Ukudla kwe-Extramammary Paget Disease!

Isingeniso

Ukudla kwe-Extramammary Paget Disease kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

I-Extramammary Paget’s disease, umdlavuza wesikhumba ongavamile ohlasela izindawo ezinezindlala ze-apocrine eziningi, uveza izinselele eziyingqayizivele ekuxilongeni nasekwelapheni. Lesi simo singenzeka kokubili kwabesilisa nabesifazane, kanye nezenzakalo eziphawulekayo ku-vulva kwabesifazane kanye nezitho zangasese noma ze-perianal emadodeni. Izimpawu ze-pathology zesifo sika-Paget's extramammary zinikeza ukuqonda okubalulekile ezicini zeselula futhi zisize ukuqondisa izinqumo zokwelashwa. Ukwelashwa ngokuvamile kuhilela ukuhlinza, futhi kwezinye izimo, ukwelashwa kwendawo noma i-radiotherapy kungase kucatshangelwe. Ikhodi ye-ICD-10 yesifo se-Paget's extramammary isiza ukubika okujwayelekile kanye nokulandelelwa kokwelashwa. I-DermNet nezinye izinsiza ze-dermatological zinikeza ulwazi olubalulekile mayelana nokwethulwa komtholampilo nokuphathwa kwalesi sifo. Nakuba isifo sika-Paget sika-extramammary sithinta ngokuyinhloko isikhumba, ukubikezela kwayo kanye nombuzo wokuthi ingabe kuyabulala kuncike ezintweni eziningana, kuhlanganise nokuba khona kwesifo esihlaselayo noma izifo eziyingozi. Ukutholakala kwesifo i-Paget’s extramammary kwengeza ubunzima bokufunda nokusiqonda, okusenza sibe isihloko socwaningo oluqhubekayo. Ngamafuphi, ukuphathwa okuphumelelayo kwesifo se-Paget's extramammary kudinga ukuqonda okuphelele kwe-pathology yayo, ukucatshangelwa ngokucophelela kwezinketho zokwelapha, nokuqwashisa ngobunzima bayo obungase bube khona, ikakhulukazi ezimweni ezithuthukile noma ezihlaselayo.

Nge-Extramammary Paget Disease ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yokuthola umdlavuza - komdlavuza njenge-Extramammary Paget Disease ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe esitshalweni ingabe kwanele umdlavuza njenge-Extramammary Paget Disease?

Isibonelo, ingabe kunendaba ukuthi i-Carrot yemifino idliwa kakhulu uma iqhathaniswa ne-Malabar Spinach? Ingabe kuyawenza umehluko uma isithelo esithi Black Elderberry sithandwa kune-Evergreen Blackberry? Futhi uma ukukhetha okufanayo kwenzelwe amantongomane/imbewu efana ne-Walnut yaseJapane phezu kwe-Chestnut yase-Europe kanye nama-pulses afana ne-Black-eyed Pea phezu kwe-Common Bean. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe Isifo Se-Extramammary Paget futhi ingabe impendulo efanayo yawo wonke umuntu onesifo esifanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Extramammary Paget Disease!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo I-Black Elderberry iqukethe izithako ezisebenzayo i-Curcumin, i-Daidzein, i-Formononetin, i-Cinnamaldehyde, i-Melatonin. Futhi i-Evergreen Blackberry iqukethe izithako ezisebenzayo i-Ellagic Acid, i-Cinnamaldehyde, i-Eugenol, i-Myricetin, i-Linalool kanye nezinye okungenzeka.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa ngenxa ye-Extramammary Paget Disease - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kwe-Extramammary Paget Disease.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okufana Nakho Kwesifo Se-Paget Esidlulele?

Ukondleka komuntu siqu komdlavuza njenge-Extramammary Paget Disease kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe kubhayoloji yezifo ze-Extramammary Paget, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene nokwelashwa okungayeka ukusebenza ngakho.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Extramammary Paget Disease

Yonke imidlavuza efana ne-Extramammary Paget Disease ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Extramammary Paget Disease. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-PI3K-AKT-MTOR Signaling, Growth Factor Signaling, Chromatin Remodeling, MAPK Signaling ziyingxenye yencazelo yesiginesha ye-Extramammary Paget Disease. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo kwe-Extramammary Paget Disease kumele kuqashelwe izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezisizayo kunconyelwa I-Extramammary Paget Disease lapho uthatha ukwelashwa komdlavuza i-Pazopanib, futhi okunye ukudla nezithako ezingeziwe akunconyiwe.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-ERBB2, PPP2R1A kanye ne-SMARCA4 izakhi zofuzo ezisezingeni eliphezulu ezibikiwe ze-Extramammary Paget Disease. I-ERBB2 ibikwa kuma-33.3 % eziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-PPP2R1A ibikwa ku-33.3 %. Idatha yesiguli esihlanganisiwe ihlanganisa iminyaka ukusuka kuye kuye. U-50.0 % wemininingwane yesiguli uhlonzwa njengabesilisa. I-Extramammary Paget Disease biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela zamakhemikhali ezinto eziphilayo kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Extramammary Paget Disease

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha i-Vegetable CARROT noma i-MALABAR SPINACH?

I-Carrot yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Gamma-linolenic Acid, i-Daidzein, i-Formononetin, i-Cinnamaldehyde. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-PI3K-AKT-MTOR Signaling nezinye. I-carrot inconywa kwi-Extramammary Paget Disease lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib. Lokhu kungenxa yokuthi i-Carrot iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Pazopanib.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino i-Malabar Spinach yi-Curcumin, i-Daidzein, i-Formononetin, i-Cinnamaldehyde, i-Melatonin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-PI3K-AKT-MTOR Signaling nezinye. I-Malabar Spinach ayinconyelwe I-Extramammary Paget Disease lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

IZAQATHI EZILIZWAYO INCONYISWA NGAPHEZU KWE-MALABAR ISIPINSHI NGESIFO SE-Pazopanib Esedlulele Kakhulu KANYE NOKWELAPHA I-Pazopanib.

Khetha i-Fruit EVERGREEN BLACKBERRY noma i-BLACK ELDERBERRY?

I-Fruit Evergreen Blackberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives njenge-Ellagic Acid, i-Cinnamaldehyde, i-Eugenol, i-Myricetin, i-Linalool. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-PI3K-AKT-MTOR Signaling nezinye. I-Evergreen Blackberry iyanconywa nge-Extramammary Paget Disease lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib. Lokhu kungenxa yokuthi i-Evergreen Blackberry ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Pazopanib.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni esithi Black Elderberry yiCurcumin, iDaidzein, iFormononetin, iCinnamaldehyde, iMelatonin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-PI3K-AKT-MTOR Signaling nezinye. I-Black Elderberry ayinconyelwe I-Extramammary Paget Disease lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

ISITHELO EVERGREEN BLACKBERRY INCONYISWA NGAPHEZU KWE-BLACK ELDERBERRY FOR Extramammary Paget Disease KANYE NOKWELAPHA I-Pazopanib.

Khetha Nut JAPANESE WALNUT noma EUROPEAN CHESTNUT?

I-Walnut yaseJapane iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Ellagic Acid, i-Daidzein, i-Cinnamaldehyde, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-PI3K-AKT-MTOR Signaling nezinye. I-Walnut yaseJapane inconywa nge-Extramammary Paget Disease lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib. Lokhu kungenxa yokuthi i-Walnut yaseJapane iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Pazopanib.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yaseYurophu yi-Curcumin, i-Ellagic Acid, i-Daidzein, i-Cinnamaldehyde, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-PI3K-AKT-MTOR Signaling nezinye. I-Chestnut yase-Europe ayinconyelwe I-Extramammary Paget Disease lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Pazopanib ngoba ilungisa lezo zindlela ze-biochemical eyenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-WALNUT YASEJAPANE INCONYISWA NGAPHEZU KWE-CHESTNUT YASE-EUROPE NGESIFO SE-Paget Esedlulele KANYE NOKWELAPHA I-Pazopanib.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa ngabantu abasengozini yofuzo ye-Extramammary Paget Disease noma umlando womndeni uthi “Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?” nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha Imifino NEW ZEALAND SPINACH noma i-CUCURBITA?

Imifino yase-New Zealand Isipinashi iqukethe izithako ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Delphinidin, i-Quercetin, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukusayinda kwe-Phospholipase, Ukusayinwa kwe-Growth Factor Signaling kanye ne-MYC Signaling nezinye. I-New Zealand Spinach inconywa engozini ye-Extramammary Paget Disease lapho ubungozi bofuzo obuhlobene buyi-ERBB2. Lokhu kungenxa yokuthi isipinashi saseNew Zealand sinyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zaso.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Cucurbita yemifino yi-Curcumin, i-Delphinidin, i-Daidzein, i-Lupeol, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-MYC Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Cucurbita ayinconywa uma ingozi ye-Extramammary Paget Disease uma ingozi yofuzo ehlotshaniswa nayo ingu-ERBB2 ngoba inyusa izindlela zokusayina kwayo.

IMIFINO ENTSHA YE-ZEALAND INCONYWA NGENXA YE-CUCURBITA YE-ERBB2 GENETIC RISK OF CANCER.

Khetha Fruit BILBERRY noma PUMMELO?

I-Fruit Bilberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Delphinidin, i-Quercetin, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezehlukene ze-biochemical ezifana nokusayina kwe-MAPK, izindawo zokuhlola ze-Cell Cycle, i-Phospholipase Signaling kanye ne-MYC Signaling nezinye. I-Bilberry inconyelwa engcupheni ye-Extramammary Paget Disease lapho ubungozi bofuzo obuhlobene buyi-ERBB2. Lokhu kungenxa yokuthi i-Bilberry inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Curcumin, i-Apigenin, i-Delphinidin, i-Naringenin, i-Hesperetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Cell Cycle Checkpoints kanye ne-Epithelial to Mesenchymal Transition nezinye. I-Pummelo ayinconywa uma ingozi ye-Extramammary Paget Disease uma ingozi yofuzo ehlotshaniswa nayo i-ERBB2 ngoba inyusa izindlela zayo zokusayina.

I-FRUIT BILBERRY INCONYISWA NGAPHEZU KWE-PUMMELO NGENGOZI YOFUZO YE-ERBB2 YOMKHANZA.

Khetha Nut COMMON HAZELNUT noma CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Delphinidin, i-Quercetin, i-Lycopene, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukusayinda kwe-Phospholipase, Ukusayinwa kwe-Growth Factor Signaling kanye ne-MYC Signaling nezinye. I-Hazelnut evamile inconywa engcupheni ye-Extramammary Paget Disease uma ingozi yofuzo ehlotshaniswa nayo i-ERBB2. Lokhu kungenxa yokuthi i-Common Hazelnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Curcumin, i-Ellagic Acid, i-Apigenin, i-Delphinidin, i-Lycopene. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Cell Cycle Checkpoints kanye ne-Epithelial to Mesenchymal Transition nezinye. I-Chestnut ayinconywa uma ingozi ye-Extramammary Paget Disease uma ingozi yofuzo ehlotshaniswa nayo ingu-ERBB2 ngoba inyusa izindlela zayo zokusayina.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-CHESTNUT NGENGOZI YOFUZO YE-ERBB2 YOMKHANZA.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Extramammary Paget Disease. Iziguli ze-Extramammary Paget Disease kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: “Yikuphi ukudla nezithasiselo zokudla okunempilo enginconyelwe kona futhi okungekona?” Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza njenge-Extramammary Paget Disease, ngasinye sinezakhi zofuzo zesimila esinokwehlukahlukana kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana ne-Carrot kuqukethe ama-bioactives ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene futhi ahlukene wezindlela ze-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli Isifo Se-Extramammary Paget?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

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• I-Daidzein yenza umsebenzi wokulwa ne-tumor ngokumelene namaseli omdlavuza wesinye ngokuvinjelwa kwendlela ye-FGFR3.
• I-Shikimic acid ikhuthaza ukwanda kwamaseli omdlavuza webele we-estrogen (ER) ngokwenza kusebenze ukusayina kwe-NF-κB.
• I-aqueous cinnamon extract (ACE-c) ephuma egxolweni leCinnamomum cassia idala i-apoptosis kumugqa weseli yomdlavuza womlomo wesibeletho (SiHa) ngokulahlekelwa amandla olwelwesi lwe-mitochondrial.
• Imiphumela yokuvimbela ye-butyric acid, i-nicotinamide, i-calcium glucarate iyodwa noma ihlangene ngesikhathi se-7, i-12-dimethylbenz (a) i-anthracene eyenge i-tumorigenesis yesikhumba segundane ngokumodulation kwe-K-Ras-PI3K-AKTpathway kanye nama-RNA amancane ahlobene.
• Inqubekelaphambili yocwaningo emiphumeleni yokulwa nomdlavuza kavithamini K2.
• https://my.clevelandclinic.org/health/diseases/24266-extramammary-pagets-disease
• https://www.ncbi.nlm.nih.gov/books/NBK493224