Ngowuphi umhlaza onokuzuza ngokubandakanya iCinnamon ekutyeni kwabo?

Iimbalasane

I-Cinnamon yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweCinnamon kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, umngcipheko wemfuza, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, iCinnamon inokuba luncedo kwabo bane-Primary Solitary Fibrous Tumor ephantsi kwe-Avastin, kodwa isenokungabi ilungile kwizigulana ezifumana iRadiation yePrimary Sclerosing Epithelioid Fibrosarcoma. Ngaphaya koko, ngelixa iCinnamon inokunceda abantu abanomngcipheko wemfuza “TERT”, ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweCinnamon kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iCinnamon lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / izongezo ezifana neCinnamon endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iCinnamon kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iCinnamon ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-TERT? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kunenzuzo ukubandakanya iCinnamon ekutyeni kwakho ukuba ufunyaniswe unePrimary Sclerosing Epithelioid Fibrosarcoma, okanye ukuba uxilongo lwakho yiPrimary Solitary Fibrous Tumor? Ngaphezu koko, kufuneka ulungelelanise ukusetyenziswa kwakho kweCinnamon ukuba ufumana unyango lwe-Avastin okanye ukuba isicwangciso sakho sonyango sisuka kwi-Avastin ukuya kwiRadiation? Kubalulekile ukuqonda ukuba iziqinisekiso ezilula ezifana 'neCinnamon yendalo, ngoko ke isoloko iluncedo' okanye 'iCinnamon yonyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya iCinnamon kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neCinnamon kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uthathele ingqalelo ifuthe le-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, onje ngePrimary Solitary Fibrous Tumor okanye Primary Sclerosing Epithelioid Fibrosarcoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neCinnamon. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-TERT uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwenye imfuza? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Solitary Fibrous Tumor ulingana nePrimary Sclerosing Epithelioid Fibrosarcoma? Ngapha koko, ngaba ukuqwalaselwa kokutya kuhlala kuyafana kwabo baphantsi kweRadiation njengakwabo bafumana i-Avastin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Cinnamon-Isongezelelo seSondlo

I-Cinnamon eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Vitamin K, i-Vitamin A, i-Palmitic Acid, i-Linalool kunye ne-Eugenol, nganye ekhoyo kwiimpawu ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-MYC Signaling, i-TGFB Signaling, i-PI3K-AKT-MTOR i-Signaling kunye ne-Stem Cell Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeCinnamon, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iCinnamon kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweCinnamon ayisosigqibo sehlabathi lonke esifanelekileyo kubo bonke abanomhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeCinnamon

Ukuphendula umbuzo othi 'Ndimele ndiyiphephe nini iCinnamon kwimeko yoMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye izibonelelo zeCinnamon ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies, zonke zidlala indima ekunqumeni ukuba iCinnamon ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Cinnamon Supplements iya kunceda i-Primary Sclerosing Epithelioid Fibrosarcoma izigulane eziphantsi konyango lweRadiation?

I-Primary Sclerosing Epithelioid Fibrosarcoma ibonakaliswe ngokuguqulwa kofuzo oluthile, oko kukuthi, i-PBRM1, i-ATRX kunye ne-PIK3C2G, ekhokelela ekutshintsheni kwiindlela ze-biochemical, ngokukodwa i-TGFB yokuSayina kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, okufana neRadiation, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Cinnamon supplement, echaphazela i-TGFB Signaling, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Sclerosing Epithelioid Fibrosarcoma xa ihamba ngeRadiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Cinnamon Supplements iya kunceda kwi-Primary Solitary Fibrous Tumor Patients eziphantsi koNyango lwe-Avastin?

I-Primary Solitary Fibrous Tumor ichongiwe ngokuguqulwa kofuzo oluthile, njenge-BRD4, i-FLI1 kunye ne-KMT2C, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Chromatin Remodeling, i-DNA Repair, i-Oncogenic Histone Methylation kunye ne-Amino Acid Metabolism. Ukusebenza kwonyango lomhlaza, njenge-Avastin, kuchongwa ngokusebenzisana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Umzekelo, isongezelelo seCinnamon lukhetho olunengqiqo kwabo banePrimary Solitary Fibrous Tumor ehamba neAvastin. Oku kungenxa yokuba iCinnamon inefuthe kwiindlela ezifana ne-MYC yokuSayina, enokuthi ithintele izinto eziqhuba i-Primary Solitary Fibrous Tumor okanye ixhamle ukusebenza kwe-Avastin.

3. Ngaba izongezo zeCinnamon zikhuselekile kubantu abasempilweni abane-TERT Mutation eManyaniswa neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Utshintsho kwi-TERT lunokuphazamisa iindlela ezibalulekileyo ze-biochemical, ezibandakanya i-Stem Cell Signaling kunye nokulungiswa kwe-DNA, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-TERT ehambelana noMhlaza we-Hematological, cinga ngokubandakanya izongezo zeCinnamon kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana neStem Cell Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kubandakanya ukutya kunye nezongezelelo ezifana neCinnamon, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

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• Indlela yokubonisa i-retinoid inqanda i-hematopoiesis kunye ne-uncouples ukusuka kwi-Hox genes ngexesha lophuhliso lwe-hematopoietic.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• cBioPortal for Cancer Genomics
• cBioPortal for Cancer Genomics
• Impembelelo yokuthintela i-linalool kwi-carcinogenesis yesikhumba ebukhali kwaye engapheliyo ye-UVB-mediated kwiimpuku ze-albino zaseSwitzerland.
• Ukumelana nonomathotholo kwiiseli zomhlaza webele kulamlwa nge-TGF-β yokubonisa, i-hybrid epithelial-mesenchymal phenotype kunye neeseli ze-cancer stem.
• Indima ye-tumor microenvironment ekuchaseni unyango lwe-anti-angiogenic.