Ngowuphi umhlaza onokuzuza ngokuquka uAshitaba kwisidlo sabo?

Iimbalasane

I-Ashitaba yaziwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuzo. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kwe-Ashitaba kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezifana nesalathiso somhlaza, ichemotherapy, olunye unyango, kunye nemfuzo yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Umzekelo, i-Ashitaba inokuba luncedo kwabo bane-Primary Penile Squamous Cell Carcinoma ephantsi kwe-Mitomycin, kodwa isenokungabi ilungile kwizigulana ezifumana i-Letrozole ye-Primary Paget isifo sebele. Ngaphaya koko, ngelixa u-Ashitaba enokunceda abantu abanobungozi kwimfuza yemfuza “ALK”, ayinakucetyiswa kwabo banomngcipheko wofuzo owahlukileyo “ATM”. Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kwe-Ashitaba kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, imingcipheko yemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba i-Ashitaba lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo ekutyeni / nezongezo ezifana ne-Ashitaba endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo ophakamayo: Ngaba kufuneka udibanise i-Ashitaba kwisidlo sakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba utye i-Ashitaba ukuba unemfuza enokuthanani nomhlaza onxulumene nofuzo lwe-ALK? Kuthekani ukuba endaweni yoko umngcipheko wakho wemfuza uvela kwijene ye-ATM? Ngaba kunenzuzo ukuquka i-Ashitaba ekutyeni kwakho ukuba ufunyaniswe unesifo se-Primary Paget yebele, okanye ukuba uxilongo lwakho yiPrimary Penile Squamous Cell Carcinoma? Ngaphezu koko, indlela oyisebenzisa ngayo i-Ashitaba kufuneka ilungelelaniswe njani ukuba ufumana unyango lwe-Mitomycin okanye ukuba isicwangciso sakho sonyango siyatshintsha sisuka kwi-Mitomycin siye kwi-Letrozole? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'ne-Ashitaba yendalo, ngoko ke isoloko iluncedo' okanye 'i-Ashitaba inyusa ukhuselo lomzimba' ayonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya i-Ashitaba kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango lwakho. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Ashitaba kwisondlo sakho ngezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, uqwalasele izinto ezifana nohlobo lomhlaza, unyango oluthile olwenzayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njengePrayimari yePenile Squamous Cell Carcinoma okanye isifo sePrayimari sePaget yebele, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, inqanaba lesi sifo, kunye nezinto ezifana nobudala kunye . isini.”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kubandakanyeka kwimingcipheko yemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana no-Ashitaba. Ngaba umngcipheko wemfuzo womhlaza osuka kutshintsho kwi-ALK uneempembelelo zendlela yebhayoloji efanayo njengotshintsho kwi-ATM? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Penile Squamous Cell Carcinoma ulingana nesifo sePrayimari sePaget yebele? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweLetrozole njengakwabo bafumana iMitomycin? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

I-Ashitaba – Isongezelelo seSondlo

I-Ashitaba eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Isobavachalcone, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa i-Lipid Metabolism, i-PI3K-AKT-MTOR Ukusayinwa kunye ne-MAPK Signaling, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwale mpembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo njenge-Ashitaba, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Ashitaba yomhlaza, kubalulekile ukuqwalasela ezi zinto zahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Ashitaba ayisosigqibo sehlabathi lonke esifanelekileyo kuwo onke ama-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha izongezo ze-Ashitaba

Ukuphendula umbuzo othi 'Ndingamphepha nini u-Ashitaba kwimeko yoMhlaza' kulucelomngeni kuba impendulo yeyomntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulana ngasinye, ukubaluleka kunye nokhuseleko okanye iinzuzo ze-Ashitaba ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, indlela yokuphila, i-BMI, kunye naluphi na uhlobo oluthile lwe-allergies ludlala indima ekunqumeni ukuba i-Ashitaba ifanelekile okanye ifanele igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Ashitaba Supplements ingasizuzisa isifo se-Primary Paget seZigulana zamabele eziphantsi konyango lwe-Letrozole?

Isifo se-Primary Paget yebele sibonakaliswe ngokuguqulwa kofuzo oluthile, oko kukuthi, i-TTN, i-MUC22 kunye ne-CCDC168, ekhokelela ekuguqulweni kwiindlela ze-biochemical, ngokukodwa i-PI3K-AKT-MTOR Umqondiso. Ukusebenza konyango lomhlaza, njengeLetrozole, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Ashitaba, esichaphazela i-PI3K-AKT-MTOR Signaling, ayinakuba yinto efanelekileyo yokukhetha kwimeko ye-Primary Paget isifo sesifuba xa i-Letrozole. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ingaba izongezo ze-Ashitaba ziya kuxhamla kwiZigulana eziphantsi koNyango lwe-Mitomycin?

I-Primary Penile Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, njenge-ABRAXAS1, i-PIK3CB kunye ne-NUP93, ebangela utshintsho kwiindlela ze-biochemical pathways, ngokukodwa i-Lipid Metabolism, i-Hematopoiesis kunye ne-Inositol Phosphate Signaling. Ukusebenza konyango lomhlaza, njengeMitomycin, kumiselwa kukudibana kwayo nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Ashitaba lukhetho olunengqiqo kulabo abanePrayimari yePenile Squamous Cell Carcinoma ehamba neMitomycin. Oku kungenxa yokuba i-Ashitaba inefuthe kwiindlela ezifana ne-Lipid Metabolism, enokuthi ithintele izinto eziqhuba i-Primary Penile Squamous Cell Carcinoma okanye izuze ukusebenza kweMitomycin.

3. Ingaba izongezo ze-Ashitaba zikhuselekile kubantu abasempilweni abane-ATM yoGuquko oluNxulumene neMngcipheko yemfuzo?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. Ufuzo lwe-ATM luqhele ukubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwi-gene ye-ATM kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa kunye nokulungiswa kweDNA, ezibandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yofuzo ichonga ukuguqulwa kwe-ATM ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi icebisa ukuphepha ukusetyenziswa kwe-Ashitaba. Oku kungenxa yokuba ukongeza i-Ashitaba ichaphazela iindlela ezifana ne-PI3K-AKT-MTOR Ukubonakaliswa, okunokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ATM kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba izongezo ze-Ashitaba zikhuselekile kubantu abasempilweni abane-ALK Mutation eNxulunyaniswe neMngcipheko yeGenetic?

I-ALK idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ALK kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, kuquka i-MAPK Signaling kunye ne-Growth Factor Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ALK ehambelana neSistim yeNervous ePhakathi, cinga ukufaka izongezo ze-Ashitaba kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-MAPK Signaling, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ALK kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana ne-Ashitaba, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• Umsebenzi wokuchasana nokudumba kunye ne-anticholinesterase ye-flavonoids ezintandathu ezizimeleyo kwiintlobo ze-Polygonum kunye ne-Dorstenia.
• Unyango lomhlaza lubumba ubume bokuqina be-clonal hematopoiesis.
• I-Isobavachalcone eyodwa kwi-Psoralea corylifolia inqanda ukwanda kweeseli kwaye yenza i-apoptosis ngokuvimbela indlela ye-AKT / GSK-3β / β-catenin kwiiseli zomhlaza we-colorectal.
• I-Isobavachalcone isebenzisa i-anti-proliferative kunye ne-pro-apoptotic iziphumo kwiiseli zomhlaza wesibindi somntu ngokujolisa kwindlela yokubonisa i-ERKs/RSK2.
• Yima kwisigaba somhlaza kwisigaba se-Ib sophando lwe-pan-phosphoinositide-3-kinase inhibitor buparlisib ene-letrozole kwi-estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer.
• [I-Cyclooxygenase-2 ibonakaliso kwiiseli zomhlaza we-esophageal kunye nokufakwa kwe-mitomycin C].