Ngowuphi umhlaza onokuzuza ngokubandakanya iBeta-carotene ekutyeni kwabo?

Iimbalasane

I-Beta-carotene yaziwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweBeta-carotene kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Beta-carotene inokuba luncedo kwabo baneNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ehamba neCisplatin, kodwa isenokungabi kuhle kwizigulana ezifumana iRadiation yePrimary Well Differentiated Liposarcoma. Ngaphaya koko, ngelixa i-Beta-carotene inokunceda abantu abanomngcipheko wemfuza "TERT", ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo "ALK". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Beta-carotene kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba iBeta-carotene lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela ebanzi ekukhetheni ukutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / izongezo ezifana neBeta-carotene endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Beta-carotene kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iBeta-carotene ukuba unemfuzo enokuthanani nomhlaza onxulumene nejini ye-TERT? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ALK gene? Ngaba kuluncedo ukubandakanya iBeta-carotene kwisidlo sakho ukuba ufunyaniswe unePrimary Well Differentiated Liposarcoma, okanye ukuba uxilongo lwakho yiNtloko yeNtloko kunye neNeck Squamous Cell Carcinoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kweBeta-carotene ukuba ufumana unyango lweCisplatin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka eCisplatin siye kwiRadiation? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'ne-Beta-carotene yendalo, ngoko isoloko iluncedo' okanye 'i-Beta-carotene yomeleza ukhuselo lomzimba' ayonelanga ekukhetheni ukutya/yezongezo.

Ukongeza, kubalulekile ukuba uphinde uvavanye ukufaneleka kokuquka i-Beta-carotene kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Beta-carotene kwisidlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions, kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye lungabikho. Nje ukuba kufunyaniswe ukuba unohlobo oluthile lomhlaza, njengeNtloko eyiNtloko kunye neNtamo ye-Squamous Cell Carcinoma okanye i-Primary Well Differentiated Liposarcoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye . isini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana neBeta-carotene. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-TERT uneempembelelo zendlela yebhayomichi efanayo njengotshintsho kwi-ALK? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana neNtloko yePrayimari kunye neNeck Squamous Cell Carcinoma ilingana nePrimary Well Differentiated Liposarcoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bakwiRadiation njengakwabo bafumana iCisplatin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Beta-carotene-Isongezelelo seSondlo

I-Beta-carotene eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Beta-carotene, nganye ekhoyo kwiimpawu ezahlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa ukulungiswa kwe-DNA, i-PI3K-AKT-MTOR Ukubonakaliswa, ukubonakaliswa kwe-MAPK kunye ne-Angiogenesis, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njengeBeta-carotene, iyodwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iBeta-carotene kumhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweBeta-carotene ayisosigqibo sehlabathi lonke esilungele zonke iimhlaza kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeBeta-carotene

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Beta-carotene kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo zeBeta-carotene ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies, zonke zidlala indima ekunqumeni ukuba i-beta-carotene ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka kobuntu. ukuqwalaselwa kwizigqibo ezinjalo.

1. Ngaba izongezo ze-Beta-carotene ziya kuxhamla kwiZigulana ze-Liposarcoma eziHlelekileyo eziphantsi koNyango lweRadiation?

I-Primary Well Differentiated Liposarcoma ibonakaliswe ngokuguqulwa kofuzo oluthile, oko kukuthi i-FGFR1, i-COL1A1 kunye ne-ZFHX3, ekhokelela ekuguquleni kwiindlela ze-biochemical pathways, ngokukodwa i-PI3K-AKT-MTOR Ukubonakaliswa, i-Angiogenesis, i-MAPK Ukubonakaliswa, i-Extracellular Matrix Remodeling kunye ne-Epithelial Translation to Mesen. Ukusebenza konyango lomhlaza, okufana neRadiation, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, i-Beta-carotene isongezelelo, echaphazela i-PI3K-AKT-MTOR Ukubonakaliswa, ingabi yinto efanelekileyo kwimeko ye-Primary Well Differentiated Liposarcoma xa ihamba ngeRadiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Beta-carotene Supplements iya kunceda i-Primary Head and Neck Squamous Cell Carcinoma Izigulana eziphantsi koNyango lweCisplatin?

Intloko eyiNtloko kunye neNeck Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-FRG1BP, TP53 kunye ne-PCDH11X, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-DNA Repair, i-Cell Cycle Checkpoints kunye ne-Apoptosis. Ukusebenza konyango lomhlaza, njengeCisplatin, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Beta-carotene lukhetho olunengqiqo kulabo abaneNtloko ePhambili kunye neNeck Squamous Cell Carcinoma ehamba neCisplatin. Oku kungenxa yokuba i-Beta-carotene ichaphazela iindlela ezifana nokulungiswa kwe-DNA, enokuthi inqanda izinto eziqhuba iNtloko ePhambili kunye neNeck Squamous Cell Carcinoma okanye izuze ukusebenza kweCisplatin.

3. Ngaba izongezo ze-Beta-carotene zikhuselekile kubantu abasempilweni abane-ALK Mutation eNxulunyaniswe noMngcipheko weGenetic?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ALK gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ALK gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-MAPK Ukubonakaliswa kunye ne-Growth Factor Signaling, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga utshintsho kwi-ALK ehambelana nomngcipheko owongeziweyo weSistim yeNervous Ephakathi, ingqiqo yenzululwazi icebisa ukuphepha ukusetyenziswa kwe-Beta-carotene. Oku kungenxa yokuba ukongeza i-Beta-carotene inefuthe kwiindlela ezifana ne-MAPK Ukubonakaliswa, oku kunokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ALK kunye neemeko zomhlaza ezinxulumene nazo.

4. Ingaba izongezo ze-Beta-carotene zikhuselekile kubantu abasempilweni abane-TERT Mutation eManyaniswa neMngcipheko yeGenetic?

I-TERT idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Utshintsho kwi-TERT lunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kubandakanya i-Angiogenesis kunye nokulungiswa kwe-DNA, echaphazela ukukhula komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-TERT ehambelana noMhlaza we-Hematological, cinga ngokubandakanya izongezo ze-Beta-carotene kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-Angiogenesis, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanotshintsho lwe-TERT kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana ne-Beta-carotene kwiinzuzo zayo, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-β-carotene Ivimbela Ukubonakaliswa kwe-c-Myc kunye ne-Cyclin E kwi-Helicobacter pylori-infected Gastric Epithelial Cells.
• Ukukhula okukhuthazwayo kweeseli ze-pulmonary adenocarcinoma yabantu kunye neeseli ezincinci ze-epithelial zomoya nge-beta-carotene ngokusebenza kwe-cAMP, i-PKA, i-CREB kunye ne-ERK1/2.
• I-PI3-K/AKT-indlela kunye neendlela zokumelana nemitha kumhlaza wemiphunga weseli engeyincinci.
• cBioPortal for Cancer Genomics
• Iziphene kwi-DNA yokuLungisa iiGenes Predict Response kwi-Neoadjuvant Cisplatin-based Chemotherapy kwi-Muscle-invasive Bladder Cancer.
• Uhlalutyo lwe-pan-cancer lwe-genomes epheleleyo.
• Umphumo wePasteurella haemolytica cytotoxin kwi-bovine polymorphonuclear leukocytes inokuthotywa ngabachasi be-beta-adrenoceptor.
• cBioPortal for Cancer Genomics
• I-β-Carotene inqanda i-neuroblastoma cell invasion kunye ne-metastasis in vitro kunye ne-vivo ngokunciphisa izinga le-hypoxia-inducible factor-1α.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.