Ukudla kwe-Retinoblastoma!

Isingeniso

Ukudla kwe-Retinoblastoma kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

I-Retinoblastoma iwumdlavuza wamehlo wengane ovela ku-retina. Kubangelwa ukuguquka kofuzo lwe-retinoblastoma (RB1) futhi kungathinta iso elilodwa noma womabili. Izimpawu ze-retinoblastoma zingase zihlanganise i-leukocoria (inhlamvu yeso ebonakala imhlophe), ukuncipha kombono, kanye ne-strabismus (ukungalungi kahle kwamehlo), ubuhlungu, iso elikhulisiwe noma eliqhumayo, igazi egunjini elingaphambili leso noma ukutheleleka, ukuvuvukala noma ukuvuvukala iso noma izicubu ezizungezile. Ukuhlonzwa kwe-retinoblastoma red reflex ngesikhathi sokuhlolwa kwamehlo kubalulekile ukuze kutholakale ngokushesha. I-Genetics idlala indima ebalulekile ku-retinoblastoma, njengoba ingazuzwa njengefa noma yenzeke ngokuzenzakalelayo. Izinketho zokwelapha ze-retinoblastoma zincike kubukhulu besimila futhi zingabandakanya ukwelashwa ngamakhemikhali, ukwelapha ngemisebe, i-cryotherapy, kanye ne-enucleation (ukususwa kokuhlinzwa kweso). Ukubambelela ngokuqinile eziqondisweni zokwelashwa kubalulekile ukuze kube nemiphumela emihle. Izinga lokubikezela kanye nokusinda liyahlukahluka kuye ngezici ezifana nesigaba sesifo kanye noshintsho oluthile lofuzo. Ukuphathwa kwe-retinoblastoma kudinga indlela ehlukahlukene ehlanganisa ongoti bezingane, odokotela bamehlo, nabeluleki bofuzo.

Ku-Retinoblastoma, ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu adlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - kumdlavuza onjenge-Retinoblastoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe esitshalweni ingabe kwanele umdlavuza onjengeRetinoblastoma?

Isibonelo, ingabe kunendaba ukuthi iThawula Lethawula lemifino lidliwa kakhulu uma liqhathaniswa ne-American Pokeweed? Ingabe kuyawenza umehluko uma isithelo iDurian sithandwa kunePomegranate? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Almond phezu kwe-European Chestnut kanye nama-pulses afana neLentils phezu kweCatjang Pea. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Retinoblastoma futhi ingabe iyimpendulo efanayo yawo wonke umuntu onokuxilonga okufanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Retinoblastoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo i-Durian iqukethe izithako ezisebenzayo i-Myricetin, i-Apigenin, i-Caffeine, i-Isoliquiritigenin, i-Allicin. Futhi iPomegranate iqukethe izithako ezisebenzayo i-Myricetin, i-Apigenin, i-Oleic Acid, i-Betulinic Acid, i-Isoliquiritigenin futhi mhlawumbe nezinye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa i-Retinoblastoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo somsoco we-Retinoblastoma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okungokwakho Kwe-Retinoblastoma?

Ukondleka komuntu siqu komdlavuza njenge-Retinoblastoma kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Retinoblastoma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengcupheni okuhlobene nokwelashwa okungayeka ukusebenza ngakho.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Retinoblastoma

Yonke imidlavuza efana ne-Retinoblastoma ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Retinoblastoma. Izindlela zamakhemikhali ezinto eziphilayo njenge-DNA Repair, Hypoxia, Cell Cycle, Cell Cycle Checkpoints ziyingxenye yencazelo yesiginesha ye-Retinoblastoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenzayo kwe-Retinoblastoma kudinga ukuqaphela izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezingeziwe kuyanconywa nge-Retinoblastoma lapho uthatha ukwelashwa komdlavuza i-Etoposide, futhi okunye ukudla nezithako ezingeziwe akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-RB1, CRTC1, BCOR, ABL2 kanye ne-SMARCA2 yizakhi zofuzo ezikleliswe phezulu ze-Retinoblastoma. I-RB1 ibikwa ku-57.8 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-CRTC1 ibikwa ku-16.7%. Idatha yesiguli esihlanganisiwe ihlanganisa iminyaka yobudala esukela kwengu-1 kuye kwengama-21. Ama-52.8 % emininingwane yesiguli ahlonzwa njengabesilisa. I-biology ye-Retinoblastoma kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical ezisayinwe kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Retinoblastoma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha I-Vegetable TOWEL GOURD noma i-AMERICAN POKEWEED?

I-Vegetable Towel Gourd iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Oleic Acid, i-Isoliquiritigenin, i-Allicin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-Hypoxia ne-PI3K-AKT-MTOR Signaling nezinye. Ithawula Lethawula liyanconywa nge-Retinoblastoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Etoposide. Lokhu kungenxa yokuthi Ithawula Gourd liguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Etoposide.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino yase-American Pokeweed yiMyricetin, Apigenin, Isoliquiritigenin, Allicin, Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-American Pokeweed ayinconyelwe i-Retinoblastoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Etoposide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

IGORD LETHAWULA LEMVIDANE INCONYISWA NGE-POKEWEED YASE-AMERICAN NGE-Retinoblastoma KANYE NOKWELASHWA Etoposide.

Khetha Isithelo IPOMEGRANATE noma i-DURIAN?

Igromegranate yesithelo iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Myricetin, i-Apigenin, i-Oleic Acid, i-Betulinic Acid, i-Isoliquiritigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Hedgehog Signaling, i-Hypoxia, Ukulungiswa kwe-DNA kanye ne-PI3K-AKT-MTOR Signaling nezinye. Ipomegranate inconywa nge-Retinoblastoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Etoposid. Lokhu kungenxa yokuthi iPomegranate iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Etoposide.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni iDurian yiMyricetin, Apigenin, Caffeine, Isoliquiritigenin, Allicin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Durian ayinconyelwe i-Retinoblastoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Etoposide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

ISITHELO IPHOMEGANETHI INCONYISWA NGE-DURIAN NGE-Retinoblastoma KANYE NE-Etoposide YOKWELAPHA.

Khetha Nut ALMOND noma EUROPEAN CHESTNUT?

I-almond iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Oleic Acid, i-Isoliquiritigenin, i-Allicin, i-Daidzein, i-Curcumin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Hypoxia ne-PI3K-AKT-MTOR Signaling nezinye. I-almond inconyelwa i-Retinoblastoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Etoposide. Lokhu kungenxa yokuthi i-almond iguqula lezo zindlela zamakhemikhali ezinto eziphilayo ezibikwe ngokwesayensi ukuze ziqwashise umthelela we-Etoposide.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yaseYurophu yi-Myricetin, i-Apigenin, i-Isoliquiritigenin, i-Allicin, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-PI3K-AKT-MTOR Signaling nezinye. I-Chestnut yase-Europe ayinconyelwe i-Retinoblastoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Etoposide ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-Alimondi INCONYISWA NGAPHEZU KWE-CHESTNUT YAseYurophu NGE-Retinoblastoma KANYE NOKWELASHWA Etoposide.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa abantu abanengozi yofuzo ye-Retinoblastoma noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithasiselo ziba zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha i-Vegetable CAULIFLOWER noma isipinashi se-MUSTARD?

I-Cauliflower yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, P53 Signaling, Cell Cycle Checkpoints kanye ne-MYC Signaling nezinye. Ukholifulawa unconywa engcupheni ye-Retinoblastoma uma ingozi yofuzo ehambisana nayo i-ABL2. Lokhu kungenxa yokuthi ukholifulawa unyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zayo zokusayina.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino yesipinashi yesinaphi yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Mustard Spinach ayinconywa uma ingozi ye-Retinoblastoma uma ingozi yofuzo ehlotshaniswa nayo i-ABL2 ngoba yandisa izindlela zayo zokusayina.

I-VEGETABLE CAULIFLOWER INCONYISWA NGAPHEZU KWESIPINSHI SEMISTARD NGENGOZI YOFUZO YE-ABL2 YOMKHANZA.

Khetha isithelo NANCE noma i-PUMMELO?

I-Fruit Nance iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kanye ne-MYC Signaling nezinye. I-Nance inconywa engcupheni ye-Retinoblastoma lapho ubungozi bofuzo obuhlobene buyi-ABL2. Lokhu kungenxa yokuthi i-Nance inyusa lezo zindlela ze-biochemical eziphikisana nabashayeli bamasignesha bayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Apigenin, i-Curcumin, i-Quercetin, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Pummelo ayinconywa uma ubungozi be-Retinoblastoma uma ingozi yofuzo ehlotshaniswa nayo iyi-ABL2 ngoba inyusa izindlela zayo zokusayina.

I-FRUIT NANCE INCONYISWA NGAPHEZU KWE-PUMMELO YE-ABL2 GENETIC RISK OF CANCER.

Khetha Nut COMMON HAZELNUT noma CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Quercetin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungisa i-DNA, i-Cell Cycle, i-Angiogenesis ne-MYC Signaling nezinye. I-Hazelnut evamile inconywa engcupheni ye-Retinoblastoma uma ingozi yofuzo ehlobene iyi-ABL2. Lokhu kungenxa yokuthi i-Common Hazelnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Daidzein. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-PI3K-AKT-MTOR Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Chestnut ayinconywa uma ingozi ye-Retinoblastoma uma ingozi yofuzo ehlotshaniswa nayo i-ABL2 ngoba inyusa izindlela zayo zokusayina.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-CHESTNUT NGE-ABL2 GENETIC RISK OF CANCER.

Ekuphetheni

Ukudla kanye Nezithasiselo ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Retinoblastoma. Iziguli ze-Retinoblastoma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunempilo engikunconyelwe futhi okungekona?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezehlukene zezinkomba zomdlavuza njenge-Retinoblastoma, ngayinye enezakhi zofuzo zesimila ezihlukene ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana nethawula Gourd kuqukethe ama-bioactives ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukile wezindlela ze-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza isinqumo sibe lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, “Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli i-Retinoblastoma?”. Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

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• I-Shikimic acid ikhuthaza ukwanda kwamaseli omdlavuza webele we-estrogen (ER) ngokwenza kusebenze ukusayina kwe-NF-κB.
• Ukulawulwa okungekuhle kwe-transducer yesiginali kanye ne-activator ye-transcription-3 signaling cascade nge-lupeol ivimbela ukukhula futhi yenze i-apoptosis kumaseli e-hepatocellular carcinoma.
• I-Brassinin ivimbela indlela yokusayina ye-STAT3 ngokushintshwa kwe-PIAS-3 ne-SOCS-3 expression futhi iqwashise i-xenograft yomdlavuza wamaphaphu womuntu kumagundane anqunu ku-paclitaxel.
• Sengupta S et al, Indian J Opthalmol., 2016
• https://my.clevelandclinic.org/health/diseases/retinoblastoma
• https://www.ncbi.nlm.nih.gov/books/NBK545276