Ngowuphi umhlaza onokuzuza ngokubandakanya iPycnogenol kukutya kwabo?

Iimbalasane

I-Pycnogenol yaziwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yofuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kwePycnogenol kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iPycnogenol inokuba luncedo kwabo banePrimary Mucinous colorectal adenocarcinoma ephantsi kweCetuximab, kodwa isenokungabi ilungile kwizigulana ezifumana iRadiation yePrimary Adamantinoma. Ngaphezu koko, ngelixa i-Pycnogenol inokunceda abantu abane-genetic risk factor "ALK", ayinakucetyiswa kwabo banomngcipheko wemfuza eyahlukileyo "CTNNB1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwePycnogenol kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iPycnogenol lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana nePycnogenol endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iPycnogenol kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iPycnogenol ukuba unemfuza ekhokelela kumhlaza ohambelana ne-ALK gene? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-CTNNB1 gene? Ngaba kuluncedo ukubandakanya iPycnogenol kukutya kwakho ukuba ufunyaniswe une-Adamantinoma yasePrimary, okanye ukuba uxilongo lwakho yiPrimary Mucinous colorectal adenocarcinoma? Ngapha koko, ukusetyenziswa kwakho kwePycnogenol kufanele kuhlengahlengiswe njani ukuba ufumana unyango lwe-Cetuximab okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Cetuximab ukuya kwiRadiation? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'nePycnogenol yendalo, ngoko isoloko iluncedo' okanye 'iPycnogenol inyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iPycnogenol kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana nePycnogenol kwisondlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Mucinous colorectal adenocarcinoma okanye i-Primary Adamantinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kunokubangela imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana nePycnogenol. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-ALK uneempembelelo zendlela yebhayokhemikhali efanayo njengotshintsho kwi-CTNNB1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrimary Mucinous colorectal adenocarcinoma ulingana nePrimary Adamantinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bakwiRadiation njengakwabo bafumana iCetuximab? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Pycnogenol -Isongezelelo seSondlo

I-Pycnogenol eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Pycnogenol, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC yokuSayina kunye noxinzelelo lwe-Oxidative, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengePycnogenol, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iPycnogenol kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwePycnogenol ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zePycnogenol

Ukujongana nombuzo othi 'Ndimele ndiyiphephe nini iPycnogenol kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyodwa kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukufaneleka kunye nokhuseleko okanye iinzuzo zePycnogenol ziyahluka ngokuxhomekeka kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekunqumeni ukuba i-Pycnogenol ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba iPycnogenol Supplements iya kunceda iZigulana zaseAdamantinoma eziphantsi konyango lweRadiation?

I-Adamantinoma eyiprayimari ibonakaliswe ngokuguqulwa kofuzo oluthile, oku kukuthi i-ARHGAP45, i-PI4KB kunye ne-SDSL, ekhokelela kwiinguqu kwiindlela ze-biochemical, ngokukodwa i-Oxidative Stress kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Pycnogenol supplement, echaphazela i-Oxidative Stress, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Adamantinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba iPycnogenol Supplements iya kunceda i-Primary Mucinous colorectal adenocarcinoma Izigulana eziphantsi koNyango lwe-Cetuximab?

I-Primary Mucinous colorectal adenocarcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TTN, i-APC kunye ne-KRAS, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Angiogenesis, i-G-protein-coupled Receptor Signaling kunye ne-Growth Factor Signaling. Ukusebenza konyango lomhlaza, njenge-Cetuximab, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo sePycnogenol lukhetho olunengqiqo kwabo banePrimary Mucinous colorectal adenocarcinoma ehamba neCetuximab. Oku kungenxa yokuba i-Pycnogenol inefuthe kwiindledlana ezifana ne-MYC yokuSayina, enokuthi ithintele izinto eziqhuba i-Primary Mucinous colorectal adenocarcinoma okanye izuze ukusebenza kwe-Cetuximab.

3. Ngaba iPycnogenol Supplements ikhuselekile kuBantu abasempilweni abaneCTNNB1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-CTNNB1 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CTNNB1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Oxidative Stress, i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yezofuzo ichonga ukuguqulwa kwe-CTNNB1 ehambelana nomngcipheko okhulayo we-Adrenocortical Carcinoma, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwePycnogenol yokuncedisa. Oku kungenxa yokuba ukongeza i-Pycnogenol inefuthe kwiindlela ezifana ne-Oxidative Stress, enokukhokelela kwimiphumo emibi kumxholo we-CTNNB1 ukuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba i-Pycnogenol Supplements ikhuselekile kubantu abaphilileyo abane-ALK Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-ALK idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ALK kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-MYC Signaling kunye ne-Growth Factor Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yezofuzo ityhila ukuguqulwa kwe-ALK ehambelana neSistim yeNervous ePhakathi, cinga ukufaka izongezo zePycnogenol kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-MYC Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ALK kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana nePycnogenol, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Indima ye-KEAP1/NRF2 kunye ne-TP53 yoGuquko kwiLung Squamous Cell Carcinoma Development kunye noKuchasana neRadiation.
• Ukuthelekiswa kwamaqela xa iziphumo zikwizinga elicwangcisiweyo.
• cBioPortal for Cancer Genomics
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• Isicatshulwa sexolo esisemgangathweni sePinus pinaster Aiton (Pycnogenol^®) ukuthomalalisa isifo semiphunga esingapheliyo nge-Erk-sp1 indlela yomqondiso.
• cBioPortal for Cancer Genomics
• I-Pycnogenol iphucula i-endothelial cell antioxidant ukukhusela.