Ngowuphi umhlaza onokuzuza ngokubandakanya iRye kwisidlo sabo?

Iimbalasane

I-Rye yaziwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweRye kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengophawu lomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Rye inokuba luncedo kwabo bane-Primary Solitary Fibrous Tumor ephantsi kwe-Avastin, kodwa isenokungabi ilungile kwizigulana ezifumana i-Gemcitabine ye-Primary Sarcomoid Carcinoma ye-Urinary Bladder. Ngaphaya koko, ngelixa i-Rye inokunceda abantu abanomngcipheko wemfuza “TERT”, ayinakucetyiswa kwabo banobungozi bofuzo olwahlukileyo “B2M”. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Rye kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iRye lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neRye endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iRye kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iRye ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela kumfuza we-B2M? Ngaba kuluncedo ukuquka iRye kukutya kwakho ukuba ufunyaniswe une-Primary Sarcomatoid Carcinoma ye-Urinary Bladder, okanye ukuba uxilongo lwakho yi-Primary Solitary Fibrous Tumor? Ngaphezu koko, ukusetyenziswa kwakho kwe-Rye kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lwe-Avastin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Avastin ukuya kwi-Gemcitabine? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'nerayi yindalo, ngoko ke isoloko iluncedo' okanye 'I-Rye ikhulisa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Rye kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Rye kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Solitary Fibrous Tumor okanye i-Primary Sarcomatoid Carcinoma ye-Urinary Bladder, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye . isini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba unobangela wemingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neRye. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-TERT uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwi-B2M? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Solitary Fibrous Tumor ulingana nePrimary Sarcomatoid Carcinoma ye-Urinary Bladder? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo baphantsi kweGemcitabine njengakwabo bafumana i-Avastin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Rye-Isongezelelo seSondlo

I-Rye yokuncedisa iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Palmitic Acid, i-Oleic Acid, i-Glycine, i-L-phenylalanine kunye ne-D-aspartic Acid, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela ze-molecular, ngokukodwa i-MYC Signaling, i-PI3K-AKT-MTOR yokuSayina, i-NFKB yokuSayina kunye ne-Cell Cycle Checkpoints, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeRye, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iRye kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Rye ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka senziwe umntu.

Ukukhetha izongezo zeRye

Ukuphendula umbuzo othi 'Ndingayiphepha nini iRye kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeRye ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Rye ifanelekile okanye ifanele igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Rye Supplements iya kuzuza i-Primary Sarcomatoid Carcinoma ye-Urinary Bladder Patients eziphantsi konyango lwe-Gemcitabine?

I-Primary Sarcomatoid Carcinoma ye-Urinary Bladder ibonakaliswe ngokuguqulwa kofuzo oluthile, oluyi-ERCC2, i-KRAS kunye ne-LATS2, ekhokelela ekutshintsheni kwiindlela ze-biochemical, ngokukodwa i-PI3K-AKT-MTOR Ukubonakaliswa, ukulungiswa kwe-DNA, i-Chromatin Remodeling, i-G-protein-coupled Receptor Signing. , Umqondiso wokuKhula kweFactor kunye ne-Hippo Signaling. Ukusebenza konyango lomhlaza, njengeGemcitabine, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Rye, esichaphazela i-PI3K-AKT-MTOR Isignali, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Sarcomatoid Carcinoma ye-Urinary Bladder xa i-Gemcitabine. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezelelo zeRye ziya kuxhamla kwiZigulana eziNgqongileyo eziZimeleyo ezikwiTumor eziphantsi koNyango lwe-Avastin?

I-Primary Solitary Fibrous Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-BRD4, i-FLI1 kunye ne-KMT2C, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza kwonyango lomhlaza, njenge-Avastin, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Rye lukhetho olunengqiqo kwabo bane-Primary Solitary Fibrous Tumor ehamba ne-Avastin. Oku kungenxa yokuba i-Rye inefuthe kwiindlela ezifana ne-MYC yokuSayina, enokuthi ithintele izinto eziqhuba i-Primary Solitary Fibrous Tumor okanye izuze ukusebenza kwe-Avastin.

3. Ngaba izongezo zeRye zikhuselekile kuBantu abasempilweni abane-B2M yoGuquko oluNxulunyaniswe neMngcipheko yemfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-B2M idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-B2M kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-NFKB Signaling kunye ne-Antigen Presentation, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-B2M ehambelana nomngcipheko owongeziweyo we-Diffuse Large B-cell Lymphoma, ingqiqo yesayensi icebisa ukuba kuthintelwe ukusetyenziswa kwe-Rye eyongezelelweyo. Oku kungenxa yokuba ukongeza i-Rye inefuthe kwiindlela ezifana ne-NFKB Signaling, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-B2M kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo zeRye zikhuselekile kubantu abasempilweni abane-TERT Mutation eManyaniswa neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Uguquko kwi-TERT lunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Cell Cycle Checkpoints kunye nokulungiswa kwe-DNA, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-TERT ehambelana noMhlaza we-Hematological, cinga ngokubandakanya izongezo ze-Rye kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezinje ngeCell Cycle Checkpoints, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana neRye, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• I-Anti-cancer ejolise kwi-telomerase inhibitors: i-β-rubromycin kunye ne-oleic acid.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Indima ye-NF-kappaB kunye ne-Akt / PI3K ekuchaseni imigca yeseli ye-pancreatic carcinoma ngokumelene ne-gemcitabine-induced cell death.
• Indima ye-tumor microenvironment ekuchaseni unyango lwe-anti-angiogenic.
• I-Oleic acid yenza i-apoptosis kunye ne-autophagy kunyango lwe-Tongue Squamous cell carcinomas.