Ukudla kwe-Esophagogastric Adenocarcinoma!

Isingeniso

Ukudla kwe-Esophagogastric Adenocarcinoma kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Nge-Esophagogastric Adenocarcinoma, ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abangaba sengcupheni yomdlavuza ukuthi - komdlavuza njenge-Esophagogastric Adenocarcinoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza onjenge-Esophagogastric Adenocarcinoma?

Isibonelo, ingabe kunendaba ukuthi i-Wild Leek yemifino idliwa kakhulu uma iqhathaniswa ne-Lettuce? Ingabe kuyawenza umehluko uma izithelo i-Malabar Plum zikhethwa kune-Red Raspberry? Futhi uma ukukhetha okufanayo kwenzelwe amantongomane/imbewu efana ne-Common Hazelnut phezu kwe-Chestnut kanye nama-pulses afana nobhontshisi obanzi phezu kukabhontshisi oluhlaza. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Esophagogastric Adenocarcinoma futhi ingabe iyimpendulo efanayo yawo wonke umuntu onesifo esifanayo noma engozini yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Esophagogastric Adenocarcinoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo i-Malabar Plum iqukethe izithako ezisebenzayo i-Curcumin, i-Formononetin, i-Lupeol, i-Phloretin, i-Daidzein. Futhi okusajingijolo okubomvu kuqukethe izithako ezisebenzayo i-Ellagic Acid, i-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol futhi mhlawumbe nezinye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa kwe-Esophagogastric Adenocarcinoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngoba izithako ezisebenzayo ezahlukahlukene eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo somsoco we-Esophagogastric Adenocarcinoma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okufana Nakho Kwe-Esophagogastric Adenocarcinoma?

Ukondleka komuntu siqu komdlavuza njenge-Esophagogastric Adenocarcinoma iqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Esophagogastric Adenocarcinoma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Esophagogastric Adenocarcinoma

Yonke imidlavuza efana ne-Esophagogastric Adenocarcinoma ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zesiginesha ze-Esophagogastric Adenocarcinoma. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-RAS-RAF Signaling, i-mRNA Splicing, i-Oncogenic Cancer Epigenetics, i-PI3K-AKT-MTOR Ukusayinda iyingxenye yencazelo yesiginesha ye-Esophagogastric Adenocarcinoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo kwe-Esophagogastric Adenocarcinoma kudingeka kuqashelwe izindlela ezihambisana nesiginesha ze-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithasiselo kunconywa nge-Esophagogastric Adenocarcinoma lapho uthatha ukwelashwa komdlavuza I-radiation, futhi okunye ukudla nezithako ezingeziwe akunconyiwe.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-DNMT3A, PPM1D, CDKN2A, SMAD4 kanye ne-TET2 yizakhi zofuzo ezikleliswe phezulu ze-Esophagogastric Adenocarcinoma. I-DNMT3A ibikwa ku-11.0 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-PPM1D ibikwa ku-3.2%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esuka ku-23 kuya ku-89. U-75.2 % wemininingwane yesiguli uhlonzwa njengabesilisa. I-Esophagogastric Adenocarcinoma biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical ezisayinwe kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni zaziwa futhi lokho kufanele kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Esophagogastric Adenocarcinoma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha iVegetable WILD LEEK noma LETTUCE?

I-Vegetable Wild Leek iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Formononetin, i-Lupeol, i-Phloretin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukusayinda kwe-TGFB, Ukusayina kwe-NFKB kanye Nokucindezeleka Kwe-Oxidative nezinye. I-Wild Leek iyanconywa nge-Esophagogastric Adenocarcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuyiRadiation. Lokhu kungenxa yokuthi i-Wild Leek ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela woMsebe.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Lettuce yemifino yi-Quercetin, i-Curcumin, i-Formononetin, i-Vitamin D3, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress nezinye. Ulethisi awunconyelwe ku-Esophagogastric Adenocarcinoma uma ukwelashwa komdlavuza okuqhubekayo kuwuMisebe ngoba ulungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-VEGETABLE WILD LEEK INCONYISWA NGAPHEZU KWE-LETTUCE YE-Esophagogastric Adenocarcinoma KANYE NOKWELASHWA kwemisebe.

Khetha Isithelo RED RASPBERRY noma i-MALABAR PLUM?

I-Fruit Red Raspberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Ellagic Acid, i-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezehlukene ze-biochemical ezifana ne-MAPK Signaling, DNA Repair, PI3K-AKT-MTOR Signaling kanye ne-Oxidative Stress nezinye. Okusajingijolo Okubomvu kunconyelwe i-Esophagogastric Adenocarcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuyiRadiation. Lokhu kungenxa yokuthi i-Red Raspberry iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela Wokukhishwa Kwemisebe.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Malabar Plum yi-Curcumin, i-Formononetin, i-Lupeol, i-Phloretin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Epithelial kuya ku-Mesenchymal Transition kanye ne-Oxidative Stress nezinye. I-Malabar Plum ayinconyelwe i-Esophagogastric Adenocarcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuwuMisebe ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-RASPBERRY EBOMVU YESITHELO INCONYISWA NGAPHEZU KWE-MALABAR PLUM YE-Esophagogastric Adenocarcinoma KANYE NOKWELASHWA kwemisebe.

Khetha Nut COMMON HAZELNUT noma CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Curcumin, i-Formononetin, i-Lupeol, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukulungiswa kwe-DNA, Ukusayina kwe-NFKB kanye Nokucindezeleka Kwe-Oxidative nezinye. I-Hazelnut evamile iyanconywa nge-Esophagogastric Adenocarcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuwuMisebe. Lokhu kungenxa yokuthi i-Hazelnut Ejwayelekile iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela Wokukhishwa Kwemisebe.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Ellagic Acid, i-Curcumin, i-Formononetin, i-Lupeol, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Epithelial kuya ku-Mesenchymal Transition kanye ne-Oxidative Stress nezinye. I-Chestnut ayinconyelwe i-Esophagogastric Adenocarcinoma uma ukwelashwa komdlavuza okuqhubekayo kuwuMisebe ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-CHESTNUT NGE-Esophagogastric Adenocarcinoma KANYE NOKWELASHWA kwemisebe.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa abantu abanengozi yofuzo ye-Esophagogastric Adenocarcinoma noma umlando womndeni uthi “Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?” nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha Vegetable GIANT BUTTERBUR noma YAM?

I-Vegetable Giant Butterbur iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukulungiswa kwe-DNA, Ukusayinwa kwe-Stem Cell kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Giant Butterbur inconyelwa engcupheni ye-Esophagogastric Adenocarcinoma lapho ubungozi bofuzo obuhlobene kuyi-CDKN2A. Lokhu kungenxa yokuthi i-Giant Butterbur inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Yam yemifino yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye nokusayina kwe-Stem Cell nokunye. I-Yam ayinconywa uma ingozi ye-Esophagogastric Adenocarcinoma uma ingozi yofuzo ehlotshaniswa nayo iyi-CDKN2A ngoba inyusa izindlela zayo zokusayina.

IBUTTERBUR OMKHULU WOKUMVUNO INCONYISWA NGE-YAM NGE-CDKN2A INGOZI YOFUZO YOMKHANSA.

Khetha isithelo NANCE noma iPUMMELO?

I-Fruit Nance iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukulungiswa kwe-DNA, Ukusayinwa kwe-Stem Cell kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Nance inconyelwa engcupheni ye-Esophagogastric Adenocarcinoma lapho ubungozi bofuzo obuhlobene kuyi-CDKN2A. Lokhu kungenxa yokuthi i-Nance inyusa lezo zindlela ze-biochemical eziphikisana nabashayeli bamasignesha bayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Apigenin, i-Curcumin, i-Lupeol, i-Quercetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye nokusayina kwe-Stem Cell nokunye. I-Pummelo ayinconywa uma ingozi ye-Esophagogastric Adenocarcinoma uma ingozi yofuzo ehlotshaniswa nayo iyi-CDKN2A ngoba inyusa izindlela zayo zokusayina.

I-FRUIT NANCE INCONYISWA NGAPHEZU KWE-PUMMELO YE-CDKN2A GENETIC RISK OF CANCER.

Khetha Nut BUTTERNUT noma EUROPEAN CHESTNUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokusayina kwe-MAPK, Ukulungiswa kwe-DNA, Ukusayinwa kwe-Stem Cell kanye ne-Cell Cycle Checkpoints nezinye. I-Butternut inconyelwa engcupheni ye-Esophagogastric Adenocarcinoma lapho ubungozi bofuzo obuhlobene buyi-CDKN2A. Lokhu kungenxa yokuthi i-Butternut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yaseYurophu yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Quercetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye nokusayina kwe-Stem Cell nokunye. I-Chestnut yase-Europe ayinconyiwe uma ingozi ye-Esophagogastric Adenocarcinoma uma ingozi yofuzo ehlobene iyi-CDKN2A ngoba inyusa izindlela zayo zokusayina.

I-BUTTERNUT INCONYISWA NGE-CHESTNUT YAseYurophu NGE-CDKN2A INGOZI YOFUZO YOMKHANSA.

Ekuphetheni

Ukudla kanye Nezithasiselo ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Esophagogastric Adenocarcinoma. Iziguli ze-Esophagogastric Adenocarcinoma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunempilo engikunconyelwe futhi okungekona?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Esophagogastric Adenocarcinoma, ngayinye enezakhi zofuzo zesimila ezihlukile ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana ne-Wild Leek kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukile wezindlela ze-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda kwezinhlobo ezahlukene zokwelapha ngamakhemikhali. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, “Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli i-Esophagogastric Adenocarcinoma?”. Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

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