Ukudla Kwe-Myelofibrosis Eyisisekelo!

Isingeniso

Ukudla Kwe-Myelofibrosis Eyisisekelo kufanele kube okomuntu siqu kumuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene maqondana nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zendlela yokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Nge-Primary Myelofibrosis, ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu ayidlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - komdlavuza njenge-Primary Myelofibrosis ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele lokho kumdlavuza onjengePrimary Myelofibrosis?

Isibonelo, ingabe kunendaba ukuthi i-Cluster Bean yemifino idliwa kakhulu uma iqhathaniswa ne-Cucurbita? Ingabe kuyawenza umehluko uma isithelo esithi Black Elderberry sithandwa kuneBlack Mulberry? Futhi uma ukukhetha okufanayo kwenzelwe amantongomane/imbewu efana ne-Black Walnut phezu kwe-European Chestnut kanye nama-pulses afana ne-Alfalfa phezu kwe-Catjang Pea. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe i-Primary Myelofibrosis futhi ingabe iyimpendulo efanayo yawo wonke umuntu onokuxilonga okufanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba ye-Primary Myelofibrosis!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo I-Black Elderberry iqukethe izithako ezisebenzayo i-Linalool, i-Formononetin, i-Quercetin, i-Lycopene, i-Apigenin. Futhi I-Black Mulberry iqukethe izithako ezisebenzayo i-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin kanye nezinye okungenzeka.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa kwe-Primary Myelofibrosis - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo somsoco we-Primary Myelofibrosis.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okufana Nakho Kwe-Myelofibrosis Eyisisekelo?

Ukondleka komuntu siqu komdlavuza njenge-Primary Myelofibrosis kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe kubhayoloji ye-Myelofibrosis Eyisisekelo, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Primary Myelofibrosis

Yonke imidlavuza efana ne-Primary Myelofibrosis ingabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Primary Myelofibrosis. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-RAS-RAF Signaling, Cytokine Signaling, Oncogenic Cancer Epigenetics, JAK-STAT Signaling ziyingxenye yencazelo yesiginesha yePrimary Myelofibrosis. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Izindlela zokwelapha ezisebenza ngempumelelo ku-Primary Myelofibrosis zidinga ukuqaphela izindlela ze-biochemical zesiginesha ehambisanayo yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezingeziwe kuyanconywa nge-Primary Myelofibrosis lapho uthatha ukwelashwa komdlavuza i-Ruxolitinib, futhi okunye ukudla nezithako zokudla akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-JAK2, ASXL1, TET2, DNMT3A kanye ne-CALR izakhi zofuzo ezikleliswe phezulu ezibikwayo ze-Primary Myelofibrosis. I-JAK2 ibikwa ku-58.3 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-ASXL1 ibikwa ku-31.7%. Idatha yesiguli esihlanganisiwe ihlanganisa iminyaka ukusuka kuye kuye. Amaphesenti angu-0.0 emininingwane yesiguli ahlonzwa njengabesilisa. I-Primary Myelofibrosis biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela zamakhemikhali ezinto eziphilayo kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako ze-Myelofibrosis Eyisisekelo

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha iVegetable CLUSTER BEAN noma i-CUCURBITA?

I-Vegetable Cluster Bean iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Stigmasterol, i-Vitamin C, i-Beta-sitosterol, i-Linolenic Acid, i-Oleic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-Hypoxia, i-RAS-RAF Signaling kanye ne-MAPK Signaling nezinye. I-Cluster Bean inconywa nge-Primary Myelofibrosis lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Ruxolitinib. Lokhu kungenxa yokuthi i-Cluster Bean ilungisa lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Ruxolitinib.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Cucurbita yemifino yi-Formononetin, i-Protocatechuic Acid, i-Phloretin, i-Curcumin, i-Bergapten. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling kanye ne-MYC Signaling nezinye. I-Cucurbita ayinconyelwe ku-Primary Myelofibrosis uma ukwelashwa komdlavuza okuqhubekayo kuyi-Ruxolitinib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

UBHONSI WE-VEGETABLE CLUSTER BEAN KUNCONYISWA NGE-CUCURBITA YE-Primary Myelofibrosis KANYE NOKWELASHWA I-Ruxolitinib.

Khetha Isithelo EMNYAMA MULBERRY noma EMNYAMA ELDERBERRY?

I-Fruit Black Mulberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, Hypoxia, MAPK Signaling kanye ne-MYC Signaling nezinye. I-Black Mulberry iyanconywa nge-Primary Myelofibrosis lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Ruxolitinib. Lokhu kungenxa yokuthi uMulberry Omnyama uguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Ruxolitinib.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni esithi Black Elderberry yi-Linalool, i-Formononetin, i-Quercetin, i-Lycopene, i-Apigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling kanye ne-Oncogenic Cancer Epigenetics nezinye. I-Black Elderberry ayinconyelwe ku-Primary Myelofibrosis uma ukwelashwa komdlavuza okuqhubekayo kuyi-Ruxolitinib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-FRUIT MULBERRY EMNYAMA INCONYISWA NGAPHEZU KWE-BLACK ELDERBERRY NGE-Myelofibrosis Eyisisekelo KANYE NOKWELASHWA I-Ruxolitinib.

Khetha Nut BLACK WALNUT noma EUROPEAN CHESTNUT?

I-Black Walnut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-RAS-RAF Signaling, PI3K-AKT-MTOR Signaling kanye ne-MYC Signaling nezinye. I-Black Walnut iyanconywa nge-Primary Myelofibrosis lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Ruxolitinib. Lokhu kungenxa yokuthi I-Walnut Emnyama ilungisa leyo migudu ye-biochemical ebikwe ngokwesayensi ukuze iqwashise umthelela we-Ruxolitinib.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yase-Europe yi-Formononetin, i-Quercetin, i-Apigenin, i-Protocatechuic Acid, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling kanye ne-Oncogenic Cancer Epigenetics nezinye. I-Chestnut yase-Europe ayinconywa nge-Primary Myelofibrosis uma ukwelashwa komdlavuza okuqhubekayo kuyi-Ruxolitinib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-WALNUT EMNYAMA INCONYISWA NGE-CHESTNUT YAseYurophu NGE-Myelofibrosis Eyisisekelo KANYE NOKWELASHWA I-Ruxolitinib.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa ngabantu abasengozini yofuzo ye-Primary Myelofibrosis noma umlando womndeni uthi “Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?” nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha iVegetable GREEN BELL PEPPER noma i-BEET EJWAYELEKILE?

I-Vegetable Green Bell Pepper iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Resveratrol, i-Bergapten, i-Formononetin, i-Luteolin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Suppressive Histone Methylation, i-Cytokine Signaling, i-Oncogenic Cancer Epigenetics kanye ne-Hematopoiesis nezinye. I-Green Bell Pepper iyanconywa ngengozi ye-Primary Myelofibrosis lapho ubungozi bofuzo obuhlobene buyi-ASXL1. Lokhu kungenxa yokuthi iGreen Bell Pepper inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino I-Common Beet yi-Bergapten, i-Formononetin, i-Stigmasterol, i-Phloretin, i-Myricetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cytokine Signaling kanye ne-Oncogenic Cancer Epigenetics nezinye. I-Common Beet ayituswa uma ingozi ye-Myelofibrosis Eyisisekelo lapho ingozi yofuzo ehlotshaniswa nayo i-ASXL1 ngoba inyusa izindlela zayo zokusayina.

I-VEGETABLE GREEN BEELL PEPPER INCONYISWA NGAPHEZU KWESIBHETHI EJWAYELEKILE NGENGOZI YOMFUZA I-ASXL1.

Khetha Fruit FIG noma PUMMELO?

I-Fruit Fig iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Quercetin, i-Bergapten, i-Formononetin, i-Phloretin, i-Stigmasterol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, i-Suppressive Histone Methylation, i-AGE-RAGE Signaling kanye ne-Cytokine Signaling nezinye. I-Fig inconyelwa engcupheni ye-Primary Myelofibrosis lapho ubungozi bofuzo obuhlobene buyi-ASXL1. Lokhu kungenxa yokuthi i-Fig inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Quercetin, i-Bergapten, i-Formononetin, i-Naringin, i-Phloretin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokuguqulwa kokuthunyelwe kokuhumusha kanye nokusayina kwe-Cytokine nokunye. I-Pummelo ayinconywa uma ubungozi be-Primary Myelofibrosis uma ubungozi bofuzo obuhlobene buyi-ASXL1 ngoba inyusa izindlela zayo zokusayina.

ISITHELO ESIQINISEKISO IYANCONYISWA NGAPHEZU KWE-PUMMELO NGENGOZI YOMKHANZA YE-ASXL1 yofuzo.

Khetha Imbewu Yamantongomane YETHUNGA noma I-ALMOND?

Imbewu yethanga iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Cucurbitacin I, i-Stigmasterol, i-Linolenic Acid, i-Salicylic Acid, i-Beta-sitosterol. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, AGE-RAGE Signaling, Cytokine Signaling kanye ne-Hematopoiesis nezinye. Imbewu yethanga inconywa engcupheni ye-Primary Myelofibrosis lapho ubungozi bofuzo obuhlobene buyi-ASXL1. Lokhu kungenxa yokuthi Imbewu Yethanga inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesignesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Almond yiBergapten, Formononetin, Phloretin, Stigmasterol, Isorhamnetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cytokine Signaling kanye ne-IL27 Signaling nezinye. I-almond ayinconywa uma ubungozi be-Primary Myelofibrosis uma ubungozi bofuzo obuhlobene buyi-ASXL1 ngoba inyusa izindlela zayo zokusayina.

IZIMBEWO ZAMATHANGA INCONYISWA NGAPHEZU KWE-ALIMOND NGENGOZI YOFUZO YE-ASXL1 YOMDLALO.

Ekuphetheni

Ukudla kanye Nezithasiselo ezikhethiwe izinqumo ezibalulekile zomdlavuza njenge-Primary Myelofibrosis. Iziguli eziyinhloko ze-Myelofibrosis kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: “Yikuphi ukudla nezithasiselo zokudla okunomsoco enginconyelwe zona futhi iziphi ezinganconyelwe?” Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Primary Myelofibrosis, ngayinye enezakhi zofuzo zesimila ezihlukene ngokuhlukahluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana ne-Cluster Bean kuqukethe ama-bioactives ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukile wezindlela ze-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo sokwenza kube ngokwakho umsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo, “Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli I-Primary Myelofibrosis?”. Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• Aml Ohsu 2018
• Imiphumela yokuvimbela ye-butyric acid, i-nicotinamide, i-calcium glucarate iyodwa noma ihlangene ngesikhathi se-7, i-12-dimethylbenz (a) i-anthracene eyenge i-tumorigenesis yesikhumba segundane ngokumodulation kwe-K-Ras-PI3K-AKTpathway kanye nama-RNA amancane ahlobene.
• Inqubekelaphambili yocwaningo emiphumeleni yokulwa nomdlavuza kavithamini K2.
• I-Formononetin-induced oxidative stress iqeda ukwenziwa kusebenze kwe-STAT3/5 signing axis futhi icindezela ukukhula kwesimila kumodeli ye-myeloma preclinical eminingi.
• I-Stigmasterol ikhombisa imiphumela enamandla ye-antitumor kumaseli omdlavuza wesisu somuntu alamula ngokuvinjwa kokufuduka kwamaseli, ukuboshwa komjikelezo wamaseli, i-apoptosis ye-mitochondrial mediated kanye nokuvinjwa kwendlela yokusayina ye-JAK/STAT.
• I-Isorhamnetin icindezela umdlavuza wesikhumba ngokuvinjwa okuqondile kwe-MEK1 ne-PI3-K.