Ngowuphi umhlaza onokuthi uxhamle ekufakeni ubisi lwe-Milk Thistle ekutyeni kwabo?

Iimbalasane

I-Milk Thistle yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweMilk Thistle kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iMilk Thistle inokuba luncedo kwabo banePrayimari yePenile Squamous Cell Carcinoma ephantsi kweMitomycin, kodwa isenokungabi ilungile kwizigulana ezifumana iRadiation yePrimary Fibromatosis. Ngaphaya koko, ngeli lixa ubisi lwe-Milk Thistle lunokunceda abantu abanomngcipheko wemfuzo “TERT”, akunakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo “CTNNB1”. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweMilk Thistle kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba ngaba iMilk Thistle lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, kugxilwe kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / izongezo ezifana neMilk Thistle endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise ubisi lwe-Milk Thistle kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iMilk Thistle ukuba unemfuzo enokuthambekela kumhlaza onxulumene nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-CTNNB1 gene? Ngaba kunenzuzo ukubandakanya ubisi lwe-Milk Thistle ekutyeni kwakho ukuba ufunyaniswe une-Primary Fibromatosis, okanye ukuba uxilongo lwakho yiPrimary Penile Squamous Cell Carcinoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweMitomycin ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwiMitomycin siye kwiRadiation? Kubalulekile ukuqaphela ukuba iinkcazo ezilula ezifana 'neNhlaba yobisi yindalo, ngoko ke isoloko iluncedo' okanye 'Ubisi lwekhava lomeleza ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuphinda uvavanye ukufaneleka kokubandakanya ubisi lwe-Milk Thistle kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeMilk Thistle kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo zebhayoloji yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Penile Squamous Cell Carcinoma okanye iPrimary Fibromatosis, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neMilk Thistle. Ngaba umngcipheko wemfuzo womhlaza osuka kuguquko kwi-TERT uneempembelelo zendlela yebhayokhemikhali efanayo njengotshintsho kwi-CTNNB1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrayimari yePenile Squamous Cell Carcinoma ilingana nePrimary Fibromatosis? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweRadiation njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Milk Thistle-Isongezelelo seSondlo

I-Milk Thistle eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Silibinin, i-Vitamin E, i-Palmitic Acid, i-Oleic Acid kunye ne-Linoleic Acid, nganye ekhoyo kwiimpawu ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa ukulungiswa kwe-DNA, i-Epithelial kwi-Mesenchymal Transition kunye ne-MYC Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeMilk Thistle, yodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa ubisi lwe-Milk Thistle kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweMilk Thistle ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka yenziwe ibe yeyakho.

Ukukhetha izongezo zeMilk Thistle

Ukuphendula umbuzo othi 'Ndingaluphepha nini ubisi lwe-Milk Thistle kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeMilk Thistle ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba ludlala indima ekunqumeni ukuba ubisi lwe-Milk Thistle lufanelekile okanye lufanele luphetshwe, lugxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba izongezo zeMilk Thistle ziya kunceda izigulana zePrimary Fibromatosis eziphantsi konyango lweRadiation?

I-Primary Fibromatosis ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-CTNNB1, i-KDR kunye ne-CIC, ekhokelela ekuguquleni kwiindlela ze-biochemical pathways, ngokukodwa i-Epithelial ukuya kwi-Mesenchymal Transition, i-Adherens junction, i-Androgen Signaling, i-Angiogenesis kunye ne-RAS-RAF Signaling. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Milk Thistle supplement, echaphazela i-Epithelial ukuya kwi-Mesenchymal Transition, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Fibromatosis xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho lwemfuza olwaziwayo.

2. Ingaba izongezo zeMilk Thistle ziya kunceda izigulana eziphantsi koNyango lweMitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngeenguqu ezithile zofuzo, ezifana ne-ABRAXAS1, i-PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-DNA Repair, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seMilk Thistle lukhetho olunengqiqo kwabo banePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba iMilk Thistle inefuthe kwiindlela ezifana noLungiso lweDNA, olunokuthi luthintele izinto eziqhuba iPrimary Penile Squamous Cell Carcinoma okanye luncede ukusebenza kweMitomycin.

3. Ingaba izongezo zeMilk Thistle zikhuselekile kubantu abasempilweni abaneCTNNB1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-CTNNB1 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-CTNNB1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga utshintsho kwi-CTNNB1 ehambelana nomngcipheko owongeziweyo we-Adrenocortical Carcinoma, ingqiqo yezenzululwazi icebisa ukuphepha ukusetyenziswa kwe-Milk Thistle. Oku kungenxa yokuba ukongeza ubisi lwe-Milk Thistle luchaphazela iindlela ezifana ne-Epithelial ukuya kwi-Mesenchymal Transition, enokukhokelela kwimiphumo emibi kumxholo we-CTNNB1 yokuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeNciba yobisi zikhuselekile kubantu abasempilweni abane-TERT Mutation eManyaniswe neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Utshintsho kwi-TERT lunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kubandakanya i-MYC Signaling kunye nokulungiswa kwe-DNA, enefuthe kuphuhliso lomhlaza. Ukuba iphaneli yakho yemfuzo ityhila utshintsho kwi-TERT ehambelana noMhlaza we-Hematological, cinga ngokubandakanya izongezo zobisi lwe-Milk Thistle kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-MYC yokuSayina, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanywa ukutya kunye nezongezo ezifana neMilk Thistle, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Ukusetyenziswa kwe-PPAR gamma kunye ne-delta nge-conjugated linoleic acid ilamla ukhuseleko kwisifo sesibindi sokudumba.
• Impembelelo yokuthintela i-tocotrienol kwi-eukaryotic DNA polymerase lambda kunye ne-angiogenesis.
• cBioPortal for Cancer Genomics
• Ukumelana nonomathotholo kwiiseli zomhlaza webele kulamlwa nge-TGF-β yokubonisa, i-hybrid epithelial-mesenchymal phenotype kunye neeseli ze-cancer stem.
• Impembelelo ye-DNA yokusilela ukulungisa i-cytotoxicity yeziyobisi ezisetyenziselwa unyango lomhlaza - ukuphononongwa.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• cBioPortal for Cancer Genomics
• Indima ye-phospholipase D ekufudukeni kunye nokuhlasela okubangelwa yi-linoleic acid kwiiseli zomhlaza webele.