Ukudla Kwesisu I-Adenocarcinoma!

Isingeniso

Ukudla kwe-Adenocarcinoma Yesisu kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Nge-Adenocarcinoma Yesisu kunendaba ukuthi imifino, izithelo, amantongomane, imbewu umuntu udlani?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - komdlavuza njenge-Stomach Adenocarcinoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza njenge-Stomach Adenocarcinoma?

Isibonelo, ingabe kunendaba ukuthi isipinashi saseNew Zealand sidliwa kakhulu uma siqhathaniswa ne-Jerusalem Artichoke? Ingabe kuyawenza umehluko uma isithelo iPummelo sithandwa kuneFrench Plantain? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Butternut phezu kwe-Chestnut kanye nama-pulses afana no-Broad Bean phezu kwe-Catjang Pea. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe I-Adenocarcinoma Yesisu futhi ingabe impendulo efanayo yawo wonke umuntu onesimo esifanayo sokuxilonga noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Adenocarcinoma Yesisu!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo iPummelo iqukethe izithako ezisebenzayo iQuercetin, iCurcumin, iPhloretin, iLycopene, iLupeol. Futhi i-French Plantain iqukethe izithako ezisebenzayo i-Quercetin, i-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin futhi mhlawumbe nezinye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa kwe-Stomach Adenocarcinoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngoba izithako ezisebenzayo ezahlukahlukene eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kwe-Adenocarcinoma Yesisu.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okufana Nakho Kwesisu I-Adenocarcinoma?

Ukondleka komuntu siqu komdlavuza njenge-Stomach Adenocarcinoma kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Biology ye-Adenocarcinoma Yesisu, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Stomach Adenocarcinoma

Yonke imidlavuza efana ne-Adenocarcinoma Yesisu ingabonakala ngesethi ehlukile yezindlela zamakhemikhali ezinto eziphilayo - izindlela zokusayina ze-Stomach Adenocarcinoma. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-Apoptosis, i-MAPK Signaling, Small Molecule Transport, PI3K-AKT-MTOR Signaling ziyingxenye yencazelo yesiginesha ye-Stomach Adenocarcinoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo kwe-Adenocarcinoma Yesisu kudingeka kuqashelwe izindlela ezihambisana namakhemikhali we-biochemical esigulini ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithasiselo kunconywa nge-Adenocarcinoma Yesisu lapho uthatha ukwelashwa komdlavuza i-Oxaliplatin, futhi okunye ukudla nezithako ezingeziwe akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-TP53, PDE4DIP, MUC16, SLX4 kanye ne-ADCY10 yizakhi zofuzo ezisezingeni eliphezulu ezibikwayo ze-Stomach Adenocarcinoma. I-TP53 ibikwa ku-7.4 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-PDE4DIP ibikwa ku-3.5%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esuka ku-32 kuya ku-90. Amaphesenti angu-60.5 emininingwane yesiguli ahlonzwa njengabesilisa. I-Biology ye-Adenocarcinoma Yesisu kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical ezisayinwe kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithasiselo Zesisu I-Adenocarcinoma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha Imifino NEW ZEALAND SPINACH noma I-JERUSALEM ARTICHOKE?

Imifino ye-New Zealand Isipinashi iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, Umjikelezo Weseli, Ukusayinda kwe-MAPK kanye Nokusinda Kweseli nezinye. Isipinashi saseNew Zealand sinconyelwe I-Adenocarcinoma Yesisu lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Oxaliplatin. Lokhu kungenxa yokuthi Isipinashi saseNew Zealand silungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Oxaliplatin.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino ye-Jerusalem Artichoke yi-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial kuya ku-Mesenchymal Transition, i-WNT Beta Catenin Signaling kanye ne-Oxidative Stress nezinye. I-Jerusalem Artichoke ayinconyelwe I-Adenocarcinoma Yesisu lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Oxaliplatin ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

IMIFINO ENTSHA YE-ZEALAND INCONYWA NGAPHEZU KWE-JERUSALEM ARTICHOKE NGE-Adenocarcinoma Yesisu KANYE NOKWELASHWA I-Oxaliplatin.

Khetha i-Fruit FRENCH PLANTAIN noma i-PUMMELO?

Izithelo ze-French Plantain ziqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, Umjikelezo Weseli, Ukusayinda kwe-MAPK kanye Nokusinda Kweseli nezinye. I-French Plantain inconyelwa i-Adenocarcinoma Yesisu lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Oxaliplatin. Lokhu kungenxa yokuthi i-French Plantain ilungisa lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Oxaliplatin.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Quercetin, i-Curcumin, i-Phloretin, i-Lycopene, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Oxidative Stress nezinye. I-Pummelo ayinconyelwe I-Adenocarcinoma Yesisu uma ukwelashwa komdlavuza okuqhubekayo kuyi-Oxaliplatin ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-FRUIT FRENCH PLANTAIN INCONYISWA NGAPHEZU KWE-PUMMELO YE-Adenocarcinoma Yesisu KANYE NOKWELASHWA I-Oxaliplatin.

Khetha Nut BUTTERNUT noma CHESTNUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, Cell Survival, DNA Repair kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Butternut inconywa nge-Adenocarcinoma Yesisu lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Oxaliplatin. Lokhu kungenxa yokuthi i-Butternut iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Oxaliplatin.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Ellagic Acid, i-Myricetin, i-Luteolin, i-Curcumin, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Epithelial kuya ku-Mesenchymal Transition, i-WNT Beta Catenin Signaling kanye ne-Oxidative Stress nezinye. I-Chestnut ayinconyelwe I-Adenocarcinoma Yesisu lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Oxaliplatin ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

IBUTTERNUT INCONYISWA NGAPHEZU KWE-CHESTNUT NGE-Adenocarcinoma Yesisu KANYE NOKWELASHWA I-Oxaliplatin.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa abantu abanengozi yofuzo ye-Adenocarcinoma Yesisu noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha I-Vegetable WILD Carrot noma I-GARLAND CHRYSANTHEMUM?

I-Vegetable Wild Carrot iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, P53 Signaling, i-MAPK Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Wild Carrot inconywa engcupheni ye-Adenocarcinoma Yesisu lapho ubungozi bofuzo obuhlobene buyi-ADCY10. Lokhu kungenxa yokuthi i-Wild Carrot inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zayo zokusayina.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino ye-Garland Chrysanthemum yi-Apigenin, i-Curcumin, i-Formononetin, i-Daidzein, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-TGFB Signaling nezinye. I-Garland Chrysanthemum ayituswa uma ingozi ye-Adenocarcinoma Yesisu uma ingozi yofuzo ehlotshaniswa nayo ingu-ADCY10 ngoba inyusa izindlela zayo zokusayina.

IZAQATHI ZASEMJINI INCONYWA NGAPHEZU KWE-GARLAND CHRYSANTHEMUM NGENGOZI YE-ADCY10 YOFUZO LOMDLALO.

Khetha Isithelo NANCE noma GRAPEFRUIT?

I-Fruit Nance iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Formononetin, i-Daidzein, i-Lupeol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-TGFB Signaling, i-P53 Signaling kanye ne-DNA Repair nezinye. I-Nance inconywa engcupheni ye-Adenocarcinoma Yesisu lapho ubungozi bofuzo obuhlobene buyi-ADCY10. Lokhu kungenxa yokuthi i-Nance inyusa lezo zindlela ze-biochemical eziphikisana nabashayeli bamasignesha bayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni I-Grapefruit yi-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Extracellular Matrix Remodeling kanye ne-G-protein-coupled Receptor Signaling nezinye. I-Grapefruit ayituswa uma ubungozi be-Stomach Adenocarcinoma uma ingozi yofuzo ehlotshaniswa nayo i-ADCY10 ngoba yandisa izindlela zayo zokusayina.

ISITHELO NANCE KUNCONYWA NGAPHEZU KWEGILIPIZULU NGE-ADCY10 GENETIC RISK OF CANCER.

Khetha Nut COMMON WALNUT noma FLEXSEED?

I-Walnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Ellagic Acid, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezehlukene ze-biochemical ezifana nokulungisa i-DNA, i-Cell Cycle kanye ne-G-protein-coupled Receptor Signaling nezinye. I-Walnut evamile inconywa engcupheni ye-Stomach Adenocarcinoma uma ingozi yofuzo ehlotshaniswa nayo i-ADCY10. Lokhu kungenxa yokuthi i-Common Walnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Flaxseed yi-Apigenin, i-Curcumin, i-Formononetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, i-PI3K-AKT-MTOR Signaling kanye ne-G-protein-coupled Receptor Signaling nezinye. I-Flaxseed ayituswa uma ingozi ye-Stomach Adenocarcinoma uma ingozi yofuzo ehlotshaniswa nayo ingu-ADCY10 ngoba inyusa izindlela zayo zokusayina.

I-WALNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-FLEXSEED NGE-ADCY10 GENETIC RISK OF CANCER.

Ekuphetheni

Ukudla kanye Nezithasiselo ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Stomach Adenocarcinoma. Iziguli ze-Adenocarcinoma yesisu kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: “Yikuphi ukudla nezithasiselo zokudla okunempilo engikunconyelwe futhi okungenjalo?” Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezehlukene zezinkomba zomdlavuza njenge-Stomach Adenocarcinoma, ngayinye enezakhi zofuzo zesimila ezihlukile ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana nesipinashi saseNew Zealand kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukene wezindlela zamakhemikhali ezinto eziphilayo. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli I-Adenocarcinoma Yesisu?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

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• I-Myricetin yenza i-apoptosis ngokuvimbela i-P21 ecushiwe i-kinase 1 (PAK1) ekhombisa ukugeleza kwe-hepatocellular carcinoma.
• I-Vitamin C ithuthukisa ukuguqulwa kwe-epigenetic okubangelwa i-5-azacytidine kanye nokuboshwa komjikelezo weseli kumigqa yeseli ye-hepatocellular carcinoma i-HLE ne-Huh7.
• I-Eugenol idala i-apoptosis kumaseli omdlavuza webele ngokusebenzisa i-E2F1/survivin down-regulation.
• I-Geraniol, ingxenye yamafutha abalulekile ezitshalo, iqwashisa amangqamuzana omdlavuza womuntu wekholoni ekwelashweni kwe-5-Fluorouracil.