Ngowuphi umhlaza onokuzuza ngokubandakanya iFolic Acid kwisidlo sabo?

Iimbalasane

I-Folic Acid yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kwe-Folic Acid kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Folic Acid inokuba luncedo kwabo banePrimary Myxoid Chondrosarcoma bephantsi kwe-Dactinomycin, kodwa isenokungalungeli kwizigulana ezifumana i-Exemestane yePrimary Uterine Corpus Endometrial Carcinoma. Ngaphaya koko, ngelixa i-Folic Acid inokunceda abantu abanomngcipheko wemfuzo "i-ATM", ayinakucetyiswa kwabo basengozini yemfuzo eyahlukileyo "i-KRAS". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Folic Acid kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iFolic Acid lukhetho olufanelekileyo kusini na. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, igxile kwiziphumo ezipheleleyo zawo onke amalungu asebenzayo ekutyeni/ezongezo ezifana ne-Folic Acid endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungasihoyi ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise i-Folic Acid kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iFolic Acid ukuba unemfuzo enokuthanani nomhlaza onxulumene nofuzo lwe-ATM? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela kumfuza we-KRAS? Ngaba kuluncedo ukuquka i-Folic Acid ekutyeni kwakho ukuba ufunyaniswe unePrimary Uterine Corpus Endometrial Carcinoma, okanye ukuba uxilongo lwakho yiPrimary Myxoid Chondrosarcoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kwe-Folic Acid ukuba ufumana unyango lwe-Dactinomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Dactinomycin siye kwi-Exemestane? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neFolic Acid yeyendalo, ngoko isoloko iluncedo' okanye 'iFolic Acid yonyusa ukhuselo lomzimba' azanelanga ekutyeni okunolwazi/kukhetho lokongezelela.

Ukongeza, kubalulekile ukuba uphinde uvavanye ukufaneleka kokubandakanya i-Folic Acid kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeFolic Acid kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Myxoid Chondrosarcoma okanye iPrimary Uterine Corpus Endometrial Carcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeke kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neFolic Acid. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-ATM unefuthe elifanayo le-biochemical pathway njengotshintsho kwi-KRAS? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana nePrimary Myxoid Chondrosarcoma ulingana nePrimary Uterine Corpus Endometrial Carcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bakwi-Exemestane njengakwabo bafumana iDactinomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Folic Acid – Isongezo seSondlo

I-Folic Acid eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kubandakanywa i-Folic Acid, nganye ekhoyo kwiindidi ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa ii-Checkpoints ze-Cell Cycle, i-PI3K-AKT-MTOR Ukubonakaliswa, i-Growth Factor Signaling kunye ne-Hypoxia, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunika le mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeFolic Acid, iyodwa okanye idityanisiwe, iba sisigqibo esibalulekileyo kwimeko yesondlo somhlaza. Xa ucinga ukusebenzisa i-Folic Acid kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kwe-Folic Acid ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka yenziwe ibe yeyakho.

Ukukhetha iiFolic Acid Supplements

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Folic Acid kwimeko yoMhlaza' ngumngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye uncedo lwe-Folic Acid kuyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Folic Acid ifanelekile okanye kufuneka ithintelwe, kugxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba i-Folic Acid Supplements iya kunceda i-Primary Uterine Corpus Endometrial Carcinoma Izigulana eziphantsi konyango lwe-Exemestane?

I-Primary Uterine Corpus Endometrial Carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, oku kukuthi i-RELA, i-ARID1A kunye ne-KMT2D, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-PI3K-AKT-MTOR Ukubonakaliswa, ukuPhathwa kwe-Immune Evasion Signaling, i-T-Cell Receptor Signaling, i-Androgen Signaling, i-Chromatin , I-Oncogenic ye-Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza konyango lomhlaza, njenge-Exemestane, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Folic Acid, esichaphazela i-PI3K-AKT-MTOR Signaling, isenokungabi lukhetho olufanelekileyo kwimeko yePrimary Uterine Corpus Endometrial Carcinoma xa i-Exemestane. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba izongezo ze-Folic Acid ziyakunceda kwizigulana zasePrimary Myxoid Chondrosarcoma eziphantsi koNyango lwe-Dactinomycin?

I-Primary Myxoid Chondrosarcoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-IDH1, i-NR2E1 kunye ne-WDFY4, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Cell Cycle Checkpoints, i-Oncogenic Cancer Epigenetics kunye ne-Glutathione Metabolism. Ukusebenza konyango lomhlaza, njenge-Dactinomycin, kugqitywe kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo se-Folic Acid lukhetho olunengqiqo kwabo bane-Primary Myxoid Chondrosarcoma ehamba neDactinomycin. Oku kungenxa yokuba i-Folic Acid inefuthe kwiindlela ezinje ngeCell Cycle Checkpoints, ezinokuthi zithintele izinto eziqhuba iPrimary Myxoid Chondrosarcoma okanye zizuze ukusebenza kweDactinomycin.

3. Ngaba izongezo ze-Folic Acid zikhuselekile kubantu abasempilweni abane-KRAS Mutation eNxulunyaniswe neMngcipheko yemfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-gene ye-KRAS idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-gene ye-KRAS kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Growth Factor Signaling, i-MAPK Signaling, i-PI3K-AKT-MTOR Umqondiso kunye ne-RAS-RAF Signaling, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga utshintsho kwi-KRAS olunxulunyaniswa nomngcipheko owongeziweyo woMhlaza weMiphunga, ingqiqo yenzululwazi icebisa ukuba kuthintelwe ukusetyenziswa kweFolic Acid eyongezelelweyo. Oku kungenxa yokuba ukongeza i-Folic Acid inefuthe kwiindlela ezifana ne-Growth Factor Signaling, enokukhokelela kwiziphumo ezibi kumxholo wenguqu ye-KRAS kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo ze-Folic Acid zikhuselekile kubantu abasempilweni abane-ATM yoGuquko oluNxulunyaniswe neMngcipheko yeGenetic?

I-ATM idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ATM kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Hypoxia kunye nokulungiswa kwe-DNA, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ATM ehambelana ne-Chronic Myelomonocytic Leukemia, cinga ukufaka izongezo ze-Folic Acid kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-Hypoxia, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-ATM kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanywa ukutya kunye nezongezo ezifana ne-Folic Acid, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Iiseti ezichazwe ngokwemfuza zomhlaza wepancreatic womntu zibonisa eyodwa kwi-vitro chemosensitivity.
• Intetho enqamlezileyo phakathi kwe-steroid-receptor-mediated kunye ne-cell-membrane-receptor-mediated signaling pathways iphumela kwi-vivo modulation ye-c-Met kunye ne-ornithine decarboxylase gene expression in mouse kidney expression.
• Ukulahleka kwe-capillary ye-Peritubular emva kwe-mouse acute nephrotoxicity correlates kunye ne-down-regulation ye-vascular endothelial growth factor-A kunye ne-hypoxia-inducible factor-1 alpha.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• Iziphumo zokunqongophala kwe-folate ekubonakalisweni kofuzo kwi-apoptosis kunye neendlela zomhlaza kwiiseli zomhlaza wekoloni.
• cBioPortal for Cancer Genomics
• Ukubonakaliswa kweprotooncogene elandelelanayo ekuvuseleleni izintso emva kokwenzakala okubukhali kwezintso.
• cBioPortal for Cancer Genomics
• Yima kwisigaba somhlaza kwisigaba se-Ib sophando lwe-pan-phosphoinositide-3-kinase inhibitor buparlisib ene-letrozole kwi-estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.