Ukudla kwe-Anal Gland Adenocarcinoma!

Isingeniso

Ukudla kwe-Adenocarcinoma kufanele kube okomuntu siqu kumuntu ngamunye futhi kufanele ivumelane nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Nge-Anal Gland Adenocarcinoma, ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - komdlavuza njenge-Adenocarcinoma ye-Anal Gland ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza onjenge-Anal Gland Adenocarcinoma?

Isibonelo, ingabe kunendaba ukuthi imifino ye-Red Beetroot idliwa kakhulu uma iqhathaniswa ne-Okra? Ingabe kuyawenza umehluko uma izithelo zeGrapefruit/pummelo Hybrid zikhethwa kuneBlackcurrant? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Common Hazelnut phezu kwe-Butternut kanye nama-pulses afana ne-Yardlong Bean phezu kwe-Cowpea. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Adenocarcinoma ye-Anal Gland futhi ingabe iyimpendulo efanayo yawo wonke umuntu onesifo esifanayo noma engozini yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Anal Gland Adenocarcinoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo I-Grapefruit/pummelo Hybrid iqukethe izithako ezisebenzayo I-Caffeine, i-Curcumin, i-Luteolin, i-Genistein, i-Apigenin. Futhi i-Blackcurrant iqukethe izithako ezisebenzayo i-Quercetin, i-Caffeine, i-Ferulic Acid, i-Curcumin, i-Gallic Acid kanye nezinye okungenzeka.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa kwe-Anal Gland Adenocarcinoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kwe-Anal Gland Adenocarcinoma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukondleka Kube Ngokwakho Nge-Anal Gland Adenocarcinoma?

Ukondleka komuntu siqu komdlavuza njenge-Anal Gland Adenocarcinoma iqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Anal Gland Adenocarcinoma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhambisana nakho lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Anal Gland Adenocarcinoma

Yonke imidlavuza efana ne-Adenocarcinoma ye-Anal ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Adenocarcinoma ye-Anal. Izindlela ze-Biochemical ezifana ne-mRNA Splicing, Ukulungiswa Kwe-DNA, I-Oncogenic Cancer Epigenetics, I-Suppressive Histone Methylation iyingxenye yencazelo yesiginesha ye-Anal Gland Adenocarcinoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo ku-Adenocarcinoma ye-Anal kufanele kuqashelwe izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezingeziwe kuyanconywa nge-Adenocarcinoma ye-Anal uma uthatha ukwelashwa komdlavuza I-radiation, nokunye ukudla nezithako ezingeziwe akunconyiwe.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-DNMT3A, ASXL1, PPM1D, TET2 kanye ne-CHEK2 yizakhi zofuzo ezikleliswe phezulu ze-Anal Gland Adenocarcinoma. I-DNMT3A ibikwa kuma-36.8 % eziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-ASXL1 ibikwa ku-15.8%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esuka ku-32 kuya ku-80. Ama-38.6 % emininingwane yesiguli ahlonzwa njengabesilisa. I-Anal Gland Adenocarcinoma biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimelelwe izindlela zamakhemikhali ezinto eziphilayo kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Adenocarcinoma ye-Anal Gland

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha iVegetable RED BEETROOT noma i-OKRA?

I-Vegetable Red Beetroot iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Caffeine, i-Ferulic Acid, i-Curcumin, i-Beta-carotene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Red Beetroot iyanconywa nge-Adenocarcinoma ye-Anal Gland lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Radiation. Lokhu kungenxa yokuthi i-Red Beetroot iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela woMsebe.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Okra yemifino yi-Quercetin, i-Curcumin, i-Luteolin, i-Genistein, i-Apigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Okra ayinconywa nge-Anal Gland Adenocarcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuwuMisebe ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-BEETROOT EBOMVU YEZINJINI INCONYISWA NGAPHEZU KWE-OKRA NGENdlala Ye-Adenocarcinoma KANYE NOKWELASHWA kwemisebe.

Khetha Isithelo BLACKCURRANT noma GRAPEFRUIT/PUMMELO HYBRID?

I-Fruit Blackcurrant iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Caffeine, i-Ferulic Acid, i-Curcumin, i-Gallic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Blackcurrant inconywa nge-Adenocarcinoma ye-Anal Gland lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Radiation. Lokhu kungenxa yokuthi i-Blackcurrant ilungisa lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela woMsebe.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni I-Grapefruit/pummelo Hybrid yi-Caffeine, i-Curcumin, i-Luteolin, i-Genistein, i-Apigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Grapefruit/pummelo Hybrid ayinconywa nge-Anal Gland Adenocarcinoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Radiation ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

ISITHELO EMNYAMA KUNCONYWA NGAPHEZU KWEGILIPISI/PUMMELO HYBRID YENdlala ye-Adenocarcinoma KANYE NOKWELASHWA.

Khetha Nut COMMON HAZELNUT noma BUTTERNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Caffeine, i-Curcumin, i-Genistein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Hazelnut evamile inconywa nge-Adenocarcinoma ye-Anal Gland lapho ukwelashwa komdlavuza okuqhubekayo kuwuMisebe. Lokhu kungenxa yokuthi i-Hazelnut Ejwayelekile iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela Wokukhishwa Kwemisebe.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Butternut yi-Caffeine, i-Curcumin, i-Luteolin, i-Juglone, i-Genistein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Butternut ayinconywa nge-Adenocarcinoma ye-Anal Gland uma ukwelashwa komdlavuza okuqhubekayo kuyi-Radiation ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWEBHUTTERNUT YENdlala Yezindunu I-Adenocarcinoma KANYE NOKWELASHWA kwemisebe.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa ngabantu abasengozini yofuzo ye-Adenocarcinoma noma umlando womndeni uthi “Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?” nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha iVegetable GIANT BUTTERBUR noma i-RAPINI?

I-Vegetable Giant Butterbur iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oncogenic Cancer Epigenetics, i-MYC Signaling, i-MAPK Signaling kanye ne-DNA Repair nezinye. I-Butterbur Enkulu inconyelwe engcupheni ye-Adenocarcinoma ye-Anal Gland lapho ingozi yofuzo ehlobene i-ASXL1. Lokhu kungenxa yokuthi i-Giant Butterbur inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Rapini yemifino yi-Apigenin, i-Curcumin, i-Lupeol, i-Protocatechuic Acid, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Rapini ayinconywa uma ubungozi be-Adenocarcinoma ye-Anal uma ubungozi bofuzo obuhlobene buyi-ASXL1 ngoba inyusa izindlela zayo zokusayina.

IBUTTERBUR ENKULU YEMVIDO INCONYISWA NGAPHEZU KWE-RAPINI NGENGOZI YOMFUZA I-ASXL1 YE-ASXLXNUMX.

Khetha isithelo NANCE noma i-PUMMELO?

I-Fruit Nance iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Protocatechuic Acid, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oncogenic Cancer Epigenetics, i-MYC Signaling, i-MAPK Signaling kanye ne-DNA Repair nezinye. I-Nance inconywa engcupheni ye-Adenocarcinoma ye-Anal Gland lapho ubungozi bofuzo obuhlobene buyi-ASXL1. Lokhu kungenxa yokuthi i-Nance inyusa lezo zindlela ze-biochemical eziphikisana nabashayeli bamasignesha bayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Pummelo ayinconywa uma ubungozi be-Adenocarcinoma ye-Anal uma ubungozi bofuzo obuhlobene buyi-ASXL1 ngoba inyusa izindlela zayo zokusayina.

I-FRUIT NANCE INCONYISWA NGAPHEZU KWE-PUMMELO NGENGOZI YOMKHANZA YE-ASXL1 yofuzo.

Khetha Nut BLACK WALNUT noma PILI NUT?

I-Black Walnut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives njenge-Apigenin, i-Curcumin, i-Lupeol, i-Ellagic Acid, i-Protocatechuic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-RAS-RAF Signaling, i-Apoptosis, i-MAPK Signaling kanye ne-P53 Signaling nezinye. I-Walnut Emnyama inconywa engcupheni ye-Adenocarcinoma ye-Anal Gland uma ingozi yofuzo ehlobene i-ASXL1. Lokhu kungenxa yokuthi i-Black Walnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Pili Nut yi-Apigenin, i-Curcumin, i-Lycopene, i-Lupeol, i-Protocatechuic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Pili Nut ayituswa uma ubungozi be-Adenocarcinoma ye-Anal lapho ubungozi bofuzo buhambisana ne-ASXL1 ngoba kwandisa izindlela zokusayina.

I-WALNUT EMNYAMA INCONYISWA NGAPHEZU KWE-PILI NUT NGENGOZI YOFUZO YE-ASXL1 YOMKHANZA.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Adenocarcinoma ye-Anal Gland. Iziguli ezine-Adenocarcinoma ye-Anal Gland kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithasiselo zokudla okunempilo engikunconyelwe futhi okungekona?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Anal Gland Adenocarcinoma, ngayinye enezakhi zofuzo zesimila ezihlukene ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana ne-Red Beetroot kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukene wezindlela zamakhemikhali ezinto eziphilayo. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli i-Adenocarcinoma ye-Anal?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• Msk Ch 2020
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• I-BRCA1 ne-BRCA2 njengokuhlosiwe kwamangqamuzana e-phytochemicals indole-3-carbinol kanye ne-genistein kumaseli omdlavuza webele kanye ne-prostate.
• I-Paederia foetida idala umsebenzi wokulwa nomdlavuza ngokushintsha ama-enzyme okuguqula i-chromatin futhi iguqule ukubonakaliswa kwezakhi zofuzo ze-cytokine ezinokuvuvukala kumaseli omdlavuza wendlala yesinye.