Ngowuphi umhlaza onokuthi uxhamle ngokubandakanya iPerilla kukutya kwabo?

Iimbalasane

IPerilla yaziwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kwePerilla kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Perilla inokuxhamla abo banoMhlaza oyiPrayimari weSinyi seSinyi esincinci esiphantsi kwe-Methotrexate, kodwa kusenokungabi kuhle kwizigulana ezifumana iRadiation yePrimary Urethral Squamous Cell Carcinoma. Ngaphaya koko, ngelixa i-Perilla inokunceda abantu abanomngcipheko wemfuza "KMT2D", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "B2M". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Perilla yesigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iPerilla lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana nePerilla endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayihoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi yokucwangcisa ukutya komhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise iPerilla kukutya kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iPerilla ukuba unemfuza enokuthanani nomhlaza onxulumene nejini ye-KMT2D? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela kumfuza we-B2M? Ngaba kunenzuzo ukuquka iPerilla ekutyeni kwakho ukuba ufunyaniswe une-Primary Urethral Squamous Cell Carcinoma, okanye ukuba ukuxilongwa kwakho nguMhlaza weSinyi esiNcinane weSinyi? Ngaphezu koko, ukusetyenziswa kwakho kwePerilla kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lweMethotrexate okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwiMethotrexate siye kwiRadiation? Kubalulekile ukuqonda ukuba iziqinisekiso ezilula ezifana 'nePerilla yendalo, ngoko ihlala iluncedo' okanye 'iPerilla inyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Perilla kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngePerilla kwisondlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo zebhayoloji yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe uhlobo oluthile lomhlaza, njengePrimary Small Cell Bladder Cancer okanye Primary Urethral Squamous Cell Carcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini. .”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana nePerilla. Ngaba umngcipheko wemfuzo womhlaza ovela kuguquko kwi-KMT2D unefuthe elifanayo le-biochemical pathway njengotshintsho kwi-B2M? Ngokwembono yesondlo, ngaba umngcipheko onxulumene noMhlaza weSinyi esiNcinane weSinyi ulingana nePrimary Urethral Squamous Cell Carcinoma? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo baphantsi kweRadiation njengabo bafumana iMethotrexate? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Perilla – Isongezo seSondlo

I-Perilla yokuncedisa iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Stigmasterol, i-Shikimic Acid, i-Perillaldehyde, i-Linalool kunye ne-Caffeic Acid, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC yokuSayina, ukulungiswa kwe-DNA, i-TWEAK Signaling kunye ne-DAP12 Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengePerilla, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iPerilla kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwePerilla ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka senziwe umntu.

Ukukhetha izongezo zePerilla

Ukuphendula umbuzo othi 'Ndifanele ndiyiphephe nini i-Perilla kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zePerilla ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies, zonke zidlala indima ekunqumeni ukuba i-Perilla ifanelekile okanye kufuneka ithintelwe, kugxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Perilla Supplements iya kuxhamla kwi-Primary Urethral Squamous Cell Carcinoma izigulane eziphantsi konyango lweRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-BLM, i-BRCA1 kunye ne-CTCF, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Androgen Signaling kunye ne-DNA Repair. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Perilla supplement, echaphazela ukulungiswa kwe-DNA, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Urethral Squamous Cell Carcinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Perilla Supplements iya kuxhamla kwiZigulana zoMhlaza weSinyi eziNcinane eziphantsi koNyango lweMethotrexate?

Umhlaza weSinyi esiNcinane esiNcinane ichongiwe ngotshintsho oluthile lwemfuza, olufana ne-TERT kunye ne-TP53, olukhokelela kutshintsho kwiindlela ze-biochemical, ngakumbi i-MYC Signaling, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza kwonyango lomhlaza, njenge-Methotrexate, kugqitywe ngokusebenzisana kwezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo sePerilla lukhetho olunengqiqo kwabo banoMhlaza oyiPrayimari oyiPrayimari yeSini esincinci esiphantsi kweMethotrexate. Oku kungenxa yokuba i-Perilla inefuthe kwiindlela ezifana ne-MYC Signaling, enokuthi ithintele izinto eziqhuba uMhlaza weSinyi esiNcinci esiNcinane okanye izuze ukusebenza kweMethotrexate.

3. Ingaba izongezo zePerilla zikhuselekile kuBantu abasempilweni abaneB2M yoGuquko oluManyaniswe neMngcipheko yemfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-B2M idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-B2M kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-TWEAK Signaling kunye ne-Antigen Presentation, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-B2M ehambelana nomngcipheko owongeziweyo we-Diffuse Large B-cell Lymphoma, ingqiqo yenzululwazi icebisa ukuba kuthintelwe ukusetyenziswa kwePerilla yokongeza. Oku kungenxa yokuba ukongeza i-Perilla inefuthe kwiindlela ezifana ne-TWEAK Signaling, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-B2M kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zePerilla zikhuselekile kuBantu abasempilweni abane-KMT2D Mutation eNxulunyaniswe neMngcipheko yemfuza?

I-KMT2D idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-KMT2D kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-DAP12 Signaling kunye ne-Oncogenic Histone Methylation, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-KMT2D ehambelana ne-Bladder Urothelial Carcinoma, cinga ukufaka izongezo zePerilla kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-DAP12 Umqondiso, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-KMT2D kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana nePerilla, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-Caffeic acid, i-phenolic phytochemical kwikhofi, inqanda ngokuthe ngqo umsebenzi we-Fyn kinase kunye ne-UVB-induced expression ye-COX-2.
• Ukwahlula kweChromatographic kunye nokumiselwa kwe-electrochemical ye-cholesterol hydroperoxides eyenziwe yisenzo sefotodynamic.
• cBioPortal for Cancer Genomics
• I-genomics yeklinikhi edibeneyo yomhlaza we-metastatic.
• Ukulawulwa kweempendulo ezivuthayo yinoveli ye-caffeic acid ester derivative ngokunqanda i-NF-kappa B.
• I-Histone deacetylase inhibitor ibuyisela umva ukunganyangeki kweziyobisi ezininzi ngokunciphisa inqanaba le-nucleophosmin nge-PI3K / Akt indlela yomhlaza webele.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.