Ukusetshenziswa kwe-Aloe Vera Extract / Ijusi ezigulini zomdlavuza

Amaphuzu avelele

Ucwaningo lubonisa ukuthi ukusetshenziswa kwe-aloe vera mouthwash kungase kuzuze iziguli ze-leukemia ne-lymphoma ekunciphiseni i-chemotherapy-induced stomatitis, kanye ne-radiation-induced mucositis ezigulini ezinomdlavuza wekhanda nentamo. Kodwa-ke, ubufakazi besayensi obuphakamisa izinzuzo zokungeniswa ngomlomo kwejusi ye-aloe vera yiziguli ezinomdlavuza ezilashwa ngamakhemikhali noma nge-radiation buncane. Ucwaningo lwango-2009 lwaphakamisa izinzuzo ezingaba khona zenhlaba yomlomo ekwehliseni usayizi wesimila, ukulawula izifo kanye nokwenza ngcono ukuphila kweminyaka emi-3. Nokho, kudingeka izifundo ezinkulu ukuze kuqinisekiswe lezi zinzuzo ku umdlavuza iziguli (kungakhathaliseki ukuthi zelashwa ngamakhemikhali/ngemisebe noma cha) kanye nokuhlola ubuthi, ukuphepha kanye nemiphumela engemihle yokumunca ngomlomo ijusi ye-Aloe vera ngaphambi kokutusa ukusetshenziswa kwayo.

Yini i-Aloe Vera?

I-Aloe Vera iyisitshalo esimnandi somuthi esikhula ezindaweni ezomile nezishisayo e-Afrika, e-Asia, eYurophu nakwezinye izingxenye ze-United States. Leli gama lasuselwa egameni lesi-Arabhu elithi “Alloeh” elisho ukuthi “ukucwebezela into ebabayo,” negama lesiLatini elithi “vera” elisho ukuthi “iqiniso”. 

Ijusi nejeli ekhishwe ezitshalweni ze-Aloe vera zaziwa ngezindawo zazo zokuphulukisa. I-aloe vera ibisetshenziswa njengesitshalo okwelapha amakhulu eminyaka ukwelapha izimo ezahlukahlukene zempilo nezesikhumba. Amanye amakhemikhali asemqoka asebenzayo afaka:

• Ama-anthraquinones afana neBarbaloin (Aloin A), Chrysophanol, Aloe-emodin, Aloenin, Aloesaponol
• AmaNaphthalenones
• Ama-polysaccharides afana ne-Acemannan
• AmaSterols afana neLupeol
• Amaprotheni nama-Enzyme
• Ama-Organic Acids 

Izinzuzo Zokufakwa Kwezinhlobonhlobo ze-Aloe Vera Gel

Aloe vera ikhombisa uhla lwezakhiwo zokwelapha ezihlanganisa i-anti-inflammatory, anti-microbial, anti-viral, kanye ne-antioxidant. Ijeli ye-Aloe vera isetshenziselwa ukuphulukisa nokupholisa amanxeba/imihuzuko yesikhumba, ukusha okuncane, ukushiswa yilanga, ukulimala kwesikhumba okubangelwa yimisebe, izimo zesikhumba ezihambisana ne-psoriasis, induna, inkwethu kanye nesikhumba esimanzi. Ijeli iyasiza ekudambiseni isikhumba esivuvukele. Ine-sterols engakhuthaza ukukhiqizwa kwe-collagen ne-hyaluronic acid engase isize ukuvuselela isikhumba futhi ithuthukise ukuthungwa kwesikhumba, ngaleyo ndlela yehlise ukubukeka kwemibimbi.

Izinzuzo zokuphuza i-Aloe Vera Juice

Izinzuzo ezingaba khona zokuphuza ijusi ye-Aloe vera by umdlavuza iziguli ezelashwa njenge-chemotherapy noma i-radiation therapy kanye nalezo ezingalashwanga, akwaziwa.

Kodwa-ke, okulandelayo ngezinye zezinzuzo zayo zezempilo ezingaba khona (okujwayelekile).

• Sebenzisa ijusi le-Aloe vera njengokugeza umlomo kunciphisa uqweqwe lokwakha nokuvuvukala kwezinsini
• Igcina isikhumba sinamanzi, sithuthukisa impilo yesikhumba, sinciphise izinduna okuholela ekususeni isikhumba
• Isiza ekwehliseni ukuqunjelwa 
• Izinsiza zokulawula amazinga kashukela egazini
• Isiza ekukhipheni ubuthi bemvelo emzimbeni
• Isiza ekwehliseni isilungulela / i-acid reflux 

Imiphumela Emibi Yokungeniswa Kwamajusi e-Aloe Vera

Ngaphandle kwezinzuzo ezingaba khona ezishiwo ngaphambili, ukungeniswa ngomlomo kwejusi le-Aloe vera kuhlotshaniswa nemiphumela emibi eminingi ebandakanya:

1. Ukuqunjelwa nohudo- uma okukhiphayo kuqukethe inani eliphezulu le-aloin, inhlanganisela etholakala phakathi kweqabunga elingaphandle lesitshalo se-Aloe vera nejeli ngaphakathi, elinemiphumela yokuthambisa.
2. I-nausea nokuhlanza
3. Amazinga we-potassium aphansi lapho ijusi le-Aloe vera lithathwa kanye ne-chemotherapy
4. I-aloe vera idale ubuthi obudala ukuquleka nokungalingani kwe-electrolyte.
5. Ukusebenzisana nezidakamizwa okuyizigaba ezingaphansi kweCytochrome P450 3A4 ne-2D6.

Njengokungeniswa kwejusi le-aloe vera, imijovo ye-Aloe vera nayo ayinconywa ezigulini zomdlavuza. Emuva ngawo-1990, iziguli eziningi ezinomdlavuza zafa ngemuva kokuthola imijovo ye-Aloe vera (acemannan) njengengxenye yokwelashwa komdlavuza. Ngakho-ke, umuntu kufanele acabangele imiphumela emibi engaba khona futhi abonisane nochwepheshe wezokunakekelwa kwezempilo ngaphambi kokuthatha ijusi le-aloe vera.

Izifundo ezihambisana nokusetshenziswa kwe-Aloe Vera kuCancer

Abukho ubufakazi obukhombisa izinzuzo ezingaba khona zokuphuza ijusi le-aloe vera yiziguli ezinomdlavuza. Kodwa-ke, ezinye izinzuzo ze-aloe vera mouthwash kanye nokusetshenziswa kwezihloko ezigulini zomdlavuza kuchazwe ngezansi.

Umthelela we-Aloe Vera Mouthwash ku-Chemotherapy-Induced Stomatitis eLymphoma kanye Neziguli Zegazi 

I-Chemotherapy iyindlela yokuqala yokwelapha i-leukemia ne-lymphoma. Omunye wemiphumela emibi kakhulu ye-chemotherapy yi-stomatitis. I-Stomatitis, eyaziwa nangokuthi i-oral mucositis, ukuvuvukala okubuhlungu noma isilonda esenzeka emlonyeni. I-Stomatitis noma i-mucositis yomlomo imvamisa iholela ezinkingeni ezinjengokutheleleka nokopha kwe-mucosal okuholela ebunzimeni bokudla, ukuphazamiseka kokudla okunomsoco nokungahlaliseki.

Esivivinyweni somtholampilo esenziwe ngabaphenyi baseShiraz University of Medical Sciences, e-Iran ngo-2016, bahlole umphumela wesisombululo se-Aloe vera ku-stomatitis kanye nobukhulu obuhlobene nobuhlungu ezigulini ezingama-64 ezine-Acute Myeloid Leukemia (AML) ne-Acute Lymphocytic Leukemia (BONKE) welashwa ngamakhemikhali. Iqembu elincane lalezi ziguli lacelwa ukuthi lisebenzise i-Aloe vera mouthwash imizuzu emibili kathathu ngosuku amasonto ama-2, kanti ezinye iziguli zisebenzisa izisuli zomlomo ezijwayelekile ezinconywe yizikhungo zomdlavuza. (UParisa Mansouri et al, Intwifery yabahlengikazi base-Int J., 2016)

Ucwaningo luthole ukuthi iziguli ezisebenzisa isisombululo se-Aloe vera mouthwash ziye zancipha kakhulu kwi-stomatitis kanye nobukhulu obuhlobene nobuhlungu uma kuqhathaniswa nalabo abasebenzisa ama-mouthwashes ajwayelekile. Abaphenyi baphetha ngokuthi ukuhlanzwa komlomo kwe-Aloe vera kungasiza ekunciphiseni i-stomatitis noma i-oral mucositis kanye nobukhulu obuhlobene nobuhlungu besifo se-leukemia kanye ne-lymphoma eselashwa ngamakhemikhali, futhi kungathuthukisa isimo somsoco seziguli.

Umthelela we-Aloe vera mouthwash ku-Radiation-indosed Mucositis Ezigulini Zomdlavuza WeKhanda Nentamo

I-Mucositis isho ukuvuvukala okubuhlungu noma isilonda sezinambuzane ezinamafinyila noma yikuphi lapho kutholakala khona emathunjini, kungagcini emlonyeni. Esivivinyweni somtholampilo esenziwe futhi sashicilelwa ngabaphenyi baseTehran University of Medical Sciences (TUMS), e-Iran ngo-2015, bahlola ukusebenza kwe-Aloe vera mouthwash ekwehliseni i-mucositis eyenziwe ngemisebe ezigulini ezingama-26 zomdlavuza wekhanda nentamo okwakuhlelwe ukuthi zithole ukwelashwa okuvamile kwemisebe futhi ukukuqhathanisa ne-benzydamine mouthwash. (Mahnaz Sahebjamee et al, Oral Health Prev Dent., 2015)

Ucwaningo luthole ukuthi izikhathi eziphakathi kokwelashwa ngemisebe kanye nokuqala kwe-mucositis kanye nobukhulu obukhulu be-mucositis ziyefana neqembu lesiguli elisebenzisa i-Aloe vera (izinsuku eziyi-15.69 ± 7.77 nezinsuku ezingama-23.38 ± 10.75 ngokulandelana) kanye neqembu elisebenzisa i-benzydamine ( Izinsuku eziyi-15.85 ± 12.96 nezinsuku ezingama-23.54 ± 15.45 ngokulandelana). 

Abaphenyi baphetha ngokuthi i-Aloe vera mouthwash ingasebenza njenge-benzydamine mouthwash ekubambezeleni i-mucositis eyenziwe ngemisebe, ngaphandle kwemiphumela emibi.

Umthelela wama-Aloe arborescens ezigulini ezinomdlavuza weMetastatic 

I-Aloe arborescens, ngesinye isitshalo esinomsoco esisohlobo olufanayo i-Aloe, esabiwe yi-Aloe vera. 

Ocwaningweni lomtholampilo olushicilelwe ngabaphenyi besibhedlela iSt. Gerardo e-Italy, abacwaningi bahlole iziguli ezingama-240 ezinesimila esiqinile se-metastatic ezathola i-chemotherapy nge-Aloe noma ngaphandle kwayo. Phakathi kweziguli ezifakiwe ocwaningweni, iziguli ezinomdlavuza wamaphaphu zithole i-cisplatin ne-etoposide noma i-vinorelbine, iziguli ezinomdlavuza we-colorectal zithole i-oxaliplatin kanye ne-5-FU, iziguli ezinomdlavuza esiswini zithole i-5-FU kanye neziguli ezinomdlavuza wepancreatic zithole iGemcitabine. Iqembu elincane lalezi ziguli liphinde lathola i-Aloe ngomlomo. (UPaolo Lissoni et al, eVivo., Jan-Feb 2009)

Lolu cwaningo luthole ukuthi iziguli ezithola zombili i-chemotherapy kanye ne-Aloe zinamaphesenti aphezulu wokuncishiswa kosayizi wesimila, ukulawula izifo kanye neziguli ezisinde okungenani iminyaka emithathu.

Kodwa-ke, kunconywa izifundo ezinkulu ukuhlola ubuthi, ukuphepha kanye nemiphumela emibi yokungeniswa ngomlomo kwe-Aloe arborescens / aloe vera.

Umthelela Wokusetshenziswa Kwama-Topical ku-Dermatitis eyenziwe nge-Radiation ezigulini zomdlavuza

I-Dermatitis isho ukuvuvukala kwesikhumba. Imisebe ebangelwa imisebe ivamile ezigulini ezinomdlavuza ezithola i-radiotherapy.

1. Esivivinyweni sangaphambilini sasemtholampilo esenziwe ngabaphenyi baseTehran University of Medical Sciences e-Iran, bafunde ngomthelela we-Aloe vera lotion ku-dermatitis eyenziwe ngemisebe ezigulini ezingama-60 zomdlavuza kubandakanya nalabo abanomdlavuza webele, umdlavuza we-pelvic, umdlavuza wekhanda nentamo neminye imidlavuza, okwakuhlelwe ukuthi ithole i-radiotherapy. Ezingu-20 zalezi ziguli nazo zathola i-chemotherapy kanyekanye. Ngokuya ngemiphumela yalolu cwaningo, abacwaningi baphethe ngokuthi ukusetshenziswa kwe-Aloe vera kungasiza ekwehliseni ukuqina kwesikhumba esibangelwa yimisebe. (P Haddad et al, Curr Oncol., 2013)

2. Ocwaningweni olushicilelwe ngo-2017, abacwaningi baseShiraz University of Medical Sciences e-Iran benze ucwaningo olufanayo ezigulini eziyi-100 ezitholakale zinomdlavuza webele ukuze zihlole umthelela we-Aloe vera gel kwi-radiation-induced dermatitis. Kodwa-ke, okutholakele kulolu cwaningo kutholakale ukuthi ukufaka isicelo se-Aloe vera gel akunamphumela omuhle ekusakazekeni noma ebucayi besikhumba esibangelwa yimisebe ezigulini zomdlavuza webele. (UNiloofar Ahmadloo et al, I-Asian Pac J Cancer Prev., 2017)

Ngenxa yemiphumela ephikisanayo, asikwazi ukuphetha ukuthi ngabe isicelo se-topical aloe vera siyasiza yini ekwehliseni i-dermatitis eyenziwe ngemisebe ezigulini ezinomdlavuza, ikakhulukazi iziguli ezinomdlavuza webele. 

Umthelela Wokusetshenziswa Kwama-Topical ku-Proctitis eyenziwe ngemisebe ezigulini zomdlavuza wePelvic 

I-Proctitis isho ukuvuvukala kolwelwesi lwe-rectum yangaphakathi. 

Ocwaningweni olushicilelwe ngo-2017, abacwaningi beMazandaran University of Medical Sciences e-Iran bahlole umthelela wokusetshenziswa kwezingqungqulu zamafutha e-Aloe vera kuma-proctitis abangelwa yimisebe ezigulini ezinomdlavuza we-pelvic ezingama-20. Lezi ziguli ezinomdlavuza zikhombise eyodwa noma eziningi zezimpawu kubandakanya ukopha kwamachaphaza, ubuhlungu besisu / be-rectal, isifo sohudo noma ukuphuthuma kwendle. Ucwaningo luthole ukuthuthuka okuphawulekayo kuhudo, ukuphuthuma kwezindle nendlela yokuphila. Kodwa-ke, imiphumela ayibonisanga ukuthuthuka okuphawulekayo ekuphumeni kwegazi kanye nobuhlungu besisu / be-rectal. (Adeleh Sahebnasagh et al, J Altern Complement Med., 2017)

Abaphenyi baphetha ngokuthi ukufakwa kwamafutha e-Aloe vera kungasiza ekunciphiseni ezimbalwa zezimpawu ezihambisana ne-proctitis eyenziwe ngemisebe efana nohudo nokuphuthuma kwezindle.

Izifundo ze-in vitro ezihlola izakhiwo ezilwa nomdlavuza zengxenye esebenzayo (i-Aloe-emodin)

Ucwaningo lwe-in vitro luthole ukuthi i-Aloe-emodin, i-phytoestrogen ekhona e-Aloe vera enezici ze-estrogenic, ingasiza ekunciphiseni ukwanda kwamangqamuzana omdlavuza webele. (UPao-Hsuan Huang et al, i-Evid Based Complement Alternat Med., 2013)

Olunye ucwaningo lwe-in vitro luthole nokuthi i-Aloe-emodin ingadala i-apoptosis encike ekucindezelekeni (ukufa kwamangqamuzana) kumaseli womdlavuza obala ngokwezibalo. (UChunsheng Cheng et al, Med Sci Monit., 2018)

Kodwa-ke, abukho ubufakazi besayensi obusekela ukusetshenziswa kwe-Aloe-emodin kubantu ekwelashweni komdlavuza.

Isiphetho

Okutholakele okubalulekile kocwaningo kubonisa ukuthi ukusetshenziswa kwe-aloe vera mouthwash kungasiza ekwehliseni i-chemotherapy-induced stomatitis ezigulini ze-leukemia ne-lymphoma, kanye ne-mucositis ebangelwa imisebe ezigulini ezinomdlavuza wekhanda nentamo. Ubufakazi besayensi obuphakamisa izinzuzo zokungeniswa ngomlomo kwejusi ye-aloe vera ezigulini ezinomdlavuza mancane. Ucwaningo olwahlola umthelela wokumunca inhlaba ekhishwe ku-Aloe arborescens (esinye isitshalo esohlobo olufanayo lwe-Aloe vera) ezigulini ezinomdlavuza we-metastatic elashwa nge-chemotherapy, lwaphakamisa inzuzo engaba khona yenhlaba yomlomo ekunciphiseni isimila. ubukhulu, ukulawula izifo kanye nokwenza ngcono isibalo seziguli eziphila iminyaka emi-3. Kodwa-ke, ucwaningo olukhudlwana luyadingeka ukuze kutholwe lokhu okutholakele kanye nokuhlola ubuthi, ukuphepha kanye nemiphumela engemihle yokungenwa ngomlomo kwejusi ye-Aloe vera, ikakhulukazi umdlavuza iziguli ezithola ukwelashwa ngamakhemikhali kanye ne-radiation therapy. Nakuba ubufakazi besayensi buphakamisa ukuthi ukusetshenziswa kwe-aloe vera kungasiza ekwehliseni ezinye zezimpawu ze-proctitis ebangelwa imisebe ezigulini ezinomdlavuza wezitho zangasese, umthelela wayo ku-dermatitis ebangelwa imisebe awukholeki.

Ukudla okudlayo nokuthi yikuphi okunezelayo okwenzayo yisinqumo osithathayo. Isinqumo sakho kufanele sifake ukucutshungulwa kwezakhi zofuzo zomdlavuza, okuwumdlavuza, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imininingwane yokuphila, isisindo, ubude nemikhuba.

Ukuhlelela okunomsoco komdlavuza kusuka ku-addon akususelwa ekusesheni kwe-inthanethi. Kwenzela wena ukuthathela izinqumo ngokuya ngesayensi yamangqamuzana eyenziwe ososayensi bethu nonjiniyela be-software. Kungakhathalekile ukuthi ngabe uyakukhathalela ukuqonda okuyisisekelo kwamakhemikhali amakhemikhali noma cha - wokuhlelela umsoco ukuhlela lokho kudinga ukuqonda.

Qalisa MANJE ngokuhlela kwakho okunomsoco ngokuphendula imibuzo egameni lomdlavuza, ukuguquka kwezakhi zofuzo, ukwelashwa okuqhubekayo kanye nezithasiselo, noma yikuphi ukungezwani komzimba, imikhuba, indlela yokuphila, iqembu lobudala nobulili.

Iziguli ezinomdlavuza ngokuvamile kufanele zibhekane nokuhlukile imiphumela emibi ye-chemotherapy okuthinta ikhwalithi yempilo yabo futhi babheke ezinye izindlela zokwelapha umdlavuza. Ukuthatha ukudla okunomsoco nezithasiselo ezisuselwa ekucabangeni kwesayensi (ukugwema ukuqagela nokukhetha okungahleliwe) yikhambi elingcono kakhulu lemvelo lomdlavuza nemiphumela emibi ehlobene nokwelashwa.

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