Ngowuphi umhlaza onokuzuza ngokubandakanya iMint kwisidlo sabo?

Iimbalasane

I-Mint yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweMint kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iMint inokuba luncedo kwabo banePrimary Myxoid Chondrosarcoma ephantsi kweDactinomycin, kodwa isenokungabi ilungile kwizigulana ezifumana iRadiation yePrimary Urethral Squamous Cell Carcinoma. Ngaphaya koko, ngelixa i-Mint inokunceda abantu abanomngcipheko wemfuza "i-ATM", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "CTNNB1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweMint kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iMint lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana neMint endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iMint kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iMint ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-ATM? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-CTNNB1 gene? Ngaba kunenzuzo ukubandakanya iMint ekutyeni kwakho ukuba ufunyaniswe une-Primary Urethral Squamous Cell Carcinoma, okanye ukuba uxilongo lwakho yiPrimary Myxoid Chondrosarcoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweMint ukuba ufumana unyango lwe-Dactinomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwiDactinomycin ukuya kwiRadiation? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neMint yendalo, ngoko ke isoloko iluncedo' okanye 'iMint yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Mint kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeMint kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Myxoid Chondrosarcoma okanye iPrimary Urethral Squamous Cell Carcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba unobangela wemingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, njengeMint. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-ATM unefuthe elifanayo le-biochemical pathway njengenguqu kwi-CTNNB1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrimary Myxoid Chondrosarcoma ulingana nePrimary Urethral Squamous Cell Carcinoma? Ngapha koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweRadiation njengabo bafumana iDactinomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Mint – iSongezo seSondlo

I-Mint yokongeza iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Apigenin, i-Vitamin C, i-Trans-trans-farnesol, i-Rosmarinic Acid kunye ne-Vitamin A, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Apoptosis, i-RAS-RAF Signaling, i-NFKB Signaling kunye ne-MYC Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeMint, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Mint yomhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweMint ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeMint

Ukuphendula umbuzo othi 'Ndimele ndiyiphephe nini iMint kumxholo woMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeMint ziyahluka ngokuxhomekeke kwiimeko zomntu. Imiba efana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekunqumeni ukuba iMint ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Mint Supplements iya kuxhamla kwi-Primary Urethral Squamous Cell Carcinoma Izigulana eziphantsi konyango lweRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakala ngokuguqulwa kofuzo oluthile, okuyi-BLM, i-BRCA1 kunye ne-CTCF, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-RAS-RAF Signaling, i-Androgen Signaling kunye nokulungiswa kwe-DNA. Ukusebenza konyango lomhlaza, okufana neRadiation, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Mint supplement, echaphazela i-RAS-RAF Signaling, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Urethral Squamous Cell Carcinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ingaba izongezo zeMint ziyakuzinceda izigulana zasePrimary Myxoid Chondrosarcoma eziphantsi koNyango lweDactinomycin?

I-Myxoid Primary Chondrosarcoma ichongiwe ngokuguqulwa kwemfuza ethile, njenge-IDH1, i-NR2E1 kunye ne-WDFY4, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Apoptosis, i-Oncogenic Cancer Epigenetics kunye ne-Glutathione Metabolism. Ukusebenza konyango lomhlaza, njenge-Dactinomycin, kugqitywe kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seMint lukhetho olunengqiqo kwabo banePrimary Myxoid Chondrosarcoma ehamba neDactinomycin. Oku kungenxa yokuba i-Mint inefuthe kwiindlela ezifana ne-Apoptosis, enokuthi ithintele izinto eziqhuba i-Primary Myxoid Chondrosarcoma okanye izuze impumelelo ye-Dactinomycin.

3. Ingaba izongezo zeMint zikhuselekile kubantu abasempilweni abaneCTNNB1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-CTNNB1 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CTNNB1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-NFKB Signaling, i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga utshintsho kwi-CTNNB1 ehambelana nomngcipheko owongeziweyo we-Adrenocortical Carcinoma, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-supplement Mint. Oku kungenxa yokuba isongezelelo se-Mint sinefuthe kwiindlela ezifana ne-NFKB Signaling, enokukhokelela kwimiphumo emibi kumxholo we-CTNNB1 utshintsho kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeMinti zikhuselekile kubantu abasempilweni abaneATM yoGuquko oluNxulunyaniswe neMngcipheko yemfuzo?

I-ATM idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ATM kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-MYC Signaling kunye ne-DNA Repair, enefuthe kuphuhliso lomhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ATM ehambelana neChronic Myelomonocytic Leukemia, cinga ukufaka izongezo zeMint kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-MYC yokuSayina, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-ATM kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neMint, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-Palaeonthropology. Ixesha leeNeanderthals zokugqibela.
• cBioPortal for Cancer Genomics
• Uhlalutyo lwe-molecular field field ye-flavonoid inhibitors ye-PIM-1 kinase.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-Flavonoids njenge-receptor tyrosine kinase FLT3 inhibitors.
• Impembelelo ye-oncogenic K-RAS kwi-YB-1 phosphorylation eyenziwa yi-ionizing radiation.
• Ulwakhiwo-proteasome-inhibitory umsebenzi wobudlelwane be-flavonoids yokutya kwiiseli zomhlaza womntu.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• cBioPortal for Cancer Genomics
• Ukufunyanwa kwee-flavones ezincinci ezingaziwa njenge-inhibitors ye-NF-κB yokubonisa kwi-MDA-MB-231 iiseli zomhlaza webele-Isifundo se-SAR.