Amaphuzu avelele
Imbewu emnyama namafutha embewu emnyama inganciphisa imiphumela emibi yokwelashwa ngamakhemikhali ezinhlobonhlobo zomdlavuza. Imbewu emnyama iqukethe izithako ezihlukene zokudla okunomsoco njenge-Thymoquinone. Izinzuzo zokulwa nomdlavuza zembewu emnyama ne-Thymoquinone zihloliwe ezigulini nasezifundweni zelabhu. Izibonelo ezimbalwa zezinzuzo ze-thymoquinone, njengoba ziqokonyiswa yilolu cwaningo zihlanganisa ukuncipha kwemfiva kanye nezifo ezivela emazingeni aphansi e-neutrophil kumdlavuza wobuchopho bezingane, umphumela ongaseceleni ohlobene we-methotrexate (chemotherapy) wobuthi ku-leukemia kanye nokusabela okungcono ezigulini ezinomdlavuza webele ezilashwa nge-tamoxifen. ukwelashwa. Ngoba amafutha embewu emnyama ayababa - ngokuvamile athathwa noju. Ngokusekelwe kulokho umdlavuza kanye nokwelashwa, ezinye izithasiselo zokudla nezinomsoco zingase zingaphephile. Ngakho-ke, uma isiguli somdlavuza webele selashwa nge-tamoxifen futhi sisebenzisa amafutha embewu emnyama - khona-ke kubalulekile ukugwema iParsley, Isipinashi kanye Netiye Elihlaza, kanye nezithako zokudla ezifana ne-Quercetin. Ngakho-ke, kubaluleke kakhulu ukwenza ukudla okunomsoco kufane nomdlavuza othile kanye nokwelashwa ukuze uthole izinzuzo zokudla okunomsoco kanye nokuphepha.
Yilabo kuphela abathinteka ekuxilongeni okungalindelekile komdlavuza kanye nabathandekayo babo abazi kahle ukuthi kuba matasa kangakanani ukuzama ukuthola indlela ezayo, ekutholeni odokotela abangcono kakhulu, izinketho zokwelashwa ezingcono kakhulu, kanye nanoma iyiphi enye indlela yokuphila, ukudla nezinye izindlela ezengeziwe. bangasebenzisa ithuba lokulwa ukuze bangabi nomdlavuza. Futhi, abaningi bakhungathekile ngokwelashwa ngamakhemikhali okufanele babhekane nakho naphezu kwemiphumela engemihle kakhulu futhi babheke izindlela zokuthuthukisa ukwelashwa kwabo ngamakhemikhali ngezinketho zezithasiselo zemvelo ukuze banciphise imiphumela emibi futhi bathuthukise impilo yabo evamile. Esinye sezithako zemvelo ezinedatha eyanele ye-preclinical ku umdlavuza imigqa yamaseli namamodeli ezilwane angamafutha embewu emnyama.
Amafutha Omnyama Wembewu kanye ne-Thymoquinone
Amafutha wembewu emnyama atholakala ezimbewini ezimnyama, imbewu yesitshalo esibizwa nge-Nigella sativa enezimbali eziphephuli, eziluhlaza okwesibhakabhaka noma ezimhlophe, ezaziwa kakhulu ngokuthi izimbali ze-fennel. Imbewu emnyama ijwayele ukusetshenziselwa ukudla kwase-Asia naseMedithera. Imbewu emnyama yaziwa nangokuthi ikhumini elimnyama, i-kalonji, i-caraway emnyama nembewu ka-anyanisi omnyama.
Imbewu emnyama isetshenziselwe ukwenza imithi iminyaka eyizinkulungwane. Esinye sezithako eziyinhloko zokudla okune-bioactive kawoyela omnyama wembewu one-antioxidant, anti-inflammatory kanye ne-anti-cancer izakhiwo yi-Thymoquinone.
Izinzuzo Ezijwayelekile Zezempilo ze-Black Seed Oil / Thymoquinone
Ngenxa yezakhi zayo zokulwa ne-antioxidant kanye ne-anti-inflammatory, u-Black seed oil / Thymoquinone uthathwa njengezinzuzo eziningi zezempilo. Ezinye zezimo uwoyela wembewu Emnyama ongasebenza kuzo yilezi:
- Isifuba Somoya: Imbewu emnyama inganciphisa ukukhwehlela, ukuvunguza, nokusebenza kwamaphaphu kwabanye abantu abane-asthma.
- Diabetes: Imbewu emnyama ingathuthukisa amazinga kashukela egazini namazinga e-cholesterol kubantu abanesifo sikashukela.
- Umfutho wegazi ophezulu: Ukuthatha imbewu emnyama kunganciphisa umfutho wegazi ngenani elincane.
- Ukungabi nenzalo kowesilisa: Ukuthatha uwoyela wembewu omnyama kungakhuphula inani lesidoda nokuthi zishesha kangakanani emadodeni anokuzala.
- Ubuhlungu besifuba (i-mastalgia): Ukufaka ijeli equkethe uwoyela wembewu omnyama emabeleni ngesikhathi somjikelezo wokuya esikhathini kunganciphisa ubuhlungu kwabesifazane abanobuhlungu besifuba.
Imiphumela emibi ye-Black Seed Oil / Thymoquinone
Uma kudliwe ngamanani amancane njengesinongo ekudleni, imbewu emnyama kanye namafutha embewu emnyama kungenzeka kuphephe kubantu abaningi. Kodwa-ke, ukusebenzisa uwoyela wembewu omnyama noma izithasiselo kulezi zimo ezilandelayo kungahle kungaphephi.
- Ukukhulelwa: Gwema ukudla kakhulu uwoyela wembewu emnyama noma okukhishwayo ngesikhathi sokukhulelwa ngoba kunganciphisa isibeletho ekutholeni inkontileka.
- Ukuphazamiseka Kopha: Ukudla kukawoyela omnyama ongahle kube nomthelela ekunqandeni kwegazi futhi kwandise ingozi yokopha. Ngakho-ke, kunethuba lokuthi ukutholwa kwembewu emnyama kungenza ukuphazamiseka kokopha kube kubi kakhulu.
- I-Hypoglycemia: Njengoba uwoyela wembewu omnyama ungehlisa amazinga kashukela egazini, iziguli ezinesifo sikashukela ezithatha imishanguzo kufanele zibheke izimpawu zeshukela eliphansi egazini.
- Umfutho wegazi ophansi: Gwema uwoyela wembewu omnyama uma unengcindezi yegazi ephansi ngoba imbewu emnyama ingase yehlise umfutho wegazi ngokuqhubekayo.
Ngenxa yalezi zingcuphe ezingaba khona nemiphumela engemihle, umuntu kufanele agweme ukusebenzisa uwoyela wembewu emnyama uma kuhlelelwe ukuhlinzwa.
Ukudla Okufanele Ukudla Ngemuva Kokuxilongwa Komdlavuza!
Akukho mdlavuza owodwa ofanayo. Dlulela ngale kwemihlahlandlela ejwayelekile yokudla kuwo wonke umuntu futhi wenze izinqumo ezenziwe ngezifiso ngokudla nezithasiselo ngokuzethemba.
I-Thymoquinone / I-Black Seed Oil Use ekuthuthukiseni i-Chemotherapy Efficacy noma ukunciphisa imiphumela emibi emdlavuza
Ukubuyekezwa kwakamuva emaphephandabeni ezesayensi abukeze inqwaba yezifundo zokuhlola kumaseli noma izinhlobo zezilwane zomdlavuza ohlukahlukene okhombise izakhiwo ezinhlobonhlobo ze-Thymoquinone ezivela ku-oyela wembewu omnyama, kufaka phakathi ukuthi zingashukumisa kanjani izicubu kwamanye amakhemikhali ajwayelekile nokwelashwa ngemisebe (UMostafa AGM et al, Front Pharmacol, 2017; UKhan MA et al, Oncotarget 2017).
Kodwa-ke, kukhona ucwaningo olulinganiselwe kanye nezifundo kubantu ezitholakalayo ezihlola imiphumela ye-thymoquinone noma uwoyela wembewu emnyama ngezindlela ezahlukene. zomdlavuza lapho welashwa nge-chemotherapies ethile noma ngaphandle kwayo. Ngomdlavuza omningi, i-chemotherapy noma i-radiation therapy inikezwa ngemuva kokuhlinzwa ukuze kuqedwe noma yimaphi amaseli omdlavuza asele. Kodwa lezi zindlela zokwelapha azihlali ziphumelela futhi zingalimaza izinga lempilo yesiguli. Kule bhulogi, sizohlola izifundo ezihlukene zomtholampilo zamafutha embewu emnyama noma i-thymoquinone kumdlavuza futhi sithole ukuthi ukusetshenziswa kwawo kuyazuzisa iziguli ezinomdlavuza futhi kungasetshenziswa ukwenza ngcono Ukudla kweziguli ezinomdlavuza.
Imbewu Emnyama / i-Thymoquinone kanye neChemotherapy kunganciphisa imiphumela emibi ye-Febrile Neutropenia ezinganeni ezinezicubu zeBongo
Kuyini i-Febrile Neutropenia?
Eminye yemiphumela emibi yokwelashwa ngamakhemikhali ukucindezela umnkantsha kanye namaseli omzimba. I-Febrile neutropenia yisimo lapho ngenxa yenani eliphansi kakhulu lama-neutrophils, uhlobo lwamaseli amhlophe egazi emzimbeni, isiguli singathola izifo kanye nomkhuhlane. Lokhu kungumphumela ohlangothini ovamile obonwa ezinganeni ezinamathumba obuchopho abelashwa ngamakhemikhali.
Ukufundwa Nokutholwa Okubalulekile
Esifundweni somtholampilo esingahleliwe, esenziwe e-Alexandria University eGibhithe, abacwaningi bahlole umphumela wokuthatha imbewu emnyama ngamakhemikhali, ngomphumela oseceleni we-febrile neutropenia ezinganeni ezinezicubu zobuchopho. Izingane ezingama-80 ezineminyaka ephakathi kwengu-2-18 ubudala ezinamathumba obuchopho, ezelashwa ngamakhemikhali, zabelwa amaqembu amabili. Iqembu elilodwa lezingane ezingama-40 lithole u-5 g wembewu emnyama nsuku zonke kulo lonke ukwelashwa ngamakhemikhali kanti elinye iqembu lezingane ezingama-40 lithole ukwelashwa ngamakhemikhali kuphela. (UMousa HFM et al, Ingqondo Yezingane Yezinzwa., 2017).
Imiphumela yalolu cwaningo iveze ukuthi zingu-2.2% kuphela izingane eziseqenjini elithatha imbewu emnyama ezazine-febrile neutropenia ngenkathi eseqenjini elilawulayo, izingane ezingama-19.2% zazinemiphumela engemihle ye-febrile neutropenia. Lokhu kusho ukuthi ukudla imbewu emnyama kanye ne-chemotherapy kunciphise izehlakalo zeziqephu ze-febrile neutropenia ngama-88% uma kuqhathaniswa neqembu elilawulayo.
I-Black Seed Oil / Thymoquinone inganciphisa i-Methotrexate Chemotherapy eyenziwe nge-Side-Effect Yesibindi / I-Hepato-toxicity ezinganeni ezine-Leukemia
I-acute lymphoblastic leukemia ingenye yomdlavuza ovame kakhulu wezingane. I-Methotrexate iyi-chemotherapy ejwayelekile esetshenziselwa ukwandisa izinga lokusinda ezinganeni ezine-leukemia. Kodwa-ke, ukwelashwa kwe-methotrexate kungaholela emiphumeleni emibi ye-chemotherapy ye-hepatotoxicity noma ubuthi besibindi, ngaleyo ndlela kunciphise umthelela wayo.
Ukufundwa Nokutholwa Okubalulekile
A Isivivinyo esilawulwa ngokungahleliwe esenziwe ngabaphenyi abavela eNyuvesi yaseTanta eGibhithe sahlola umthelela wokwelashwa kukawoyela omnyama wembewu ku-methotrexate eyenga i-hepatotoxicity ezinganeni ezingama-40 zaseGibhithe ezitholwe zine-acute lymphoblastic leukemia. Uhhafu weziguli welashwa ngemethotrexate therapy kanye no-Black seed oil kwathi ingxenye yokuphumula yaphathwa ngemethotrexate therapy kanye ne-placebo (into engenaxabiso lokwelapha). Lolu cwaningo lubandakanya nezingane ezingama-20 ezinempilo ezifaniswa nobudala nobulili futhi zisetshenziswe njengeqembu lokulawula. (Adel A Hagag et al, Infect Disord Drug Target., 2015)
Ucwaningo luthole ukuthi uwoyela omnyama wembewu omnyama / i-thymoquinone inciphise i-methotrexate chemotherapy ebangelwe yimiphumela emibi ye-hepatotoxicity futhi inyuse iphesenti leziguli ezithola ukuxolelwa okuphelele cishe ngama-30%, zinciphise ukubuyela emuva cishe ngama-33%, kanye nokwenza ngcono ukusinda okungenazifo cishe ngama-60% uma kuqhathaniswa ne-placebo ezinganeni ezine-acute lymphoblastic leukemia; kodwa-ke, bekungekho ntuthuko ephawulekayo ekusindeni jikelele. Abaphenyi baphetha ngokuthi uwoyela omnyama wembewu / i-thymoquinone inganconywa njengesidakamizwa esisebenzisayo ezinganeni ezine-Leukemia ezelashwa ngemethotrexate.
Ukuthatha i-Thymoquinone kanye ne-Tamoxifen kungathuthukisa ukusebenza kwayo ezigulini zomdlavuza webele
Umdlavuza webele ungomunye wezifo ezivame kakhulu zomdlavuza kwabesifazane emhlabeni wonke. I-Tamoxifen indinganiso yokunakekelwa kwe-hormonal therapy esetshenziswa kumdlavuza webele we-estrogen receptor positive (ER+ve). Kodwa-ke, ukuthuthukiswa kokumelana ne-tamoxifen kungenye yezinkinga ezinkulu. I-Thymoquinone, isithako esisebenzayo sikawoyela wembewu emnyama, itholwe iyi-cytotoxic ezinhlotsheni ezimbalwa zemigqa yamaseli omdlavuza womuntu amelana nezidakamizwa eziningi.
Ukufundwa Nokutholwa Okubalulekile
Ocwaningweni olwenziwe ngabaphenyi baseCentral University of Gujarat eNdiya, Tanta University eGibhithe, Taif University eSaudi Arabia naseBenha University eGibhithe, bahlole umthelela wokusebenzisa i-thymoquinone (isithako esiyinhloko samafutha embewu emnyama) kanye tamoxifen ezigulini ezinomdlavuza webele. Ucwaningo lubandakanya iziguli ezingama-80 zesifazane ezinomdlavuza webele ezazingelashwa, zelashwa nge-tamoxifen yodwa, zelashwa nge-thymoquinone (evela embewini emnyama) iyodwa noma zelashwa ngazo zombili i-thymoquinone ne-tamoxifen. (U-Ahmed M Kabel et al, J Can Sci Res., 2016)
Ucwaningo luthole ukuthi ukuthatha i-thymoquinone kanye ne-Tamoxifen kube nomthelela ongcono kunalezi zidakamizwa zodwa ezigulini ezinomdlavuza webele. Abaphenyi baphetha ngokuthi ukwengezwa kwe-thymoquinone (kusuka kuwoyela omnyama wembewu) kuya ku-tamoxifen kungabonisa indlela yokwelapha entsha yokuphathwa komdlavuza webele.
I-Thymoquinone ingahle iphephe ezigulini ezinomdlavuza we-Refractory Advanced, kepha kungenzeka ingabi nayo Impact Therapeutic
Ukufundwa Nokutholwa Okubalulekile
Esigabeni engangisicwaninga esenziwa ngo-2009, ngabaphenyi baseKing Fahd Hospital yaseYunivesithi naseKing Faisal University eSaudi Arabia, bahlola ukuphepha, ubuthi kanye nomthelela wokwelapha we-thymoquinone ezigulini ezinomdlavuza osezingeni eliphezulu ezazingenalo ukwelashwa okujwayelekile noma izinyathelo zokudambisa. Ocwaningweni, iziguli ezingama-21 zabantu abadala ezinamathumba aqinile noma amakhemikhali e-hematological ahlulekile noma abuyele emuva ekwelashweni okujwayelekile anikezwe i-thymoquinone ngomlomo ezingeni lokuqala le-3, 7, noma i-10mg / kg / ngosuku. Ngemuva kwesikhathi esimaphakathi samaviki angu-3.71, ayikho imiphumela emibi ebikiwe. Kodwa-ke, akukho miphumela yokulwa nomdlavuza nayo ebonwe kulolu cwaningo. Ngokuya ngocwaningo abacwaningi baphetha ngokuthi i-thymoquinone ibekezeleleke kahle kumthamo osukela ku-75mg / ngosuku kuye ku-2600mg / ngosuku kungabikho ubuthi noma izimpendulo zokwelapha ezibikiwe. (Ali M. Al-Amri no-Abdullah O. Bamosa, uShiraz E-Med J., 2009)
Isiphetho
Izifundo eziningi ze-preclinical kuma-cell lines kanye nezinhlobonhlobo umdlavuza amamodeli amamodeli ngaphambilini athole izakhiwo eziningi zokulwa nomdlavuza ze-Thymoquinone kumafutha embewu emnyama. Ucwaningo olumbalwa lwezokwelapha luphinde lwabonisa ukuthi ukuphuza amafutha embewu emnyama/i-thymoquinone kunganciphisa umphumela ongaseceleni we-chemotherapy we-febrile neutropenia ezinganeni ezinezicubu zobuchopho, i-Methotrexate ibangele ubuthi besibindi ezinganeni ezine-leukemia futhi ingase ithuthukise impendulo ekwelashweni kwe-tamoxifen ezigulini ezinomdlavuza webele. . Kodwa-ke, izithasiselo zikawoyela wembewu emnyama noma izithasiselo ze-thymoquinone kufanele zithathwe njengengxenye yokudla kuphela ngemuva kokubonisana nomhlinzeki wakho wokunakekelwa kwezempilo ukuze ugweme noma yikuphi ukusebenzelana okungalungile nokwelashwa okuqhubekayo kanye nemiphumela engemihle ngenxa yezinye izimo zezempilo.
Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.
Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.
Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.
Ukudla Okungokwakho Komdlavuza!
Umdlavuza uyashintsha ngokuhamba kwesikhathi. Enza ngendlela oyifisayo futhi uguqule umsoco wakho ngokusekelwe kunkomba yomdlavuza, ukwelashwa, indlela yokuphila, okuncamelayo kokudla, izinto ezingakuphathi kahle nezinye izici.
Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.