Ukudla Kwe-Nasopharyngeal Cancer!

Isingeniso

Ukudla komdlavuza weNasopharyngeal kufanele kube okomuntu siqu kumuntu ngamunye futhi kufanele kuzivumelanise nezimo lapho ukwelashwa komdlavuza noma ukuguquka kofuzo lwesimila. Ukwenza kube ngokwakho nokuzivumelanisa nezimo kufanele kucabangele zonke izithako ezisebenzayo noma ama-bioactives aqukethwe ekudleni okuhlukene ngokuphathelene nebhayoloji yezicubu zomdlavuza, izakhi zofuzo, ukwelashwa, izimo zokuphila kanye nezintandokazi zokudla. Ngakho-ke nakuba ukudla okunomsoco kungenye yezinqumo ezibaluleke kakhulu okufanele zenziwe esigulini somdlavuza kanye nomuntu osengcupheni yomdlavuza - ukukhetha ukudla ozokudla akuwona umsebenzi olula.

KuCancer Nasopharyngeal, ingabe kunendaba ukuthi iyiphi imifino, izithelo, amantongomane, imbewu umuntu adlayo?

Umbuzo ovame kakhulu wokudla okunomsoco obuzwe iziguli ezinomdlavuza kanye nabantu abasengozini yokuthola umdlavuza - komdlavuza onjengoCancer Nasopharyngeal ingabe kunendaba ukuthi yikuphi ukudla engikudlayo nokuthi yikuphi engingakudli? Noma uma ngilandela ukudla okusekelwe ezitshalweni ingabe kwanele umdlavuza onjengoCancer Nasopharyngeal?

Isibonelo, ingabe kunendaba ukuthi i-Butterbur yemifino idliwa kakhulu uma iqhathaniswa ne-Malabar Spinach? Ingabe kuyawenza umehluko uma izithelo ze-Bilberry zikhethwa kune-Red Raspberry? Futhi uma ukukhetha okufanayo kwenzelwe amantongomane/imbewu efana ne-Common Hazelnut phezu kwe-European Chestnut kanye nama-pulses afana ne-Black-eyed Pea phezu kukabhontshisi ovamile. Futhi uma lokho engikudlayo kubalulekile - khona-ke umuntu ukukhomba kanjani ukudla okunconyelwe I-Cancer Nasopharyngeal futhi ingabe impendulo efanayo kuwo wonke umuntu onokuxilongwa okufanayo noma ingozi yofuzo?

Yebo! Ukudla okudlayo kuyindaba yomdlavuza weNasopharyngeal!

Izincomo zokudla zingase zingafani kuwo wonke umuntu futhi zingahluka ngisho nasekuxilongweni okufanayo nobungozi bofuzo.

Konke ukudla (imifino, izithelo, amantongomane, imbewu, ama-pulses, amafutha njll.) kanye nezithako zokudla okunomsoco kwakhiwa ngaphezu kwesithako samangqamuzana esisebenzayo esingaphezu kwesisodwa noma ama-bio-active ngezilinganiso namanani ahlukene. Isithako ngasinye esisebenzayo sinomshini wokusebenza oyingqayizivele - okungase kube ukuqalisa noma ukuvimbela izindlela ezahlukene ze-biochemical. Kalula nje ukudla nezithako ezinconyiwe yilezo ezingabangeli ukwanda kwamangqamuzana abangela umdlavuza kodwa eziwehlisayo. Uma kungenjalo lokho kudla akufanele kunconywe. Ukudla kuqukethe izithako ezisebenzayo eziningi - ngakho-ke lapho uhlola ukudla nezithako zokudla udinga ukucabangela umthelela wazo zonke izithako ezisebenzayo ngokunqwabelanayo kunokuba ucabange ngazodwana.

Isibonelo i-Bilberry iqukethe izithako ezisebenzayo i-Curcumin, i-Resveratrol, i-Apigenin, i-Lycopene, i-Isoliquiritigenin. Futhi okusajingijolo okubomvu kuqukethe izithako ezisebenzayo i-Curcumin, i-Ellagic Acid, i-Isoliquiritigenin, i-Quercetin, i-Daidzein futhi mhlawumbe nabanye.

Iphutha elivamile elenziwe lapho kunqunywa futhi kukhethwa ukudla okuzodliwa ku-Cancer Nasopharyngeal - ukuhlola izithako ezikhethiwe kuphela ezisebenzayo eziqukethwe ekudleni futhi ungazinaki ezinye. Ngenxa yokuthi izithako ezihlukahlukene ezisebenzayo eziqukethwe ekudleni zingase zibe nemiphumela ephikisanayo kubashayeli bomdlavuza - awukwazi ukukhetha izithako ezisebenzayo ekudleni nasezithasiselweni ukuze wenze isinqumo sokudla ku-Nasopharyngeal Cancer.

YEBO – IZIKHETHO ZOKUDLA ZIBALULEKILE EMHLABENI. IZINQUMO ZOKUDLA KUFANELE ZICABANGE ZONKE IZITHAKO EZISEBENZAYO ZOKUDLA.

Amakhono Adingekayo Ekwenzeni Ukudla Okunempilo Komdlavuza We-Nasopharyngeal?

Ukondleka komuntu siqu komdlavuza njengomdlavuza weNasopharyngeal kuqukethe ukudla okunconyiwe / izithasiselo; ukudla okunganconyiwe / izithasiselo ezinezibonelo zokupheka ezibeka phambili ukusetshenziswa kokudla okunconyiwe. Isibonelo sokudla komuntu siqu singabonakala kulokhu isixhumanisi.

Ukunquma ukuthi yikuphi ukudla okunconyiwe noma okunganconyiwe kuyinkimbinkimbi kakhulu, kudinga ubuchwepheshe ku-Nasopharyngeal Cancer biology, isayensi yokudla, izakhi zofuzo, i-biochemistry kanye nokuqonda kahle ukuthi ukwelashwa komdlavuza kusebenza kanjani kanye nokuba sengozini okuhambisanayo lapho ukwelashwa kungayeka ukusebenza kahle.

UBUCHWEPHESHE OBUNINGI OBUDINGEKA UBUCHWEPHESHE BOMUNTU WOKUDLA KWAMUNTU KOMDLALO YI: IBHYOLOGY YOMDLAVUZA, ISAYENSI YOKUDLA, UKWELASHWA KOMDLAVUZA KANYE NOFUZO.

Izimpawu zomdlavuza njenge-Nasopharyngeal Cancer

Wonke ama-cancer afana ne-Nasopharyngeal Cancer angabonakala ngesethi eyingqayizivele yezindlela ze-biochemical - izindlela zokusayina ze-Nasopharyngeal Cancer. Izindlela ze-Biochemical ezifana ne-Cytoskeletal Dynamics, i-MAPK Signaling, i-PI3K-AKT-MTOR Signaling, i-G-protein-coupled Receptor Signaling iyingxenye yencazelo yesiginesha ye-Nasopharyngeal Cancer. Izakhi zofuzo zomdlavuza womuntu ngamunye zingahluka futhi yingakho isiginesha yabo ethile yomdlavuza ingase ihluke.

Izindlela zokwelapha ezisebenza ngempumelelo ku-Nasopharyngeal Cancer zidinga ukuqaphela izindlela ezihambisanayo zesiginesha ye-biochemical yesiguli ngasinye somdlavuza kanye nomuntu osengozini yofuzo. Ngakho-ke ukwelashwa okuhlukene okunezindlela ezahlukene zezenzo kusebenza kahle ezigulini ezahlukene. Ngokufanayo futhi ngenxa yezizathu ezifanayo ukudla nezithasiselo kudingeka kube okomuntu siqu kumuntu ngamunye. Ngakho-ke okunye ukudla nezithako ezisizayo kunconyelwa umdlavuza weNasopharyngeal lapho uthatha ukwelashwa komdlavuza i-Vincristine, futhi okunye ukudla nezithasiselo akunconywa.

Imithombo efana cBioPortal kanye nezinye eziningi zinikeza idatha emele isiguli engaziwa evela ezivivinyweni zomtholampilo kuzo zonke izinkomba zomdlavuza. Le datha iqukethe imininingwane yocwaningo lomtholampilo efana nosayizi wesampula / inombolo yeziguli, amaqembu obudala, ubulili, ubuzwe, ukwelashwa, indawo yesimila nanoma yikuphi ukuguqulwa kofuzo.

I-KMT2D, CDKN2A, TP53, RYR2 kanye ne-NSD1 yizakhi zofuzo ezikleliswe phezulu zeNasopharyngeal Cancer. I-KMT2D ibikwa ku-5.5 % weziguli ezimele kuzo zonke izivivinyo zomtholampilo. Futhi i-CDKN2A ibikwa ku-4.4%. Idatha ehlanganisiwe yesiguli ihlanganisa iminyaka yobudala esukela kwengama-36 kuye kwengama-80. U-74.0 % wemininingwane yesiguli uhlonzwa njengabesilisa. I-Nasopharyngeal Cancer biology kanye nezakhi zofuzo ezibikiwe ndawonye zichaza inani labantu elimele izindlela ze-biochemical ezisayinwe kulo mdlavuza. Uma izakhi zofuzo zesimila somdlavuza ngamunye noma izakhi zofuzo ezifaka engcupheni nazo zaziwa lokho kufanele futhi kusetshenziselwe ukwenza kube ngokwakho ukudla okunomsoco.

IZIKHETHO ZOKUDLA KOKUDLA KUFANELE ZIHVANE NESIGINISHA YOMUNTU NGAMUNYE YOMDLAVUZA.

Ukudla Nezithako Zomdlavuza We-Nasopharyngeal

Kweziguli Zomdlavuza

Iziguli zomdlavuza ekwelapheni noma ekunakekelweni okudambisa umzimba zidinga ukwenza izinqumo ngokudla nezithako ezisizayo - zama-kilojoule okudla adingekayo, zokulawula noma yimiphi imiphumela emibi yokwelashwa kanye nokuphathwa komdlavuza okuthuthukisiwe. Konke ukudla okusekelwe ezitshalweni akulingani futhi ukukhetha nokubeka phambili ukudla okuqondene nomuntu siqu futhi okwenziwe ngokwezifiso ekwelashweni komdlavuza okuqhubekayo kubalulekile futhi kuyinkimbinkimbi. Nazi izibonelo ezinikeza imihlahlandlela yokwenza izinqumo zokudla okunomsoco.

Khetha iVegetable GIANT BUTTERBUR noma i-MALABAR SPINACH?

I-Vegetable Giant Butterbur iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Apigenin, i-Lycopene, i-Isoliquiritigenin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana neCell Cycle, Carbohydrate Metabolism, Microtubule Dynamics kanye neChemokine Signaling nezinye. I-Giant Butterbur inconywa kuCancer Nasopharyngeal lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Vincristine. Lokhu kungenxa yokuthi i-Giant Butterbur ilungisa lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Vincristine.

Ezinye zezithako ezisebenzayo noma ama-bioactives emifino i-Malabar Spinach yi-Curcumin, i-Apigenin, i-Lycopene, i-Isoliquiritigenin, i-Quercetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Ceramide Signaling, i-PI3K-AKT-MTOR Signaling kanye ne-Oxidative Stress nezinye. I-Malabar Spinach ayinconyelwe Umdlavuza We-Nasopharyngeal lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Vincristine ngoba ilungisa lezo zindlela ze-biochemical eyenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

IBUTTERBUR ENKULU YEZINJINI INCONYISWA NGAPHEZU KWESIPINSHI SAMALABAR SOmdlavuza weNasopharyngeal KANYE NOKWELASHWA I-Vincristine.

Khetha Isithelo RED RASPBERRY noma i-BILBERRY?

I-Fruit Red Raspberry iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Ellagic Acid, i-Isoliquiritigenin, i-Quercetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-MAPK Signaling, i-Microtubule Dynamics kanye ne-MYC Signaling nezinye. I-Red Raspberry inconywa kuCancer Nasopharyngeal lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Vincristine. Lokhu kungenxa yokuthi i-Red Raspberry iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umphumela we-Vincristine.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Bilberry yi-Curcumin, i-Resveratrol, i-Apigenin, i-Lycopene, i-Isoliquiritigenin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Ceramide Signaling ne-Oxidative Stress nezinye. I-Bilberry ayinconyelwe I-Nasopharyngeal Cancer uma ukwelashwa komdlavuza okuqhubekayo kuyi-Vincristine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungaphenduli kahle.

I-RASPBERRY EBOMVU YESITHELO INCONYISWA NGENXA YE-BILBERRY YOmdlavuza we-Nasopharyngeal KANYE NOKWELASHWA I-Vincristine.

Khetha Nut COMMON HAZELNUT noma EUROPEAN CHESTNUT?

I-Hazelnut evamile iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Lycopene, i-Isoliquiritigenin, i-Quercetin, i-Daidzein. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-MYC Signaling, i-Microtubule Dynamics ne-Chemokine Signaling nezinye. I-Hazelnut evamile inconywa kuCancer Nasopharyngeal lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Vincristine. Lokhu kungenxa yokuthi i-Common Hazelnut iguqula lezo zindlela ze-biochemical eziye zabikwa ngokwesayensi ukuze ziqwashise umthelela we-Vincristine.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Chestnut yaseYurophu yi-Curcumin, i-Ellagic Acid, i-Apigenin, i-Isoliquiritigenin, i-Quercetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Ceramide Signaling, i-PI3K-AKT-MTOR Signaling kanye ne-Oxidative Stress nezinye. I-Chestnut yase-Europe ayinconyelwe Umdlavuza We-Nasopharyngeal lapho ukwelashwa komdlavuza okuqhubekayo kuyi-Vincristine ngoba ilungisa lezo zindlela zamakhemikhali ezinto eziphilayo ezenza ukwelashwa komdlavuza kungazweli noma kungasabeli kahle.

I-HAZELNUT EJWAYELEKILE INCONYISWA NGAPHEZU KWE-CHESTNUT YASE-EUROPE NGOKUTHOLA Umdlavuza weNasopharyngeal KANYE NOKWELASHWA I-Vincristine.

Kubantu abaneGenetic Risk of Cancer

Umbuzo obuzwa ngabantu abanengozi yofuzo ye-Nasopharyngeal Cancer noma umlando womndeni uthi "Yini Okufanele Ngiyidle Ngokuhlukile Kunangaphambili?" nokuthi kufanele bakukhethe kanjani ukudla kanye nezithako ukuze balawule ubungozi besifo. Njengoba engcupheni yomdlavuza akukho okungenziwa mayelana nokwelashwa - izinqumo zokudla nezithako zibalulekile futhi kube ngenye yezinto ezimbalwa kakhulu ezingenziwa. Konke ukudla okusekelwe ezitshalweni akulingani futhi kusekelwe kufuzo oluhlonziwe kanye nesiginesha yendlela - ukukhetha kokudla kanye nezithako kufanele kube okomuntu siqu.

Khetha imifino ye-CALABASH noma i-RADISH?

I-Vegetable Calabash iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-Amino Acid Metabolism, i-P53 Signaling ne-Angiogenesis nezinye. I-Calabash inconyelwe engcupheni Yomdlavuza We-Nasopharyngeal lapho ubungozi bofuzo obuhambisanayo kuyi-CDKN2A. Lokhu kungenxa yokuthi i-Calabash inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives kuRadish yemifino yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-Cell Cycle, Stem Cell Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. Isithombo asinconyiwe uma ingozi ye-Nasopharyngeal Cancer uma ingozi yofuzo ehambisana nayo i-CDKN2A ngoba inyusa izindlela zayo zokusayina.

I-Vegetable CALABASH INCONYISWA NGAPHEZU KWERADISHI NGE-CDKN2A GENETIC RISK OF CANCER.

Khetha I-Fruit PAPAYA noma i-PUMMELO?

I-Fruit Papaya iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin, i-Linalool. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, Stem Cell Signaling, P53 Signaling kanye ne-MYC Signaling nezinye. I-Papaya inconyelwa engcupheni Yomdlavuza We-Nasopharyngeal lapho ingozi yofuzo ehlotshaniswa nayo i-CDKN2A. Lokhu kungenxa yokuthi i-Papaya inyusa lezo zindlela ze-biochemical eziphikisana nabashayeli bamasignesha bayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives esithelweni i-Pummelo yi-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Stem Cell Signaling kanye ne-Cell Cycle Checkpoints nezinye. I-Pummelo ayituswa uma ingozi ye-Nasopharyngeal Cancer uma ingozi yofuzo ehlotshaniswa nayo i-CDKN2A ngoba inyusa izindlela zayo zokusayina.

I-PAPAYA YESITHELO INCONYISWA NGAPHEZU KWE-PUMMELO YE-CDKN2A GENETIC RISK OF CANCER.

Khetha Nut BUTTERNUT noma I-CASHEW NUT?

I-Butternut iqukethe izithako eziningi ezisebenzayo noma ama-bioactives afana ne-Apigenin, i-Curcumin, i-Lupeol, i-Daidzein, i-Formononetin. Lezi zithako ezisebenzayo zilawula izindlela ezahlukahlukene ze-biochemical ezifana ne-Cell Cycle, i-Amino Acid Metabolism, i-P53 Signaling ne-Angiogenesis nezinye. I-Butternut inconyelwa engcupheni Yomdlavuza We-Nasopharyngeal lapho ingozi yofuzo ehambisanayo iyi-CDKN2A. Lokhu kungenxa yokuthi i-Butternut inyusa lezo zindlela ze-biochemical eziphikisana nezishayeli zesiginesha zayo.

Ezinye zezithako ezisebenzayo noma ama-bioactives ku-Cashew Nut yi-Curcumin, i-Lupeol, i-Daidzein, i-Quercetin, i-Formononetin. Lezi zithako ezisebenzayo zikhohlisa izindlela ezahlukahlukene ze-biochemical njenge-MAPK Signaling kanye ne-PI3K-AKT-MTOR Signaling nezinye. I-Cashew Nut ayituswa uma ingozi ye-Nasopharyngeal Cancer uma ingozi yofuzo ehlotshaniswa nayo i-CDKN2A ngoba inyusa izindlela zayo zokusayina.

I-BUTTERNUT INCONYISWA NGAPHEZU KWE-CASHEW NUTI NGE-CDKN2A GENETIC RISK YOMKHANZA.

Ekuphetheni

Ukudla kanye Nezithako ezikhethiwe yizinqumo ezibalulekile zomdlavuza njenge-Nasopharyngeal Cancer. Iziguli zomdlavuza we-Nasopharyngeal kanye nabantu abasengozini yofuzo bahlala benalo mbuzo: "Yikuphi ukudla nezithako zokudla okunomsoco engikunconyelwe futhi ezingekho?" Kunenkolelo evamile okuwumbono oyiphutha wokuthi konke ukudla okusekelwe ezitshalweni kungaba yinzuzo noma cha kodwa ngeke kube yingozi. Ukudla okuthile kanye nezithako zokudla kungaphazamisa ukwelashwa komdlavuza noma kukhuthaze abashayeli bendlela yamangqamuzana omdlavuza.

Kunezinhlobo ezahlukene zezinkomba zomdlavuza njenge-Nasopharyngeal Cancer, ngayinye ene-tumor genetics ehlukahlukene ngokuhlukahluka kwe-genomic kumuntu ngamunye. Ngaphezu kwalokho konke ukwelashwa komdlavuza kanye ne-chemotherapy kunendlela ehlukile yokusebenza. Ukudla ngakunye okufana ne-Giant Butterbur kuqukethe ama-bioactives ahlukahlukene ngamanani ahlukene, anomthelela kumasethi ahlukene nahlukile wezindlela ze-biochemical. Incazelo yokondleka komuntu siqu izincomo zokudla komuntu ngamunye zezinkomba zomdlavuza, ukwelashwa, izakhi zofuzo, indlela yokuphila nezinye izici. Izinqumo zokudla okunomsoco zomdlavuza zidinga ulwazi lwebhayoloji yomdlavuza, isayensi yokudla kanye nokuqonda kwezinhlobo ezahlukene zokwelapha ngamakhemikhali. Ekugcineni uma kukhona izinguquko zokwelashwa noma ukuhlonzwa kwe-genomics entsha - ukwenza kube ngokwakho ukudla okunomsoco kudinga ukuhlolwa kabusha.

Isixazululo somuntu siqu somsoco we-addon senza isinqumo sibe lula futhi sisuse konke ukuqagela ekuphenduleni umbuzo othi, "Yikuphi ukudla okufanele ngikukhethe noma ngingakukhetheli I-Nasopharyngeal Cancer?". Ithimba le-addon elixube izigwegwe eziningi lihlanganisa odokotela bomdlavuza, ososayensi bezokwelapha, onjiniyela bezinhlelo zokusebenza nososayensi bedatha.

Okubhekwayo

• Hnc Mskcc 2016
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• I-Vitamin C ithuthukisa ukuguqulwa kwe-epigenetic okubangelwa i-5-azacytidine kanye nokuboshwa komjikelezo weseli kumigqa yeseli ye-hepatocellular carcinoma i-HLE ne-Huh7.
• Izingxenye ezithile zejusi yepomegranate njengama-inhibitors angaba khona we-prostate cancer metastasis.
• I-Lycopene idala ngokuhlukile ukuthula kanye ne-apoptosis emigqeni yamaseli omdlavuza we-prostate osabelayo futhi ozimele.
• Ukulawulwa okungekuhle kwe-transducer yesiginali kanye ne-activator ye-transcription-3 signaling cascade nge-lupeol ivimbela ukukhula futhi yenze i-apoptosis kumaseli e-hepatocellular carcinoma.
• Ukukhuthazwa ukukhula kwamaseli e-adenocarcinoma yamaphaphu kanye namaseli amancane e-epithelial yomoya nge-beta-carotene ngokwenza kusebenze i-cAMP, i-PKA, i-CREB ne-ERK1/2.