Ukudla kwe-Myelodysplastic Syndrome ehlobene nokwelashwa!

Isingeniso

Ukudla kwe-Myelodysplastic Syndrome ehlobene nokwelashwa kufanele kube okomuntu siqu kumuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukushintsha kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Nge-Therapy-related Myelodysplastic Syndrome ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yokuthola umdlavuza - komdlavuza ofana ne-Therapy-related Myelodysplastic Syndrome ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza onjenge-Therapy-related Myelodysplastic Syndrome?

Isibonelo, ingabe kunendaba uma uLethisi wemifino udliwa kakhulu uma uqhathaniswa ne-Arrowhead? Ingabe kuyawenza umehluko uma isithelo iPummelo sithandwa kuneMandarin Orange (clementine, Tangerine)? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Butternut phezu kwe-Macadamia Nut kanye nama-pulses afana ne-Broad Bean phezu kukabhontshisi ovamile. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Myelodysplastic Syndrome ehlobene nokwelashwa futhi ingabe iyimpendulo efanayo kuwo wonke umuntu onesimo esifanayo sokuxilonga noma ubungozi bofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Myelodysplastic Syndrome ehlobene nokwelashwa!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo i-Pummelo iqukethe izithako ezisebenzayo i-Apigenin, i-Curcumin, i-Lycopene, i-Protocatechuic Acid, i-Lupeol. Futhi i-Mandarin Orange (i-clementine, i-Tangerine) iqukethe izithako ezisebenzayo i-Curcumin, i-Linalool, i-Protocatechuic Acid, i-Lupeol, i-Daidzein futhi mhlawumbe nabanye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa ngenxa ye-Therapy-related Myelodysplastic Syndrome - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo somsoco we-Therapy-related Myelodysplastic Syndrome.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukondleka Okuthandwa Nguwe kwe-Myelodysplastic Syndrome ehlobene nokwelashwa?

Ukondleka komuntu siqu komdlavuza njenge-Therapy-related Myelodysplastic Syndrome iqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Therapy-related Myelodysplastic Syndrome biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Therapy-related Myelodysplastic Syndrome

Yonke imidlavuza efana ne-Therapy-related Myelodysplastic Syndrome ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Therapy-related Myelodysplastic Syndrome. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-PI3K-AKT-MTOR Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints ziyingxenye yencazelo yesiginesha ye-Therapy-related Myelodysplastic Syndrome. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo kwe-Myelodysplastic Syndrome ehlobene nokwelashwa kudingeka kuqashelwe izindlela ezihambisana nesiginesha ze-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezingeziwe kuyanconywa nge-Therapy-related Myelodysplastic Syndrome lapho uthatha ukwelashwa komdlavuza i-Fludarabine, futhi okunye ukudla nezithako ezingeziwe akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-TP53, TET2, ASXL1, EZH2 kanye ne-ZRSR2 yizakhi zofuzo ezisezingeni eliphezulu ezibikwayo ze-Myelodysplastic Syndrome ehlobene nokwelapha. I-TP53 ibikwa kuma-63.6 % eziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-TET2 ibikwa kuma-27.3%. Idatha yesiguli esihlanganisiwe ihlanganisa iminyaka ukusuka kuye kuye. Amaphesenti angu-0.0 emininingwane yesiguli ahlonzwa njengabesilisa. I-Therapy-related Myelodysplastic Syndrome biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela zokusayina ze-biochemical kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Myelodysplastic Syndrome ehlobene nokwelashwa

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha i-LETTUCE yemifino noma i-ARROWHEAD?

I-Lettuce Yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Protocatechuic Acid, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Apoptosis, i-PI3K-AKT-MTOR Signaling kanye ne-MYC Signaling nezinye. Ulethisi uyanconywa nge-Therapy-related Myelodysplastic Syndrome lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Fludarabine. Lokhu kungenxa yokuthi u-Lettuce uguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Fludarabine.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Arrowhead yemifino yi-Apigenin, i-Curcumin, i-Lycopene, i-Protocatechuic Acid, i-Lupeol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Cell Cycle Checkpoints ne-mRNA Splicing nezinye. I-Arrowhead ayinconywa nge-Therapy-related Myelodysplastic Syndrome lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Fludarabine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

ULETHISI LWEMVIDANE KUNCONYWA NGENXA YE-ARROWHEAD maqondana nokwelapha okuhlobene ne-Myelodysplastic Syndrome KANYE NOKWELASHWA I-Fludarabine.

Khetha Isithelo I-MANDARIN ORANGE (CLEMENTINE, TANGERINE) noma i-PUMMELO?

I-Fruit Mandarin Orange (i-clementine, i-Tangerine) iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Linalool, i-Protocatechuic Acid, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Apoptosis, i-P53 Signaling, i-MAPK Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Mandarin Orange (i-clementine, i-Tangerine) inconywa nge-Therapy-related Myelodysplastic Syndrome lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Fludarabine. Lokhu kungenxa yokuthi i-Mandarin Orange (i-clementine, i-Tangerine) iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Fludarabine.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Apigenin, i-Curcumin, i-Lycopene, i-Protocatechuic Acid, i-Lupeol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Cell Cycle Checkpoints, i-PI3K-AKT-MTOR Signaling ne-mRNA Splicing nezinye. I-Pummelo ayinconyelwe I-Myelodysplastic Syndrome ehlobene Nokwelashwa lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Fludarabine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

ISITHELO I-MANDARIN ORANGE (CLEMENTINE, TANGERINE) INCONYISWA NGAPHEZU KWE-PUMMELO NGENXA YOKWELAPHA I-Myelodysplastic Syndrome KANYE NOKWELASHWA I-Fludarabine.

Khetha Nut BUTTERNUT noma MACADAMIA NUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lycopene, i-Protocatechuic Acid, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Apoptosis, i-P53 Signaling, i-MAPK Signaling kanye ne-MYC Signaling nezinye. I-Butternut iyanconywa nge-Therapy-related Myelodysplastic Syndrome lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Fludarabine. Lokhu kungenxa yokuthi i-Butternut iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Fludarabine.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Macadamia Nut yi-Apigenin, i-Curcumin, i-Protocatechuic Acid, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-MAPK Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Macadamia Nut ayinconyelwe I-Myelodysplastic Syndrome ehlobene Nokwelashwa lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Fludarabine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-BUTTERNUT INCONYISWA NGAPHEZU KWE-MACADAMIA NUT FOR Therapy-related Myelodysplastic Syndrome KANYE NOKWELASHWA I-Fludarabine.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa abantu abanengozi yofuzo ye-Myelodysplastic Syndrome ehlobene nokwelashwa noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha Imifino CALABASH noma YAM?

I-Vegetable Calabash iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, P53 Signaling, MAPK Signaling kanye neCell Cycle Checkpoints nezinye. I-Calabash inconyelwa engcupheni ye-Myelodysplastic Syndrome ehlobene nokwelashwa lapho ingozi yofuzo ehlotshaniswa nayo i-ASXL1. Lokhu kungenxa yokuthi i-Calabash inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Yam yemifino yi-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress kanye ne-Oncogenic Cancer Epigenetics nezinye. I-Yam ayinconywa uma ubungozi be-Myelodysplastic Syndrome ehlobene nokwelashwa uma ingozi yofuzo ehlotshaniswa nayo i-ASXL1 ngoba inyusa izindlela zayo zokusayina.

I-Vegetable CALABASH INCONYISWA NGAPHEZU KWE-YAM NGE-ASXL1 GENETIC RISK OF CANCER.

Khetha Isithelo WATERMELON noma i-ALASKA BLUEBERRY?

I-Watermelon yesithelo iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Bergapten. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, P53 Signaling, MAPK Signaling kanye neCell Cycle Checkpoints nezinye. Ikhabe liyanconywa ngengozi ye-Therapy-related Myelodysplastic Syndrome lapho ubungozi bofuzo obuhlobene buyi-ASXL1. Lokhu kungenxa yokuthi i-Watermelon inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Alaska Blueberry yi-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress kanye ne-Oncogenic Cancer Epigenetics nezinye. I-Alaska Blueberry ayinconywa uma ingozi ye-Therapy-related Myelodysplastic Syndrome lapho ingozi yofuzo ehlotshaniswa nayo i-ASXL1 ngoba inyusa izindlela zayo zokusayina.

I-WATERMELON YESITHELO INCONYISWA NGAPHEZU KWE-ALASKA BLUEBERRY NGENGOZI YOFUZO YE-ASXL1 YOMKHANZA.

Khetha Nut COMMON HAZELNUT noma CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Quercetin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, P53 Signaling, MAPK Signaling kanye neCell Cycle Checkpoints nezinye. I-Hazelnut evamile inconywa engozini ye-Myelodysplastic Syndrome ehlobene nokwelashwa lapho ingozi yofuzo ehlotshaniswa nayo i-ASXL1. Lokhu kungenxa yokuthi i-Common Hazelnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Formononetin, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress kanye ne-Oncogenic Cancer Epigenetics nezinye. I-Chestnut ayinconywa uma ingozi ye-Myelodysplastic Syndrome ehlobene nokwelashwa uma ingozi yofuzo ehlotshaniswa nayo i-ASXL1 ngoba inyusa izindlela zayo zokusayina.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-CHESTNUT NGE-ASXL1 GENETIC RISK YOMKHANZA.

Ekuphetheni

Ukudla Nezithako ezikhethiwe yizinqumo ezibalulekile zomdlavuza njenge-Therapy-related Myelodysplastic Syndrome. Iziguli ezihlobene nokwelashwa kwe-Myelodysplastic Syndrome kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunempilo engikunconyelwe futhi okungenjalo?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza njenge-Therapy-related Myelodysplastic Syndrome, ngayinye inofuzo oluhlukile lwesimila esinokwehluka okwengeziwe kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana noLethisi kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukene wezindlela zamakhemikhali ezinto eziphilayo. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli I-Myelodysplastic Syndrome ehlobene nokwelapha?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

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