Ngowuphi umhlaza onokuzuza ngokubandakanya iSesamin kwisidlo sabo?

Iimbalasane

I-Sesamin yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweSesamin kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Sesamin inokuba luncedo kwabo bane-Primary Glioblastoma ephantsi kwe-Temozolomide, kodwa isenokungabi ilungile kwizigulana ezifumana i-Dacarbazine ye-Primary Pulmonary artery intimal sarcoma. Ngaphaya koko, ngelixa i-Sesamin inokunceda abantu abanomngcipheko wemfuza "ALK", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "ERCC2". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweSesamin kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iSesamin lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neSesamin endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi yokucwangcisa ukutya komhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise iSesamin kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iSesamin ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-ALK? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ERCC2 gene? Ngaba kuluncedo ukuquka iSesamin ekutyeni kwakho ukuba ufunyaniswe une-Primary Pulmonary artery intimal sarcoma, okanye ukuba uxilongo lwakho yiPrimary Glioblastoma? Ngaphezu koko, ukusetyenziswa kwakho kweSesamin kufuneka kulungiswe njani ukuba ufumana unyango lweTemozolomide okanye ukuba isicwangciso sakho sonyango sisuka kwiTemozolomide ukuya kwiDacarbazine? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neSesamin yendalo, ngoko ke isoloko iluncedo' okanye 'iSesamin yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iSesamin kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeSesamin kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Glioblastoma okanye iPrimary Pulmonary artery intimal sarcoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neSesamin. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-ALK uneempembelelo zendlela ye-biochemical efanayo njengotshintsho kwi-ERCC2? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Glioblastoma ulingana nePrayimari yePulmonary artery intimal sarcoma? Ngaphezu koko, ngaba ukuqwalaselwa kokutya kuhlala kufana nakwabo baphantsi kweDacarbazine njengabo bafumana iTemozolomide? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

ISesamin – Isongezo seSondlo

I-Sesamin eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Sesamin, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-JAK-STAT yokuSayina, i-Cell Cycle Checkpoints kunye ne-MAPK Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeSesamin, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iSesamin kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweSesamin ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeSesamin

Ukuphendula umbuzo othi 'Ndingayiphepha nini iSesamin kwimeko yoMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeSesamin ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies, zonke zidlala indima ekunqumeni ukuba i-Sesamin ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Sesamin Supplements iya kunceda i-Primary Pulmonary artery intimal sarcoma Izigulane eziphantsi konyango lwe-Dacarbazine?

I-Primary Pulmonary artery intimal sarcoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-PDGFRB, i-ALK kunye ne-ATM, ekhokelela ekuguquleni kwiindlela ze-biochemical pathways, ngokukodwa i-MAPK Signaling, i-Growth Factor Signaling, i-JAK-STAT Signaling, i-DNA Repair kunye ne-Cell Cycle Checkpoints. Ukusebenza kwonyango lomhlaza, njengeDacarbazine, kuxhomekeke kwindlela yokusebenza kwezi ndlela ezithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Sesamin, esichaphazela i-Checkpoints ye-Cell Cycle, ayinakuba lukhetho olufanelekileyo kwimeko ye-Primary Pulmonary artery intimal sarcoma xa uqhuba i-Dacarbazine. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezo zeSesamin ziya kunceda iZigulana zeGlioblastoma eziphambili eziphantsi koNyango lweTemozolomide?

I-Glioblastoma eyiprayimari ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TRBV7-7, TAS2R46 kunye ne-TP53, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-JAK-STAT Signaling, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza kwonyango lomhlaza, njengeTemozolomide, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seSesamin lukhetho olunengqiqo kulabo abanePrayimari yeGlioblastoma ehamba neTemozolomide. Oku kungenxa yokuba i-Sesamin inefuthe kwiindlela ezifana ne-JAK-STAT Signaling, enokuthintela izinto eziqhuba i-Primary Glioblastoma okanye izuze ukusebenza kweTemozolomide.

3. Ingaba izongezo zeSesamin zikhuselekile kubantu abasempilweni abaneERCC2 Mutation eNxulunyaniswe neMngcipheko yeGenetic?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-ERCC2 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-ERCC2 kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Cell Cycle Checkpoints kunye ne-DNA Repair, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-ERCC2 ehambelana nomngcipheko owongeziweyo woMhlaza woLusu, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kweSesamin yokongeza. Oku kungenxa yokuba ukongeza i-Sesamin inefuthe kwiindlela ezifana ne-Cell Cycle Checkpoints, ezinokukhokelela kwimiphumo emibi kumxholo we-ERCC2 ukuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo zeSesamin zikhuselekile kubantu abasempilweni abane-ALK Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-ALK idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ALK kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-MAPK Signaling kunye ne-Growth Factor Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ALK ehambelana neSistim yeNervous ePhakathi, cinga ngokubandakanya izongezo zeSesamin kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-MAPK Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ALK kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana neSesamin, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Utshintsho kwindlela ye-p53 kunye nenkcazo ye-p16INK4a iqikelela ukusinda ngokubanzi kwizigulane ze-metastatic melanoma eziphathwa nge-dacarbazine.
• cBioPortal for Cancer Genomics
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• cBioPortal for Cancer Genomics
• I-Sesamin yenza ukuba kubanjwe umjikelo weseli kunye ne-apoptosis ngokuthintelwa kwe-transducer yesiginali kunye ne-activator ye-transcription ye-3 yomqondiso kwi-hepatocellular carcinoma cell line HepG2.
• I-RRAD ikhuthaza i-EGFR-mediated STAT3 activation kwaye ibangela ukuxhathisa i-temozolomide ye-glioblastoma eyingozi.
• Imeko ye-somatic genomic ye-glioblastoma.
• Ukuvinjelwa kwenkqubo yokufa kwe-1 (PD-L1) ibonakaliso kwiiseli zomhlaza webele nge-sesamin.