Ngowuphi umhlaza onokuzuza ngokubandakanya iPterostilbene kukutya kwabo?

Iimbalasane

I-Pterostilbene yaziwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basemngciphekweni wemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kwePterostilbene kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Pterostilbene inokuba luncedo kwabo bane-Primary Mucinous colorectal adenocarcinoma ephantsi kwe-Cetuximab, kodwa isenokungabi ilungile kwizigulana ezifumana iRadiation yePrimary Sinonasal Adenocarcinoma. Ngaphaya koko, ngelixa i-Pterostilbene inokunceda abantu abanomngcipheko wemfuza "TERT", isenokungacetyiswa kwabo banomngcipheko wemfuzo owahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Pterostilbene kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezinjengohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iPterostilbene lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana ne-Pterostilbene endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungasihoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise iPterostilbene kukutya kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Pterostilbene ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kuluncedo ukubandakanya iPterostilbene kukutya kwakho ukuba ufunyaniswe unePrimary Sinonasal Adenocarcinoma, okanye ukuba uxilongo lwakho yiPrimary Mucinous colorectal adenocarcinoma? Ngapha koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kwePterostilbene ukuba ufumana unyango lwe-Cetuximab okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Cetuximab siye kwiRadiation? Kubalulekile ukuqonda ukuba iziqinisekiso ezilula ezifana 'nePterostilbene yendalo, ke isoloko iluncedo' okanye 'i-Pterostilbene yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuphinda uvavanye ukufaneleka kokubandakanya i-Pterostilbene kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngePterostilbene kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Mucinous colorectal adenocarcinoma okanye iPrimary Sinonasal Adenocarcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olunje ngePterostilbene. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-TERT uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrimary Mucinous colorectal adenocarcinoma ulingana nePrimary Sinonasal Adenocarcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bakwiRadiation njengakwabo bafumana iCetuximab? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi kubantu abasengozini eyahlukeneyo yemfuza kunye nonyango lomhlaza.

I-Pterostilbene-Isongezelelo seSondlo

I-Pterostilbene eyongezelelweyo ibandakanya uluhlu lwezithako ezisebenzayo, kubandakanya i-Pterostilbene, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC yokuSayina, i-Notch Signaling, i-Chromatin Remodeling kunye ne-Cell Cycle, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ngokunikwa le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengePterostilbene, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Pterostilbene yomhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwePterostilbene ayisosigqibo sehlabathi liphela esilungele zonke iimhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zePterostilbene

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Pterostilbene kumxholo woMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zePterostilbene ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nakuphi na ukwaliwa konke kudlala indima ekumiseleni ukuba i-Pterostilbene ifanelekile okanye kufuneka iphetshwe, kugxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba iPterostilbene Supplements iya kuxhamla kwiZigulana zasePrimary Sinonasal Adenocarcinoma eziphantsi konyango lweRadiation?

I-Primary Sinonasal Adenocarcinoma ibonakala ngokuguqulwa kofuzo oluthile, okuyi-ATRX, NOTCH1 kunye ne-PTPRD, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Notch Signaling kunye ne-RUNX Signaling. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Pterostilbene supplement, echaphazela i-Notch Signaling, isenokungabi lolona khetho lufanelekileyo kwimeko ye-Primary Sinonasal Adenocarcinoma xa isenziwa kwiRadiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba iPterostilbene Supplements ingaba luncedo kwizigulana eziphantsi koNyango lwe-Cetuximab?

I-Primary Mucinous colorectal adenocarcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TTN, i-APC kunye ne-KRAS, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Angiogenesis, i-G-protein-coupled Receptor Signaling kunye ne-Growth Factor Signaling. Ukusebenza konyango lomhlaza, njenge-Cetuximab, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo sePterostilbene lukhetho olusengqiqweni kwabo banePrimary Mucinous colorectal adenocarcinoma ephantsi kweCetuximab. Oku kungenxa yokuba i-Pterostilbene inefuthe kwiindledlana ezinje nge-MYC Signaling, enokuthi ithintele izinto eziqhuba iPrimary Mucinous colorectal adenocarcinoma okanye izuze ukusebenza kwe-Cetuximab.

3. Ingaba izongezo zePterostilbene zikhuselekile kuBantu abasempilweni abane-TERT Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-TERT kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kubandakanywa i-Cell Cycle kunye ne-DNA Repair, enefuthe kuphuhliso lomhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-TERT enxulumene noMhlaza we-Hematological, cinga ngokubandakanya izongezo zePterostilbene kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana neCell Cycle, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezo ezifana nePterostilbene, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Ukuthelekiswa kwamaqela xa iziphumo zikwizinga elicwangcisiweyo.
• cBioPortal for Cancer Genomics
• INotshi yokuJonga ukoyisa ukuxhathisa ngemitha.
• Ukutya kokutya kwe-pterostilbene, icandelo le-blueberries, inqanda i-beta-catenin / p65 indlela yomqondiso esezantsi kunye ne-colon carcinogenesis kwiigundane.
• I-Pterostilbene yenza umsebenzi we-antitumor ngendlela ye-Notch1 yokubonisa kwiiseli zemiphunga ye-adenocarcinoma yabantu.
• I-Pterostilbene ilawula phantsi i-hTERT ekugxilweni komzimba kwiiseli zomhlaza wamabele: Ngokunokwenzeka ngokuthintelwa kwe-cMyc.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• cBioPortal for Cancer Genomics
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.