Ngowuphi umhlaza onokuzuza ngokubandakanya iNeem Extract ekutyeni kwabo?

Iimbalasane

I-Neem Extract yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweNeem Extract kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Neem Extract ingaba luncedo kwabo baneNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ehamba neCisplatin, kodwa isenokungabi kuhle kwizigulane ezifumana i-Temozolomide ye-Primary Meningioma. Ngaphaya koko, ngelixa i-Neem Extract inokunceda abantu abanomngcipheko wemfuzo "CDH1", ayinakucetyiswa kwabo banomngcipheko wemfuzo owahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweNeem Extract kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iNeem Extract lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke iinxalenye ezisebenzayo kukutya / izongezo ezifana ne-Neem Extract endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Neem Extract kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Neem Extract ukuba unemfuzo yomhlaza ohambelana ne-CDH1 gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kunenzuzo ukubandakanya i-Neem Extract kwisidlo sakho ukuba ufunyanwe une-Primary Meningioma, okanye ukuba ukuxilongwa kwakho yiNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma? Ngaphezu koko, ukusetyenziswa kwakho kweNeem Extract kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lweCisplatin okanye ukuba isicwangciso sakho sonyango sitshintsha ukusuka kwiCisplatin ukuya kwiTemozolomide? Kubalulekile ukuqaphela ukuba iinkcazo ezilula ezifana 'neNeem Extract yendalo, ngoko isoloko iluncedo' okanye 'I-Neem Extract ibomeleza ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Neem Extract kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Neem Extract kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njengeNtloko eyiNtloko kunye neNeck Squamous Cell Carcinoma okanye i-Primary Meningioma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, isigaba sesifo, kunye nezinto ezifana nobudala kunye nesini. ”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neNeem Extract. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDH1 unefuthe elifanayo le-biochemical pathway njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana neNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ilingana nePrimary Meningioma? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo bafumana iTemozolomide njengabo bafumana iCisplatin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Neem Extract – iSongezo seSondlo

I-extract ye-Neem Extract iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Nimbolide, i-Azadirachtin kunye ne-Gedunin, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngakumbi i-Epithelial kwi-Mesenchymal Transition kunye ne-Hedgehog Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leselula, elifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeNeem Extract, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iNeem Extract yomhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Neem Extract ayisosigqibo sehlabathi lonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyakho.

Ukukhetha iiNeem Extract Supplements

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Neem Extract kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukubaluleka kunye nokhuseleko okanye inzuzo ye-Neem Extract iyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Neem Extract ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba iNeem Extract Supplements iya kuxhamla kwiZigulana zasePrimary Meningioma eziphantsi konyango lweTemozolomide?

I-Primary Meningioma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-DNMT3A, TET2 kunye ne-NF2, ekhokelela ekuguquleni kwiindlela ze-biochemical pathways, ngokukodwa i-Hedgehog Signaling, i-Oncogenic Cancer Epigenetics, i-Hippo Signaling kunye ne-Cytoskeletal Dynamics. Ukusebenza kwonyango lomhlaza, njengeTemozolomide, kuxhomekeke kwindlela yokusebenza kwezi ndlela ezithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Neem Extract supplement, echaphazela i-Hedgehog Signaling, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Meningioma xa i-Temozolomide. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Neem Extract Supplements iya kunceda i-Primary Head and Neck Squamous Cell Carcinoma Patients eziphantsi koNyango lweCisplatin?

Intloko eyiNtloko kunye neNtamo ye-Squamous Cell Carcinoma ichongiwe ngokuguqulwa kwemfuza ethile, njenge-FRG1BP, i-TP53 kunye ne-PCDH11X, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-Epithelial kwi-Mesenchymal Transition, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njengeCisplatin, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Neem Extract lukhetho olunengqiqo kulabo abaneNtloko eyiNtloko kunye neNeck Squamous Cell Carcinoma ehamba neCisplatin. Oku kungenxa yokuba i-Neem Extract ichaphazela iindlela ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, enokuthi inqanda izinto eziqhuba iNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma okanye izuze ukusebenza kweCisplatin.

3. Ngaba iNeem Extract Supplements ikhuselekile kuBantu abasempilweni abaneCDH1 Mutation Associated Genetic Risk?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka izongezo ze-Neem Extract kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abane-CDH1 yokuguqulwa kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana neNeem Extract, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-Gedunin inqanda umhlaza we-pancreatic ngokuguqula indlela yokubonisa i-sonic hedgehog.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• Ukuvinjelwa kwe-Sonic hedgehog kunye ne-Notch pathways kwandisa ubuntununtunu be-CD133 (+) iiseli ze-glioma ze-glioma kunyango lwe-temozolomide.
• Ukujolisa kwinguqu ye-epithelial-mesenchymal kunye neeseli zesifo somhlaza we-chemoresistant ovarian cancer.