Ngowuphi umhlaza onokuthi uxhamle ekuqukeni uPedra ekutyeni kwabo?

Iimbalasane

I-Pedra yamkelwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kwePedra kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nomhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Pedra inokuba luncedo kwabo bane-Primary Stomach Adenocarcinoma ephantsi kwe-Oxaliplatin, kodwa isenokungabi ilungile kwizigulana ezifumana i-Trifluridine ye-Primary Stomach signet ring cell carcinoma. Ngaphaya koko, ngexa iPedra inokunceda abantu abanomngcipheko wemfuzo “ALK”, ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo “KMT2D”. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwePedra kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Imiba ebalulekileyo njengodidi lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iPedra lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, kugxilwe kwiziphumo ezipheleleyo zawo onke amalungu asebenzayo ekutyeni/ezongezo ezifana nePedra endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukeneyo okanye ukungahoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise iPedra kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iPedra ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-ALK? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela kumfuza we-KMT2D? Ngaba kunenzuzo ukuquka iPedra kukutya kwakho ukuba ufunyaniswe une-Primary Stomach signet ring cell carcinoma, okanye ukuba uxilongo lwakho yiPrimary Stomach Adenocarcinoma? Ngapha koko, indlela osebenzisa ngayo iPedra kufuneka ihlengahlengiswe njani ukuba ufumana unyango lwe-Oxaliplatin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Oxaliplatin siye kwi-Trifluridine? Kubalulekile ukuqaphela ukuba iinkcazo ezilula ezifana 'nePedra yendalo, ngoko isoloko iluncedo' okanye 'iPedra yongeza ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iPedra kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Ngamafutshane, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana nePedra kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka ucinge ngeziphumo zebhayomichi yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Xa ufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Stomach Adenocarcinoma okanye i-Primary Stomach signet ring cell carcinoma, izicwangciso zonyango kufuneka zenziwe ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini. ”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeke kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana nePedra. Ngaba umngcipheko wemfuzo womhlaza osuka kuguquko kwi-ALK uneempembelelo zendlela yebhayokhemikhali efanayo njengotshintsho kwi-KMT2D? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Stomach Adenocarcinoma ulingana ne-Primary Stomach signet ring cell carcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kwe-Trifluridine njengakwabo bafumana i-Oxaliplatin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

Pedra – ISongezo seSondlo

I-Pedra eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka iMyrcene, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Extracellular Matrix Remodelling, i-TGFB Signaling kunye ne-MAPK Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengePedra, iyodwa okanye idityanisiwe, iba sisigqibo esibalulekileyo kwimeko yesondlo somhlaza. Xa ucinga ukusebenzisa iPedra kumhlaza, kubalulekile ukuqwalasela le miba eyahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kwePedra ayisosigqibo esifanelekileyo kubo bonke abantu abanomhlaza kodwa kufuneka senziwe umntu.

Ukukhetha izongezo zePedra

Ukuphendula umbuzo othi 'Ndingayiphepha nini iPedra kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufanayo nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zePedra ziyahluka ngokuxhomekeke kwiimeko zomntu. Imiba efana nohlobo oluthile lomhlaza, imfuzo, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, iBMI, kunye nakuphi na ukwalana nazo zonke zidlala indima ekumiseleni ukuba iPedra ifanelekile na okanye kufuneka iphetshwe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Pedra Supplements iya kuxhamla kwi-Primary Stomach signet ring cell carcinoma Izigulana eziphantsi konyango lwe-Trifluridine?

I-Primary Stomach signet ring cell carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, oku kukuthi i-TTN, i-CSMD1 kunye ne-SLITRK2, ekhokelela kutshintsho kwiindlela ze-biochemical, ngokukodwa i-TGFB Signaling. Ukusebenza konyango lomhlaza, njenge-Trifluridine, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Pedra supplement, echaphazela i-TGFB Signaling, isenokungabi yinto efanelekileyo kwimeko ye-Primary Stomach signet ring cell carcinoma xa i-Trifluridine. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho lwemfuza olwaziwayo.

2. Ngaba i-Pedra Supplements izakuxhamla kwi-Primary Stomach Adenocarcinoma Izigulana eziphantsi koNyango lwe-Oxaliplatin?

I-Adenocarcinoma yesisu esisisiseko ichongiwe ngokuguqulwa kwemfuza ethile, njenge-TP53, TTN kunye ne-PEG3, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Extracellular Matrix Remodelling, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njenge-Oxaliplatin, kumiselwa kukunxibelelana kwezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo sePedra lukhetho olunengqiqo kwabo bane-Primary Stomach Adenocarcinoma ehamba ne-Oxaliplatin. Oku kungenxa yokuba iPedra inefuthe kwiindlela ezifana ne-Extracellular Matrix Remodelling, enokuthi ithintele izinto eziqhuba i-Primary Stomach Adenocarcinoma okanye izuze ukusebenza kwe-Oxaliplatin.

3. Ingaba izongezo zePedra zikhuselekile kubantu abasempilweni abane-KMT2D Mutation eNxulunyaniswe neMngcipheko yemfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. Ufuzo lwe-KMT2D luqhele ukubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-KMT2D kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Extracellular Matrix Remodeling kunye ne-Oncogenic Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga uguquko kwi-KMT2D ehambelana nomngcipheko owongeziweyo we-Bladder Urothelial Carcinoma, ingqiqo yenzululwazi icebisa ukuba kuthintelwe ukusetyenziswa kwePedra. Oku kungenxa yokuba ukongeza i-Pedra inefuthe kwiindlela ezifana ne-Extracellular Matrix Remodelling, enokukhokelela kwiziphumo ezibi kumxholo we-KMT2D ukuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo zePedra zikhuselekile kubantu abasempilweni abane-ALK Mutation eNxulunyaniswe neMngcipheko yemfuzo?

I-ALK idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ALK kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-MAPK Signaling kunye ne-Growth Factor Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ALK ehambelana neSistim yeNervous esembindini, cinga ngokubandakanya izongezo zePedra kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-MAPK Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ALK kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana nePedra, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• Indima ye-MMP7 kunye ne-cross-talk kunye nenkqubo ye-FAS/FASL ngexesha lokufumana i-chemoresistance kwi-oxaliplatin.
• Indlela ye-TGF-β isebenze ngonyango lwe-5-fluorouracil kwiiseli ze-colorectal carcinoma ezinganyangekiyo ngamachiza.
• cBioPortal for Cancer Genomics
• Ukubonakaliswa kwe-molecular ebanzi ye-adenocarcinoma yesisu.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-Myrcene, i-Aromatic Volatile Compound, iphucula ukuguga okungaphaya koLusu loMntu ngoLawulo lweMveliso yeMMPs.