Ngowuphi umhlaza onokuzuza ngokubandakanya uDan Shen kwisidlo sabo?

Iimbalasane

UDan Shen waziwa ngokubanzi ngezibonelelo zempilo kwaye usetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kukaDan Shen kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, uDan Shen unokuzuza abo baneNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ehamba neCisplatin, kodwa isenokungabi yinto efanelekileyo kwizigulane ezifumana i-Dabrafenib ye-Primary Thyroid Cancer. Ngaphaya koko, ngelixa uDan Shen enokunceda abantu abanomngcipheko wemfuzo "CDKN2A", akunakucetyiswa kwabo basengozini eyahlukileyo yemfuza. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kukaDan Shen kwisigulana somhlaza kufuneka kube ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba ngaba uDan Shen lolona khetho lufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana noDan Shen endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise uDan Shen kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye uDan Shen ukuba unemfuza yomhlaza onxulumene ne-CDKN2A gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kunenzuzo ukubandakanya uDan Shen kwisidlo sakho ukuba ufunyanwe unoMhlaza weNdlala yeNdlala ePhambili, okanye ukuba uxilongo lwakho yiNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma? Ngaphezu koko, kufuneka uhlengahlengiso njani ukusetyenziswa kwakho kweDan Shen ukuba ufumana unyango lweCisplatin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka eCisplatin siye eDabrafenib? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'noDan Shen yindalo, ngoko ke kusoloko kuluncedo' okanye 'uDan Shen womeleza ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya uDan Shen kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana noDan Shen kwisidlo sakho ngenxa yezibonelelo zakho, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, imfuzo. izinto ezilindelekileyo, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njengeNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma okanye i-Primary Thyroid Cancer, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, isigaba sesifo, kunye nezinto ezifana nobudala kunye nesini. .”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba unobangela wemingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, njengoDan Shen. Ngaba umngcipheko wemfuza womhlaza osuka kutshintsho kwi-CDKN2A uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana neNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ilingana nePrimary Thyroid Cancer? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweDabrafenib njengakwabo bafumana iCisplatin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

UDan Shen – Isongezelelo seSondlo

I-supplement Dan Shen iquka uluhlu lwezithako ezisebenzayo, kuquka i-Miltirone kunye ne-Tanshinone I, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela ze-molecular, ngokukodwa i-NFKB Signaling, i-Oxidative Stress kunye ne-Cell Cycle Checkpoints, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yezinto eziphilayo, ukukhetha izongezo ezifanelekileyo ezifana noDan Shen, yedwa okanye ngokudibeneyo, kuba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa uDan Shen kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kukaDan Shen ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeDan Shen

Ukuphendula umbuzo othi 'Ndingamphepha nini uDan Shen kwimeko yoMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukufaneleka kunye nokhuseleko okanye iinzuzo zikaDan Shen ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies ludlala indima ekunqumeni ukuba uDan Shen ufanelekile okanye kufuneka agwenywe, kugxininisa ukubaluleka koqwalaselo lomntu. kwizigqibo ezinjalo.

1. Ngaba ii-Dan Shen Supplements ziya kuxhamla kwi-Primary Thyroid Cancer Patients eziphantsi konyango lwe-Dabrafenib?

I-Primary Thyroid Cancer ibonakaliswe ngotshintsho oluthile lwemfuza, oko kukuthi, i-BRAF, i-TERT kunye ne-NRAS, ekhokelela kwiinguqu kwiindlela ze-biochemical, ngokukodwa i-Oxidative Stress, i-RAS-RAF Signaling, i-MAPK Signaling, i-Cell Cycle Checkpoints, i-Apoptosis, i-G-protein-coupled Receptor Signaling. kunye noMqondiso weFactor yokuKhula. Ukusebenza konyango lomhlaza, okufana ne-Dabrafenib, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Dan Shen supplement, echaphazela i-Oxidative Stress, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Thyroid Cancer xa i-Dabrafenib. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Dan Shen Supplements iya kuxhamla kwi-Primary Head and Neck Squamous Cell Carcinoma izigulane ezifumana unyango lwe-Cisplatin?

Intloko eyiNtloko kunye neNtamo ye-Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-FRG1BP, i-TP53 kunye ne-PCDH11X, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-NFKB Signaling, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njengeCisplatin, kumiselwa kukunxibelelana kwezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo sikaDan Shen lukhetho olunengqiqo kulabo abaneNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma ehamba neCisplatin. Oku kungenxa yokuba uDan Shen uphembelela iindlela ezifana ne-NFKB Signaling, enokuthi inqanda izinto eziqhuba iNtloko ePhambili kunye neNeck Squamous Cell Carcinoma okanye izuze ukusebenza kweCisplatin.

3. Ingaba izongezo zeDan Shen zikhuselekile kubantu abasempilweni abaneCDKN2A Mutation Associated Genetic Risk?

I-CDKN2A idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-CDKN2A kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-Cell Cycle Checkpoints kunye ne-Cell Cycle, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-CDKN2A ehambelana noMhlaza woLusu, cinga ngokubandakanya izongezo zikaDan Shen kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana neCell Cycle Checkpoints, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-CDKN2A kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana noDan Shen, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Umphumo wokuchasana nokuvuvukala we-miltirone kwisifo sofuba esivuthayo nge-TLR4 / NF-κB / IQGAP2 indlela yokubonisa.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Ukufaneleka kwendlela encinci ye-GTPase Rac1 kwindlela yokumelana neziyobisi kunye nerediyo: Amathuba kunyango lomhlaza.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• I-Nuclear Factor-kappa B njengoMba wokuNchasa kwiPlatinam-based Antineoplasic Drugs.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• I-Miltirone yenza i-G2 / M ye-Cell Cycle ukubanjwa kunye ne-Apoptosis kwi-CCRF-CEM ye-Acute Lymphoblastic Leukemia Cells.