Ngowuphi umhlaza oza kuzuza ngokubandakanya iChitrak ekudleni kwabo?

Iimbalasane

I-Chitrak iyaziwa ngokubanzi ngenxa yeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli bomhlaza kunye nabo basengozini yofuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweChitrak kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Chitrak inokuzuza abo bane-Primary Uterine Undifferentiated Carcinoma ehamba nge-Letrozole Ngaphezu koko, ngelixa i-Chitrak inokunceda abantu abane-genetic risk factor "KIT", ayinakucetyiswa kulabo abanomngcipheko wemfuza eyahlukileyo. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kweChitrak kwisigulane somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, i-genetic makeup, ingozi yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila ibalulekile ekunqumeni ukuba i-Chitrak lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, igxininise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana neChitrak endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Chitrak ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba udle i-Chitrak ukuba une-genetic predisposition kumhlaza ohambelana ne-KIT gene? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza usuka kumfuza? Ngaba kunenzuzo ukubandakanya i-Chitrak ekudleni kwakho ukuba ufunyanwe ukuba une-Primary Uterine Undifferentiated Carcinoma? Ngaphezu koko, ukusetyenziswa kwakho kweChitrak kufuneka kuhlengahlengiswe njani ukuba ufumana unyango lweLetrozole okanye ukuba isicwangciso sakho sonyango siyatshintsha kwiLetrozole? Kubalulekile ukuqaphela ukuba iziqinisekiso ezilula ezifana 'neChitrak yendalo, ngoko ihlala iluncedo' okanye 'iChitrak inyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongezelela, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Chitrak ekudleni kwakho ukuba kukho utshintsho kwirejimeni yonyango. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana neChitrak kwisondlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele yonke imiphumo ye-biochemical yazo zonke izithako, ngokuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengePrimary Uterine Undifferentiated Carcinoma, iindlela zonyango kufuneka zenziwe ngokwezifiso ngokusekwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye nesini.

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba unobangela wemingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, njengeChitrak. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwiKIT uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwenye imfuza? Ukusuka kumbono wesondlo, ngaba umngcipheko ohambelana ne-Primary Uterine Undifferentiated Carcinoma ulingana nomnye umhlaza? Ngaphaya koko, ngaba ukuqwalaselwa kokutya kuhlala kunjalo kwabo bafumana olunye unyango njengabo bafumana iLetrozole? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Chitrak - Isongezo seSondlo

I-Chitrak eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Plumbagin, nganye ekhoyo kwiindawo ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-PI3K-AKT-MTOR Umqondiso, olawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yezinto eziphilayo, ukukhetha izongezo ezifanelekileyo ezifana neChitrak, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Chitrak yomhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweChitrak ayisosigqibo sehlabathi lonke esifanelekileyo kuwo onke ama-cancer kodwa kufuneka sibe ngumntu.

Ukukhetha izongezo zeChitrak

Ukujongana nombuzo othi 'Ndimele ndiphephe nini i-Chitrak kumxholo weCancer' ngumngeni kuba impendulo ixhomekeke kakhulu kumntu ngamnye - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukufaneleka kunye nokhuseleko okanye inzuzo yeChitrak iyahluka ngokuxhomekeka kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies yonke idlala indima ekunqumeni ukuba i-Chitrak ifanelekile okanye ifanele igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Chitrak Supplements iya kunceda i-Primary Uterine Undifferentiated Carcinoma izigulane eziphantsi koNyango lweLetrozole?

I-Primary Uterine Undifferentiated Carcinoma ichongiwe ngokuguqulwa kwemfuza ethile, njenge-KMT2C, TP53 kunye ne-NSD1, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-PI3K-AKT-MTOR Ukubonakaliswa, i-Oncogenic Histone Methylation, i-Amino Acid Metabolism, i-Cell Cycle Checkpoints, i-Apoptosis kunye ne-Chroma. Uhlengahlengiso. Ukusebenza konyango lomhlaza, njengeLetrozole, kugqitywe ngokudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Chitrak lukhetho olunengqiqo kulabo abane-Primary Uterine Undifferentiated Carcinoma ehamba nge-Letrozole. Oku kungenxa yokuba i-Chitrak inefuthe kwiindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, okunokuthi kuthintele izinto eziqhuba i-Primary Uterine Undifferentiated Carcinoma okanye inzuzo yokusebenza kweLetrozole.

2. Ngaba i-Chitrak Supplements ikhuselekile kubantu abaphilileyo kunye ne-KIT Mutation eNxulunyaniswe ne-Genetic Risk?

I-KIT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-KIT kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kubandakanywa i-PI3K-AKT-MTOR Ukubonakaliswa kunye ne-Growth Factor Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-KIT ehambelana noMhlaza weGastric, cinga ukufaka izongezo zeChitrak kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-KIT kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana neChitrak, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• Ukoyisa ukuchasana okufunyenweyo kwi-letrozole ngokujolisa kwi-PI3K / AKT / mTOR indlela kwiiseli zomhlaza webele.
• I-Plumbagin Yandisa Ukufa kwe-Paclitaxel-Induced Cell kunye nokuNyisa i-Paclitaxel Resistance kwi-Breast Cancer Cells ngokusebenzisa i-ERK-Mediated Apoptosis Induction.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• cBioPortal for Cancer Genomics