Ngowuphi umhlaza onokuzuza ngokubandakanya u-Angelica ekutyeni kwabo?

Iimbalasane

I-Angelica yamkelwa ngokubanzi ngezibonelelo zayo zempilo kwaye isetyenziswa rhoqo ngabaguli abanomhlaza kunye nabo basengozini yemfuza. Nangona kunjalo, ukhuseleko kunye nokusebenza kakuhle kwe-Angelica kwizigulana ezinomhlaza kuxhomekeke kwizinto ezininzi ezinjengomhlaza, ichemotherapy, olunye unyango, kunye nemfuza yethumba. Ukwazi ukuba ezinye ukutya kunye nezongezelelo, ezinje ngegrapefruit kunye nesipinatshi, zinokusebenzisana kakubi namayeza omhlaza kwaye zibangele ukusabela okubi kubalulekile.

Ukutya kubaluleke kakhulu kunyango lomhlaza njengoko kunokuchaphazela iziphumo zonyango. Izigulana ezinomhlaza kufuneka zikhethe ngononophelo kwaye zifake ukutya okufanelekileyo kunye nezongezo kwizidlo zabo. Ngokomzekelo, u-Angelica unokuzuza abo bane-Primary Urethral Squamous Cell Carcinoma ehamba neRadiation, kodwa kusenokungabi kuhle kwizigulane ezifumana i-Docetaxel ye-Primary Cervical Neuroendocrine Tumor. Ngapha koko, ngelixa u-Angelica enokunceda abantu abane-genetic risk factor "ERBB2", ayinakucetyiswa kwabo banomngcipheko ohlukileyo wemfuza "ASXL1". Ukwenza izicwangciso zokutya ezisekelwe kwimpilo, unyango, kunye nofuzo kubalulekile.

Ukuqonda ukuba ukwenza isigqibo malunga nokufaneleka kuka-Angelica kwisigulana somhlaza kufuneka sibe ngumntu ngamnye kubalulekile. Izinto ezibalulekileyo ezifana nohlobo lomhlaza, iindlela zonyango, ukwakheka kwemfuzo, umngcipheko wemfuza, ubudala, ubunzima bomzimba, kunye nendlela yokuphila zibalulekile ekwenzeni isigqibo sokuba i-Angelica lukhetho olufanelekileyo. I-Genomics kunye ne-genomics, ngokukodwa, yingqwalasela ebalulekileyo. Kuba ezi zinto zinokuvela, kubalulekile ukuphonononga rhoqo kwaye ulungelelanise ukhetho lokutya ukuhambelana notshintsho kwisimo sempilo kunye nonyango.

Ukuqukumbela, indlela epheleleyo yokhetho lokutya ibalulekile, ijolise kwiziphumo ezipheleleyo zazo zonke izinto ezisebenzayo kukutya / izongezo ezifana ne-Angelica endaweni yokuvavanya isithako ngasinye esisebenzayo ngokwahlukileyo okanye ukungayinaki ngokupheleleyo. Lo mbono ubanzi ukhuthaza indlela enengqiqo nenzululwazi kwisicwangciso sokutya somhlaza.

Uluhlu olufutshane

Ukusetyenziswa kokutya okusekelwe kwizityalo kunye nezongezelelo, ezinje ngeevithamini, imifuno, iiminerali, iiprobiotics, kunye nezongezelelo ezahlukeneyo ezikhethekileyo, ziyenyuka phakathi kwabaguli abanomhlaza. Ezi zongezo ziyilelwe ukuhambisa ugxininiso oluphezulu lwezithako ezithile ezisebenzayo, uninzi lwazo zikwakukutya okwahlukeneyo. Ugxininiso kunye nokwahlukana kwezithako ezisebenzayo ziyahluka phakathi kokutya okupheleleyo kunye nezongezelelo. Ukutya ngokuqhelekileyo kunika uluhlu lwezithako ezisebenzayo kodwa kwiindawo ezisezantsi, ngelixa izongezelelo zibonelela ngoxinzelelo oluphezulu lwezithako ezithile.

Ukuthathela ingqalelo imisebenzi eyahlukeneyo yesayensi kunye neyebhayoloji yesithako ngasinye esisebenzayo kwinqanaba leemolekyuli, kubalulekile ukunika ingxelo ngeziphumo ezidityanisiweyo zala malungu xa uthatha isigqibo malunga nokutya kunye nezongezo eziza kutyiwa okanye hayi.

Umbuzo obalulekileyo uvela: Ngaba kufuneka udibanise i-Angelica ekudleni kwakho njengento yokutya okanye isongezelelo? Ngaba kuyacetyiswa ukuba udle u-Angelica ukuba unesifo sofuzo kumhlaza ohambelana ne-ERBB2 gene? Kuthekani ukuba endaweni yoko ingozi yakho yemfuza ivela kwi-ASXL1 gene? Ngaba kunenzuzo ukubandakanya u-Angelica ekutyeni kwakho ukuba ufunyanwe une-Primary Cervical Neuroendocrine Tumor, okanye ukuba ukuxilongwa kwakho yi-Primary Urethral Squamous Cell Carcinoma? Ngaphezu koko, kufuneka kuhlengahlengiswe njani ukusetyenziswa kwakho kwe-Angelica ukuba ufumana unyango lweRadiation okanye ukuba isicwangciso sakho sonyango siyatshintsha ukusuka kwiRadiation ukuya kwiDocetaxel? Kubalulekile ukuqonda ukuba iinkcazo ezilula ezifana 'ne-Angelica yendalo, ngoko isoloko iluncedo' okanye 'i-Angelica inyusa ukhuselo lomzimba' akonelanga kukhetho lokutya / lokongezelela.

Ukongeza, kubalulekile ukuvavanya kwakhona ukufaneleka kokubandakanya u-Angelica kwisidlo sakho ukuba kukho utshintsho kwirejimeni yonyango. Isishwankathelo, xa usenza izigqibo malunga nokubandakanya ukutya okanye izongezo ezifana ne-Angelica kwisidlo sakho ngenxa yezibonelelo zayo, kuya kufuneka uqwalasele iziphumo ze-biochemical yazo zonke izithako, ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluthile oluhambayo, i-genetic predispositions. , kunye nokukhetha indlela yokuphila.

Cancer

Umhlaza usengumceli mngeni obalulekileyo kwicandelo lezonyango, ngokufuthi ubangela unxunguphalo oluxhaphakileyo. Nangona kunjalo, ukuqhubela phambili kwamva nje kuye kwaphucula iziphumo zonyango, ngakumbi ngeendlela zonyango zomntu, iindlela zokujonga ezingaphazamisiyo kusetyenziswa igazi kunye neesampulu zamathe, kunye nophuhliso lwe-immunotherapy. Ukufunyaniswa kwangethuba kunye nokungenelela kwangethuba kuye kwaba yinto ebalulekileyo ekuphembeleleni ngokufanelekileyo iziphumo zonyango ngokubanzi.

Uvavanyo lwemfuzo lunikeza isithembiso esibalulekileyo ekuvavanyeni umngcipheko womhlaza kunye nokuba sesichengeni kwangoko. Nangona kunjalo, kubantu abaninzi abaneemeko zosapho kunye nemfuzo kumhlaza, ukhetho longenelelo lonyango, nokuba lubekwe esweni rhoqo, luhlala lulinganiselwe okanye alukho. Emva kokuba ufumene uhlobo oluthile lomhlaza, njenge-Primary Urethral Squamous Cell Carcinoma okanye i-Primary Cervical Neuroendocrine Tumor, izicwangciso zonyango kufuneka zenziwe ngokwezifiso ngokusekelwe kwi-tumor genetics yomntu, isigaba sesifo, kunye nezinto ezifana nobudala kunye nesini. ”

Emva konyango, ukubeka iliso okuqhubekayo kubalulekile ukuze kubonwe naziphi na iimpawu zokubuyela kwakhona komhlaza kunye nokwazisa izigqibo ezilandelayo. Uninzi lwezigulana ezinomhlaza kunye nabo basemngciphekweni bahlala befuna iingcebiso malunga nokubandakanya ukutya okuthile kunye nezongezo kwizidlo zabo, ezidlala indima ebalulekileyo kwinkqubo yabo yokuthatha isigqibo malunga nolawulo lwezempilo.

Umbuzo obalulekileyo ngowokuba ingaba kunokubangela umngcipheko wemfuza kunye noxilongo oluthile lomhlaza xa uthatha isigqibo malunga nokhetho lokutya, olufana no-Angelica. Ngaba umngcipheko wemfuza womhlaza ovela kuguquko kwi-ERBB2 unefuthe elifanayo le-biochemical pathway njengenguqu kwi-ASXL1? Ukusuka kwimbono yesondlo, ngaba umngcipheko ohambelana ne-Primary Urethral Squamous Cell Carcinoma ulingana nePrimary Cervical Neuroendocrine Tumor? Ngaphaya koko, ngaba uqwalaselo lokutya luhlala lufana kwabo baphantsi kweDocetaxel njengakwabo bafumana iRadiation? Ezi ngqwalasela zibalulekile ekwenzeni ukhetho lokutya olunolwazi lwabantu abaneengozi ezahlukeneyo zemfuza kunye nonyango lomhlaza.

Angelica - Isongezelelo seZondlo

I-Angelica eyongezelelweyo iquka uluhlu lwezithako ezisebenzayo, kuquka i-Quercetin, nganye ekhoyo kwiimpawu ezihlukeneyo. Ezi zithako zinefuthe kwiindlela zeemolekyuli, ngokukodwa ukulungiswa kwe-DNA, i-Cell Cycle, i-Cell Cycle Checkpoints kunye ne-Oncogenic Histone Methylation, elawula imiba ebalulekileyo yomhlaza kwinqanaba leeselula, ezifana nokukhula kwe-tumor, ukusasazeka, kunye nokufa kweeseli. Ukunikezelwa kwempembelelo yebhayoloji, ukukhetha izongezo ezifanelekileyo ezifana ne-Angelica, yedwa okanye ngokudibeneyo, iba sisigqibo esibalulekileyo kumxholo wesondlo somhlaza. Xa ucinga ukusebenzisa i-Angelica kumhlaza, kubalulekile ukuqwalasela ezi zinto ezahlukeneyo kunye neendlela. Oku kungenxa yokuba, ngokufana nonyango lomhlaza, ukusetyenziswa kwe-Angelica ayisosigqibo sehlabathi lonke esilungele zonke ii-cancer kodwa kufuneka ibe yeyomntu.

Ukukhetha iAngelica Supplements

Ukuphendula umbuzo othi 'Ndingamphepha nini u-Angelica kwimeko yoMhlaza' kulucelomngeni kuba impendulo ixhomekeke kumntu ngamnye kakhulu - ngokulula 'Kuxhomekeke!'. Ngokufana nendlela naluphi na unyango lomhlaza olunokuthi lungasebenzi kwisigulane ngasinye, ukufaneleka kunye nokhuseleko okanye iinzuzo ze-Angelica ziyahluka ngokuxhomekeke kwiimeko zomntu. Izinto ezifana nohlobo oluthile lomhlaza, i-genetic predispositions, unyango lwangoku, ezinye izongezo ezithathwayo, iindlela zokuphila, i-BMI, kunye naluphi na uhlobo oluthile lomzimba wonke ludlala indima ekunqumeni ukuba i-Angelica ifanelekile okanye ifanele igwenywe, igxininisa ukubaluleka koqwalaselo lomntu izigqibo ezinjalo.

1. Ngaba i-Angelica Supplements iya kuzuza i-Primary Cervical Neuroendocrine Tumor Patients eziphantsi konyango lwe-Docetaxel?

I-Primary Cervical Neuroendocrine Tumor ibonakaliswe ngokuguqulwa kofuzo oluthile, okuyi-ABHD6, STOX1 kunye ne-PDZD4, ekhokelela ekuguquleni kwiindlela ze-biochemical, ngokukodwa i-Cell Cycle. Ukusebenza konyango lomhlaza, njenge-Docetaxel, kuxhomekeke kwindlela yayo yokusebenza kwezi ndlela zikhethekileyo. Esona sicwangciso sifanelekileyo siquka ukulungelelanisa isenzo sonyango kunye neendlela eziqhuba umhlaza, ngaloo ndlela kuqinisekiswa indlela yobuqu nesebenzayo. Kwiimeko ezinjalo, ukuphepha ukutya okanye izongezo zesondlo ezinokuchasa iziphumo zonyango okanye ukunciphisa olu lungelelwaniso kubalulekile. Ngokomzekelo, isongezelelo se-Angelica, esichaphazela i-Cell Cycle, ayinakuba lukhetho olufanelekileyo kwimeko ye-Primary Cervical Neuroendocrine Tumor xa i-Docetaxel. Oku kungenxa yokuba isenokuthi iqhubele phambili ngakumbi isifo okanye iphazamise ukusebenza konyango. Xa ukhetha isicwangciso sesondlo, kubalulekile ukuqwalasela izinto ezifana nohlobo lomhlaza, unyango oluqhubekayo, ubudala, isini, i-BMI, indlela yokuphila, kunye naluphi na utshintsho olwaziwayo lwemfuzo.

2. Ngaba i-Angelica Supplements iya kuxhamla kwi-Primary Urethral Squamous Cell Carcinoma izigulane eziphantsi koNyango lweRadiation?

I-Primary Urethral Squamous Cell Carcinoma ichongiwe ngokuguqulwa kofuzo oluthile, olufana ne-BLM, i-BRCA1 kunye ne-CTCF, ebangela utshintsho kwiindlela ze-biochemical, ngokukodwa i-Androgen Signaling kunye ne-DNA Repair. Ukusebenza konyango lomhlaza, okufana neRadiation, kumiselwa yintsebenziswano nezi ndlela. Injongo kukuqinisekisa ukuba unyango luhambelana kakuhle neendlela eziqhuba umhlaza, okwenza kube nendlela yonyango lomntu. Kulo mxholo, ukutya okanye izongezo ezihambelana nonyango okanye ukuphucula oku kulungelelaniswa kufuneka kuthathelwe ingqalelo. Ngokomzekelo, isongezelelo se-Angelica lukhetho olunengqiqo kulabo abane-Primary Urethral Squamous Cell Carcinoma ehamba neRadiation. Oku kungenxa yokuba i-Angelica inefuthe kwiindlela ezifana nokulungiswa kwe-DNA, enokuthi ithintele izinto eziqhuba i-Primary Urethral Squamous Cell Carcinoma okanye izuze ukusebenza kweRadiation.

3. Ngaba iAngelica Supplements ikhuselekile kubantu abasempilweni abane-ASXL1 Mutation Associated Genetic Risk?

Iinkampani ezahlukeneyo zibonelela ngeephaneli zemfuza zokuvavanya umngcipheko wemfuza weentlobo ezahlukeneyo zomhlaza. Ezi panels ziquka imizila yemfuza enxulunyaniswa nebele, i-ovarian, i-uterine, i-prostate, kunye nomhlaza wesisu. Ukuvavanya ezi genes kunokuqinisekisa ukuxilongwa kunye nokwazisa unyango kunye nezicwangciso zokulawula. Ukuchonga umahluko obangela isifo kunokuncedisa ngakumbi ekuvavanyeni nasekuxilongweni kwezalamane ezinokuba sengozini. I-ASXL1 gene idla ngokubandakanywa kwezi panels zovavanyo lomngcipheko womhlaza.

Ukuguqulwa kwe-ASXL1 gene kuchaphazela iindlela ze-biochemical okanye iinkqubo, ezifana ne-Cell Cycle Checkpoints, i-Oncogenic Cancer Epigenetics kunye ne-Suppressive Histone Methylation, ebandakanyeka ngokuthe ngqo okanye ngokungathanga ngqo ekuqhubeni umhlaza kwinqanaba le-molecular. Xa iphaneli yezofuzo ichaza ukuguqulwa kwe-ASXL1 ehambelana nomngcipheko okhulayo we-Chronic Myelomonocytic Leukemia, ingqiqo yesayensi ibonisa ukuphepha ukusetyenziswa kwe-Angelica yokuncedisa. Oku kungenxa yokuba ukongeza i-Angelica inefuthe kwiindlela ezifana ne-Cell Cycle Checkpoints, enokukhokelela kwimiphumo emibi kumxholo wenguqu ye-ASXL1 kunye neemeko zomhlaza ezinxulumene nazo.

4. Ngaba i-Angelica Supplements ikhuselekile kubantu abasempilweni abane-ERBB2 Mutation Associated Genetic Risk?

I-ERBB2 idlala indima ebalulekileyo kuvavanyo lomngcipheko womhlaza. Ukuguqulwa kwe-ERBB2 kunokuphazamisa iindlela ezibalulekileyo ze-biochemical, ezibandakanya i-Oncogenic Histone Methylation, i-Growth Factor Signaling kunye ne-PI3K-AKT-MTOR Signaling, echaphazela ukuphuhliswa komhlaza. Ukuba iphaneli yakho yemfuza ityhila utshintsho kwi-ERBB2 ehambelana ne-Esophageal Adenocarcinoma, cinga ukufaka i-Angelica izongezo kwisicwangciso sakho sesondlo. Ezi zongezelelo zinokuphembelela ngokufanelekileyo iindlela ezifana ne-Oncogenic Histone Methylation, inzuzo ngokubonelela ngenkxaso efanelekileyo kubantu abanokuguqulwa kwe-ERBB2 kunye neenkxalabo zempilo ezinxulumene nazo.

Ukuququmbela

Ezona zinto zimbini zibalulekileyo ekufuneka uzikhumbule kukuba unyango lomhlaza kunye nesondlo azinakuze zifane kumntu wonke. Isondlo, kuquka ukutya kunye nezongezelelo ezifana ne-Angelica, sisixhobo esisebenzayo esinokulawulwa nguwe ngelixa ujongene nomhlaza.

"Ndingatya ntoni?" ngowona mbuzo udla ngokubuzwa ngabaguli abanomhlaza kunye nabo basemngciphekweni womhlaza. Impendulo echanekileyo kukuba ixhomekeke kwizinto ezifana nohlobo lomhlaza, imfuzo yethumba, unyango lwangoku, ukungezwani komzimba, indlela yokuphila, kunye ne-BMI.

Fumana isondlo sakho somhlaza kwi-addon ngokucofa ikhonkco elingezantsi kwaye uphendule imibuzo malunga nohlobo lomhlaza wakho, unyango, indlela yokuphila, i-allergies, ubudala, kunye nesini.

Ucaphulo

• cBioPortal for Cancer Genomics
• Imbonakalo yomhlaba eguqukayo yomhlaza we-metastatic ityhilwe kulandelelwano lwezonyango olulindelekileyo lwezigulana ezili-10,000.
• cBioPortal for Cancer Genomics
• I-genomics yeklinikhi edibeneyo yomhlaza we-metastatic.
• [Uqulunqo olusisiseko lwemisebenzi yemfundo eyodwa ekubuyiseleni kwisimo sangaphambili sabakhubazekileyo ngokwasemzimbeni].
• Ubume beCrystal bomntu oxhomekeke kwi-cyclin-kinase 6 ene-flavonol inhibitor, i-fisetin.
• I-Paclitaxel inqanda ukuqhubela phambili kweeseli ze-mitotic ukuya kwisigaba se-G1 ngokuphazamiseka kokubunjwa kwe-spindle ngaphandle kokuchaphazela eminye imisebenzi ye-microtubule ngexesha le-anaphase kunye ne-telephase.
• Indlela ye-Pharmacoinformatics yokuchongwa kwe-Polo-like kinase-1 inhibitors ukusuka kwimithombo yendalo njengama-anti-cancer agents.
• Inkcazo ye-BRCA1 ibuyisela ukuxhathisa kwimitha kwi-BRCA1-eneeseli zomhlaza ezineziphene ngokuphucula ukulungiswa kwe-DNA eshicilelweyo.