Ukudla kwe-Angiocentric Glioma!

Isingeniso

Ukudla kwe-Angiocentric Glioma kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Ku-Angiocentric Glioma, ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - komdlavuza onjenge-Angiocentric Glioma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele ngomdlavuza onjenge-Angiocentric Glioma?

Isibonelo, ingabe kunendaba ukuthi uLethisi wemifino udliwa kakhulu uma uqhathaniswa ne-Chinese Broccoli? Ingabe kuyawenza umehluko uma isithelo iPummelo sithandwa kuneSoursop? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Pistachio phezu kwe-European Chestnut kanye nama-pulses afana no-Broad Bean phezu kuka-Common Bean. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Angiocentric Glioma futhi ingabe iyimpendulo efanayo yawo wonke umuntu onesifo esifanayo noma engozini yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Angiocentric Glioma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo iPummelo iqukethe izithako ezisebenzayo iLycopene, Protocatechuic Acid, Daidzein, Apigenin, Lupeol. Futhi i-Soursop iqukethe izithako ezisebenzayo i-Protocatechuic Acid, i-Myricetin, i-Daidzein, i-Apigenin, i-Lupeol futhi mhlawumbe nezinye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa i-Angiocentric Glioma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngoba izithako ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kwe-Angiocentric Glioma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okungokwakho Kwe-Angiocentric Glioma?

Ukondleka komuntu siqu komdlavuza njenge-Angiocentric Glioma kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Angiocentric Glioma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhambisana nakho lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Angiocentric Glioma

Yonke imidlavuza efana ne-Angiocentric Glioma ingabonakala ngesethi ehlukile yezindlela ze-biochemical - izindlela zokusayina ze-Angiocentric Glioma. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-Oncogenic Cancer Epigenetics, i-PI3K-AKT-MTOR Signaling, i-Oncogenic Histone Methylation, i-MAPK Signaling iyingxenye yencazelo yesiginesha ye-Angiocentric Glioma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Izindlela zokwelapha ezisebenza ngempumelelo ku-Angiocentric Glioma zidinga ukuqaphela izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithasiselo kunconywa nge-Angiocentric Glioma lapho uthatha ukwelashwa komdlavuza i-Lomustine, futhi okunye ukudla nezithako ezingeziwe akunconyiwe.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-KMT2D, KRAS, NOTCH4, TET2 kanye ne-YES1 yizakhi zofuzo ezikleliswe phezulu ze-Angiocentric Glioma. I-KMT2D ibikwa ku-25.0 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-KRAS ibikwa ku-25.0%. Idatha yesiguli esihlanganisiwe ihlanganisa iminyaka yobudala esukela kweyisi-9 kuye kwengama-78. Ama-47.1 % emininingwane yesiguli ahlonzwa njengabesilisa. I-Angiocentric Glioma biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical ezisayinwe kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Angiocentric Glioma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha I-LETTUCE Yemifino noma I-BROCCOLI YASE-CHINESE?

I-Lettuce Yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Protocatechuic Acid, i-Daidzein, i-Vitamin D3, i-Lupeol, i-Cinnamaldehyde. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling kanye ne-MYC Signaling nezinye. Ulethisi uyanconywa nge-Angiocentric Glioma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Lomustine. Lokhu kungenxa yokuthi u-Lettuce uguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Lomustine.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino yaseShayina Broccoli yiProtocatechuic Acid, Myricetin, Daidzein, Apigenin, Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali afana ne-Oncogenic Cancer Epigenetics nezinye. I-Broccoli yaseShayina ayinconyelwe i-Angiocentric Glioma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Lomustine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

ULETHISI LWEMVIDANE KUNCONYWA NGAPHEZU KWE-BROCCOLI YASECHINE NGE-Angiocentric Glioma KANYE NOKWELAPHA I-Lomustine.

Khetha isithelo SOURSOP noma i-PUMMELO?

I-Fruit Soursop iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Protocatechuic Acid, i-Myricetin, i-Daidzein, i-Apigenin, i-Lupeol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling kanye ne-MAPK Signaling nezinye. I-Soursop inconywa nge-Angiocentric Glioma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Lomustine. Lokhu kungenxa yokuthi i-Soursop iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Lomustine.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni iPummelo yiLycopene, Protocatechuic Acid, Daidzein, Apigenin, Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali afana ne-Oncogenic Cancer Epigenetics nezinye. I-Pummelo ayinconyelwe i-Angiocentric Glioma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Lomustine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

ISITHELO SOURSOP INCONYISWA NGAPHEZU KWE-PUMMELO YE-Angiocentric Glioma KANYE NOKWELAPHA I-Lomustine.

Khetha Nut PISTACHIO noma EUROPEAN CHESTNUT?

I-Pistachio iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Protocatechuic Acid, i-Daidzein, i-Lupeol, i-Formononetin, i-Cinnamaldehyde. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling, MAPK Signaling kanye ne-MYC Signaling nezinye. I-Pistachio inconywa nge-Angiocentric Glioma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Lomustine. Lokhu kungenxa yokuthi i-Pistachio iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Lomustine.

Ezinye zezithako ezisebenzayo noma ama-bioactives e-European Chestnut yi-Protocatechuic Acid, Ellagic Acid, Myricetin, Daidzein, Apigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali afana ne-Oncogenic Cancer Epigenetics nezinye. I-Chestnut yase-Europe ayinconyelwe i-Angiocentric Glioma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Lomustine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-PISTACHIO INCONYISWA NGE-CHESTNUT YAseYurophu NGE-Angiocentric Glioma KANYE NOKWELASHWA I-Lomustine.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwe abantu abasengozini yofuzo ye-Angiocentric Glioma noma umlando womndeni uthi "Yini Okufanele Ngidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha Imifino CALABASH noma SHALLOT?

I-Vegetable Calabash iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress, Angiogenesis, JAK-STAT Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Calabash inconyelwa engcupheni ye-Angiocentric Glioma lapho ingozi yofuzo ehlotshaniswa nayo iyi-KMT2D. Lokhu kungenxa yokuthi i-Calabash inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Shallot yemifino yi-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress nezinye. I-Shallot ayinconywa uma ingozi ye-Angiocentric Glioma uma ingozi yofuzo ehlotshaniswa nayo iyi-KMT2D ngoba inyusa izindlela zayo zokusayina.

I-Vegetable CALABASH INCONYISWA NGE-SHALLOT NGENGOZI YOFUZO YE-KMT2D YOMDLALO.

Khetha isithelo i-NANCE noma i-FIG?

I-Fruit Nance iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Angiogenesis, i-JAK-STAT Signaling, i-PI3K-AKT-MTOR Signaling kanye ne-P53 Signaling nezinye. I-Nance inconywa engcupheni ye-Angiocentric Glioma lapho ubungozi bofuzo obuhlobene buyi-KMT2D. Lokhu kungenxa yokuthi i-Nance inyusa lezo zindlela ze-biochemical eziphikisana nabashayeli bamasignesha bayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni Fig yi-Curcumin, i-Quercetin, i-Linalool, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress nezinye. I-Fig ayinconywa uma ingozi ye-Angiocentric Glioma uma ingozi yofuzo ehlotshaniswa nayo i-KMT2D ngoba inyusa izindlela zayo zokusayina.

I-FRUIT NANCE INCONYISWA NGAPHEZU KWE-FIG YE-KMT2D GENETIC RISK OF CANCER.

Khetha Nut COMMON HAZELNUT noma CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Quercetin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress, Angiogenesis, JAK-STAT Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Hazelnut evamile inconywa engcupheni ye-Angiocentric Glioma lapho ingozi yofuzo ehlotshaniswa nayo iyi-KMT2D. Lokhu kungenxa yokuthi i-Common Hazelnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress nezinye. I-Chestnut ayinconywa uma ingozi ye-Angiocentric Glioma uma ingozi yofuzo ehlotshaniswa nayo iyi-KMT2D ngoba inyusa izindlela zayo zokusayina.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-CHESTNUT NGENGOZI YOFUZO YE-KMT2D YOMDLALO.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe yizinqumo ezibalulekile zomdlavuza njenge-Angiocentric Glioma. Iziguli ze-Angiocentric Glioma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: “Yikuphi ukudla nezithasiselo zokudla okunempilo enginconyelwe kona futhi okungenjalo?” Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Angiocentric Glioma, ngayinye inezakhi zofuzo zesimila esinokwehluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana noLethisi kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukene wezindlela zamakhemikhali ezinto eziphilayo. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, “Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli i-Angiocentric Glioma?”. Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• Msk Ch 2020
• Ukwelashwa komdlavuza kulolonga isimo sokufaneleka se-clonal hematopoiesis.
• I-protein-tyrosine kinase inhibition: ukutholakala okusekelwe kumshini wama-antitumor agents.
• I-Paederia foetida idala umsebenzi wokulwa nomdlavuza ngokushintsha ama-enzyme okuguqula i-chromatin futhi iguqule ukubonakaliswa kwezakhi zofuzo ze-cytokine ezinokuvuvukala kumaseli omdlavuza wendlala yesinye.
• Indlela yamangqamuzana ecindezela ukuziphatha okuhlaselayo okubangelwa i-PMA kumaseli e-adenocarcinoma yamaphaphu omuntu nge-cis- ne-trans-cinnamic acid.
• Inqubekelaphambili yocwaningo emiphumeleni yokulwa nomdlavuza kavithamini K2.
• I-Retinol yehlisa amazinga e-beta-catenin amaprotheni emigqeni yamaseli omdlavuza we-colon we-retinoic acid.
• Imiphumela yokuvimbela ye-butyric acid, i-nicotinamide, i-calcium glucarate iyodwa noma ihlangene ngesikhathi se-7, i-12-dimethylbenz (a) i-anthracene eyenge i-tumorigenesis yesikhumba segundane ngokumodulation kwe-K-Ras-PI3K-AKTpathway kanye nama-RNA amancane ahlobene.
• Imiphumela kanye nokubaluleka kwe-formononetin emazingeni e-HIF-1α kanye ne-VEGF kumathishu omdlavuza womlomo wesibeletho wegundane.