Ukudla Kwe-Cutaneous Squamous Cell Carcinoma!

Isingeniso

Ukudla Kwe-Cutaneous Squamous Cell Carcinoma kufanele kube okuqondene nomuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

I-Cutaneous squamous cell carcinoma (cSCC) wuhlobo oluvamile lomdlavuza wesikhumba ovela kumaseli e-squamous esikhumbeni. Ukuhlelwa okunembile kwe-cSCC kubalulekile ekunqumeni izinga lomdlavuza kanye nezinqumo zokwelashwa eziqondisayo. I-Metastasis, noma ukusabalala kwe-cSCC kwezinye izingxenye zomzimba, ukukhathazeka ngezigaba ezithuthukile. Isigameko se-cSCC sibalulekile, ikakhulukazi kubantu abanomlando wokuchayeka elangeni noma amasosha omzimba abuthakathaka. Odokotela besikhumba basebenzisa uhlaka lwe-pathology ukuhlonza izici nezici ze-cSCC. Izinketho zokwelapha ze-cSCC zihlanganisa ukuhlinza, ukwelapha ngemisebe, kanye nemithi yokwelapha, kuye ngesiteji nendawo yomdlavuza. Ukubikezelwa kwe-cSCC ngokuvamile kuyathandeka, namazinga aphezulu okusinda lapho etholwa futhi ephathwa kusenesikhathi. Ukubhala amakhodi ngendlela efanele kusetshenziswa uhlelo lwe-ICD-10 kuqinisekisa imibhalo enembile ye-cSCC kumarekhodi ezokwelapha. Kwezinye izimo, i-cSCC ingase ibe in situ, okusho ukuthi ivalelwe ungqimba olungaphezulu lwesikhumba. Kodwa-ke, izigaba ezithuthukisiwe zingase zidinge ukwelashwa okunolaka nokuqapha eduze. Kubalulekile ukuhlukanisa i-cSCC kweminye imidlavuza yesikhumba, njengemelanoma, edinga izindlela zokuphatha ezihlukene. I-epidemiology ye-cSCC igqamisa ukubaluleka kokutholwa kusenesikhathi nemizamo yokuvimbela. Muva nje, ukusetshenziswa kwe-immunotherapy nge-cemiplimab kubonise isithembiso njengendlela yokwelapha ye-Advanced or Metastatic cSCC. Ucwaningo oluqhubekayo nemihlahlandlela yokwelapha inomthelela emiphumeleni engcono kubantu abane-cSCC. Kubalulekile ukuthi abantu abasengozini bavikele isikhumba sabo emisebeni ye-UV eyingozi futhi bahlolwe njalo isikhumba ukuze bathole futhi belaphe i-cSCC kusenesikhathi.

KuCutaneous Squamous Cell Carcinoma ingabe kunendaba ukuthi imifino, izithelo, amantongomane, imbewu umuntu udlani?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwa iziguli ezinomdlavuza kanye nabantu abangaba sengcupheni yomdlavuza ukuthi - komdlavuza ofana neCutaneous Squamous Cell Carcinoma ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza ofana neCutaneous Squamous Cell Carcinoma?

Isibonelo, ingabe kunendaba ukuthi iCauliflower yemifino idliwa kakhulu uma iqhathaniswa neMalabar Spinach? Ingabe kuyawenza umehluko uma isithelo iPummelo sithandwa kuneNance? Futhi uma ukukhetha okufanayo kwenziwa kumantongomane/imbewu efana ne-Butternut phezu kwe-Chestnut kanye nama-pulses afana ne-Adzuki Bean phezu kwe-Pigeon Pea. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukuhlonza kanjani ukudla okunconyelwe I-Cutaneous Squamous Cell Carcinoma futhi ingabe iyimpendulo efanayo yawo wonke umuntu onesifo esifanayo noma engozini yofuzo?

Yebo! Ukudla okudlayo kuyindaba yeCutaneous Squamous Cell Carcinoma!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo iPummelo iqukethe izithako ezisebenzayo iQuercetin, Formononetin, Lupeol, Naringin, Curcumin. Futhi i-Nance iqukethe izithako ezisebenzayo i-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Isoliquiritigenin futhi mhlawumbe nezinye.

Iphutha elivamile elenziwa lapho kunqunywa futhi kukhethwa ukudla okuzodliwa yi-Cutaneous Squamous Cell Carcinoma - ukuhlola izithako ezisebenzayo ezikhethiwe kuphela eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla kweCutaneous Squamous Cell Carcinoma.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Ayadingeka Ekwenzeni Ukudla Okufana Nakho Kwe-Cutaneous Squamous Cell Carcinoma?

Ukondleka komuntu siqu komdlavuza njengeCutaneous Squamous Cell Carcinoma kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Cutaneous Squamous Cell Carcinoma biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelapha umdlavuza kusebenza kanjani kanye nokuba sengozini okuhambisana nakho lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njengeCutaneous Squamous Cell Carcinoma

Yonke imidlavuza efana neCutaneous Squamous Cell Carcinoma ingabonakala ngesethi ehlukile yezindlela ze-biochemical - izindlela zesiginesha. Izindlela zamakhemikhali ezinto eziphilayo ezifana ne-Oncogenic Cancer Epigenetics, i-Suppressive Histone Methylation, i-Extracellular Matrix Remodelling, i-Small Molecule Transport iyingxenye yencazelo yesiginesha ye-Cutaneous Squamous Cell Carcinoma. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Ukwelashwa okusebenza ngempumelelo ku-Cutaneous Squamous Cell Carcinoma kudingeka kuqashelwe izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithasiselo kunconywa ku-Cutaneous Squamous Cell Carcinoma lapho uthatha ukwelashwa komdlavuza i-Cemiplimab, futhi okunye ukudla nezithako ezingeziwe akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-RELN, APOB, FAT4, MUC16 kanye ne-COL11A1 yizakhi zofuzo ezikleliswe phezulu ezibikwayo ze-Cutaneous Squamous Cell Carcinoma. I-RELN ibikwa ku-17.3% weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-APOB ibikwa ku-15.6%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esukela ku-37 kuya ku-93. U-77.4 % wemininingwane yesiguli uhlonzwa njengabesilisa. I-Cutaneous Squamous Cell Carcinoma biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimelelwe izindlela zamakhemikhali ezinto eziphilayo kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako zeCutaneous Squamous Cell Carcinoma

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha iVegetable CAULIFLOWER noma i-MALABAR SPINACH?

I-Cauliflower yemifino iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Brassinin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-JAK-STAT Signaling, PI3K-AKT-MTOR Signaling, Suppressive Histone Methylation kanye ne-MYC Signaling nezinye. Ukholifulawa unconywa ngeCutaneous Squamous Cell Carcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cemiplimab. Lokhu kungenxa yokuthi uCauliflower uguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Cemiplimab.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino iMalabar Spinashi yiQuercetin, Formononetin, Lupeol, Curcumin, Cinnamaldehyde. Lezi zithako ezisebenzayo zilawula izindlela ezehlukene ze-biochemical ezifana ne-DNA Repair, i-G-protein-coupled Receptor Signaling kanye ne-Natural Killer Cell Activation nezinye. I-Malabar Spinach ayinconyelwe ku-Cutaneous Squamous Cell Carcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cemiplimab ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-VEGETABLE CAULIFLOWER INCONYISWA NGAPHEZU KWE-MALABAR ISIPINSHI NGE-Cutaneous Squamous Cell Carcinoma KANYE NOKWELAPHA I-Cemiplimab.

Khetha isithelo NANCE noma iPUMMELO?

I-Fruit Nance iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Isoliquiritigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Angiogenesis, i-JAK-STAT Signaling, i-PI3K-AKT-MTOR Signaling kanye ne-Natural Killer Cell Activation nezinye. I-Nance inconywa nge-Cutaneous Squamous Cell Carcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cemiplimab. Lokhu kungenxa yokuthi uNance ulungisa lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Cemiplimab.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Quercetin, i-Formononetin, i-Lupeol, i-Naringin, i-Curcumin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-PPAR Signaling kanye ne-Interferon Signaling nezinye. I-Pummelo ayinconyelwe i-Cutaneous Squamous Cell Carcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cemiplimab ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

ISITHELO NANCE KUNCONYWA NGAPHEZU KWE-PUMMELO YE-Cutaneous Squamous Cell Carcinoma KANYE NOKWELAPHA I-Cemiplimab.

Khetha Nut BUTTERNUT noma CHESTNUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde, i-Isoliquiritigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Amino Acid Metabolism, i-JAK-STAT Signaling, i-PI3K-AKT-MTOR Signaling kanye ne-MYC Signaling nezinye. I-Butternut inconywa nge-Cutaneous Squamous Cell Carcinoma lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Cemiplimab. Lokhu kungenxa yokuthi i-Butternut iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Cemiplimab.

Ezinye zezithako ezisebenzayo noma ama-bioactive ku-Chestnut yi-Ellagic Acid, i-Formononetin, i-Lupeol, i-Curcumin, i-Cinnamaldehyde. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-WNT Beta Catenin Signaling, i-G-protein-coupled Receptor Signaling kanye ne-PPAR Signaling nezinye. I-Chestnut ayinconyelwe i-Cutaneous Squamous Cell Carcinoma uma ukwelashwa komdlavuza okuqhubekayo kuyi-Cemiplimab ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-BUTTERNUT INCONYISWA NGAPHEZU KWE-CHESTNUT NGE-Cutaneous Squamous Cell Carcinoma KANYE NOKWELASHWA I-Cemiplimab.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwe abantu abasengozini yofuzo ye-Cutaneous Squamous Cell Carcinoma noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha iVegetable GIANT BUTTERBUR noma iRADISH?

I-Vegetable Giant Butterbur iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-MYC Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling kanye ne-P53 Signaling nezinye. I-Butterbur Enkulu inconyelwa engcupheni ye-Cutaneous Squamous Cell Carcinoma lapho ubungozi bofuzo obuhlobene buyi-APOB. Lokhu kungenxa yokuthi i-Giant Butterbur inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactive kuRadish yemifino yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling, Complement Cascade kanye ne-MYC Signaling nezinye. Umthombo awunconyiwe uma ubungozi beCutaneous Squamous Cell Carcinoma uma ubungozi bofuzo obuhlotshaniswayo buyi-APOB ngoba inyusa izindlela zayo zokusayina.

IBUTTERBUR ENKULU YEMVIDO INCONYISWA NGAPHEZU KWERADISHI NGENGOZI YOFUZO YE-APOB YOMKHANZA.

Khetha isithelo i-JAVA PLUM noma i-NATAL PLUM?

I-Fruit Java Plum iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-MYC Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling kanye ne-Apoptosis nezinye. I-Java Plum inconyelwa engcupheni ye-Cutaneous Squamous Cell Carcinoma uma ingozi yofuzo ehlotshaniswa nayo i-APOB. Lokhu kungenxa yokuthi i-Java Plum inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni iNatal Plum yi-Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezehlukene ze-biochemical ezifana ne-Small Molecule Transport, i-Extracellular Matrix Remodeling kanye ne-Cell Cycle Checkpoints nezinye. I-Natal Plum ayinconywa uma ubungozi beCutaneous Squamous Cell Carcinoma uma ubungozi bofuzo obuhlobene buyi-APOB ngoba inyusa izindlela zayo zokusayina.

ISITHELO JAVA PLUM INCONYISWA NGAPHEZU KWE-NATAL PLUM YE-APOB GENETIC INGOZI YOMKHANZA.

Khetha Nut COMMON HAZELNUT noma FLXSEED?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Beta-sitosterol. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njengezindawo zokuhlola i-Cell Cycle, i-PI3K-AKT-MTOR Signaling, Focal Adhesion kanye ne-P53 Signaling nezinye. I-Hazelnut Ejwayelekile inconywa engcupheni ye-Cutaneous Squamous Cell Carcinoma uma ubungozi bofuzo obuhlobene buyi-APOB. Lokhu kungenxa yokuthi i-Common Hazelnut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactive ku-Flaxseed yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical ezifana ne-PI3K-AKT-MTOR Signaling, Complement Cascade kanye ne-MYC Signaling nezinye. I-Flaxseed ayinconywa uma ingozi ye-Cutaneous Squamous Cell Carcinoma uma ingozi yofuzo ehlotshaniswa nayo i-APOB ngoba inyusa izindlela zayo zokusayina.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-FLEXSEED NGENGOZI YOFUZO YE-APOB YOMDLALO.

Ekuphetheni

Ukudla kanye Nezithasiselo ezikhethiwe izinqumo ezibalulekile zomdlavuza njengeCutaneous Squamous Cell Carcinoma. Iziguli ezine-Cutaneous Squamous Cell Carcinoma kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunempilo engikunconyelwe futhi okungekona?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza njengeCutaneous Squamous Cell Carcinoma, ngayinye enezakhi zofuzo zesimila esinokwehluka kofuzo kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana nokholifulawa kuqukethe ama-bioactive ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene futhi ahlukene emizila ye-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda izindlela zokwelapha ezihlukene ze-chemotherapy. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza ukwenza izinqumo kube lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli I-Cutaneous Squamous Cell Carcinoma?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• I-Msk Impact 2017
• Ukuhlaziywa kwe-genomic kwe-metastatic cutaneous squamous cell carcinoma.
• Imiphumela yokudla ye-D-glucarate kuma-biomarker okuvuvukala phakathi nezigaba zangaphambi kokuqala kwe-benzo[a]i-pyrene-induced lung tumorigenesis kumagundane e-A/J.
• Imiphumela kanye nokubaluleka kwe-formononetin emazingeni e-HIF-1α kanye ne-VEGF kumathishu omdlavuza womlomo wesibeletho wegundane.
• I-Vitamin C ithuthukisa ukuguqulwa kwe-epigenetic okubangelwa i-5-azacytidine kanye nokuboshwa komjikelezo weseli kumigqa yeseli ye-hepatocellular carcinoma i-HLE ne-Huh7.
• I-Brassinin ivimbela indlela yokusayina ye-STAT3 ngokushintshwa kwe-PIAS-3 ne-SOCS-3 expression futhi iqwashise i-xenograft yomdlavuza wamaphaphu womuntu kumagundane anqunu ku-paclitaxel.
• Ukusebenza kwe-ROS-mediated kanye nokudluliselwa kwe-mitochondrial kwe-CaMKII kunomthelela ekwehleni kwe-mitochondrial encike ku-Drp1 kanye ne-apoptosis kumaseli omdlavuza webele one-triple-negative nge-isorhamnetin ne-chloroquine.
• I-Betulinic acid ilimaza i-metastasis futhi inciphisa amangqamuzana avikela amasosha omzimba kumamodeli omdlavuza webele.
• I-Estrogen receptor modulators i-genistein, i-daidzein ne-ERB-041 ivimbela ukufuduka kwamangqamuzana, ukuhlasela, ukwanda kanye nokwakheka kwendawo ngokushintshashintsha kwe-FAK kanye ne-PI3K/AKT yokusayina kumdlavuza wesibeletho.