Ngowuphi umhlaza onokuzuza ngokubandakanya iAtractylode ekutyeni kwabo?

Iimbalasane

I-Atractylode yaziwa ngokubanzi ngeenzuzo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kweAtractylode kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, i-Atractylode inokuzuza abo bane-Primary Esophageal Neuroendocrine Tumor ehamba neRadiation, kodwa isenokungabi kuhle kwizigulana ezifumana iRadiation yePrimary Urethral Squamous Cell Carcinoma. Ngaphezu koko, ngelixa i-Atractylode inokunceda abantu abane-genetic risk factor "KMT2D", ayinakucetyiswa kwabo banomngcipheko ohlukileyo wemfuza "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Atractylode yesigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekuthatheni isigqibo sokuba iAtractylode lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana ne-Atractylode endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise iAtractylode kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye iAtractylode ukuba unemfuza enokuthanani nomhlaza onxulumene nejini ye-KMT2D? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kunenzuzo ukubandakanya i-Atractylode kwisidlo sakho ukuba ufunyanwe une-Primary Urethral Squamous Cell Carcinoma, okanye ukuba ukuxilongwa kwakho yi-Primary Esophageal Neuroendocrine Tumor? Ngaphezu koko, kufuneka ulungelelaniswe njani ukusetyenziswa kwakho kweAtractylode ukuba ufumana unyango lweRadiation okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwiRadiation ukuya kwiRadiation? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'neAtractylode yendalo, ngoko ke isoloko iluncedo' okanye 'iAtractylode ibomeleza ukhuselo lomzimba' ayonelanga ekukhetheni ukutya/yezongezo.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Atractylode kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Atractylode kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njenge-Primary Esophageal Neuroendocrine Tumor okanye i-Primary Urethral Squamous Cell Carcinoma, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, isigaba sesifo, kunye nezinto ezifana nobudala kunye nesini. ”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kuchaphazeleka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana ne-Atractylode. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-KMT2D unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ASXL1? Ukusuka kumbono wesondlo, ngaba umngcipheko ohambelana ne-Primary Esophageal Neuroendocrine Tumor ilingana nePrimary Urethral Squamous Cell Carcinoma? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo bakwiRadiation njengakwabo bafumana iRadiation? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Atractylode-Isongezelelo seSondlo

I-Atractylode eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, ezibandakanya i-Syringin, i-Stigmasterol, i-Scopoletin, i-Protocatechuic Acid kunye ne-Palmitic Acid, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngakumbi i-MYC Signaling, DNA Repair, i-mRNA Splicing kunye ne-RAS-RAF Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwethumba, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwempembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njenge-Atractylode, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa iAtractylode yomhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kweAtractylode ayisosigqibo sehlabathi lonke esilungele zonke iicancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo zeAtractylode

Ukuphendula umbuzo othi 'Ndingayiphepha nini i-Atractylode kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukufaneleka kunye nokhuseleko okanye izibonelelo ze-Atractylode ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba, zonke zidlala indima ekunqumeni ukuba i-Atractylode ifanelekile okanye kufuneka igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Atractylode Supplements iya kuxhamla kwi-Primary Urethral Squamous Cell Carcinoma izigulane eziphantsi konyango lweRadiation?

I-Primary Urethral Squamous Cell Carcinoma ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-BLM, i-BRCA1 kunye ne-CTCF, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Androgen Signaling kunye ne-DNA Repair. Ukusebenza konyango lomhlaza, njengeRadiation, kuxhomekeke kwindlela yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Atractylode, esichaphazela ukulungiswa kwe-DNA, ayinakuba lukhetho olufanelekileyo kwimeko ye-Primary Urethral Squamous Cell Carcinoma xa i-Radiation. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Atractylode Supplements iya kunceda i-Primary Esophageal Neuroendocrine Tumor Patients eziphantsi koNyango lweRadiation?

I-Primary Esophageal Neuroendocrine Tumor ichongiwe ngokuguqulwa kwemfuza ethile, njenge-TP53, i-RB1 kunye ne-APEX1, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-MYC Signaling, i-Cell Cycle Checkpoints, i-Apoptosis kunye nokulungiswa kwe-DNA. Ukusebenza konyango lomhlaza, okufana neRadiation, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Atractylode lukhetho olunengqiqo kulabo abane-Primary Esophageal Neuroendocrine Tumor ehamba ngeRadiation. Oku kungenxa yokuba i-Atractylode inefuthe kwiindlela ezifana ne-MYC Signaling, enokuthi ithintele izinto eziqhuba i-Primary Esophageal Neuroendocrine Tumor okanye izuze ukusebenza kweRadiation.

3. Ngaba izongezo ze-Atractylode zikhuselekile kubantu abasempilweni abane-ASXL1 yoGuquko oluNxulumene neMngcipheko yemfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-mRNA Splicing, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-Atractylode yokuncedisa. Oku kungenxa yokuba ukongeza i-Atractylode inefuthe kwiindlela ezifana ne-mRNA Splicing, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ASXL1 kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo ze-Atractylode zikhuselekile kubantu abasempilweni abane-KMT2D yoGuquko oluNxulunyaniswe neMngcipheko yeMfuzo?

I-KMT2D idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-KMT2D kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-RAS-RAF Signaling kunye ne-Oncogenic Histone Methylation, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-KMT2D ehambelana ne-Bladder Urothelial Carcinoma, cinga ukufaka izongezo ze-Atractylode kwisicwangciso sakho sesondlo. Ezi zongezo zinokuphembelela ngendlela eyiyo iindlela ezifana ne-RAS-RAF Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abaneenguqu ze-KMT2D kunye neenkxalabo zempilo ezinxulumeneyo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezo ezifana ne-Atractylode, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• I-redox-resistant sirtuin-1 mutant ikhusela kwi-hepatic metabolic kunye noxinzelelo lwe-oxidant.
• cBioPortal for Cancer Genomics
• I-lipidomics esebenzayo: I-Palmitic acid iphazamisa uphuhliso lwe-hepatocellular carcinoma ngokumodareyitha ulwelo lwe-membrane kunye ne-glucose metabolism.
• cBioPortal for Cancer Genomics
• Impembelelo ye-oncogenic K-RAS kwi-YB-1 phosphorylation eyenziwa yi-ionizing radiation.
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• Inkcazo ye-BRCA1 ibuyisela ukuxhathisa kwimitha kwi-BRCA1-eneeseli zomhlaza ezineziphene ngokuphucula ukulungiswa kwe-DNA eshicilelweyo.