Ngowuphi umhlaza onokuthi uxhamle ngokubandakanya iTea eluhlaza ekutyeni kwabo?

Iimbalasane

I-Green Tea yamkelwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweTea eluhlaza kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iTea eluhlaza inokuba luncedo kwabo bane-Primary Solitary Fibrous Tumor ephantsi kwe-Avastin, kodwa isenokungalungeli kwizigulana ezifumana iRadiation yePrimary Sinonasal Adenocarcinoma. Ngaphaya koko, ngelixa i-Green Tea inokunceda abantu abane-genetic risk factor "CDH1", ayinakucetyiswa kwabo banomngcipheko wemfuzo owahlukileyo "ERBB2". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweTea eluhlaza kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iTea eluhlaza lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana neTea eluhlaza endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungahoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iTea eluhlaza kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iTea eluhlaza ukuba unemfuza enokuthanani nomhlaza onxulumene ne-CDH1 gene? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ERBB2 gene? Ngaba kunenzuzo ukuquka iTea eluhlaza kwisidlo sakho ukuba ufunyaniswe une-Primary Sinonasal Adenocarcinoma, okanye ukuba uxilongo lwakho yi-Primary Solitary Fibrous Tumor? Ngaphezu koko, kufuneka ulungelelanise ukusetyenziswa kwakho kweTea eluhlaza ukuba ufumana unyango lwe-Avastin okanye ukuba isicwangciso sakho sonyango sisuka kwi-Avastin ukuya kwiRadiation? Kubalulekile ukuqonda ukuba iintetho ezilula ezifana 'neTea eluhlaza yendalo, ngoko isoloko iluncedo' okanye 'iTea eluhlaza yongeza ukhuselo lomzimba' akonelanga ekutyeni okunolwazi/ukhetho lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iTea eluhlaza kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neTea eluhlaza kwisidlo sakho ngenxa yeenzuzo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile oluhambayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangethuba. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye lungabikho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njenge-Primary Solitary Fibrous Tumor okanye iPrimary Sinonasal Adenocarcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo sokukhetha ukutya, okufana neTea eluhlaza. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-CDH1 unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ERBB2? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Solitary Fibrous Tumor ulingana nePrimary Sinonasal Adenocarcinoma? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo baphantsi kweRadiation njengakwabo bafumana i-Avastin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

Iti eluhlaza – iSongezo seSondlo

I-Tea ehlaza eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Geraniin, i-Epigallocatechin Gallate, i-Epicatechin Gallate, i-Rutin kunye ne-Epigallocatechin 3- (3-methylgallate), nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC yokuSayina, i-Notch Signaling, i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Oncogenic Histone Methylation, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeTea eluhlaza, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Green Tea yomhlaza, kubalulekile ukuqwalasela le miba eyahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kweTea eluhlaza ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeTea eluhlaza

Ukuphendula umbuzo othi 'Ndingayiphepha nini iTea eluhlaza kumxholo woMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeTea eluhlaza kuyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo lomzimba wonke ludlala indima ekunqumeni ukuba iTea eluhlaza ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba izongezo zeTea eziHlaza ziza kunceda iZigulana zePrimary Sinonasal Adenocarcinoma eziphantsi konyango lweRadiation?

I-Primary Sinonasal Adenocarcinoma ibonakala ngokuguqulwa kofuzo oluthile, okuyi-ATRX, NOTCH1 kunye ne-PTPRD, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Notch Signaling kunye ne-RUNX Signaling. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo seTea eluhlaza, echaphazela i-Notch Signaling, ayinakuba lukhetho olufanelekileyo kwimeko ye-Primary Sinonasal Adenocarcinoma xa ihamba ngeRadiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ingaba izongezo zeTea eziHlaza ziya kunceda izigulana ezikwiPrimary Solitary Fibrous Tumor eziphantsi koNyango lwe-Avastin?

I-Primary Solitary Fibrous Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-BRD4, i-FLI1 kunye ne-KMT2C, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza kwonyango lomhlaza, njenge-Avastin, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seTea eluhlaza lukhetho olunengqiqo kwabo bane-Primary Solitary Fibrous Tumor ehamba ne-Avastin. Oku kungenxa yokuba iTea yoHlaza inefuthe kwiindlela ezifana ne-MYC yokuSayila, enokuthi ithintele izinto eziqhuba iTumor eyiPrimary Solitary Fibrous Tumor okanye izuze ukusebenza kwe-Avastin.

3. Ingaba izongezo zeTea eziHlaza zikhuselekile kubantu abasempilweni abaneERBB2 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-ERBB2 idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-ERBB2 kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Growth Factor Signaling kunye ne-PI3K-AKT-MTOR Signaling, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ERBB2 ehambelana nomngcipheko okhulayo we-Esophageal Adenocarcinoma, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kweTea eluhlaza. Oku kungenxa yokuba ukongeza i-Green Tea ichaphazela iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, okungakhokelela kwimiphumo emibi kumxholo we-ERBB2 ukuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo zeTea eziHlaza zikhuselekile kubantu abasempilweni abaneCDH1 Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Oncogenic Histone Methylation, i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka izongezo zeTea eluhlaza kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-Oncogenic Histone Methylation, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abane-CDH1 yeenguqu kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana neTea eluhlaza, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• Ukunyanzeliswa kwe-lipopolysaccharide-induced nuclear factor-kappaB umsebenzi we-theaflavin-3,3'-digallate ukusuka kwiti emnyama kunye nezinye iipolyphenols ngolawulo oluphantsi lomsebenzi we-IkappaB kinase kwi-macrophages.
• cBioPortal for Cancer Genomics
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.