Ukudla komdlavuza wesibeletho!

Isingeniso

Ukudla kwe-Ovarian Cancer kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

Ngomdlavuza we-Ovarian ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu adlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abasengozini yomdlavuza uwukuthi - komdlavuza onjengoCancer Ovarian ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza onjenge-Ovarian Cancer?

Isibonelo, ingabe kunendaba ukuthi ukholifulawa wemifino udliwa kakhulu uma uqhathaniswa neGarden Tomato? Ingabe kuyawenza umehluko uma isithelo esithi Black Elderberry sithandwa kunePomegranate? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Butternut phezu kwe-Brazil Nut kanye nama-pulses afana no-Broad Bean phezu kweChickpea. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe umdlavuza we-Ovarian futhi ingabe impendulo efanayo yawo wonke umuntu onesifo esifanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba yomdlavuza we-Ovarian!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Ngokwesibonelo Black Elderberry iqukethe izithako ezisebenzayo Lycopene, Curcumin, Isoliquiritigenin, Quercetin, Myricetin. Futhi iPomegranate iqukethe izithako ezisebenzayo i-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Myricetin, i-Naringin futhi mhlawumbe nezinye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa ku-Ovarian Cancer - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla komdlavuza we-Ovarian.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Adingekayo Ekwenzeni Ukondleka Ngokwakho Komdlavuza We-Ovarian?

Ukondleka komuntu siqu komdlavuza njenge-Ovarian Cancer kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Ovarian Cancer biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhlobene lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Ovarian Cancer

Wonke ama-cancer afana ne-Ovarian Cancer angabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Ovarian Cancer. Izindlela ze-Biochemical ezifana nokuvuvukala, i-NFKB Signaling, i-Cell Cycle Checkpoints, i-Apoptosis iyingxenye yencazelo yesiginesha ye-Ovarian Cancer. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo ku-Ovarian Cancer kumele kuqashelwe izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezisizayo kunconyelwa umdlavuza we-Ovarian lapho uthatha ukwelashwa komdlavuza i-Olaparib, futhi okunye ukudla nezithasiselo akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-TP53, i-MUC16, i-NF1, i-RYR2 kanye ne-KMT2C yizakhi zofuzo ezikleliswe phezulu zomdlavuza we-Ovarian. I-TP53 ibikwa kuma-29.2 % eziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-MUC16 ibikwa ku-3.2%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esukela kwengama-26 kuye kwengama-89. U-0.0 % wemininingwane yesiguli uhlonzwa njengabesilisa. I-Ovarian Cancer biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical ezisayinwe kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako Zomdlavuza Wezibeletho

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha i-Vegetable CAULIFLOWER noma UTAMATO WEGARDEN?

I-Cauliflower yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Isoliquiritigenin, i-Cinnamaldehyde, i-Psoralen, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokuvuvukala, ukusayina kwe-MAPK, ukusayina kwe-TWEAK kanye nokusayina kwe-MYC nokunye. Ukholifulawa utuswa kuCancer Ovarian lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Olaparib. Lokhu kungenxa yokuthi ukholifulawa uguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Olaparib.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-vegetable Garden Tomato yi-Lycopene, i-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Myricetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene zamakhemikhali ezinto eziphilayo njenge-DNA Repair nezinye. I-Garden Tomato ayinconyelwe Umdlavuza We-Ovarian lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Olaparib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-VEGETABLE CAULIFLOWER INCONYISWA PHEZU KUKATOMATO WASANGADI WOKUTHOLA Umdlavuza We-Ovarian KANYE NOKWELASHWA I-Olaparib.

Khetha Isithelo IPOMEGRANATE noma i-BLACK ELDERBERRY?

Igromegranate yesithelo iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Isoliquiritigenin, i-Quercetin, i-Myricetin, i-Naringin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial kuya ku-Mesenchymal Transition, Ukuvuvukala kanye nokusayina kwe-MAPK nokunye. Ipomegranate inconywa kuCancer Ovarian lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Olaparib. Lokhu kungenxa yokuthi iPomegranate iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Olaparib.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni Black Elderberry yiLycopene, Curcumin, Isoliquiritigenin, Quercetin, Myricetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye ne-MAPK Signaling nezinye. I-Black Elderberry ayinconyelwe umdlavuza we-Ovarian uma ukwelashwa komdlavuza okuqhubekayo kuyi-Olaparib ngoba ilungisa lezo zindlela ze-biochemical ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

ISITHELO IPHOMEGANETHI INCONYISWA NGAPHEZU KWE-BLACK ELDERBERRY FOR Ovarian Cancer NOKWELASHWA I-Olaparib.

Khetha Nut BUTTERNUT noma BRAZIL NUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Lycopene, i-Curcumin, i-Isoliquiritigenin, i-Myricetin, i-Caffeine. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, i-Epithelial kuya ku-Mesenchymal Transition, Ukuvuvukala kanye nokusayina kwe-MAPK nokunye. I-Butternut inconywa kuCancer Ovarian lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Olaparib. Lokhu kungenxa yokuthi i-Butternut ilungisa lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Olaparib.

Ezinye zezithako ezisebenzayo noma ama-bioactives e-Brazil Nut yi-Curcumin, i-Isoliquiritigenin, i-Cinnamaldehyde, i-Psoralen, i-Ellagic Acid. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Epithelial kuya ku-Mesenchymal Transition, Ukuvuvukala kanye ne-TWEAK Signaling nezinye. I-Brazil Nut ayinconyelwe Umdlavuza We-Ovarian lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Olaparib ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-BUTTERNUT INCONYISWA NGAPHEZU KWE-BRAZIL NUTENGAZI WOmdlavuza Wezibeletho KANYE NOKWELAPHA I-Olaparib.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa abantu abanengozi yofuzo yeCancer Ye-Ovarian noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha iVegetable KALE noma i-AMERICAN POKEWEED?

I-Vegetable Kale iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Lupeol, i-Indole-3-carbinol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, Umjikelezo Weseli, Ukusayinda kwe-MAPK kanye Nokusayina kwe-MYC nokunye. I-Kale inconywa engcupheni yomdlavuza we-Ovarian lapho ingozi yofuzo ehlobene i-KMT2C. Lokhu kungenxa yokuthi i-Kale inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-American Pokeweed yemifino yi-Apigenin, i-Curcumin, i-Lupeol, i-Quercetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye ne-MAPK Signaling nezinye. I-American Pokeweed ayinconywa uma ingozi ye-Ovarian Cancer uma ingozi yofuzo ehlotshaniswa nayo i-KMT2C ngoba yandisa izindlela zayo zokusayina.

IMIFINO KALE INCONYISWA NGAPHEZU KWE-POKEWEED YASE-AMERICA NGE-KMT2C GENETIC RISK OF CANCER.

Khetha Isithelo RED RASPBERRY noma i-PUMMELO?

I-Fruit Red Raspberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Ellagic Acid, i-Lupeol, i-Quercetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-P53 Signaling, i-DNA Repair kanye ne-MYC Signaling nezinye. Okusajingijolo Okubomvu kunconywa engcupheni Yomdlavuza Weqanda lapho ingozi yofuzo ehlotshaniswa nayo i-KMT2C. Lokhu kungenxa yokuthi i-Red Raspberry inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Apigenin, i-Curcumin, i-Lupeol, i-Lycopene, i-Quercetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA kanye ne-Extracellular Matrix Remodeling nezinye. I-Pummelo ayinconywa uma ingozi Yomdlavuza Weqanda uma ingozi yofuzo ehlotshaniswa nayo i-KMT2C ngoba yandisa izindlela zayo zokusayina.

I-RASPBERRY EBOMVU ISITHELO INCONYISWA NGAPHEZU KWE-PUMMELO YE-KMT2C GENETIC RISK OF CANCER.

Khetha Nut BLACK WALNUT noma CHESTNUT?

I-Walnut Emnyama iqukethe izithako eziningi ezisebenzayo noma ama-bioactives njenge-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Quercetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, P53 Signaling, i-MAPK Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Walnut Emnyama inconywa engcupheni Yomdlavuza We-Ovarian lapho ingozi yofuzo ehlobene iyi-KMT2C. Lokhu kungenxa yokuthi i-Black Walnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yi-Apigenin, i-Curcumin, i-Ellagic Acid, i-Lupeol, i-Lycopene. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana nokulungiswa kwe-DNA, Ukulungiswa kabusha kwe-Matrix ye-Extracellular kanye nezindawo zokuhlola i-Cell Cycle nezinye. I-Chestnut ayinconywa uma ingozi yomdlavuza we-Ovarian uma ingozi yofuzo ehlotshaniswa nayo kuyi-KMT2C ngoba inyusa izindlela zayo zokusayina.

I-WALNUT EMNYAMA INCONYISWA NGAPHEZU KWE-CHESTNUT NGENGOZI YOFUZO YE-KMT2C YOMDLALO.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe yizinqumo ezibalulekile zomdlavuza onjengoCancer Ovarian. Iziguli zomdlavuza we-Ovarian kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla kanye nezithako zokudla okunomsoco engikunconyelwe futhi okungezona?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza ezifana ne-Ovarian Cancer, ngayinye ene-tumor genetics ehlukahlukene ngokuhlukahluka kwe-genomic kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana nokholifulawa kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene futhi ahlukene emizila ye-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli Umdlavuza We-Ovarian?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• I-Msk Impact 2017
• Ukuhlaziywa komdlavuza we-pan-cancer kuwo wonke ama-genomes.
• I-Isoliquiritigenin Ivimbela i-Ovarian Cancer Metastasis ngokuhlehlisa i-Epithelial-to-Mesenchymal Transition.
• I-Betulinic Acid Icindezela I-Metastasis Yomdlavuza Webele ngokukhomba i-GRP78-Mediated Glycolysis kanye ne-ER Stress Apoptotic Pathway.
• I-Gallic acid idala ukulimala kwe-DNA futhi icindezela i-DNA yokulungisa isakhi sofuzo kumaseli omdlavuza womuntu we-prostate PC-3.
• I-Brassinin ivimbela indlela yokusayina ye-STAT3 ngokushintshwa kwe-PIAS-3 ne-SOCS-3 expression futhi iqwashise i-xenograft yomdlavuza wamaphaphu womuntu kumagundane anqunu ku-paclitaxel.
• Uvithamini C ubulala ngokukhetha amaseli omdlavuza we-colorectal we-KRAS kanye ne-BRAF ngokukhomba i-GAPDH.
• I-Geraniol, ingxenye yamafutha abalulekile ezitshalo, iqwashisa amangqamuzana omdlavuza womuntu wekholoni ekwelashweni kwe-5-Fluorouracil.