Ukudla kwe-Gastrointestinal Stromal Sarcoma!

Isingeniso

Ukudla kwe-Gastrointestinal Stromal Sarcoma kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Nge-Gastrointestinal Stromal Sarcoma ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - komdlavuza njenge-Gastrointestinal Stromal Sarcoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza njengeGastrointestinal Stromal Sarcoma?

Isibonelo, ingabe kunendaba ukuthi iBitter Gourd yemifino idliwa kakhulu uma iqhathaniswa ne-Kohlrabi? Ingabe kuyawenza umehluko uma isithelo iPummelo sithandwa kunePomegranate? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Butternut phezu kwe-Chestnut kanye nama-pulses afana ne-Adzuki Bean phezu kwe-Lima Bean. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Gastrointestinal Stromal Sarcoma futhi ingabe iyimpendulo efanayo yawo wonke umuntu onokuxilonga okufanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Gastrointestinal Stromal Sarcoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo i-Pummelo iqukethe izithako ezisebenzayo i-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Futhi iPomegranate iqukethe izithako ezisebenzayo i-Ellagic Acid, Quercetin, Curcumin, Formononetin, Lupeol kanye nezinye okungenzeka.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa kwe-Gastrointestinal Stromal Sarcoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kwe-Gastrointestinal Stromal Sarcoma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okufana Nakho Kwe-Gastrointestinal Stromal Sarcoma?

Ukondleka komuntu siqu komdlavuza njenge-Gastrointestinal Stromal Sarcoma iqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Gastrointestinal Stromal Sarcoma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Gastrointestinal Stromal Sarcoma

Yonke imidlavuza efana ne-Gastrointestinal Stromal Sarcoma ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Gastrointestinal Stromal Sarcoma. Izindlela ze-Biochemical ezifana ne-Cell Cycle, i-MAPK Signaling, i-PI3K-AKT-MTOR Signaling, Growth Factor Signaling ziyingxenye yencazelo yesiginesha ye-Gastrointestinal Stromal Sarcoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo kwe-Gastrointestinal Stromal Sarcoma kudingeka kuqashelwe izindlela ezihambisana nesiginesha ze-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezingeziwe kuyanconywa nge-Gastrointestinal Stromal Sarcoma lapho uthatha ukwelashwa komdlavuza i-Octreotide, futhi okunye ukudla nezithasiselo akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-KIT, i-TSC1, i-SETD2, i-MAX kanye ne-PDGFRA izakhi zofuzo ezisezingeni eliphezulu ezibikwayo ze-Gastrointestinal Stromal Sarcoma. I-KIT ibikwa ku-5.2 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-TSC1 ibikwa ku-1.1%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esukela kweyi-16 kuye kwengama-90. Amaphesenti angama-55.2 emininingwane yesiguli ahlonzwa njengabesilisa. I-Gastrointestinal Stromal Sarcoma biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimelelwe izindlela zamakhemikhali ezinto eziphilayo kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Gastrointestinal Stromal Sarcoma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha iVegetable BITTER GOURD noma i-KOHLRABI?

I-Vegetable Bitter Gourd iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Isoliquiritigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-MAPK Signaling, i-JAK-STAT Signaling, i-Angiogenesis ne-PI3K-AKT-MTOR Signaling nezinye. I-Bitter Gourd iyanconywa nge-Gastrointestinal Stromal Sarcoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Octreotide. Lokhu kungenxa yokuthi i-Bitter Gourd iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Octreotide.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino ye-Kohlrabi yi-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-MAPK Signaling, i-WNT Beta Catenin Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Kohlrabi ayinconyelwe i-Gastrointestinal Stromal Sarcoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Octreotide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kube ukumelana noma kungaphenduli kahle.

IGORD EBITTER VEGETABLE INCONYISWA NGAPHEZU KWE-KOHLRABI NGE-Gastrointestinal Stromal Sarcoma KANYE NOKWELASHWA I-Octreotide.

Khetha Isithelo IPOMEGRANATE noma i-PUMMELO?

Igromegranate yesithelo iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Ellagic Acid, i-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-MAPK Signaling, i-Angiogenesis, i-Growth Factor Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. Ipomegranate iyanconywa nge-Gastrointestinal Stromal Sarcoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Octreotide. Lokhu kungenxa yokuthi iPomegranate iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Octreotide.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Pummelo ayinconyelwe i-Gastrointestinal Stromal Sarcoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Octreotide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

ISITHELO IPHOMEGRANATE INCONYWA NGENXA YE-PUMMELO YE-Gastrointestinal Stromal Sarcoma KANYE NE-Octreotide YOKWELAPHA.

Khetha Nut BUTTERNUT noma CHESTNUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Isoliquiritigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-MAPK Signaling, i-JAK-STAT Signaling, i-Angiogenesis ne-PI3K-AKT-MTOR Signaling nezinye. I-Butternut iyanconywa nge-Gastrointestinal Stromal Sarcoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Octreotide. Lokhu kungenxa yokuthi i-Butternut ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Octreotide.

Ezinye zezithako ezisebenzayo noma ama-bioactive ku-Chestnut yi-Ellagic Acid, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Chestnut ayinconyelwe i-Gastrointestinal Stromal Sarcoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Octreotide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kuzwele noma kungasabeli kahle.

I-BUTTERNUT INCONYISWA NGAPHEZU KWE-CHESTNUT NGE-Gastrointestinal Stromal Sarcoma KANYE NOKWELASHWA I-Octreotide.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwe abantu abasengozini yofuzo ye-Gastrointestinal Stromal Sarcoma noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha i-Vegetable CAULIFLOWER noma I-RED BELL PEPPER?

I-Cauliflower yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Lupeol, i-Isoliquiritigenin, i-Daidzein, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-MAPK Signaling, i-RAS-RAF Signaling, i-Angiogenesis ne-PI3K-AKT-MTOR Signaling nezinye. Ukholifulawa unconywa ngengozi ye-Gastrointestinal Stromal Sarcoma uma ubungozi bofuzo obuhambisanayo kuyi-KIT. Lokhu kungenxa yokuthi ukholifulawa unyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zayo zokusayina.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino e-Red Bell Pepper yi-Quercetin, i-Curcumin, i-Lupeol, i-Luteolin, i-Isoliquiritigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-MAPK Signaling kanye ne-Stem Cell Signaling nezinye. I-Red Bell Pepper ayituswa uma ingozi ye-Gastrointestinal Stromal Sarcoma uma ingozi yofuzo ehlotshaniswa nayo kuyi-KIT ngoba inyusa izindlela zayo zokusayina.

I-VEGETABLE CAULIFLOWER INCONYISWA NGAPHEZU KWE-RED BELL ELIBOMVU NGEKIT GENETIC RISK OF CANCER.

Khetha Fruit BILBERRY noma SWEET ORANGE?

I-Fruit Bilberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Quercetin, i-Curcumin, i-Lupeol, i-Luteolin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukusayinda kwe-MYC, Ukusayinda kwe-Stem Cell kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Bilberry inconyelwa engcupheni ye-Gastrointestinal Stromal Sarcoma uma ingozi yofuzo ehlotshaniswa nayo kuyi-KIT. Lokhu kungenxa yokuthi i-Bilberry inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni I-Sweet Orange yi-D-limonene, i-Curcumin, i-Lupeol, i-Vitamin D3, i-Luteolin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Cell Cycle, Stem Cell Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Orange Emnandi ayinconywa uma ingozi ye-Gastrointestinal Stromal Sarcoma uma ingozi yofuzo ehlotshaniswa nayo kuyi-KIT ngoba inyusa izindlela zayo zokusayina.

I-FRUIT BILBERRY INCONYISWA NGAPHEZU KOKUWOLISHI OMNANDI NGEKIT GENETIC RISK YOMKHANZA.

Khetha Nut COMMON HAZELNUT noma EUROPEAN CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Curcumin, i-Lupeol, i-Isoliquiritigenin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukusayinda kwe-MYC, Ukusayinda kwe-Stem Cell kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Hazelnut evamile iyanconywa ngengozi ye-Gastrointestinal Stromal Sarcoma lapho ubungozi bofuzo obuhlobene kuyi-KIT. Lokhu kungenxa yokuthi i-Common Hazelnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yase-Europe yi-Apigenin, i-Quercetin, i-Curcumin, i-Ellagic Acid, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Stem Cell Signaling nezinye. I-Chestnut yase-Europe ayinconywa uma ingozi ye-Gastrointestinal Stromal Sarcoma uma ingozi yofuzo ehlotshaniswa nayo kuyi-KIT ngoba inyusa izindlela zayo zokusayina.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-CHESTNUT YAseYurophu NGEKIT GENETIC INGOZI YOMKHANZA.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Gastrointestinal Stromal Sarcoma. Iziguli ze-Gastrointestinal Stromal Sarcoma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunomsoco engikunconyelwe futhi okungenjalo?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza njenge-Gastrointestinal Stromal Sarcoma, ngayinye enofuzo oluhlukile lwesimila esinokwehluka okwengeziwe kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana ne-Bitter Gourd kuqukethe ama-bioactives ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukile wezindlela ze-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, “Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli i-Gastrointestinal Stromal Sarcoma?”. Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• I-Msk Impact 2017
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• Imiphumela yokuvimbela ye-butyric acid, i-nicotinamide, i-calcium glucarate iyodwa noma ihlangene ngesikhathi se-7, i-12-dimethylbenz (a) i-anthracene eyenge i-tumorigenesis yesikhumba segundane ngokumodulation kwe-K-Ras-PI3K-AKTpathway kanye nama-RNA amancane ahlobene.
• I-Betulinic acid ivimbela ukukhula komdlavuza wendlala yesinye ngokuvimbela izici ezithile zokubhalwa kwamaprotheni.
• I-Gallic acid, i-phenolic compound, inemiphumela ephikisana ne-angiogenic ngokusebenzisa i-PTEN/AKT/HIF-1α/VEGF indlela yokubonisa kumaseli omdlavuza wesibeletho.
• Ukukhuthazwa ukukhula kwamaseli e-adenocarcinoma yamaphaphu kanye namaseli amancane e-epithelial yomoya nge-beta-carotene ngokwenza kusebenze i-cAMP, i-PKA, i-CREB ne-ERK1/2.
• Imiphumela kanye nokubaluleka kwe-formononetin emazingeni e-HIF-1α kanye ne-VEGF kumathishu omdlavuza womlomo wesibeletho wegundane.
• Ukulawulwa okungekuhle kwe-transducer yesiginali kanye ne-activator ye-transcription-3 signaling cascade nge-lupeol ivimbela ukukhula futhi yenze i-apoptosis kumaseli e-hepatocellular carcinoma.
• I-Chlorogenic acid ivimbela ukwanda futhi ibangele i-apoptosis kumaseli omdlavuza wezinso we-A498 ngokusebenzisa indlela yokusayina ye-PI3K/Akt/mTOR engasebenzi.
• I-Brassinin ivimbela indlela yokusayina ye-STAT3 ngokushintshwa kwe-PIAS-3 ne-SOCS-3 expression futhi iqwashise i-xenograft yomdlavuza wamaphaphu womuntu kumagundane anqunu ku-paclitaxel.
• Ukuqala kwe-transient receptor engaba khona uhlobo loku-1 lwe-vanilloid (TRPV1) nge-capsaicin kubangela i-apoptosis ye-Fas/CD95-mediated yamaseli omdlavuza we-urothelial ngendlela encike ku-ATM.