Ngowuphi umhlaza onokuzuza ngokubandakanya iFeverfew kwisidlo sabo?

Iimbalasane

I-Feverfew yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kwe-Feverfew kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba okunye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Feverfew inokuba luncedo kwabo bane-Primary Penile Squamous Cell Carcinoma ephantsi kwe-Mitomycin, kodwa isenokungabi ilungile kwizigulana ezifumana i-Pembrolizumab ye-Primary Mucinous Stomach Adenocarcinoma. Ngaphaya koko, ngelixa i-Feverfew inokunceda abantu abane-genetic risk factor "KIT", ayinakucetyiswa kwabo banomngcipheko ohlukileyo wemfuza "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Feverfew kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba i-Feverfew lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / izongezo ezifana neFeverfew endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise i-Feverfew kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Feverfew ukuba unemfuzo enokuthanani nomhlaza onxulumene nofuzo lwe-KIT? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kuluncedo ukubandakanya i-Feverfew kwisidlo sakho ukuba ufunyaniswe une-Primary Mucinous Stomach Adenocarcinoma, okanye ukuba uxilongo lwakho yiPrimary Penile Squamous Cell Carcinoma? Ngaphezu koko, ukusetyenziswa kwakho kwe-Feverfew kufanele kuhlengahlengiswe njani ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Mitomycin siye kwi-Pembrolizumab? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'ne-Feverfew yendalo, ngoko ke isoloko iluncedo' okanye 'i-Feverfew yonyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Feverfew kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezinje ngeFeverfew kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ezipheleleyo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njenge-Primary Penile Squamous Cell Carcinoma okanye i-Primary Mucinous Stomach Adenocarcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, isigaba sesifo, kunye nezinto ezifana nobudala kunye nesini. ”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kujongwe imingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana ne-Feverfew. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-KIT unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ASXL1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Penile Squamous Cell Carcinoma ulingana nePrimary Mucinous Stomach Adenocarcinoma? Ngapha koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kwePembrolizumab njengabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Feverfew-Isongezelelo seSondlo

Isongezelelo Feverfew ibandakanya uluhlu lwezithako esebenzayo, kuquka Luteolin, Vitamin K, Centaureidin kunye Parthenolide, nganye ekhoyo kwi zoxinaniso ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Extracellular Matrix Remodelling, i-WNT Beta Catenin Signaling, ukulungiswa kwe-DNA kunye ne-Oncogenic Cancer Epigenetics, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeFeverfew, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Feverfew kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufanayo nonyango lomhlaza, ukusetyenziswa kwe-Feverfew ayisosigqibo sehlabathi lonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeFeverfew

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Feverfew kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo ze-Feverfew ziyahluka ngokuxhomekeke kwiimeko zomntu. Imiba efana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye nayo nayiphi na i-allergies yonke idlala indima ekunqumeni ukuba i-Feverfew ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba izongezo ze-Feverfew ziya kuxhamla kwi-Primary Mucinous Stomach Adenocarcinoma Izigulana eziphantsi konyango lwe-Pembrolizumab?

I-Primary Mucinous Stomach Adenocarcinoma ibonakaliswe ngotshintsho oluthile lwemfuza, oko kukuthi, i-GRIN3A, TMEM26 kunye ne-TP53, ekhokelela kwiinguqu kwiindlela ze-biochemical, ngokukodwa i-WNT Beta Catenin Signaling, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njengePembrolizumab, kuxhomekeke kwindlela yokusebenza kwezi ndlela zithile. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Feverfew supplement, echaphazela i-WNT Beta Catenin Signaling, isenokungabi yinto efanelekileyo xa i-Primary Mucinous Stomach Adenocarcinoma xa ihamba nge-Pembrolizumab. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ingaba izongezo zeFeverfew ziyakuzinceda izigulana eziphantsi koNyango lwe-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-ABRAXAS1, i-PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Extracellular Matrix Remodelling, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Feverfew lukhetho olunengqiqo kwabo banePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba i-Feverfew inefuthe kwiindlela ezifana ne-Extracellular Matrix Remodelling, enokuthi ithintele izinto eziqhuba i-Primary Penile Squamous Cell Carcinoma okanye izuze ukusebenza kweMitomycin.

3. Ingaba izongezo zeFeverfew zikhuselekile kubantu abasempilweni abaneASXL1 Mutation eNxulunyaniswe neMngcipheko yeMfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana nokulungiswa kwe-DNA, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-Fiverfew yokuncedisa. Oku kungenxa yokuba ukongeza i-Feverfew inefuthe kwiindlela ezifana nokulungiswa kwe-DNA, enokukhokelela kwimiphumo emibi kumxholo we-ASXL1 yokuguqulwa kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo ze-Feverfew zikhuselekile kubantu abasempilweni abane-KIT Mutation eNxulunyaniswe neMngcipheko yeMfuzo?

I-KIT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-KIT kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Oncogenic Cancer Epigenetics kunye ne-Growth Factor Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuzo ityhila utshintsho kwi-KIT ehambelana noMhlaza weGastric, cinga ngokubandakanya izongezo ze-Feverfew kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-Oncogenic Cancer Epigenetics, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-KIT kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana ne-Feverfew, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Ubume beCrystal bomntu oxhomekeke kwi-cyclin-kinase 6 ene-flavonol inhibitor, i-fisetin.
• Ukuvinjelwa kwe-hypoxia-induced epithelial mesenchymal transition yi-luteolin kwiiseli zomhlaza wemiphunga engeyiyo encinci.
• Ukuzibandakanya kwe-integrinβ1 kubangela ukuxhathisa kweeseli zomhlaza wesinyi kwi-mitomycin-C.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-Luteolin ikhuthaza ukufa kweeseli ze-apoptotic ngokunyuswa kwe-Nrf2 inkcazo nge-DNA demethylase kunye nokusebenzisana kwe-Nrf2 kunye ne-p53 kwiiseli zomhlaza wekholoni yomntu.
• Ukusebenza kwamajoni omzimba kunye nokuphendula kwi-pembrolizumab kwi-POLE-mutant endometrial cancer.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.