Ngowuphi umhlaza onokuzuza ngokubandakanya imbotyi yeSoy kukutya kwabo?

Iimbalasane

I-Soy Bean yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kweSoy Bean kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Soy Bean ingaba luncedo kwabo bane-Primary Solitary Fibrous Tumor ehamba ne-Avastin, kodwa isenokungabi yinto efanelekileyo kwizigulana ezifumana i-Cisplatin yeNtloko eyiNtloko kunye neNeck Squamous Cell Carcinoma. Ngaphaya koko, ngelixa i-Soy Bean inokunceda abantu abanomngcipheko wemfuza "CREBBP", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "ERCC2". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweSoy Bean kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iSoy Bean lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke iinxalenye ezisebenzayo kukutya / izongezo ezifana ne-Soy Bean endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi yokucwangcisa ukutya komhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Soy Bean kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iimbotyi zeSoya ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-CREBBP? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ERCC2 gene? Ngaba kunenzuzo ukubandakanya i-Soy Bean ekutyeni kwakho ukuba ufunyaniswe ukuba une-Primary Head kunye neNeck Squamous Cell Carcinoma, okanye ukuba ukuxilongwa kwakho yi-Primary Solitary Fibrous Tumor? Ngaphezu koko, kufuneka ulungelelanise ukusetyenziswa kwakho kwe-Soy Bean ukuba ufumana unyango lwe-Avastin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Avastin ukuya kwi-Cisplatin? Kubalulekile ukuqonda ukuba iintetho ezilula ezifana 'neSoya Bean yeyendalo, ngoko ke isoloko iluncedo' okanye 'Imbotyi yeSoya yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya/ lokongezelela.

Ukongeza, kubalulekile ukuphinda uvavanye ukufaneleka kokubandakanya imbotyi yeSoya kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Soy Bean kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Solitary Fibrous Tumor okanye i-Primary Head kunye neNeck Squamous Cell Carcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye . isini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olunje ngeSoy Bean. Ngaba umngcipheko wezofuzo womhlaza ovela kuguquko kwi-CREBBP unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ERCC2? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Solitary Fibrous Tumor ulingana neNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo bafumana iCisplatin njengakwabo bafumana iAvastin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

Imbotyi yeSoya – Isongezo seSondlo

Isongezo se-Soy Bean sibandakanya uluhlu lwezithako ezisebenzayo, ezibandakanya i-Vitamin K, i-Lecithin, i-Palmitic Acid, i-Aescin kunye ne-D-glucose, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC Signaling, i-Oxidative Stress, i-Angiogenesis kunye ne-TGFB Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeSoy Bean, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iSoy Bean kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweSoy Bean ayisosigqibo sehlabathi lonke esilungele zonke iimhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeembotyi zeSoya

Ukuphendula umbuzo othi 'Ndingayiphepha nini iSoy Bean kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeSoy Bean ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Soy Bean ifanelekile okanye ifanele igwenywe, igxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba iSoy Bean Supplements iya kunceda i-Primary Head and Neck Squamous Cell Carcinoma Patients eziphantsi konyango lweCisplatin?

Intloko eyiNtloko kunye neNtamo ye-Squamous Cell Carcinoma ibonakala ngokuguqulwa kofuzo oluthile, okuyi-FRG1BP, TP53 kunye ne-PCDH11X, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Oxidative Stress, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njengeCisplatin, kuxhomekeke kwindlela yokusebenza kwezi ndlela zithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Soy Bean, esichaphazela i-Oxidative Stress, ayinakuba lukhetho olufanelekileyo kwimeko yeNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma xa uhamba neCisplatin. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezo zeSoy Bean ziya kuxhamla kwiZigulana eziNgqongileyo eziNgqongileyo eziphantsi koNyango lweAvastin?

I-Primary Solitary Fibrous Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-BRD4, i-FLI1 kunye ne-KMT2C, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza kwonyango lomhlaza, njenge-Avastin, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Soy Bean lukhetho olunengqiqo kwabo bane-Primary Solitary Fibrous Tumor ehamba ne-Avastin. Oku kungenxa yokuba i-Soy Bean inefuthe kwiindlela ezifana ne-MYC Signaling, enokuthi ithintele izinto eziqhuba i-Primary Solitary Fibrous Tumor okanye izuze ukusebenza kwe-Avastin.

3. Ingaba izongezo zembotyi yeSoya zikhuselekile kubantu abasempilweni abaneERCC2 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-ERCC2 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-ERCC2 kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Angiogenesis kunye ne-DNA Repair, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-ERCC2 ehambelana nomngcipheko owongeziweyo woMhlaza woLusu, ingqiqo yezenzululwazi icebisa ukuphepha ukusebenzisa isongezelelo seSoy Bean. Oku kungenxa yokuba ukongeza i-Soy Bean inefuthe kwiindlela ezifana ne-Angiogenesis, enokukhokelela kwiziphumo ezibi kumxholo we-ERCC2 ukuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo zembotyi yeSoya zikhuselekile kubantu abasempilweni abaneCREBBP yoGuquko oluNxulunyaniswe neMngcipheko yeMfuzo?

I-CREBBP idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CREBBP kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-TGFB Signaling kunye ne-Histone / Protein Acetylation, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CREBBP ehambelana neFollicular Lymphoma, cinga ukufaka izongezo zeSoy Bean kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-TGFB Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-CREBBP kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanywa ukutya kunye nezongezo ezifana ne-Soy Bean, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-subunits ye-glutamate cysteine ​​​​ligase iphucula ukuxhathisa kwe-cisplatin kumntu ongeyena mncinci womhlaza wemiphunga we-xenografts kwi-vivo.
• cBioPortal for Cancer Genomics
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.