Ngowuphi umhlaza onokuzuza ngokubandakanya iHorse Chestnut kwisidlo sabo?

Iimbalasane

I-Horse Chestnut yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweHorse Chestnut kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Horse Chestnut inokuba luncedo kwabo bane-Primary Mucosal Melanoma ye-Urethra ephantsi kwe-Doxorubicin, kodwa isenokungabi kuhle kwizigulana ezifumana i-Radiation ye-Primary Sclerosing Epithelioid Fibrosarcoma. Ngaphezu koko, ngelixa i-Horse Chestnut inokunceda abantu abane-genetic risk factor "CDH1", ayinakucetyiswa kwabo banomngcipheko ohlukileyo wemfuza "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Horse Chestnut kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iHorse Chestnut lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana ne-Horse Chestnut endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba ufanele udibanise i-Horse Chestnut ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Horse Chestnut ukuba une-genetic predisposition kumhlaza ohambelana ne-CDH1 gene? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kunenzuzo ukubandakanya i-Horse Chestnut kwisidlo sakho ukuba ufunyanwe une-Primary Sclerosing Epithelioid Fibrosarcoma, okanye ukuba ukuxilongwa kwakho yi-Primary Mucosal Melanoma ye-Urethra? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kwe-Horse Chestnut ukuba ufumana unyango lwe-Doxorubicin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Doxorubicin siye kwiRadiation? Kubalulekile ukuqaphela ukuba iinkcazo ezilula ezifana 'neChestnut yeHashe yindalo, ngoko isoloko iluncedo' okanye 'iHorse Chestnut yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Horse Chestnut kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Horse Chestnut kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye lungabikho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Mucosal Melanoma ye-Urethra okanye i-Primary Sclerosing Epithelioid Fibrosarcoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini. .”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba unobangela wemingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, njengeHorse Chestnut. Ngaba umngcipheko wemfuza womhlaza ovela kwinguqu kwi-CDH1 ineempembelelo zendlela ye-biochemical efanayo njengenguqu kwi-ASXL1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Mucosal Melanoma ye-Urethra ilingana ne-Primary Sclerosing Epithelioid Fibrosarcoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bakwiRadiation njengakwabo bafumana iDoxorubicin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Horse Chestnut – Isongezo seSondlo

I-supplement Horse Chestnut iquka uluhlu lwezithako ezisebenzayo, kuquka i-Esculin kunye ne-Aescin, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa ii-Checkpoints zeCell Cycle, i-TGFB Signaling and Inflammation, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeHorse Chestnut, yodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Horse Chestnut kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Horse Chestnut ayisosigqibo sendalo yonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha iHorse Chestnut Supplements

Ukuphendula umbuzo othi 'Ndingakuphepha nini ukuba ndiphephe i-Horse Chestnut kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukufaneleka kunye nokhuseleko okanye inzuzo ye-Horse Chestnut iyahluka ngokuxhomekeka kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies, zonke zidlala indima ekunqumeni ukuba i-Horse Chestnut ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba i-Horse Chestnut Supplements iya kunceda i-Primary Sclerosing Epithelioid Fibrosarcoma Izigulana eziphantsi konyango lweRadiation?

I-Primary Sclerosing Epithelioid Fibrosarcoma ibonakaliswe ngokuguqulwa kofuzo oluthile, oko kukuthi, i-PBRM1, i-ATRX kunye ne-PIK3C2G, ekhokelela ekutshintsheni kwiindlela ze-biochemical, ngokukodwa i-TGFB yoMbonakaliso kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Horse Chestnut supplement, echaphazela i-TGFB Signaling, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Sclerosing Epithelioid Fibrosarcoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ingaba iHorse Chestnut Supplements iyakunceda iPrimary Mucosal Melanoma yeUrethra iZigulana eziphantsi koNyango lweDoxorubicin?

I-Primary Mucosal Melanoma ye-Urethra ichongiwe ngokuguqulwa kofuzo oluthile, njenge-TP53, SMARCA4 kunye ne-FAT1, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Cell Cycle Checkpoints, i-Apoptosis, i-Androgen Signaling kunye ne-Chromatin Remodeling. Ukusebenza konyango lomhlaza, njenge-Doxorubicin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Horse Chestnut sisisombululo esinengqiqo kulabo abane-Primary Mucosal Melanoma ye-Urethra ehamba ne-Doxorubicin. Oku kungenxa yokuba i-Horse Chestnut inefuthe kwiindlela ezinje ngeCell Cycle Checkpoints, ezinokuthi zithintele izinto eziqhuba i-Primary Mucosal Melanoma ye-Urethra okanye zizuze ukusebenza kwe-Doxorubicin.

3. Ngaba izongezo ze-Horse Chestnut zikhuselekile kubantu abasempilweni abane-ASXL1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Inflammation, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-supplement Horse Chestnut. Oku kungenxa yokuba ukongeza i-Horse Chestnut inefuthe kwiindlela ezifana nokuvuvukala, oku kunokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ASXL1 kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo zeHorse Chestnut zikhuselekile kubantu abasempilweni abaneCDH1 Mutation Associated Genetic Risk?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Cell Cycle Checkpoints, i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka izongezo ze-Horse Chestnut kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana neCell Cycle Checkpoints, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDH1 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana ne-Horse Chestnut, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Ukumelana neeseli ze-p53 zokunkqonkqoza kwi-doxorubicin kunxulumene nokwakheka okuncitshisiweyo kwe-DNA strand breaks kunokuba kuphazamiseke ukubonakaliswa kwe-apoptotic.
• cBioPortal for Cancer Genomics
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• Ukumelana nonomathotholo kwiiseli zomhlaza webele kulamlwa nge-TGF-β yokubonisa, i-hybrid epithelial-mesenchymal phenotype kunye neeseli ze-cancer stem.