Ngowuphi umhlaza onokuzuza ngokubandakanya iGalangal kwisidlo sabo?

Iimbalasane

I-Galangal yaziwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kweGalangal kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iGalangal inokuzuza abo banePrayimari yePenile Squamous Cell Carcinoma ephantsi kweMitomycin, kodwa isenokungalungelanga izigulane ezifumana iDacarbazine yePrimary Pediatric Osteosarcoma. Ngaphaya koko, ngelixa i-Galangal inokunceda abantu abanomngcipheko wemfuza "CDH1", ayinakucetyiswa kwabo banengozi eyahlukileyo yemfuza. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweGalangal kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iGalangal lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, igxile kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neGalangal endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iGalangal kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba udle i-Galangal ukuba unesifo sofuzo kumhlaza ohambelana ne-CDH1 gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kunenzuzo ukubandakanya i-Galangal ekutyeni kwakho ukuba ufunyaniswe une-Primary Pediatric Osteosarcoma, okanye ukuba uxilongo lwakho yiPrimary Penile Squamous Cell Carcinoma? Ngaphezu koko, ukusetyenziswa kwakho kweGalangal kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwi-Mitomycin ukuya kwi-Dacarbazine? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neGalangal yendalo, ngoko isoloko iluncedo' okanye 'iGalangal inyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Galangal kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeGalangal kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Penile Squamous Cell Carcinoma okanye iPrimary Pediatric Osteosarcoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kunokubangela imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neGalangal. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-CDH1 unefuthe elifanayo le-biochemical pathway njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrayimari yePenile Squamous Cell Carcinoma ilingana nePrimary Pediatric Osteosarcoma? Ngaphezu koko, ngaba ukuqwalaselwa kokutya kuhlala kufana nakwabo baphantsi kweDacarbazine njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Galangal - Isongezo seSondlo

I-Galangal eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Pinostrobin kunye ne-Galangin, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinempembelelo kwiindlela ze-molecular, ngokukodwa i-JAK-STAT Signaling, i-Angiogenesis kunye ne-PI3K-AKT-MTOR Umqondiso, olawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeGalangal, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iGalangal kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweGalangal ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeGalangal

Ukuphendula umbuzo othi 'Ndingakuphepha nini ukunqanda i-Galangal kumxholo woMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeGalangal ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Galangal ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Galangal Supplements iyakunceda kwi-Primary Pediatric Osteosarcoma izigulane eziphantsi konyango lwe-Dacarbazine?

I-Osteosarcoma yaBantwana yokuqala iphawulwa ngotshintsho oluthile lwemfuza, oko kukuthi, i-TTN, i-MUC16 kunye ne-SPTBN5, ekhokelela kutshintsho kwiindlela zebhayoloji, ngakumbi i-Angiogenesis kunye ne-Post Translation Modification. Ukusebenza kwonyango lomhlaza, njengeDacarbazine, kuxhomekeke kwindlela yokusebenza kwezi ndlela ezithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Galangal supplement, echaphazela i-Angiogenesis, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Pediatric Osteosarcoma xa i-Dacarbazine. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba iGalangal Supplements iya kuxhamla kwi-Primary Penile Squamous Cell Carcinoma Izigulana eziphantsi koNyango lwe-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-ABRAXAS1, PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-JAK-STAT Signaling, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo seGalangal lukhetho olunengqiqo kulabo abanePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba i-Galangal inefuthe kwiindlela ezifana ne-JAK-STAT Signaling, enokuthi ithintele izinto eziqhuba i-Primary Penile Squamous Cell Carcinoma okanye izuze ukusebenza kweMitomycin.

3. Ngaba izongezo zeGalangal zikhuselekile kubantu abasempilweni abaneCDH1 Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-CDH1 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDH1 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-PI3K-AKT-MTOR Ukubonakaliswa, i-Adherens junction kunye ne-Epithelial kwi-Mesenchymal Transition, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yezofuzo ityhila utshintsho kwi-CDH1 ehambelana noMhlaza weGastric, cinga ukufaka izongezo zeGalangal kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela kakuhle iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDH1 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neGalangal kwiingozi zofuzo, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• Iikhompawundi zokutya i-galangin kunye ne-myricetin zicinezela umhlaza we-ovarian cell angiogenesis.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-Dacarbazine ibangela i-transcriptional up-regulation ye-interleukin 8 kunye ne-vascular endothelial growth factor in melanoma cells: indlela yokuphunyuka kwi-chemotherapy.
• cBioPortal for Cancer Genomics
• I-Galangin inqanda ukukhula kweeseli ze-squamous carcinoma zentloko kunye nentamo yomntu kwi-vitro nakwi-vivo.
• I-Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells.
• I-Piperine (PP) unyango lwe-mitomycin-C (MMC) oluphuculweyo lomhlaza womlomo wesibeleko womntu ngokucinezela indlela yomqondiso we-Bcl-2 ngokungasebenzi i-STAT3/NF-κB.