Ngowuphi umhlaza onokuzuza ngokuquka iWillow kwisidlo sabo?

Iimbalasane

Umngcunube waziwa ngokubanzi ngezibonelelo zempilo kwaye usetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweWillow kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iWillow inokuba luncedo kwabo banePrimary Mucinous colorectal adenocarcinoma ephantsi kweCetuximab, kodwa isenokungalungeli kwizigulana ezifumana iRadiation yePrimary Adamantinoma. Ngaphaya koko, ngelixa i-Willow inokunceda abantu abanomngcipheko wemfuzo "CREBBP", ayinakucetyiswa kwabo basengozini eyahlukileyo yemfuza. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweWillow kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iWillow lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana neWillow endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukeneyo okanye ukungahoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iWillow kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iWillow ukuba unemfuzo enokuthanani nomhlaza onxulumene nofuzo lwe-CREBBP? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kuluncedo ukubandakanya iWillow ekutyeni kwakho ukuba ufunyaniswe une-Adamantinoma yasePrimary, okanye ukuba uxilongo lwakho yiPrimary Mucinous colorectal adenocarcinoma? Ngapha koko, ukusetyenziswa kwakho kweWillow kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lwe-Cetuximab okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Cetuximab siye kwiRadiation? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neWillow yindalo, ngoko ke isoloko iluncedo' okanye 'iWillow yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iWillow kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeWillow kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Mucinous colorectal adenocarcinoma okanye i-Primary Adamantinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana noWillow. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-CREBBP unefuthe elifanayo le-biochemical pathway njengenguqu kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrimary Mucinous colorectal adenocarcinoma ulingana nePrimary Adamantinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bakwiRadiation njengakwabo bafumana iCetuximab? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

Willow – Isongezelelo seSondlo

I-Willow eyongezelelweyo ibandakanya uluhlu lwezithako ezisebenzayo, ezibandakanya i-Salicin kunye ne-Salicylic Acid, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-WNT Beta Catenin Signaling, i-Oxidative Stress, i-Oncogenic Cancer Epigenetics kunye ne-Immune Evasion Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeseli, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeWillow, iyodwa okanye idityanisiwe, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iWillow kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweWillow ayisosigqibo esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeWillow

Ukuphendula umbuzo othi 'Ndingawunqanda nini uWillow kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeWillow ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies, zonke zidlala indima ekunqumeni ukuba i-Willow ifanelekile okanye ifanele igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba izongezo zeWillow ziya kuxhamla kwiZigulana zaseAdamantinoma eziphantsi konyango lweRadiation?

I-Adamantinoma eyiprayimari ibonakaliswe ngokuguqulwa kofuzo oluthile, oku kukuthi i-ARHGAP45, i-PI4KB kunye ne-SDSL, ekhokelela kwiinguqu kwiindlela ze-biochemical, ngokukodwa i-Oxidative Stress kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Willow supplement, echaphazela i-Oxidative Stress, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Adamantinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezo zeWillow ziya kuxhamla kwiZigulana eziphambili ze-Mucinous colorectal adenocarcinoma eziphantsi koNyango lwe-Cetuximab?

I-Primary Mucinous colorectal adenocarcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TTN, i-APC kunye ne-KRAS, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-WNT Beta Catenin Signaling, i-Angiogenesis, i-G-protein-coupled Receptor Signaling kunye ne-Growth Factor Signaling. Ukusebenza konyango lomhlaza, njenge-Cetuximab, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seWillow lukhetho olunengqiqo kwabo banePrimary Mucinous colorectal adenocarcinoma ephantsi kweCetuximab. Oku kungenxa yokuba iWillow inefuthe kwiindledlana ezifana ne-WNT Beta Catenin Signaling, enokuthi ithintele izinto eziqhuba iPrimary Mucinous colorectal adenocarcinoma okanye izuze ukusebenza kweCetuximab.

3. Ngaba izongezo zeWillow zikhuselekile kubantu abasempilweni abaneCREBBP yoGuquko oluManyaniswe neMngcipheko yemfuzo?

I-CREBBP idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CREBBP kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, ezibandakanya i-Immune Evasion Signaling kunye ne-Histone / Protein Acetylation, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CREBBP ehambelana neFollicular Lymphoma, cinga ngokubandakanya izongezo zeWillow kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-Immune Evasion Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CREBBP kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana neWillow, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Indima ye-KEAP1/NRF2 kunye ne-TP53 yoGuquko kwiLung Squamous Cell Carcinoma Development kunye noKuchasana neRadiation.
• cBioPortal for Cancer Genomics
• I-Salicylic acid imodareyitha uxinzelelo lwe-oxidative kunye nomsebenzi we-glutathione peroxidase kwikholoni yegundane.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• cBioPortal for Cancer Genomics
• I-lncRNA MIR100HG-derived miR-100 kunye ne-miR-125b mediate resistance cetuximab nge-Wnt/β-catenin signaling.
• I-Salicylate, i-diflunisal kunye ne-metabolites yazo inqanda i-CBP / p300 kwaye ibonise umsebenzi we-anticancer.