokungenelela okufika ngesikhathi kuye kwaba semqoka ekube nomthelela omuhle emiphumeleni yokwelapha iyonke.

Ukuhlolwa kwezakhi zofuzo kunikeza isithembiso esibalulekile ekuhloleni ingozi yomdlavuza kanye nokuba sengozini kusenesikhathi. Kodwa-ke, kubantu abaningi abanomdlavuza womndeni kanye nezakhi zofuzo, izinketho zokungenelela kwezokwelapha, ngisho nokuqapha okuvamile, ngokuvamile kunqunyelwe noma akukho. Uma kutholakala ukuthi unohlobo oluthile lomdlavuza, njenge-Primary Urethral Squamous Cell Carcinoma noma i-Primary Cervical Neuroendocrine Tumor, amasu okwelapha kudingeka enziwe ngendlela oyiyo ngokusekelwe kufuzo lwesimila somuntu, isigaba sesifo, kanye nezici ezifana neminyaka nobulili. ”

Ngemuva kokwelashwa, ukuqapha okuqhubekayo kubalulekile ukuze kutholwe noma yiziphi izimpawu zokubuya komdlavuza futhi nokwazisa izinqumo ezilandelayo. Iziguli eziningi ezinomdlavuza kanye nalezo ezisengozini zivame ukufuna izeluleko zokufaka ukudla okuthile nezithako zokudla ezikudlayo, okudlala indima ebalulekile ekuthathweni kwazo zonke izinqumo mayelana nokuphathwa kwezempilo.

Umbuzo obalulekile ngowokuthi ngabe kufanele kufakwe engcupheni yofuzo kanye nokuxilonga umdlavuza othize lapho unquma ngokukhetha ukudla, njengo-Angelica. Ingabe ingozi yofuzo yomdlavuza osukela ekuguqukeni kwe-ERBB2 inemiphumela efanayo ye-biochemical pathway njengokuguqulwa kwe-ASXL1? Ngokombono wokudla okunempilo, ingabe ingozi ehambisana ne-Primary Urethral Squamous Cell Carcinoma ilingana ne-Primary Cervical Neuroendocrine Tumor? Ngaphezu kwalokho, ingabe ukucatshangelwa kokudla kuhlala kunjalo kulabo abathola i-Docetaxel njengalabo abathola iRadiation? Lokhu kucatshangelwa kubalulekile ekwenzeni ukukhetha kokudla okunolwazi kubantu abanezingozi zofuzo ezahlukene kanye nokwelashwa komdlavuza.

I-Angelica - Isengezo Sokudla Okunomsoco

Isithasiselo i-Angelica sihlanganisa uhla lwezithako ezisebenzayo, kufaka phakathi i-Quercetin, ngayinye ekhona ngokugxila okuhlukahlukene. Lezi zithako zithonya izindlela zamangqamuzana, ikakhulukazi Ukulungiswa Kwe-DNA, Umjikelezo Weseli, Izindawo Zokuhlola I-Cell Cycle kanye ne-Oncogenic Histone Methylation, elawula izici ezibucayi zomdlavuza ezingeni lamangqamuzana, njengokukhula kwesimila, ukusabalala, nokufa kwamangqamuzana. Njengoba kunikezwe leli thonya lezinto eziphilayo, ukukhetha izithasiselo ezifanele ezifana ne-Angelica, iyodwa noma ihlangene, kuba yisinqumo esibucayi kumongo wokudla komdlavuza. Uma ucabangela ukusebenzisa i-Angelica yomdlavuza, kubalulekile ukucabangela lezi zici nezindlela ezihlukahlukene. Lokhu kungenxa yokuthi, ngokufana nokwelashwa komdlavuza, ukusetshenziswa kwe-Angelica akusona isinqumo somhlaba wonke esilungele wonke umdlavuza kodwa sidinga ukwenziwa ngezifiso.

Ukukhetha i-Angelica Supplements

Ukubhekana nombuzo othi 'Kufanele ngimgweme nini u-Angelica endabeni yomdlavuza' kuyinselele ngoba impendulo iqondene nomuntu ngamunye kakhulu - imane nje 'Kuncike!'. Ngokufana nokuthi noma yikuphi ukwelashwa komdlavuza kungase kungasebenzi kuso sonke isiguli, ukubaluleka nokuphepha noma izinzuzo ze-Angelica kuyahlukahluka kuye ngezimo zomuntu siqu. Izinto ezinjengohlobo oluthile lomdlavuza, izakhi zofuzo, ukwelashwa kwamanje, ezinye izithako ezithathwayo, imikhuba yokuphila, i-BMI, nanoma yikuphi ukungezwani komzimba nakho konke kunendima ekunqumeni ukuthi u-Angelica ufanelekile noma kufanele agwenywe, kugcizelela ukubaluleka kokucatshangelwa komuntu siqu izinqumo ezinjalo.

1. Ingabe i-Angelica Supplements izozuza Iziguli Eziyinhloko Ze-Cervical Neuroendocrine Tumor ezelashwa nge-Docetaxel?

I-Primary Cervical Neuroendocrine Tumor ibonakala ngokuguqulwa kofuzo okuthile, okuyi-ABHD6, STOX1 kanye ne-PDZD4, okuholela ekuguqulweni kwezindlela ze-biochemical, ikakhulukazi i-Cell Cycle. Ukusebenza kokwelashwa komdlavuza, okufana ne-Docetaxel, kuncike endleleni yayo yokusebenza kulezi zindlela ezithile. Isu elifanele libandakanya ukuvumelanisa isenzo sokwelashwa nezindlela ezishayela umdlavuza, ngaleyo ndlela kuqinisekiswe indlela yomuntu siqu nephumelelayo. Ezimweni ezinjalo, ukugwema ukudla noma izithasiselo zokudla okunomsoco ezingase zimelane nemiphumela yokwelashwa noma zinciphise lokhu kuqondanisa kubalulekile. Isibonelo, isengezo se-Angelica, esithinta i-Cell Cycle, ingase ingabi inketho efanele esimweni se-Primary Cervical Neuroendocrine Tumor lapho i-Docetaxel. Lokhu kungenxa yokuthi kungase kubhebhethekise ukuqhubeka kwesifo noma kuphazamise ukusebenza kahle kokwelashwa. Lapho ukhetha uhlelo lokudla okunempilo, kubalulekile ukucabangela izici ezifana nohlobo lomdlavuza, ukwelashwa okuqhubekayo, ubudala, ubulili, i-BMI, indlela yokuphila, nanoma yikuphi ukuguqulwa kofuzo okwaziwayo.

2. Ingabe i-Angelica Supplements izozizuzisa Iziguli Eziyinhloko ze-Urethral Squamous Cell Carcinoma ezelashwa Ngemisebe?

I-Primary Urethral Squamous Cell Cell Carcinoma ibonakala ngokuguqulwa kofuzo okuthile, okufana ne-BLM, BRCA1 kanye ne-CTCF, okuholela ezinguqukweni zezindlela zamakhemikhali ezinto eziphilayo, ikakhulukazi i-Androgen Signaling kanye Nokulungiswa KweDNA. Ukusebenza kokwelashwa komdlavuza, njengeRadiation, kunqunywa ukusebenzisana kwayo nalezi zindlela. Inhloso ukuqinisekisa ukuthi ukwelashwa kuhambisana kahle nezindlela eziqhuba umdlavuza, okwenza kube nendlela yokwelapha yomuntu siqu. Kulo mongo, ukudla noma izithasiselo ezihambisana nokwelashwa noma ezithuthukisa lokhu kuqondanisa kufanele kucatshangelwe. Isibonelo, isithasiselo se-Angelica siyinketho enengqondo kulabo abane-Primary Urethral Squamous Cell Carcinoma ababhekene neRadiation. Lokhu kungenxa yokuthi i-Angelica ithonya izindlela ezifana ne-DNA Repair, engavimbela izici ezishayela i-Primary Urethral Squamous Cell Carcinoma noma izuzise ukusebenza ngempumelelo KoMsebe.

3. Ingabe I-Angelica Supplements Iphephile Kubantu Abanempilo Enempilo Nge-ASXL1 Mutation Associated Genetic Risk?

Izinkampani ezehlukene zihlinzeka ngamaphaneli ofuzo okuhlola ubungozi bofuzo lwezinhlobo ezahlukene zomdlavuza. Lawa maphaneli ahlanganisa izakhi zofuzo ezixhumene nomdlavuza webele, wesibeletho, isibeletho, i-prostate, kanye nomdlavuza wesisu. Ukuhlola lezi zakhi zofuzo kungaqinisekisa ukuxilongwa futhi kwazise amasu okwelashwa nawokuphatha. Ukuhlonza okuhlukile okubangela isifo kungasiza ngokuqhubekayo ekuhlolweni nasekuxilongeni izihlobo okungenzeka zibe sengozini. Ufuzo lwe-ASXL1 luvamise ukufakwa kulawa maphaneli okuhlolwa kwengozi yomdlavuza.

Ukuguqulwa kwezakhi zofuzo ze-ASXL1 kuthinta izindlela ze-biochemical noma izinqubo, njenge-Cell Cycle Checkpoints, i-Oncogenic Cancer Epigenetics kanye ne-Suppressive Histone Methylation, ehileleke ngokuqondile noma ngokungaqondile ekushayeleni umdlavuza ezingeni lamangqamuzana. Lapho iphaneli yofuzo ikhomba uguquko ku-ASXL1 ehambisana nengozi eyengeziwe ye-Chronic Myelomonocytic Leukemia, ingqondo yesayensi iphakamisa ukugwema ukusetshenziswa kwe-Angelica eyengeziwe. Lokhu kungenxa yokuthi ukwesekwa kwe-Angelica kuthonya izindlela ezifana ne-Cell Cycle Checkpoints, okungaholela emiphumeleni emibi kumongo wokuguqulwa kwe-ASXL1 kanye nezimo zomdlavuza ezihlobene.

4. Ingabe I-Angelica Supplements Iphephile Kubantu Abanempilo Enempilo Ene-ERBB2 Mutation Associated Genetic Risk?

I-ERBB2 idlala indima ebalulekile ekuhloleni ubungozi bomdlavuza. Ukuguqulwa kwezinguquko ku-ERBB2 kungaphazamisa izindlela ezibalulekile ze-biochemical, okuhlanganisa i-Oncogenic Histone Methylation, i-Growth Factor Signaling kanye ne-PI3K-AKT-MTOR Signaling, enomthelela ekuthuthukiseni umdlavuza. Uma iphaneli yakho yofuzo yembula izinguquko ku-ERBB2 ehambisana ne-Esophageal Adenocarcinoma, cabanga ukufaka izithako ze-Angelica ohlelweni lwakho lokudla. Lezi zithako zingaba nomthelela omuhle ezindleleni ezifana ne-Oncogenic Histone Methylation, zizuze ngokunikeza usizo olufanele kubantu abanezinguquko ze-ERBB2 kanye nokukhathazeka kwezempilo okuhlobene.

Ekuphetheni

Izinto ezimbili ezibaluleke kakhulu okufanele uzikhumbule ukuthi ukwelapha umdlavuza nokudla okunempilo akufani kuwo wonke umuntu. Ukudla okunomsoco, okuhlanganisa ukudla nezithako ezifana ne-Angelica, iyithuluzi elisebenzayo elingalawulwa nguwe ngenkathi ubhekene nomdlavuza.

“Kufanele ngidleni?” umbuzo ovame ukubuzwa yiziguli ezinomdlavuza nalabo abasengozini yomdlavuza. Impendulo efanele ukuthi incike ezintweni ezifana nohlobo lomdlavuza, ufuzo lwesimila, ukwelashwa kwamanje, ukungezwani komzimba nezinto ezithile, indlela yokuphila, kanye ne-BMI.

Thola umsoco wakho womdlavuza ku-addon ngokuchofoza isixhumanisi esingezansi futhi uphendule imibuzo emayelana nohlobo lomdlavuza wakho, ukwelashwa, indlela yokuphila, izinto ezingezwani nazo, iminyaka, nobulili.

Okubhekwayo

• cBioPortal for Cancer Genomics
• Isimo esiguquguqukayo somdlavuza we-metastatic sivezwe kusukela ekulandeleni okungase kube khona kweziguli eziyi-10,000.
• cBioPortal for Cancer Genomics
• I-genomics yomtholampilo edidiyelwe yomdlavuza we-metastatic.
• [Ukwakhiwa okuyisisekelo kwemisebenzi yemfundo ekhethekile ekuvuseleleni abakhubazekile ngokomzimba].
• Isakhiwo sekristalu senkimbinkimbi encike ku-cyclin-kinase 6 yomuntu ene-flavonol inhibitor, i-fisetin.
• I-Paclitaxel ivimbela ukuqhubeka kwamaseli e-mitotic ukuya esigabeni se-G1 ngokuphazanyiswa ukwakheka kwe-spindle ngaphandle kokuthinta eminye imisebenzi ye-microtubule ngesikhathi se-anaphase ne-telephase.
• Indlela ye-Pharmacoinformatics yokuhlonza ama-Polo-like kinase-1 inhibitors emithonjeni yemvelo njengama-anti-cancer agents.
• Isisho se-BRCA1 sibuyisela ukumelana nemisebe kumaseli omdlavuza anesici se-BRCA1 ngokuthuthukisa ukulungiswa kwe-DNA okulotshiweyo okuhlanganisiwe.